KR890700584A - 헤테로아릴카르복시아미드 유도체 그의 제조방법 및 그것을 함유하는 의약조성물 - Google Patents

헤테로아릴카르복시아미드 유도체 그의 제조방법 및 그것을 함유하는 의약조성물

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KR890700584A
KR890700584A KR1019880701112A KR880701112A KR890700584A KR 890700584 A KR890700584 A KR 890700584A KR 1019880701112 A KR1019880701112 A KR 1019880701112A KR 880701112 A KR880701112 A KR 880701112A KR 890700584 A KR890700584 A KR 890700584A
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compound
carbon atoms
physiologically acceptable
hydroxy
formula
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KR1019880701112A
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KR960004827B1 (ko
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히도시 우노
다쓰야 곤
요시노리 니시까와
도꾸히꼬 신또오
히데오 나까무라
가쯔미 이시이
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후지와라 도미오
다이닛뽄 세이야꾸 가부시끼가이샤
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Furan Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Quinoline Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

내용 없음.

Description

헤테로아릴카르복시아미드 유도체 그의 제조방법 및 그것을 함유하는 의약조성물
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (10)

  1. 식(I):
    [식중, A는 탄소원자수 3 내지 5의 알킬렌기를 의미하고, X는또는를 의미하여, 그중 Ph는 페닐을 의미하고은 식;
    의 기를 의미하며, 그중 Y는 질소원자 또는 =CH-를 의미하고, R1은 히드록시, 탄소원자수 1 내지 6의 알콕시기 또는 메르캅토를 의미하며, R2은 수소원자수 할로겐원자, 탄소원자수 1 내지 6의 알킬기, 탄소원자수 1 내지 6의 알콕시기, 니트로 또는 시아노를 의미하고, R3은 탄소원자수 1 내지 6의 알킬기를 의미한다. 단, Y가 질소원자를 의미할 때 R2는 7-위치에 부착된다.]의 화합물 또는 그의 생리적으로 허용가능한 염.
  2. 제1항에 있어서, A가 테트라메틸렌인 것을 특징으로 하는 화합물.
  3. 제1항에 있어서, 식(Ia) :
    [식중, X는 제1항에서 정의된 바와같고,은 식 :
    의 기를 의미하며, 그중 R2a와 R3b는 탄소원자수 1 내지 4의 알킬기를 의미한다.]로 표시되는 것을 특징으로 하는 화합물 또는 그의 생리적으로 허용가능한 염.
  4. 제1항에 있어서, 식(Ib) :
    [식중, X는 제1항에서 정의된 바와같고, R1b는 히드록시, 탄소원자수 1 내지 4의 알콕시기 또는 메르캅토를 의미하며, R2b는 수소원자, 히드록시, 탄소원자수 1 내지 4의 알킬기, 탄소원자수 1 내지 4의 알콕시기 또는 시아노를 의미한다.]로 표시되는 것을 특징으로 하는 화합물 또는 그의 생리적으로 허용가능한 염.
  5. 제3항에 있어서, N-[4-(4-디펠리메틸렌-1-피페리딜)부틸]-4-히드록시-7-메틸-1,8-나프티리딘-3-카르복시아미드인 것을 특징으로 하는 화합물 또는 그의 생리학적으로 허용가능한 염.
  6. 제3항에 있어서, N-[4-(4-디페닐메틸-1-피페라지닐)부틸]-4-히드록시-7-메틸-1,8-나프티리딘-3-카르복시아미드인 것을 특징으로 하는 화합물 또는 그의 생리적으로 허용가능한 염.
  7. 제4항에 있어서, N-[4-(4-디페닐메틸렌-1-피페라지닐)부틸]-4-히드록시-7-메틸-8-메톡시퀴놀린-3-카르복시아미드인 것을 특징으로 하는 화합물 또는 그의 생리적으로 허용가능한 염.
  8. 제3항에 있어서, N-[4-(4-디페닐메틸-1-피페라지닐)부틸]-2-히드록시-6-이소프로필피리딘-3-카르복시아미드인 것을 특징으로 하는 화합물 또는 그의 생리적으로 허용가능한 염.
  9. 식(I);
    [식중, A, X는은 제1항에서 정의된 바와같다.]의 화합물, 또는 그의 생리적으로 허용가능한 염의 제조방법에 있어서, 식(II) :
    [식중,은 제1항에서 정의된 바와같다.]의 화합물, 또는 반응성 유도체를 식(III) :
    [식중, A와 X는 제1항에서 정의된 바와같다.]의 아민과 반응시키는 것을 특징으로 하는 제조방법.
  10. 제1항 내지 제8항중 어느 하나에서 설명된 바와같은 화합물. 또는 그의 생리적으로 허용가능한 염과 약제용 담체를 함유하는 의약 조성물.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019880701112A 1987-01-20 1988-01-20 헤테로아릴카르복시아미드 유도체, 그의 제조방법 및 그것을 함유하는 의약조성물 KR960004827B1 (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP62-11128 1987-01-20
JP1112887 1987-01-20
PCT/JP1988/000038 WO1988005435A1 (en) 1987-01-20 1988-01-20 Aromatic heterocyclic carboxylic acid amide derivatives, process for their preparation, and pharmaceutical composition containing same
CA000573044A CA1322752C (en) 1987-01-20 1988-07-26 Heteroarylcarboxamide derivatives, process for preparing the same and pharmaceutical composition containing the same

Publications (2)

Publication Number Publication Date
KR890700584A true KR890700584A (ko) 1989-04-25
KR960004827B1 KR960004827B1 (ko) 1996-04-16

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US (1) US4965266A (ko)
EP (1) EP0298134B1 (ko)
JP (1) JP2640953B2 (ko)
KR (1) KR960004827B1 (ko)
AT (1) ATE82282T1 (ko)
AU (1) AU596499B2 (ko)
CA (1) CA1322752C (ko)
DE (1) DE3875820T2 (ko)
DK (1) DK518888A (ko)
WO (1) WO1988005435A1 (ko)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2696744B1 (fr) * 1992-10-12 1994-12-30 Logeais Labor Jacques Dérivés de 2-pyrrolidone, leur procédé de préparation et leurs applications en thérapeutique.
ES2062943B1 (es) * 1993-03-23 1995-11-16 Uriach & Cia Sa J Nuevos derivados de la (2-metil-3-piridil) cianometilpiperazinas.
CA2309882A1 (en) * 1997-12-22 1999-07-01 Pharmacia & Upjohn Company 4-hydroxyquinoline-3-carboxamides and hydrazides as antiviral agents
EP2027087A2 (en) 2006-05-18 2009-02-25 MannKind Corporation Intracellular kinase inhibitors
EP1987717A1 (de) * 2007-04-30 2008-11-05 Bayer CropScience AG Pyridoncarboxamide, diese enthaltende nutzpflanzenschützende Mittel und Verfahren zu ihrer Herstellung und deren Verwendung
US9932310B2 (en) * 2016-02-08 2018-04-03 City Of Hope DNA2 inhibitors for cancer treatment

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3806526A (en) * 1972-01-28 1974-04-23 Richardson Merrell Inc 1-aroylalkyl-4-diphenylmethyl piperidines
GB1433774A (en) * 1973-02-26 1976-04-28 Allen & Hanburys Ltd Heterocyclic compounds apparatus for conveying articles
GB1444369A (en) * 1973-04-05 1976-07-28 Allen & Hanburys Ltd 1,8-naphthyridines
US3922276A (en) * 1974-12-11 1975-11-25 Robins Co Inc A H 1-Substituted-4-benzylidenepiperidines
DE3242344A1 (de) * 1982-11-16 1984-05-17 Dr. Karl Thomae Gmbh, 7950 Biberach Neue alkylendiaminoderivate, ihre herstellung und diese verbindungen enthaltende arzneimittel
JPS59118765A (ja) * 1982-12-24 1984-07-09 Fujisawa Pharmaceut Co Ltd ピペラジン誘導体
US4778796A (en) * 1985-07-19 1988-10-18 Dainippon Pharmaceutical Co., Ltd. ω-(3-pyridyl)alkenamide derivatives and anti-allergenic pharmaceutical compositions containing same
JPH0535191A (ja) * 1991-07-25 1993-02-12 Sony Corp スクリーン

Also Published As

Publication number Publication date
DE3875820T2 (de) 1993-03-18
AU596499B2 (en) 1990-05-03
US4965266A (en) 1990-10-23
EP0298134B1 (en) 1992-11-11
CA1322752C (en) 1993-10-05
JP2640953B2 (ja) 1997-08-13
DE3875820D1 (de) 1992-12-17
DK518888D0 (da) 1988-09-16
EP0298134A1 (en) 1989-01-11
JPS63301860A (ja) 1988-12-08
WO1988005435A1 (en) 1988-07-28
KR960004827B1 (ko) 1996-04-16
EP0298134A4 (en) 1989-06-26
DK518888A (da) 1988-09-16
AU1184488A (en) 1988-08-10
ATE82282T1 (de) 1992-11-15

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