KR870007919A - 항 진균성 아졸릴프로판올 유도체 - Google Patents

항 진균성 아졸릴프로판올 유도체 Download PDF

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Publication number
KR870007919A
KR870007919A KR870001668A KR870001668A KR870007919A KR 870007919 A KR870007919 A KR 870007919A KR 870001668 A KR870001668 A KR 870001668A KR 870001668 A KR870001668 A KR 870001668A KR 870007919 A KR870007919 A KR 870007919A
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South Korea
Prior art keywords
compound
halogen
hydrogen
alkyl
methyl
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KR870001668A
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English (en)
Inventor
마사루 오가따
히로시 마쓰모또
시로 기다
가쓰야 다와라
스미오 시미즈
Original Assignee
요시또시 가즈오
시오노기 세이야꾸 가부시끼 가이샤
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Application filed by 요시또시 가즈오, 시오노기 세이야꾸 가부시끼 가이샤 filed Critical 요시또시 가즈오
Publication of KR870007919A publication Critical patent/KR870007919A/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

내용 없음

Description

항 진균성 아졸릴프로판올 유도체
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (8)

  1. 하기 일반식(Ⅰ)의 화합물 또는 그의 염
    (식중, Az¹및 Az²는 각각 메틸 또는 할로겐으로 임의 치환된 이미다졸릴, 트리아졸릴 또는 피라졸릴이고, R은 C₁∼C5알킬 C₁∼C5또는 할로알킬이며, R¹은 수소, 할로겐 또는 트리플루오로 메틸이고, R²는 수소할로겐이다).
  2. 제1항에 있어서, R이 C₁∼C5알킬인 화합물.
  3. 제2항에 있어서, R¹이 수소인 화합물.
  4. 제3항에 있어서, R²가 할로겐인 화합물.
  5. 제4항에 있어서, 2-(4-클로로페닐)-1-메톡시-1, 3-비스(1H-1,2,4-트리아졸-1-일)-2-프로판올인 화합물.
  6. 유효성분으로 약학적으로 유효한량의 제1항에 따른 화합물을 일종이상의 약학적으로 수용가능한 담체희석제 및/또는 부형제와 함께 함유하는 항진균성 조성물.
  7. 제6항에 따른 항진균성 조성물을 투여함을 특징으로하는 진균증의 치료방법.
  8. 하기 일반식(Ⅳ)의 화합물을 염기 존재하에 적당한 용매중에서 아졸과 반응시킴을 특징으로 하는 하기 일반식(Ⅰ)의 화합물의 제조방법.
    (식중, Az¹및 Az²는 각각 메틸 또는 할로겐으로 임의 치환된 이미다졸릴, 트리아졸릴 또는 피라졸릴이고, R은 C₁∼C5알킬 또는 C₁∼C5할로알킬이며, R¹은 수소, 할로겐 또는 트리플루오로메틸이고, R²는 수소 또는 할로겐이다).
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR870001668A 1986-02-28 1987-02-26 항 진균성 아졸릴프로판올 유도체 KR870007919A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP45011 1986-02-28
JP61045011A JPS62201872A (ja) 1986-02-28 1986-02-28 アゾリルプロパノ−ル誘導体および抗真菌剤

Publications (1)

Publication Number Publication Date
KR870007919A true KR870007919A (ko) 1987-09-22

Family

ID=12707418

Family Applications (1)

Application Number Title Priority Date Filing Date
KR870001668A KR870007919A (ko) 1986-02-28 1987-02-26 항 진균성 아졸릴프로판올 유도체

Country Status (4)

Country Link
EP (1) EP0234499A3 (ko)
JP (1) JPS62201872A (ko)
KR (1) KR870007919A (ko)
AU (1) AU600701B2 (ko)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7968579B2 (en) 2005-10-31 2011-06-28 Daewoong Pharmaceutical Co., Ltd. Antifungal triazole derivatives
CN115521258B (zh) * 2022-10-21 2024-04-30 浙江树人学院 一种α-烷氧基唑苯乙酮类衍生物及其合成方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU562100B2 (en) * 1982-09-02 1987-05-28 Bayer Aktiengesellschaft Antimycotic t-butanol derivatives
DE3235935A1 (de) * 1982-09-29 1984-03-29 Bayer Ag, 5090 Leverkusen Azolylbutanole
EP0117578A3 (en) * 1983-02-23 1985-01-30 Shionogi & Co., Ltd. Azole-substituted alcohol derivatives
DK159205C (da) * 1983-03-16 1991-03-04 Pfizer Bis(triazol)alkanol-forbindelser, anvendelse af disse, farmaceutiske praeparater og landbrugsfungicider indeholdende disse og fremgangsmaade til behandling af planter eller froe, som har en svampeinfektion
DE3513714A1 (de) * 1985-04-17 1986-10-23 Bayer Ag, 5090 Leverkusen Bisazolylethercarbinole

Also Published As

Publication number Publication date
EP0234499A2 (en) 1987-09-02
JPS62201872A (ja) 1987-09-05
AU600701B2 (en) 1990-08-23
AU6956487A (en) 1987-09-03
EP0234499A3 (en) 1990-04-25

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