ES2062943B1 - Nuevos derivados de la (2-metil-3-piridil) cianometilpiperazinas. - Google Patents
Nuevos derivados de la (2-metil-3-piridil) cianometilpiperazinas.Info
- Publication number
- ES2062943B1 ES2062943B1 ES09300591A ES9300591A ES2062943B1 ES 2062943 B1 ES2062943 B1 ES 2062943B1 ES 09300591 A ES09300591 A ES 09300591A ES 9300591 A ES9300591 A ES 9300591A ES 2062943 B1 ES2062943 B1 ES 2062943B1
- Authority
- ES
- Spain
- Prior art keywords
- piridil
- methyl
- new derivatives
- cyanometilpiperazines
- lipoxigenase
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
Abstract
NUEVOS DERIVADOS DE DE LA (2-METIL-3-PIRIDIL)CIANOMETILPIPERAZINA DE FORMULA I, EN DONDE A REPRESENTA UN ENLACE SENCILLO O BIEN LA AGRUPACION -CONHCH(PH)-, -NHCH(PH)-, -CH(PH)NH-, -SOSI2 SCNHCH(PH)-, - NHCONHCH(PH)- O -OCONHCH(PH)-; N ES 0 O 1, Y SUS SALES. LA PRESENTE INVENCION DESCRIBE TAMBIEN PROCEDIMIENTOS PARA SU PREPARACION Y COMPOSICIONES FARMACEUTICAS QUE LOS CONTIENEN. DICHOS COMPUESTOS SON ANTAGONISTAS DUALES DEL PAF Y LA 5-LIPOXIGENASA, POR LO TANTO, UTILES EN EL TRATAMIENTO Y/O PREVENCION DE LAS ENFERMEDADES DONDE EL PAF Y/O LA 5-LIPOXIGENASA SE HALLAN IMPLICADOS. FORMULA
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES09300591A ES2062943B1 (es) | 1993-03-23 | 1993-03-23 | Nuevos derivados de la (2-metil-3-piridil) cianometilpiperazinas. |
CA002118831A CA2118831A1 (en) | 1993-03-23 | 1994-03-11 | Derivatives of (2-methyl-3-piridyl) cyanomethylpiperazine |
US08/216,583 US5420131A (en) | 1993-03-23 | 1994-03-23 | Cyanomethylpyridine derivatives |
EP94104612A EP0617032A1 (en) | 1993-03-23 | 1994-03-23 | Cyanomethylpyridine derivatives as PAF antagonists and 5-lipoxygenase inhibitors |
JP6076436A JPH072841A (ja) | 1993-03-23 | 1994-03-23 | 新規シアノメチルピリジン誘導体 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES09300591A ES2062943B1 (es) | 1993-03-23 | 1993-03-23 | Nuevos derivados de la (2-metil-3-piridil) cianometilpiperazinas. |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2062943A1 ES2062943A1 (es) | 1994-12-16 |
ES2062943B1 true ES2062943B1 (es) | 1995-11-16 |
Family
ID=8281207
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES09300591A Expired - Fee Related ES2062943B1 (es) | 1993-03-23 | 1993-03-23 | Nuevos derivados de la (2-metil-3-piridil) cianometilpiperazinas. |
Country Status (5)
Country | Link |
---|---|
US (1) | US5420131A (es) |
EP (1) | EP0617032A1 (es) |
JP (1) | JPH072841A (es) |
CA (1) | CA2118831A1 (es) |
ES (1) | ES2062943B1 (es) |
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5594021A (en) * | 1993-05-20 | 1997-01-14 | Texas Biotechnology Corporation | Thienyl-, furyl- and pyrrolyl sulfonamides and derivatives thereof that modulate the activity of endothelin |
US5591761A (en) * | 1993-05-20 | 1997-01-07 | Texas Biotechnology Corporation | Thiophenyl-, furyl-and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin |
US5962490A (en) * | 1987-09-25 | 1999-10-05 | Texas Biotechnology Corporation | Thienyl-, furyl- and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin |
US5514691A (en) * | 1993-05-20 | 1996-05-07 | Immunopharmaceutics, Inc. | N-(4-halo-isoxazolyl)-sulfonamides and derivatives thereof that modulate the activity of endothelin |
US5571821A (en) * | 1993-05-20 | 1996-11-05 | Texas Biotechnology Corporation | Sulfonamides and derivatives thereof that modulate the activity of endothelin |
US5639782A (en) * | 1992-03-04 | 1997-06-17 | Center For Innovative Technology | Neolignan derivatives as platelet activating factor receptor antagonists and 5-lipoxygenase inhibitors |
PT650485E (pt) | 1992-07-13 | 2001-03-30 | Millennium Pharm Inc | 2,5-diaril-tetra-hidro-tiofenos -furanos e analogos para o tratamento de desordens inflamatorias e imunitarias |
US5434151A (en) * | 1992-08-24 | 1995-07-18 | Cytomed, Inc. | Compounds and methods for the treatment of disorders mediated by platelet activating factor or products of 5-lipoxygenase |
US5463083A (en) | 1992-07-13 | 1995-10-31 | Cytomed, Inc. | Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders |
US6030991A (en) * | 1993-05-20 | 2000-02-29 | Texas Biotechnology Corp. | Benzenesulfonamides and the use thereof to modulate the activity of endothelin |
US6342610B2 (en) | 1993-05-20 | 2002-01-29 | Texas Biotechnology Corp. | N-aryl thienyl-, furyl-, and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin |
US6613804B2 (en) | 1993-05-20 | 2003-09-02 | Encysive Pharmaceuticals, Inc. | Biphenylsulfonamides and derivatives thereof that modulate the activity of endothelin |
US5703093A (en) * | 1995-05-31 | 1997-12-30 | Cytomed, Inc. | Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders |
US5750565A (en) | 1995-05-25 | 1998-05-12 | Cytomed, Inc. | Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders |
US5792776A (en) * | 1994-06-27 | 1998-08-11 | Cytomed, Inc., | Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders |
FR2721610B1 (fr) * | 1994-06-28 | 1996-08-23 | Adir | Nouveaux dérivés (thia)cycloalkyl [b] indoles, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent. |
US5891460A (en) * | 1995-06-07 | 1999-04-06 | University Of Southern California University Park Campus | Method for reducing or preventing post-surgical adhesion formation using ketotifen and analogs thereof |
US5977117A (en) * | 1996-01-05 | 1999-11-02 | Texas Biotechnology Corporation | Substituted phenyl compounds and derivatives thereof that modulate the activity of endothelin |
US5958905A (en) | 1996-03-26 | 1999-09-28 | Texas Biotechnology Corporation | Phosphoramidates, phosphinic amides and related compounds and the use thereof to modulate the activity of endothelin |
US5804585A (en) | 1996-04-15 | 1998-09-08 | Texas Biotechnology Corporation | Thieno-pyridine sulfonamides derivatives thereof and related compounds that modulate the activity of endothelin |
US5783705A (en) * | 1997-04-28 | 1998-07-21 | Texas Biotechnology Corporation | Process of preparing alkali metal salys of hydrophobic sulfonamides |
SK143399A3 (en) | 1997-04-28 | 2000-05-16 | Texas Biotechnology Corp | Sulfonamides for treatment of endothelin-mediated disorders |
TWI250152B (en) | 1998-07-21 | 2006-03-01 | Eisai Co Ltd | N,N-substituted cyclic amine compounds used as calcium antagonizer |
US6855715B1 (en) | 1999-06-14 | 2005-02-15 | Eli Lilly And Company | Serine protease inhibitors |
AU5413600A (en) * | 1999-06-14 | 2001-01-02 | Eli Lilly And Company | Compounds |
AU2041801A (en) * | 1999-11-11 | 2001-06-06 | Eli Lilly And Company | Oncolytic combinations for the treatment of cancer |
US6906072B1 (en) * | 2000-01-20 | 2005-06-14 | Eisai Co., Ltd. | Piperazine compound and pharmaceutical composition containing the compound |
US7074934B2 (en) * | 2000-06-13 | 2006-07-11 | Tularik Limited | Serine protease inhibitors |
MXPA05004924A (es) * | 2002-11-07 | 2005-08-18 | Univ Pittsburgh | Tratamiento para shock hemorragico. |
US20090221603A1 (en) * | 2005-12-19 | 2009-09-03 | Hassan Pajouhesh | Heterocyclic amide derivatives as calcium channel blockers |
US20090012010A1 (en) * | 2007-05-18 | 2009-01-08 | Neuromed Phramaceuticals Ltd. | Amino acid derivatives as calcium channel blockers |
CN106822080A (zh) | 2009-04-29 | 2017-06-13 | 阿马里纳药物爱尔兰有限公司 | 含有epa和心血管剂的药物组合物以及使用其的方法 |
MX2021007967A (es) | 2019-01-11 | 2021-09-21 | Naegis Pharmaceuticals Inc | Inhibidores de síntesis de leucotrienos. |
Family Cites Families (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS57165394A (en) * | 1981-04-02 | 1982-10-12 | Ono Pharmaceut Co Ltd | Phospholipid derivative, its preparation, and blood platelet activating factor antagonistic agent contraining the same |
JPS57169478A (en) * | 1981-04-10 | 1982-10-19 | Nippon Chemiphar Co Ltd | Piperazine derivative |
JPH0240648B2 (ja) * | 1981-08-25 | 1990-09-12 | Takeda Chemical Industries Ltd | Ketsushobankatsuseiinshokuseizai |
JPS6081194A (ja) * | 1983-10-11 | 1985-05-09 | Takeda Chem Ind Ltd | ケトアルキルリン脂質 |
JPS60104066A (ja) * | 1983-11-10 | 1985-06-08 | Ono Pharmaceut Co Ltd | グリセリン誘導体 |
DK160818C (da) * | 1983-12-30 | 1991-10-07 | Hoffmann La Roche | N-ring-holdige glycerolderivater, fremgangsmaade til fremstilling deraf, anvendelse deraf til fremstilling af et blodpladeaktiveringsfaktorhaemmende middel samt laegemidler indeholdende en saadan forbindelse |
EP0157609B1 (en) * | 1984-04-03 | 1992-10-14 | Takeda Chemical Industries, Ltd. | Lipid derivatives their production and use |
EP0195016A1 (en) * | 1984-08-23 | 1986-09-24 | Sandoz Ag | Cyclimmonium salts |
JPS6193191A (ja) * | 1984-10-10 | 1986-05-12 | サンド・アクチエンゲゼルシヤフト | 置換された2‐フラニルまたは5‐オキソ‐2‐フラニル‐アルコキシホスホリルアルキルシクリモニウム塩類 |
EP0178261A3 (en) * | 1984-10-10 | 1986-12-30 | Sandoz Ag | Substituted 2-furanyl or 5-oxo-2-furanyl-alkoxy phosphoryl alkyl cyclimmonium salts |
US4675390A (en) * | 1984-12-03 | 1987-06-23 | Eli Lilly And Company | 2-deoxypentose derivatives |
GB8504871D0 (en) * | 1985-02-26 | 1985-03-27 | Ici Plc | Heterocyclic compounds |
US4876346A (en) * | 1985-05-02 | 1989-10-24 | American Home Products Corporation | Quinoline compounds |
DE3662197D1 (en) * | 1985-07-15 | 1989-04-06 | Takeda Chemical Industries Ltd | 2-alkanoyloxypropane derivatives, their production and use |
DE3663255D1 (en) * | 1985-07-26 | 1989-06-15 | Sankyo Co | Phosphate ester derivatives, their preparation and their therapeutic use |
JP2556849B2 (ja) * | 1986-02-13 | 1996-11-27 | 三共株式会社 | グリセリン誘導体 |
GB8604000D0 (en) * | 1986-02-18 | 1986-03-26 | Roussel Lab Ltd | Chemical compounds |
KR950002551B1 (en) * | 1986-07-04 | 1995-03-21 | Sankyo Co | Cyclic ether derivatives, their preparation and use |
JP2561478B2 (ja) * | 1986-07-22 | 1996-12-11 | 武田薬品工業株式会社 | グリセリン誘導体 |
AU596499B2 (en) * | 1987-01-20 | 1990-05-03 | Dainippon Pharmaceutical Co. Ltd. | Aromatic heterocyclic carboxylic acid amide derivatives, process for their preparation, and pharmaceutical composition containing same |
GB8701727D0 (en) * | 1987-01-27 | 1987-03-04 | Scras | Tetrahydrofuran derivatives |
IL85700A0 (en) * | 1987-03-24 | 1988-08-31 | Takeda Chemical Industries Ltd | 1,4-disubstituted piperazine compounds,their production and use |
GB2205833B (en) * | 1987-06-12 | 1991-03-27 | Scras | Aminoacylates of glycerol acetal |
EP0301751B1 (en) * | 1987-07-31 | 1993-03-10 | Takeda Chemical Industries, Ltd. | Pyridinium derivatives, their production and use |
EP0312040B1 (en) * | 1987-10-13 | 1992-06-03 | J. URIACH & CIA. S.A. | 2,4-disubstituted derivatives of tetrahydrofuran |
ES2005031A6 (es) * | 1987-10-13 | 1989-02-16 | Uriach & Cia Sa J | Procedimiento para la obtencion de 1,3-dioxolanos 2,4-disustituidos. |
US5102881A (en) * | 1988-06-27 | 1992-04-07 | Merck Frosst Canada, Inc. | Quinoline ether alkanoic acids |
ES2013834A6 (es) * | 1989-01-30 | 1990-06-01 | Uriach & Cia Sa J | Procedimiento para la obtencion de derivados 4-sustituidos de 2-alcoxitetrahidrofurano. |
ES2010145A6 (es) * | 1989-03-02 | 1989-10-16 | Uriach & Cia Sa J | Procedimiento para la obtencion de derivados de la 2-picolilamina. |
WO1990012006A1 (en) * | 1989-04-07 | 1990-10-18 | Pfizer Inc. | Substituted 1-[3-(heteroarylmethoxy)phenyl]alkanols and related compounds in the treatment of asthma, arthritis and related diseases |
EP0441226A1 (en) * | 1990-01-29 | 1991-08-14 | J. URIACH & CIA. S.A. | (cyanomethyl)pyridines useful as PAF antagonists |
JP3216647B2 (ja) * | 1991-03-04 | 2001-10-09 | ユニバーシティー オブ バージニア | 血小板活性化因子レセプターアンタゴニストおよび5−リポキシゲナーゼインヒビターとしてのネオリグナン誘導体 |
ES2036926B1 (es) * | 1991-08-08 | 1994-01-16 | Uriach & Cia Sa J | "procedimiento para la obtencion de derivados de la (2-alquil-3-piridil)metilpiperazina". |
DE4129742A1 (de) * | 1991-09-06 | 1993-03-11 | Bayer Ag | Heterocyclisch substituierte chinolylmethoxy-phenylacetamide |
-
1993
- 1993-03-23 ES ES09300591A patent/ES2062943B1/es not_active Expired - Fee Related
-
1994
- 1994-03-11 CA CA002118831A patent/CA2118831A1/en not_active Abandoned
- 1994-03-23 EP EP94104612A patent/EP0617032A1/en not_active Ceased
- 1994-03-23 JP JP6076436A patent/JPH072841A/ja active Pending
- 1994-03-23 US US08/216,583 patent/US5420131A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
CA2118831A1 (en) | 1994-09-24 |
ES2062943A1 (es) | 1994-12-16 |
JPH072841A (ja) | 1995-01-06 |
US5420131A (en) | 1995-05-30 |
EP0617032A1 (en) | 1994-09-28 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 20040503 |