KR840001543A - 아스코크롤린 유도체의 제조 - Google Patents

아스코크롤린 유도체의 제조 Download PDF

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Publication number
KR840001543A
KR840001543A KR1019820004108A KR820004108A KR840001543A KR 840001543 A KR840001543 A KR 840001543A KR 1019820004108 A KR1019820004108 A KR 1019820004108A KR 820004108 A KR820004108 A KR 820004108A KR 840001543 A KR840001543 A KR 840001543A
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KR
South Korea
Prior art keywords
group
nucleus
substituent
ascorroline
general formula
Prior art date
Application number
KR1019820004108A
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English (en)
Other versions
KR880002433B1 (ko
Inventor
도모요시 호소가와 (외 4)
Original Assignee
우에노 기미오
쥬우가이세이야꾸 가부시기가이샤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP14166081A external-priority patent/JPS5843938A/ja
Priority claimed from JP16882181A external-priority patent/JPS5869860A/ja
Application filed by 우에노 기미오, 쥬우가이세이야꾸 가부시기가이샤 filed Critical 우에노 기미오
Publication of KR840001543A publication Critical patent/KR840001543A/ko
Application granted granted Critical
Publication of KR880002433B1 publication Critical patent/KR880002433B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/125—Saturated compounds having only one carboxyl group and containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C403/00—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
    • C07C403/14—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by doubly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
    • C07C69/708—Ethers
    • C07C69/712—Ethers the hydroxy group of the ester being etherified with a hydroxy compound having the hydroxy group bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/80—Acids; Esters in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

내용 없음

Description

아스코크롤린 유도체의 제조
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (11)

  1. (1) 일반식
  3. (식 중 M은 알카리금속을 나타낸다)로 나타내는 아스코크롤린 모노금속염과 일반식
  5. (식 중 X은 할로겐원자를, n'은 1∼5의 정수를 뜻하며 R은 후기와 동일의 뜻을 갖는다)로 나타내는 화합물을 반응시키고 이어서 필요에 따라서 가수분해하든지 아니면
  6. (2) 아스코크롤린과 일반식
  7. R'COOH
  8. (식 중 R'은 피리딜기, 치환되어 있어도 무방한 아미노기, 핵에 치환기를 가질 수 있는 페녹시 알킬기 또는 핵에 치환기를 가질 수 있는 페닐기를 뜻한다)로 나타내는 산의 반응성 유도체를 반응시켜서 일반식
  10. (식 중 R은 수산기, 저급알콜시기, 피리딜기, 치환되어 있어도 무방한 아미노기, 핵에 치환기를 가질 수 있는 페녹시알킬기 또는 핵에 치환기를 가질 수 있는 페닐기를 뜻하며 n은 0-5의 정수를 뜻한다)로 나타내는 아스코크롤린 유도체의 제법
  11. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR8204108A 1981-09-10 1982-09-10 아스코크롤린 유도체의 제법 KR880002433B1 (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP14166081A JPS5843938A (ja) 1981-09-10 1981-09-10 アスコクロリン誘導体
JP141660 1981-09-10
JP16882181A JPS5869860A (ja) 1981-10-23 1981-10-23 アスコクロリン誘導体
JP168821 1981-10-23

Publications (2)

Publication Number Publication Date
KR840001543A true KR840001543A (ko) 1984-05-07
KR880002433B1 KR880002433B1 (ko) 1988-11-12

Family

ID=26473856

Family Applications (1)

Application Number Title Priority Date Filing Date
KR8204108A KR880002433B1 (ko) 1981-09-10 1982-09-10 아스코크롤린 유도체의 제법

Country Status (9)

Country Link
US (2) US4500544A (ko)
EP (1) EP0074628B1 (ko)
KR (1) KR880002433B1 (ko)
AR (1) AR242373A1 (ko)
CA (1) CA1192557A (ko)
CS (1) CS244911B2 (ko)
DE (1) DE3271383D1 (ko)
ES (2) ES8400382A1 (ko)
MX (1) MX157777A (ko)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5409951A (en) * 1990-06-15 1995-04-25 Novo Nordisk A/S Fungicidally active compounds
US5139481A (en) * 1991-08-07 1992-08-18 The General Hospital Corporation Treatment for type II diabetes
JPH0816057B2 (ja) * 1992-09-10 1996-02-21 田村 學造 グリケイション阻害剤
US5420334A (en) * 1994-04-04 1995-05-30 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
CN1477190A (zh) 1994-12-13 2004-02-25 彼得・K・罗 控制细胞融合的方法和相关组合物
CN1200106A (zh) * 1995-08-28 1998-11-25 美国家用产品公司 苯氧基乙酸类化合物用作醛糖还原酶抑制剂和抗高血糖药
KR20010093825A (ko) * 1998-12-14 2001-10-29 추후기재 신규의 핵수용체 리간드
MXPA01009127A (es) * 1999-03-11 2003-07-14 Nuclear Receptor Res Ltd Ligandos novedosos de receptores nucleares, receptores activados por proliferacion de peroxisoma.
EP1481670A4 (en) * 2002-01-31 2005-07-13 Arigen Inc PHARMACEUTICAL COMPOSITION FOR THE DIAGNOSIS, PREVENTION OR TREATMENT OF A MULTIFACTOR SYNDROME
WO2013059606A1 (en) 2011-10-21 2013-04-25 Tufts Medical Center, Inc. Compounds and methods for the treatment of muscular disease, and related screening methods

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3546073A (en) * 1968-08-13 1970-12-08 American Cyanamid Co Fusarium fermentation
US3995061A (en) * 1974-04-09 1976-11-30 Chugai Seiyaku Kabushiki Kaisha Pharmaceutical composition and method of using the same

Also Published As

Publication number Publication date
ES515648A0 (es) 1983-11-01
ES8406995A1 (es) 1984-08-16
EP0074628A2 (en) 1983-03-23
CA1192557A (en) 1985-08-27
CS244911B2 (en) 1986-08-14
MX157777A (es) 1988-12-09
CS652682A2 (en) 1985-09-17
US4542143A (en) 1985-09-17
AR242373A1 (es) 1993-03-31
US4500544A (en) 1985-02-19
KR880002433B1 (ko) 1988-11-12
EP0074628A3 (en) 1984-01-18
DE3271383D1 (en) 1986-07-03
ES8400382A1 (es) 1983-11-01
ES522459A0 (es) 1984-08-16
EP0074628B1 (en) 1986-05-28

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