KR900700104A - 항불안제 - Google Patents

항불안제

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Publication number
KR900700104A
KR900700104A KR1019890701792A KR890701792A KR900700104A KR 900700104 A KR900700104 A KR 900700104A KR 1019890701792 A KR1019890701792 A KR 1019890701792A KR 890701792 A KR890701792 A KR 890701792A KR 900700104 A KR900700104 A KR 900700104A
Authority
KR
South Korea
Prior art keywords
group
general formula
active ingredient
acid addition
addition salts
Prior art date
Application number
KR1019890701792A
Other languages
English (en)
Other versions
KR970009078B1 (ko
Inventor
겐이찌 사이또
아끼히로 도베
헤이따로 이와따
아께미찌 바바
도시오 마쯔다
Original Assignee
에떼 다께또시
미쓰비시 가세이 가부시끼가이샤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 에떼 다께또시, 미쓰비시 가세이 가부시끼가이샤 filed Critical 에떼 다께또시
Publication of KR900700104A publication Critical patent/KR900700104A/ko
Application granted granted Critical
Publication of KR970009078B1 publication Critical patent/KR970009078B1/ko

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/64—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D319/18—Ethylenedioxybenzenes, not substituted on the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D321/00—Heterocyclic compounds containing rings having two oxygen atoms as the only ring hetero atoms, not provided for by groups C07D317/00 - C07D319/00
    • C07D321/02—Seven-membered rings
    • C07D321/10—Seven-membered rings condensed with carbocyclic rings or ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

내용없음

Description

항불안제
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (1)

  1. 하기 일반식 (I)로 표시된 피페라진 유도체 및 그의 산부가염을 유효성분으로 하는 항불안제 :
    상기식에서, m은 2,3 또는 4의 정수이고, X는(ℓ은 0 또는 1임),또는이며, Ar은 피리딜기, 피리미딘일기, 또는 할로겐 원자, 트리플루오로메틸기, 알콕시기 또는 알킬기로 치환될 수 있는 페닐기이고, 또 R1, R2, 및 R3은 동일하거나 또는 상이할 수 있는 저급 알콕시기이고, 또는 R3이 수소원자이고, R1및 R2가 함께(n은 1,2 또는 3임)을 형성한다.
    104-2
    (2) 제1항에 있어서, R1및 R2가 함께 일반식
    (여기에서 n은 1,2 또는 3임)을 형성하고, R3이 수소원자인 것을 특징으로 하는 피페라진 유도체 및 그의 산부가염을 유효성분으로 하는 항불안제.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019890701792A 1988-01-29 1989-01-27 항불안제 KR970009078B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP19055/88 1988-01-29
JP63019055A JP2712222B2 (ja) 1988-01-29 1988-01-29 抗不安薬
PCT/JP1989/000078 WO1989006961A1 (en) 1988-01-29 1989-01-27 Antianxiety drug

Publications (2)

Publication Number Publication Date
KR900700104A true KR900700104A (ko) 1990-08-11
KR970009078B1 KR970009078B1 (ko) 1997-06-05

Family

ID=11988746

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019890701792A KR970009078B1 (ko) 1988-01-29 1989-01-27 항불안제

Country Status (5)

Country Link
EP (1) EP0355169A4 (ko)
JP (1) JP2712222B2 (ko)
KR (1) KR970009078B1 (ko)
HU (1) HU205855B (ko)
WO (1) WO1989006961A1 (ko)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE8803429D0 (sv) * 1988-09-28 1988-09-28 Pharmacia Ab Novel pyridyl- and pyrimidyl derivatives
DE68918832T2 (de) * 1988-12-28 1995-02-09 Suntory Ltd Benzoxazepinderivate.
CN101759665B (zh) * 2008-12-23 2012-03-28 江苏恩华药业股份有限公司 取代苯基哌嗪芳烷醇衍生物及其在制备镇痛药物中的应用
CN102850318A (zh) * 2011-07-01 2013-01-02 中国人民解放军军事医学科学院毒物药物研究所 新的选择性5-羟色胺重摄取抑制剂及其医药用途
JP7431800B2 (ja) * 2018-08-10 2024-02-15 フィルメニッヒ インコーポレイテッド Ｔ２ｒ５４の拮抗薬ならびにその組成物および使用

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1670200A1 (de) * 1967-03-22 1972-03-02 Byk Gulden Lomberg Chem Fab Neue arylsubstituierte Piperazinylcarbonsaeureanilide und Verfahren zu deren Herstellung
BE758380A (fr) * 1969-11-04 1971-04-16 Sumitomo Chemical Co Procede de preparation de derives d'aryl-cetones
GB1574019A (en) * 1977-01-14 1980-09-03 Joullie International Sa Therapeutically useful 3,4,5-trimethoxybenzene derivatives
JPS565462A (en) * 1979-06-26 1981-01-20 Mitsubishi Chem Ind Ltd Piperazinylalkoxyindanes and their acid addition salt
JPS56122351A (en) * 1980-02-29 1981-09-25 Otsuka Pharmaceut Co Ltd Oxyindole derivative
JPS58192824A (ja) * 1982-05-07 1983-11-10 Mitsubishi Chem Ind Ltd 血圧降下剤
JPS597120A (ja) * 1982-07-02 1984-01-14 Mitsubishi Chem Ind Ltd 血圧降下剤
JPS5910517A (ja) * 1982-07-09 1984-01-20 Mitsubishi Chem Ind Ltd 血圧降下剤
JPS5929665A (ja) * 1982-08-11 1984-02-16 Sumitomo Chem Co Ltd ピペラジン誘導体及びその酸付加塩
GB8303946D0 (en) * 1983-02-12 1983-03-16 Recordati Chem Pharm Antihypertensive n-piperazinylalkanoylanilides
US4701456A (en) * 1984-09-19 1987-10-20 Warner-Lambert Company Aminoalkoxybenzopyranones as antipsychotic and anxiolytic agents
ZA856559B (en) * 1984-09-19 1986-04-30 Warner Lambert Co Aminoalkoxybenzopyranones as antipsychotic and anxiolytic agents

Also Published As

Publication number Publication date
KR970009078B1 (ko) 1997-06-05
EP0355169A1 (en) 1990-02-28
JP2712222B2 (ja) 1998-02-10
HUT57587A (en) 1991-12-30
JPH01193221A (ja) 1989-08-03
WO1989006961A1 (en) 1989-08-10
HU890980D0 (en) 1990-03-28
HU205855B (en) 1992-07-28
EP0355169A4 (en) 1991-05-22

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