KR910021398A - 트리아졸 항진균제 - Google Patents
트리아졸 항진균제 Download PDFInfo
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- KR910021398A KR910021398A KR1019910001613A KR910001613A KR910021398A KR 910021398 A KR910021398 A KR 910021398A KR 1019910001613 A KR1019910001613 A KR 1019910001613A KR 910001613 A KR910001613 A KR 910001613A KR 910021398 A KR910021398 A KR 910021398A
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- South Korea
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- compound
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- pharmaceutically acceptable
- alkyl
- acceptable salt
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/30—Halogen atoms or nitro radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/61—Halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (24)
- 일반식(I)의 화합물 또는 약제학적으로 허용되는 이의 염.상기식에서 R은 할로, -CF3및 -OCF3중에서 각각 독립적으로 선택된 치환체 1내지 3개에 의해 치환된 페닐이고 ; R1은 (C1내지 C4)알킬이며 ; R2는 H또는 (C1내지 C4)알킬이고 ; X는 CH 또는 N이며 ;Y는 F 또는 Cl이다.
- 제1항에 있어서, R이 1 또는 2개의 할로 치환체에 의해 치환된 페닐인 화합물.
- 제2항에 있어서, R이 플루오로 및 클로로중에서 각각 독립 적으로 선택된 치환체 1또는 2개에 의해 치환된 페닐인 화합물.
- 제3항에 있어서, R이 2-플루오로페닐, 4-플루오로페닐, 2, 4-디플루오로페닐, 2-클로로페닐 또는 2, 4-디클로로페닐인화합물.
- 제4항에 있어서, R이 2-플루오로페닐, 2,4-디클루오로페닐, 2-클로로페닐 또는 2,4-디클로로페닐인 화합물.
- 제1항 내지 5항중 어느 한 항에 있어서, R1이 메틸인 화합물.
- 제1항 내지 6항중 어느 한 항에 있어서, R2가 H 또는 메틸인 화합물.
- 제7항에 있어서, R2가 H인 화합물.
- 제1항 내지 8항중 어느 한 항에 있어서, X가 N인 화합물.
- 제1항 내지 9항중 어느 한 항에 있어서, Y가 F인 화합물.
- 제1항 내지 10항중 어느 한 항에 있어서, R2가 H이고, 2R, 3S-배치, 즉을 갖는 화합물.
- 2R, 3S-2(2, 4-디플루오로페닐)-3(3-플루오로피리딘-4-일)-1-(1H-1, 2, 4-트리아졸-1-일)부탄-2-올, 2R, 3S-2-(2-클로로페닐-3-(3-플루오로 피리딘-4-일)-1-(1H-1, 2, 4-트리아졸-1-일)부탄-2-올, 2R, 3S-2(2-플루오로페닐-3-(3-플루오로피리딘-4-일)-1-(1H-1, 2, 4-트리아졸-1-일)부탄-2-올, 2R, 3S-2-(2, 4-디플루오로페닐)-3-(5-플루오로피리미딘-4-일)-1-(1H-1, 2, 4-트리아졸-1-일)부탄-2-올 또는 2R, 3S-2-(2, 4-디클로로페닐)-3-(5-플루오로피리미딘-4-일)-1-(1H-1, 2, 4-트리아졸-1-일)부탄-2-올 : 또는 약제학적으로 허용되는 이의 염.
- 약제학적으로 허용되는 희석제또는 담체와 함께 제1항내 지 제12항중 어느 한 항에 따른 일반식(I)의 화합물 또는 약제학적으로 허용되는 이의 염을 함유하는 약제학적 조성물.
- 제13항에 있어서, 일반식(I)의 화합물이 사이클로덱스트린의 하이드록시알킬 유도체와 착화합되는 약제학적 조성물.
- 제14항에 있어서, 하이드록시알킬 유도체가 하이드록시프로필 유도체이고, 사이클로덱스트린의 알파-또는 베타-사이클로덱스트린인 약제학적 조성물.
- 약제로서 사용하기 위한 제1항 내지 12항중 어느 한 항 또는 제13항 내지 15항중 어느 한 항에 따른 일반식(I)의 화합물 또는 약제학적 허용되는 이의 염 또는 조성물.
- 항진균제의 제조를 위한, 제1항 내지 12항중 어느 한 항 또는 제13항 내지 15항중 어느 한 항 각각에 따른 일반식(I)의 화합물 또는 약제학적으로 허용되는 이의 염 또는 조성물의 용도.
- 일반식(Ⅳ)또는 (Ⅵ)의 화합물.상기식에서, R은 할로, -CF3및 -OCF3중에서 각각 독립적으로 선택된 치환체 1 내지 제3개에 의해 치환된 페닐이고 ; R1은 (C1내지 C4)알킬이며 ; R2는 H 또는 (C1내지 C4)알킬이고 ; X는 CH 또는 N이며 ; Y는 F 또는 Cl이고, Z는 이탈 그룹이다.
- 제18항에 있어서, Z가 클로로, 브로모 또는 (C1내지 C4)알킬설포닐옥시인 일반식(Ⅵ)의 화합물.
- 일반식(XI)의 화합물.상기식에서, R은 할로, -CF3및 -OCF3중에서 각각 독립적으로 선택된 치환체 1내지 3의 치환체에 의해 치환된 페닐이고 ; R1은 (C1내지 C4)알킬이며 ; R2는 H또는 (C1내지 C4)알킬이고 ; Y는 F 또는 C1이며 ; Z2및 Z3은 H 및 환원에 의해 선택적으로 제거될 수 있는 그룹중에서 각각 독립적으로 선택되고 ; 단 Z2및 Z3는 둘다 H일수 없다.
- 제21항에 있어서, 환원에 의해 선택적으로 제거될 수 있는 그룹이 할로인 화합물.
- 제21항에 있어서, Z2가 클로로이고, Z3가 H인 화합물.
- 4-에틸-5-플루오로피리미딘 또는 4-클로로-6-에틸-5-플루오로피리딘.
- 동물(사람을 포함)을 제1항 내지 12항중 어느 한 항 또는 제13항 내지 15항중 어느 한항에 따른 유효량의 일반식(I)의 화합물 또는 약제학적으로 허용되는 이의 염 또는 조성물로처리함을 특징으로 하여, 동물의 진균감염을 치료하거나 예방하는 처리방법.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9002375.5 | 1990-02-02 | ||
GB909002375A GB9002375D0 (en) | 1990-02-02 | 1990-02-02 | Triazole antifungal agents |
Publications (2)
Publication Number | Publication Date |
---|---|
KR910021398A true KR910021398A (ko) | 1991-12-20 |
KR930011039B1 KR930011039B1 (ko) | 1993-11-20 |
Family
ID=10670334
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019910001613A KR930011039B1 (ko) | 1990-02-02 | 1991-01-31 | 트리아졸 항진균제 |
Country Status (42)
Country | Link |
---|---|
US (2) | US5567817A (ko) |
EP (1) | EP0440372B1 (ko) |
JP (2) | JP2625584B2 (ko) |
KR (1) | KR930011039B1 (ko) |
CN (2) | CN1026788C (ko) |
AP (2) | AP9000237A0 (ko) |
AT (1) | ATE90090T1 (ko) |
AU (1) | AU625188B2 (ko) |
BA (1) | BA97298A (ko) |
BG (1) | BG60032A3 (ko) |
BR (1) | BR9100435A (ko) |
CA (2) | CA2035314C (ko) |
CZ (1) | CZ279339B6 (ko) |
DE (2) | DE69100095T2 (ko) |
DK (1) | DK0440372T3 (ko) |
EG (1) | EG19750A (ko) |
ES (1) | ES2055523T4 (ko) |
FI (3) | FI107608B (ko) |
GB (1) | GB9002375D0 (ko) |
HK (1) | HK219396A (ko) |
HU (2) | HU205351B (ko) |
IE (1) | IE64774B1 (ko) |
IL (2) | IL110322A (ko) |
IN (1) | IN176148B (ko) |
IS (1) | IS1629B (ko) |
LU (1) | LU90960I2 (ko) |
LV (1) | LV10615B (ko) |
MA (1) | MA22054A1 (ko) |
MX (1) | MX24363A (ko) |
MY (1) | MY105494A (ko) |
NL (1) | NL300100I2 (ko) |
NO (2) | NO176796C (ko) |
NZ (1) | NZ247205A (ko) |
OA (1) | OA09480A (ko) |
PE (1) | PE31691A1 (ko) |
PL (3) | PL169307B1 (ko) |
PT (1) | PT96617B (ko) |
RO (1) | RO109648B1 (ko) |
RU (2) | RU2114838C1 (ko) |
SK (1) | SK278215B6 (ko) |
YU (1) | YU48105B (ko) |
ZA (1) | ZA91761B (ko) |
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GB9002375D0 (en) * | 1990-02-02 | 1990-04-04 | Pfizer Ltd | Triazole antifungal agents |
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