KR890002079A - 1-[2-(페닐메틸)페닐]피페라진 및 그의 제조방법 - Google Patents

1-[2-(페닐메틸)페닐]피페라진 및 그의 제조방법 Download PDF

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Publication number
KR890002079A
KR890002079A KR1019880008080A KR880008080A KR890002079A KR 890002079 A KR890002079 A KR 890002079A KR 1019880008080 A KR1019880008080 A KR 1019880008080A KR 880008080 A KR880008080 A KR 880008080A KR 890002079 A KR890002079 A KR 890002079A
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South Korea
Prior art keywords
phenylmethyl
piperazine
methyl
general formula
compound
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KR1019880008080A
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KR900007315B1 (ko
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포구에트 라파엘
포르네 에르네스토
사크리스탄 아우렐리오
오르티즈 호세 에이
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포구에트 라파엘
페레르 인터내쇼날, 에스. 에이.
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
    • C07D295/027—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring
    • C07D295/033—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring with the ring nitrogen atoms directly attached to carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
    • C07D295/027—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring
    • C07D295/03—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring with the ring nitrogen atoms directly attached to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
    • C07D295/073—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Psychiatry (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

내용 없음

Description

1-[2-(페닐메틸)페닐]피페라진 및 그의 제조방법.
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (5)

  1. 다음 일반식(I)로 표시되는 1-[2-(페닐메틸)페닐]피페라진 또는 약제학적으로 허용되는 그의 산부가염 :
    위의 식에서, R1은 수소, C1-4알킬 또는 할로겐 ; R2는 수소, C1-4알킬, 할로겐 또는 C1-4알콕시 ; 그리고 R3는 수소 또는 메틸을 나타냄.
  2. 제1항에 있어서, 일반식(I)이 1-[5-메틸-2-(페닐메틸]피페라진의 화합물.
  3. 제1항에 있어서, 일반식(I)이 1-[5-메틸-2-(페닐메틸]피페라진 모노클로라이드인 화합물.
  4. 제1항에 있어서, 일반식(I)이 1-[5-메틸-2-(페닐메틸]피페라진 디하이드로클로라이드인 화합물.
  5. 항우울제로서 작용하기에 충분한 치료학적으로 효과적인 양의 청구범위 1항의 화합물과 양제학적 허용 되는 참가제로 이루어진 약제학적 조성물.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019880008080A 1987-07-29 1988-06-30 1-[2-(페닐메틸)페닐]피페라진 및 그의 산부가염 KR900007315B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ES8702460 1987-07-29
ES8702460A ES2004809A6 (es) 1987-07-29 1987-07-29 Procedimiento de obtencion de nuevas 1-(2-(fenilmetil)fenil)piperazinas

Publications (2)

Publication Number Publication Date
KR890002079A true KR890002079A (ko) 1989-04-07
KR900007315B1 KR900007315B1 (ko) 1990-10-08

Family

ID=8252272

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019880008080A KR900007315B1 (ko) 1987-07-29 1988-06-30 1-[2-(페닐메틸)페닐]피페라진 및 그의 산부가염

Country Status (9)

Country Link
US (1) US4859675A (ko)
EP (1) EP0301549B1 (ko)
JP (1) JPH0625191B2 (ko)
KR (1) KR900007315B1 (ko)
CA (1) CA1298835C (ko)
DE (1) DE3875543T2 (ko)
ES (1) ES2004809A6 (ko)
PH (1) PH24711A (ko)
ZA (1) ZA884984B (ko)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8443619B2 (en) 2008-01-16 2013-05-21 Samsung Electronics Co., Ltd. Ice making unit and refrigerator having the same

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05255089A (ja) * 1991-12-18 1993-10-05 Sanwa Kagaku Kenkyusho Co Ltd 抗ウイルス剤
EP0755923B1 (en) * 1995-01-23 2005-05-04 Daiichi Suntory Pharma Co., Ltd. Ameliorant or remedy for symptoms caused by Ischemic diseases and Phenylpiperidine compounds useful therefor
PT958280E (pt) * 1997-10-31 2005-09-30 Daiichi Suntory Pharma Co Ltd Derivados de arilpiperidinopropanol e arilpiperazinopropanol e farmacos contendo os mesmos
UA81749C2 (uk) 2001-10-04 2008-02-11 Х. Луннбек А/С Фенілпіперазинові похідні як інгібітори зворотного захоплення серотоніну
CN108299338B (zh) * 2017-01-12 2021-09-28 广东东阳光药业有限公司 (2-苄基苯基)哌嗪衍生物及其用途

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB826496A (en) * 1956-09-14 1960-01-06 Parke Davis & Co Substituted piperazines and methods for obtaining same
US3992400A (en) * 1974-04-04 1976-11-16 The Upjohn Company 1-(α-Phenyl-o-tolyl)imidazoles
GB1554897A (en) * 1976-12-10 1979-10-31 Beecham Group Ltd (substituted phenyl) - piperazines and their use in pharmaceutical compositions
CH634299A5 (en) * 1977-12-13 1983-01-31 Ciba Geigy Ag Process for preparing novel phenylazacycloalkanes
US4194049A (en) * 1979-03-29 1980-03-18 Hoffmann-La Roche Inc. 2-[[2-Methyl-1-[2-benzoyl(or benzyl)phenyl]-1H-imidazol-5-yl]methyl]-1H-isoindole-1,3(2H)-diones

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8443619B2 (en) 2008-01-16 2013-05-21 Samsung Electronics Co., Ltd. Ice making unit and refrigerator having the same

Also Published As

Publication number Publication date
PH24711A (en) 1990-10-01
EP0301549B1 (en) 1992-10-28
US4859675A (en) 1989-08-22
DE3875543D1 (de) 1992-12-03
EP0301549A1 (en) 1989-02-01
JPS6447776A (en) 1989-02-22
JPH0625191B2 (ja) 1994-04-06
KR900007315B1 (ko) 1990-10-08
DE3875543T2 (de) 1993-03-18
ZA884984B (en) 1989-03-29
ES2004809A6 (es) 1989-02-01
CA1298835C (en) 1992-04-14

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