RU1838311C - Способ получени 2-(3-пиридил)тетрагидротиапиранкарботиоамид-2-оксида-1(1R, 2R) - Google Patents

Способ получени 2-(3-пиридил)тетрагидротиапиранкарботиоамид-2-оксида-1(1R, 2R)

Info

Publication number
RU1838311C
RU1838311C SU904831525A SU4831525A RU1838311C RU 1838311 C RU1838311 C RU 1838311C SU 904831525 A SU904831525 A SU 904831525A SU 4831525 A SU4831525 A SU 4831525A RU 1838311 C RU1838311 C RU 1838311C
Authority
RU
Russia
Prior art keywords
carbothioamide
pyridyl
tetrahydrothiapyrane
synthesis
oxide
Prior art date
Application number
SU904831525A
Other languages
English (en)
Inventor
Алу Жан-Клод
Жам Клод
Марграфф Родольф
Original Assignee
Рон-Пуленк Санте
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Рон-Пуленк Санте filed Critical Рон-Пуленк Санте
Application granted granted Critical
Publication of RU1838311C publication Critical patent/RU1838311C/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Сущность изобретени : продукт - 2-(3пиридил )тетрагидротиапиранкарботиоамид -2-ОКСИД-1 (1R.2R). Синтез 1: реагент : 2-(3пиридил )тетрагидротиапиран. Реагент 2: окислитель. Услови  синтеза 1: окисление химическим путем с помощью гидроперекиси кумила или трет-бутила в присутствии индуктора асимметрии, такого как (+)-этил- тартрат или алкогол т титана (4), при температуре около -20°С или биологическим путем с помощью культуры нитевидного гриба или энзима, выделенного в присутствии агента окислени . Синтез 2: реагент 1: 2-(3-пиридил)тетрагидротиапиран-1-оксид
SU904831525A 1989-10-31 1990-10-30 Способ получени 2-(3-пиридил)тетрагидротиапиранкарботиоамид-2-оксида-1(1R, 2R) RU1838311C (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8914273A FR2653770B1 (fr) 1989-10-31 1989-10-31 Procede de preparation de (pyridyl-3)-2 tetrahydrothiopyrannecarbothioamide-2-oxydes-1-(1r,2r), les (pyridyl-3)-2 tetrhydrothiopyrannecarbothioamide-2-oxydes-1-(1r,2r) ainsi obtenus et les compositions pharmaceutiques qui les contiennent.

Publications (1)

Publication Number Publication Date
RU1838311C true RU1838311C (ru) 1993-08-30

Family

ID=9386963

Family Applications (1)

Application Number Title Priority Date Filing Date
SU904831525A RU1838311C (ru) 1989-10-31 1990-10-30 Способ получени 2-(3-пиридил)тетрагидротиапиранкарботиоамид-2-оксида-1(1R, 2R)

Country Status (25)

Country Link
US (1) US5120852A (ru)
EP (1) EP0426557B1 (ru)
JP (1) JPH03153684A (ru)
KR (1) KR910007921A (ru)
AT (1) ATE118773T1 (ru)
AU (1) AU641950B2 (ru)
CA (1) CA2028985A1 (ru)
DE (1) DE69017146T2 (ru)
DK (1) DK0426557T3 (ru)
ES (1) ES2068361T3 (ru)
FI (1) FI905358A0 (ru)
FR (1) FR2653770B1 (ru)
GR (1) GR3015159T3 (ru)
HU (1) HU212501B (ru)
IE (1) IE66252B1 (ru)
IL (1) IL96160A (ru)
MA (1) MA21989A1 (ru)
NO (1) NO177707C (ru)
NZ (1) NZ235872A (ru)
OA (1) OA09324A (ru)
PL (1) PL164269B1 (ru)
PT (1) PT95758A (ru)
RU (1) RU1838311C (ru)
TN (1) TNSN90128A1 (ru)
ZA (1) ZA908679B (ru)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9001327D0 (en) * 1990-01-19 1990-03-21 May & Baker Ltd New compositions of matter
FR2702213B1 (fr) * 1993-03-02 1995-04-07 Rhone Poulenc Rorer Sa Procédé de préparation de N-méthyl (pyridyl-3)-2 tétrahydrothiopyrannecarbothioamide-2-oxyde-1-(1R,2R).
GB9314133D0 (en) * 1993-07-08 1993-08-18 Rhone Poulenc Rorer Ltd New process
GB9321939D0 (en) * 1993-10-25 1993-12-15 Rhone Poulenc Rorer Ltd New process

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3395142A (en) * 1963-11-27 1968-07-30 Rohm & Haas Aminoethylene compositions
IE49570B1 (en) * 1979-03-30 1985-10-30 Rhone Poulenc Ind 2-(pyrid-2-yl)tetrahydrothiophene derivatives
FR2488609A1 (fr) * 1980-08-18 1982-02-19 Rhone Poulenc Ind Nouveaux derives de la thioformamide, leur preparation et les medicaments qui les contiennent
AU543387B2 (en) * 1981-05-27 1985-04-18 Rhone-Poulenc Sante Thioformamide derivatives
FR2528849B1 (fr) * 1982-06-17 1985-06-21 Rhone Poulenc Sante Nouveaux derives de la thioformamide, leur preparation et les medicaments qui les contiennent
DE3367631D1 (en) * 1983-06-16 1987-01-02 Rhone Poulenc Sante Process for the electrochemical production of sulfoxides of thioformamide derivatives useful as medicines

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
.1.Европейский патент № 97584, кл. С 07 D 409/04, 1984. *

Also Published As

Publication number Publication date
HU906945D0 (en) 1991-05-28
MA21989A1 (fr) 1991-07-01
ATE118773T1 (de) 1995-03-15
FR2653770B1 (fr) 1992-01-03
HU212501B (en) 1996-07-29
EP0426557B1 (fr) 1995-02-22
PL164269B1 (pl) 1994-07-29
NO177707C (no) 1995-11-08
IE66252B1 (en) 1995-12-27
ES2068361T3 (es) 1995-04-16
PL287557A1 (en) 1991-12-16
ZA908679B (en) 1991-08-28
DE69017146T2 (de) 1995-07-06
TNSN90128A1 (fr) 1991-03-05
NO904708L (no) 1991-05-02
NO904708D0 (no) 1990-10-30
FI905358A0 (fi) 1990-10-30
CA2028985A1 (fr) 1991-05-01
US5120852A (en) 1992-06-09
NO177707B (no) 1995-07-31
HUT59397A (en) 1992-05-28
IL96160A (en) 1995-12-31
OA09324A (fr) 1992-09-15
KR910007921A (ko) 1991-05-30
IL96160A0 (en) 1991-07-18
IE903902A1 (en) 1991-05-08
EP0426557A1 (fr) 1991-05-08
GR3015159T3 (en) 1995-05-31
DE69017146D1 (de) 1995-03-30
AU641950B2 (en) 1993-10-07
PT95758A (pt) 1991-09-13
AU6554890A (en) 1991-05-09
NZ235872A (en) 1992-05-26
JPH03153684A (ja) 1991-07-01
DK0426557T3 (da) 1995-03-27
FR2653770A1 (fr) 1991-05-03

Similar Documents

Publication Publication Date Title
RU94027576A (ru) Производные 1-бензолсульфонил-1,3-дигидро-индол-2-она, способ их получения и содержащие их фармацевтические композиции
EP0354777A3 (en) 3-(4-piperidine)-5-(2-sulfonylaminoethyl) indole derivatives
US4476308B1 (ru)
NO940523D0 (no) Nye pyrazin-derivater
RU1838311C (ru) Способ получени 2-(3-пиридил)тетрагидротиапиранкарботиоамид-2-оксида-1(1R, 2R)
ZA825428B (en) New imidazole compounds,process for the preparation thereof and pharmaceutical compositions containing them
RU95104235A (ru) Агент для контроля плодовитости и содержащая его фармацевтическая композиция
PH24207A (en) 2-acylamino-6-amino-4,5,6,7-tetrahydrobenzothiazoles
HU9600300D0 (en) Thiocarbamoyl derivatives using as antimicrobial agents and process for producing of these
SE7907656L (sv) 3,4-dihydroxikanelaldehydderivat
SU1640982A1 (ru) СПОСОБ ПОЛУЧЕНИЯ 6,14-ЭНДОЭТЕНО- ИЛИ 6,14-ЭНДОЭТАНО- 7α -(1-ГИДРОКСИ-1-МЕТИЛ-1-АЛКИЛ С-СМЕТИЛ) ТЕТРАГИДРОТЕБАИНОВ