DE3271383D1 - Ascochlorin derivatives; process for preparing the same and pharmaceutical composition containing the same - Google Patents

Ascochlorin derivatives; process for preparing the same and pharmaceutical composition containing the same

Info

Publication number
DE3271383D1
DE3271383D1 DE8282108325T DE3271383T DE3271383D1 DE 3271383 D1 DE3271383 D1 DE 3271383D1 DE 8282108325 T DE8282108325 T DE 8282108325T DE 3271383 T DE3271383 T DE 3271383T DE 3271383 D1 DE3271383 D1 DE 3271383D1
Authority
DE
Germany
Prior art keywords
same
preparing
pharmaceutical composition
composition containing
ascochlorin derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8282108325T
Other languages
English (en)
Inventor
Tomoyoshi Hosokawa
Ikutoshi Matsuura
Hidenori Takahashi
Kunio Ando
Gakuzo Tamura
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
LTT Institute Co Ltd
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP14166081A external-priority patent/JPS5843938A/ja
Priority claimed from JP16882181A external-priority patent/JPS5869860A/ja
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Application granted granted Critical
Publication of DE3271383D1 publication Critical patent/DE3271383D1/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/125—Saturated compounds having only one carboxyl group and containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C403/00—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
    • C07C403/14—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by doubly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
    • C07C69/708—Ethers
    • C07C69/712—Ethers the hydroxy group of the ester being etherified with a hydroxy compound having the hydroxy group bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/80—Acids; Esters in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE8282108325T 1981-09-10 1982-09-09 Ascochlorin derivatives; process for preparing the same and pharmaceutical composition containing the same Expired DE3271383D1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP14166081A JPS5843938A (ja) 1981-09-10 1981-09-10 アスコクロリン誘導体
JP16882181A JPS5869860A (ja) 1981-10-23 1981-10-23 アスコクロリン誘導体

Publications (1)

Publication Number Publication Date
DE3271383D1 true DE3271383D1 (en) 1986-07-03

Family

ID=26473856

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8282108325T Expired DE3271383D1 (en) 1981-09-10 1982-09-09 Ascochlorin derivatives; process for preparing the same and pharmaceutical composition containing the same

Country Status (9)

Country Link
US (2) US4500544A (de)
EP (1) EP0074628B1 (de)
KR (1) KR880002433B1 (de)
AR (1) AR242373A1 (de)
CA (1) CA1192557A (de)
CS (1) CS244911B2 (de)
DE (1) DE3271383D1 (de)
ES (2) ES8400382A1 (de)
MX (1) MX157777A (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5409951A (en) * 1990-06-15 1995-04-25 Novo Nordisk A/S Fungicidally active compounds
US5139481A (en) * 1991-08-07 1992-08-18 The General Hospital Corporation Treatment for type II diabetes
JPH0816057B2 (ja) * 1992-09-10 1996-02-21 田村 學造 グリケイション阻害剤
US5420334A (en) * 1994-04-04 1995-05-30 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
CN1477190A (zh) 1994-12-13 2004-02-25 彼得・K・罗 控制细胞融合的方法和相关组合物
WO1997008126A1 (en) * 1995-08-28 1997-03-06 American Home Products Corporation Phenoxy acetic acids as aldose reductase inhibitors and antihyperglycemic agents
US6605639B1 (en) 1998-12-14 2003-08-12 Nuclear Receptor Research, Ltd. Ligands of nuclear receptor
TR200202077T2 (tr) * 1999-03-11 2002-11-21 Nuclear Receptor Research Limited Prar nükleer reseptörleri için yeni ligandlar
JPWO2003063849A1 (ja) * 2002-01-31 2005-05-26 アリジェン株式会社 多重危険因子症候群の診断、予防又は治療用医薬組成物
WO2013059606A1 (en) 2011-10-21 2013-04-25 Tufts Medical Center, Inc. Compounds and methods for the treatment of muscular disease, and related screening methods

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3546073A (en) * 1968-08-13 1970-12-08 American Cyanamid Co Fusarium fermentation
US3995061A (en) * 1974-04-09 1976-11-30 Chugai Seiyaku Kabushiki Kaisha Pharmaceutical composition and method of using the same

Also Published As

Publication number Publication date
CS244911B2 (en) 1986-08-14
ES522459A0 (es) 1984-08-16
EP0074628A2 (de) 1983-03-23
ES515648A0 (es) 1983-11-01
ES8400382A1 (es) 1983-11-01
KR840001543A (ko) 1984-05-07
US4500544A (en) 1985-02-19
AR242373A1 (es) 1993-03-31
ES8406995A1 (es) 1984-08-16
EP0074628B1 (de) 1986-05-28
CA1192557A (en) 1985-08-27
US4542143A (en) 1985-09-17
MX157777A (es) 1988-12-09
KR880002433B1 (ko) 1988-11-12
CS652682A2 (en) 1985-09-17
EP0074628A3 (en) 1984-01-18

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: LTT INSTITUTE CO., LTD., KAWASAKI, KANAGAWA, JP

8328 Change in the person/name/address of the agent

Free format text: TAUCHNER, P., DIPL.-CHEM. DR.RER.NAT. HEUNEMANN, D., DIPL.-PHYS. DR.RER.NAT. RAUH, P., DIPL.-CHEM. DR.RER.NAT. HERMANN, G., DIPL.-PHYS. DR.RER.NAT. SCHMIDT, J., DIPL.-ING. JAENICHEN, H., DIPL.-BIOL. DR.RER.NAT., PAT.-ANWAELTE TREMMEL, H., RECHTSANW., 8000 MUENCHEN

8339 Ceased/non-payment of the annual fee