ES8406995A1 - Un procedimiento para la preparacion de un derivado de ascoclorina. - Google Patents

Un procedimiento para la preparacion de un derivado de ascoclorina.

Info

Publication number
ES8406995A1
ES8406995A1 ES522459A ES522459A ES8406995A1 ES 8406995 A1 ES8406995 A1 ES 8406995A1 ES 522459 A ES522459 A ES 522459A ES 522459 A ES522459 A ES 522459A ES 8406995 A1 ES8406995 A1 ES 8406995A1
Authority
ES
Spain
Prior art keywords
same
group
preparing
pharmaceutical composition
composition containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES522459A
Other languages
English (en)
Other versions
ES522459A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chugai Pharmaceutical Co Ltd
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP14166081A external-priority patent/JPS5843938A/ja
Priority claimed from JP16882181A external-priority patent/JPS5869860A/ja
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Publication of ES522459A0 publication Critical patent/ES522459A0/es
Publication of ES8406995A1 publication Critical patent/ES8406995A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/125—Saturated compounds having only one carboxyl group and containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C403/00—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
    • C07C403/14—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by doubly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
    • C07C69/708—Ethers
    • C07C69/712—Ethers the hydroxy group of the ester being etherified with a hydroxy compound having the hydroxy group bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/80—Acids; Esters in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE UN DERIVADO DE ASCOCLORINA.CONSISTE EN HACER REACCIONAR ASCOCLORINA CON UN DERIVADO REACTIVO DEL GRUPO CARBOXILO DE UN ACIDO DE FORMULA (II), PARA OBTENER UN DERIVADO DE ASCOCLORINA DE FORMULA (I), DONDE R ES UN GRUPO HIDROXILO, ALCOXI INFERIOR, PIRIDILO, AMINO, FENOXIALQUILO; Y R ES UN GRUPO PIRIDILO, AMINO SUSTITUIDO O NO, FENOXIALQUILO CON UN SUSTITUYENTE EN EL NUCLEO O FENILO. LA REACCION SE LLEVA A CABO EN PRESENCIA O AUSENCIA DE UN DISOLVENTE TAL COMO BENCENO, DIMETILFORMAMIDA Y OTROS, Y EN PRESENCIA DE UNA AMINATERCIARIA TAL COMO PIRIDINA, TRIETILAMINA Y OTROS, O DE UNA BASE ALCALINA TAL COMO HIDROXIDO SODICO O POTASICO. LA TEMPERATURA ESTA COMPRENDIDA ENTRE 0JC Y LA TEMPERATURA DE EBULLICION DEL DISOLVENTE.TIENE APLICACION PARA EL TRATAMIENTO DE LA DIABETES, MEJORAN EL METABOLISMO DE LOS LIPIDOS Y CONTROLAN LOS TUMORES.
ES522459A 1981-09-10 1983-05-16 Un procedimiento para la preparacion de un derivado de ascoclorina. Expired ES8406995A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP14166081A JPS5843938A (ja) 1981-09-10 1981-09-10 アスコクロリン誘導体
JP16882181A JPS5869860A (ja) 1981-10-23 1981-10-23 アスコクロリン誘導体

Publications (2)

Publication Number Publication Date
ES522459A0 ES522459A0 (es) 1984-08-16
ES8406995A1 true ES8406995A1 (es) 1984-08-16

Family

ID=26473856

Family Applications (2)

Application Number Title Priority Date Filing Date
ES515648A Granted ES515648A0 (es) 1981-09-10 1982-09-10 Un derivado de ascoclorina
ES522459A Expired ES8406995A1 (es) 1981-09-10 1983-05-16 Un procedimiento para la preparacion de un derivado de ascoclorina.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES515648A Granted ES515648A0 (es) 1981-09-10 1982-09-10 Un derivado de ascoclorina

Country Status (9)

Country Link
US (2) US4500544A (es)
EP (1) EP0074628B1 (es)
KR (1) KR880002433B1 (es)
AR (1) AR242373A1 (es)
CA (1) CA1192557A (es)
CS (1) CS244911B2 (es)
DE (1) DE3271383D1 (es)
ES (2) ES515648A0 (es)
MX (1) MX157777A (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5409951A (en) * 1990-06-15 1995-04-25 Novo Nordisk A/S Fungicidally active compounds
US5139481A (en) * 1991-08-07 1992-08-18 The General Hospital Corporation Treatment for type II diabetes
JPH0816057B2 (ja) * 1992-09-10 1996-02-21 田村 學造 グリケイション阻害剤
US5420334A (en) * 1994-04-04 1995-05-30 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
EP0743820A4 (en) 1994-12-13 1997-06-11 Peter K Law TREATMENT OF MAMMAL-SPECIFIC CONDITIONS WITH MYOBLASTS
CA2227691A1 (en) * 1995-08-28 1997-03-06 American Home Products Corporation Phenoxy acetic acids as aldose reductase inhibitors and antihyperglycemic agents
EP1142870A1 (en) 1998-12-14 2001-10-10 Nuclear Receptor Research Limited Novel ligands of nuclear receptor
BR0009474A (pt) * 1999-03-11 2001-11-27 Nuclear Receptor Res Ltd Ligandos para receptores nucleares ppar
EP1481670A4 (en) * 2002-01-31 2005-07-13 Arigen Inc PHARMACEUTICAL COMPOSITION FOR THE DIAGNOSIS, PREVENTION OR TREATMENT OF A MULTIFACTOR SYNDROME
WO2013059606A1 (en) 2011-10-21 2013-04-25 Tufts Medical Center, Inc. Compounds and methods for the treatment of muscular disease, and related screening methods

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3546073A (en) * 1968-08-13 1970-12-08 American Cyanamid Co Fusarium fermentation
US3995061A (en) * 1974-04-09 1976-11-30 Chugai Seiyaku Kabushiki Kaisha Pharmaceutical composition and method of using the same

Also Published As

Publication number Publication date
AR242373A1 (es) 1993-03-31
ES8400382A1 (es) 1983-11-01
EP0074628B1 (en) 1986-05-28
KR840001543A (ko) 1984-05-07
CA1192557A (en) 1985-08-27
EP0074628A2 (en) 1983-03-23
US4500544A (en) 1985-02-19
EP0074628A3 (en) 1984-01-18
ES522459A0 (es) 1984-08-16
ES515648A0 (es) 1983-11-01
CS652682A2 (en) 1985-09-17
CS244911B2 (en) 1986-08-14
MX157777A (es) 1988-12-09
DE3271383D1 (en) 1986-07-03
US4542143A (en) 1985-09-17
KR880002433B1 (ko) 1988-11-12

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