PA8452201A1 - Derivados de 9-desoxo-9a-aza-9a -homoeritromicina a c-4"sustituidos. - Google Patents

Derivados de 9-desoxo-9a-aza-9a -homoeritromicina a c-4"sustituidos.

Info

Publication number
PA8452201A1
PA8452201A1 PA19988452201A PA8452201A PA8452201A1 PA 8452201 A1 PA8452201 A1 PA 8452201A1 PA 19988452201 A PA19988452201 A PA 19988452201A PA 8452201 A PA8452201 A PA 8452201A PA 8452201 A1 PA8452201 A1 PA 8452201A1
Authority
PA
Panama
Prior art keywords
formula
compounds
homoeritromicina
desoxo
aza
Prior art date
Application number
PA19988452201A
Other languages
English (en)
Inventor
Takushi Kanebo
Bingwei Vera Yang
Edward Alan Glazer
Brian Scott Bronk
Michael Anthony Letavic
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21959336&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PA8452201(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of PA8452201A1 publication Critical patent/PA8452201A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biotechnology (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

ESTA INVENCION SE REFIERE A COMPUESTOS DE FORMULA (1) Y A SALES FARMACEUTICAMENTE ACEPTABLES DE LOS MISMOS. LOS COMPUESTOS DE FORMULA 1 SON AGENTES ANTIBACTERIANOS QUE PUEDEN USARSE PARA TRATAR DIVERSAS INFECCIONES BACTERIANAS Y PROTOZOARIAS. LA INVENCION TAMBIEN SE REFIERE A COMPOSICIONES FARMACEUTICAS QUE CONTIENEN LOS COMPUESTOS DE FORMULA 1 Y A PROCEDIMIENTOS PARA TRATAR LAS INFECCIONES BACTERIANAS PROTOZOARIAS ADMINISTRANDO LOS COMPUESTOS DE FORMULA 1. LA INVENCION TAMBIEN SE REFIERE A PROCEDIMIENTOS PARA PREPARAR LOS COMPUESTOS DE FORMULA 1 Y A LOS INTERMEDIOS UTILES PARA DICHA PREPARACION.
PA19988452201A 1997-06-11 1998-05-27 Derivados de 9-desoxo-9a-aza-9a -homoeritromicina a c-4"sustituidos. PA8452201A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US4934897P 1997-06-11 1997-06-11

Publications (1)

Publication Number Publication Date
PA8452201A1 true PA8452201A1 (es) 2000-05-24

Family

ID=21959336

Family Applications (1)

Application Number Title Priority Date Filing Date
PA19988452201A PA8452201A1 (es) 1997-06-11 1998-05-27 Derivados de 9-desoxo-9a-aza-9a -homoeritromicina a c-4"sustituidos.

Country Status (50)

Country Link
US (4) US6420536B1 (es)
EP (1) EP0988310B9 (es)
JP (2) JP3315704B2 (es)
KR (1) KR100396168B1 (es)
CN (4) CN1172947C (es)
AP (1) AP1231A (es)
AR (1) AR013086A1 (es)
AT (1) ATE251173T1 (es)
AU (1) AU749816B2 (es)
BG (1) BG64391B1 (es)
BR (1) BRPI9810519B8 (es)
CA (1) CA2293823C (es)
CO (1) CO4950611A1 (es)
CZ (1) CZ298556B6 (es)
DE (2) DE122004000018I2 (es)
DK (1) DK0988310T3 (es)
DZ (1) DZ2514A1 (es)
EA (1) EA002441B1 (es)
EG (1) EG24081A (es)
ES (1) ES2205487T3 (es)
FR (1) FR04C0013I2 (es)
GT (1) GT199800077A (es)
HK (3) HK1028048A1 (es)
HN (1) HN1998000086A (es)
HR (1) HRP980314B1 (es)
HU (2) HU228005B1 (es)
ID (1) ID22992A (es)
IL (1) IL132809A0 (es)
IS (1) IS1998B (es)
LU (1) LU91076I9 (es)
MA (1) MA24564A1 (es)
ME (1) ME00876B (es)
MY (1) MY123354A (es)
NL (1) NL300150I2 (es)
NO (1) NO316911B1 (es)
NZ (2) NZ500660A (es)
OA (1) OA11224A (es)
PA (1) PA8452201A1 (es)
PE (1) PE79699A1 (es)
PL (1) PL191601B1 (es)
PT (1) PT988310E (es)
RS (1) RS49675B (es)
SI (1) SI0988310T1 (es)
SK (1) SK284171B6 (es)
TN (1) TNSN98082A1 (es)
TW (1) TW472060B (es)
UA (1) UA67744C2 (es)
UY (1) UY25040A1 (es)
WO (1) WO1998056802A1 (es)
ZA (1) ZA985017B (es)

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AU731842B2 (en) * 1997-09-10 2001-04-05 Merck & Co., Inc. 9a-azalides as veterinary antimicrobial agents
EP1779853A3 (en) * 1997-09-10 2010-01-27 Merial Ltd. 9a-azalides as veterinary antimicrobial agents
AP9801420A0 (en) * 1998-01-02 1998-12-31 Pfizer Prod Inc Novel macrolides.
EP1437360A3 (en) * 1998-08-19 2005-04-06 Pfizer Products Inc. C11 Carbamates of macrolide antibacterials
US6043227A (en) * 1998-08-19 2000-03-28 Pfizer Inc. C11 carbamates of macrolide antibacterials
US6100240A (en) * 1998-10-09 2000-08-08 Pfizer Inc Macrolide derivatives
CA2292359C (en) * 1999-01-28 2004-09-28 Pfizer Products Inc. Novel azalides and methods of making same
UA67842C2 (uk) * 1999-05-18 2004-07-15 Пфайзер Продактс Інк. Кристалічні форми макролідного антибіотика
EA200100983A1 (ru) * 1999-05-24 2002-10-31 Пфайзер Продактс Инк. Производные 13-метилэритромицина
US6465437B1 (en) 1999-06-30 2002-10-15 Pfizer Inc. Diphosphate salt of a 4″-substituted-9-deoxo-9A-AZA-9A- homoerythromycin derivative and its pharmaceutical composition
DK1206476T3 (da) * 1999-08-24 2006-05-15 Abbott Lab 9a-azalider med antibakteriel virkning
US6764996B1 (en) 1999-08-24 2004-07-20 Abbott Laboratories 9a-azalides with antibacterial activity
US6608033B1 (en) * 1999-08-27 2003-08-19 Pfizer Inc. Treatment or prevention of coccidiosis
WO2001055158A1 (en) * 2000-01-27 2001-08-02 Pfizer Products Inc. Azalide antibiotic compositions
PL359861A1 (en) * 2000-04-27 2004-09-06 Pfizer Products Inc. The use of azalide antibiotic compositions for treating or preventing a bacterial or protozoal infection in mammals
BR0209241A (pt) * 2001-04-27 2004-06-15 Pfizer Prod Inc Processo para preparação de derivados de9-deoxo-9a-aza-9a-homoeritromicina a 4-substituida
AU2002317415A1 (en) * 2001-08-01 2003-02-17 Pfizer Products Inc. Azalide antibiotic compositions
WO2004080391A2 (en) 2003-03-10 2004-09-23 Optimer Pharmaceuticals, Inc. Novel antibacterial agents
WO2005030227A1 (en) 2003-09-23 2005-04-07 Enanta Pharmaceuticals, Inc. 9a, 11-3C-BICYCLIC 9a-AZALIDE DERIVATIVES
CN1882360A (zh) * 2003-11-21 2006-12-20 辉瑞产品公司 抗生素作为疫苗佐剂的用途
EP2360165A3 (de) * 2004-03-16 2012-01-04 Boehringer Ingelheim International GmbH Glucopyranosyl-substituierte Benzol-Derivate, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung
US7468428B2 (en) * 2004-03-17 2008-12-23 App Pharmaceuticals, Llc Lyophilized azithromycin formulation
US20060116336A1 (en) * 2004-03-17 2006-06-01 American Pharmaceutical Partners, Inc. Lyophilized azithromycin formulation
US7402568B2 (en) 2004-09-29 2008-07-22 Enanta Pharmaceuticals, Inc. Bicyclic 9a-azalide derivatives
US7767797B1 (en) * 2004-09-30 2010-08-03 Synovo Gmbh Macrocyclic compounds and methods of use thereof
US7271155B2 (en) 2005-01-07 2007-09-18 Enanta Pharmaceuticals, Inc. 9A, 11-2C-bicyclic 9a-azalide derivatives
ATE429921T1 (de) * 2005-01-14 2009-05-15 Glaxosmithkline Zagreb 9a-carbamoyl- und thiocarbamoylazalide mit antimalariawirkung
CA2703475A1 (en) 2007-10-25 2009-04-30 Cempra Pharmaceuticals, Inc. Process for the preparation of macrolide antibacterial agents
EP2358379B1 (en) * 2008-10-24 2015-12-16 Cempra Pharmaceuticals, Inc. Biodefenses using triazole-containing macrolides
US9937194B1 (en) * 2009-06-12 2018-04-10 Cempra Pharmaceuticals, Inc. Compounds and methods for treating inflammatory diseases
US9480679B2 (en) 2009-09-10 2016-11-01 Cempra Pharmaceuticals, Inc. Methods for treating malaria, tuberculosis and MAC diseases
PL2550286T3 (pl) 2010-03-22 2016-07-29 Cempra Pharmaceuticals Inc Krystaliczne postaci makrolidu i ich zastosowanie
CN102917708B (zh) 2010-05-20 2015-11-25 森普拉制药公司 制备大环内酯和酮内酯及其中间体的方法
US9815863B2 (en) 2010-09-10 2017-11-14 Cempra Pharmaceuticals, Inc. Hydrogen bond forming fluoro ketolides for treating diseases
JP5908479B2 (ja) * 2010-09-20 2016-04-26 ノバルティス ティーアゲズントハイト アーゲー クラジノース環のＣ−４”をエポキシド基で修飾した９−デオキソ−９ａ−アザ−９ａ−ホモエリスロマイシンＡの新規製造方法
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WO2013004116A1 (zh) * 2011-07-06 2013-01-10 洛阳惠中兽药有限公司 C-3取代的-9-脱氧-9a-氮杂-9a-高红霉素a衍生物
CN102260306B (zh) * 2011-07-22 2012-07-18 山东鲁抗舍里乐药业有限公司 一种制备泰拉霉素的方法
EP2736915A1 (en) 2011-07-27 2014-06-04 Farma GRS, d.o.o. New crystalline forms of tulathromycin
CN104470527B (zh) 2012-03-27 2019-05-28 森普拉制药公司 用于施用大环内酯抗生素的肠胃外制剂
CN102786569B (zh) * 2012-09-07 2016-12-07 安徽中升药业有限公司 泰拉霉素中间体及其制备方法与泰拉霉素的制备方法
WO2014152326A1 (en) 2013-03-14 2014-09-25 Cempra Pharmaceuticals, Inc. Methods for treating respiratory diseases and formulations therefor
US9751908B2 (en) 2013-03-15 2017-09-05 Cempra Pharmaceuticals, Inc. Convergent processes for preparing macrolide antibacterial agents
SI3027634T1 (sl) * 2013-07-31 2018-10-30 Farma Grs, D.O.O. Proces za pripravo tulatromicina
CN103497227B (zh) * 2013-09-13 2015-09-30 青岛科技大学 一种泰拉菌素中间体的制备方法
CN104725446B (zh) * 2015-03-26 2017-10-27 宁夏泰瑞制药股份有限公司 一种从泰拉霉素粗品中分离泰拉霉素a和泰拉霉素b的方法
CN104861018A (zh) * 2015-06-17 2015-08-26 瑞普（天津）生物药业有限公司 一种泰拉菌素的制备方法
CN105646617A (zh) * 2016-01-21 2016-06-08 杭州海尔希畜牧科技有限公司 一种制备泰拉霉素的方法
FR3048612B1 (fr) * 2016-03-14 2020-10-02 Septeos Tulathromycine potentialisee
CN106046077B (zh) * 2016-08-04 2019-07-26 湖北美天生物科技股份有限公司 一种泰拉霉素a的合成方法
CN108003207B (zh) * 2017-12-19 2019-05-10 海门慧聚药业有限公司 制备泰拉霉素的方法
CN111087433B (zh) * 2018-10-23 2023-03-21 湖北美天生物科技股份有限公司 一种泰拉霉素中间体的制备方法

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Also Published As

Publication number Publication date
FR04C0013I1 (es) 2004-06-11
DZ2514A1 (fr) 2003-02-01
US20040180842A1 (en) 2004-09-16
BG64391B1 (bg) 2004-12-30
GT199800077A (es) 1999-12-02
PE79699A1 (es) 1999-08-25
SI0988310T1 (en) 2004-02-29
AU7347598A (en) 1998-12-30
BRPI9810519A (pt) 2000-09-19
HK1088014A1 (en) 2006-10-27
KR20010013632A (ko) 2001-02-26
RS49675B (sr) 2007-11-15
NZ500660A (en) 2002-03-01
MA24564A1 (fr) 1998-12-31
TW472060B (en) 2002-01-11
ZA985017B (en) 1999-12-17
HU228005B1 (en) 2012-08-28
FR04C0013I2 (es) 2005-10-21
LU91076I2 (fr) 2004-07-05
JP2000514098A (ja) 2000-10-24
NO316911B1 (no) 2004-06-21
HK1028048A1 (en) 2001-02-02
HUS1200028I1 (hu) 2016-08-29
JP2002316933A (ja) 2002-10-31
OA11224A (en) 2003-07-16
AU749816B2 (en) 2002-07-04
NZ514871A (en) 2003-08-29
NO996106D0 (no) 1999-12-10
ATE251173T1 (de) 2003-10-15
EP0988310B9 (en) 2006-03-08
YU58699A (es) 2002-08-12
NL300150I2 (nl) 2004-09-01
DE69818665T2 (de) 2004-04-29
ES2205487T3 (es) 2004-05-01
CN101691390A (zh) 2010-04-07
PL337505A1 (en) 2000-08-28
BG103945A (en) 2000-07-31
US20040023896A1 (en) 2004-02-05
CZ298556B6 (cs) 2007-11-07
SK284171B6 (sk) 2004-10-05
BRPI9810519B8 (pt) 2022-11-16
CO4950611A1 (es) 2000-09-01
LU91076I9 (en) 2018-07-02
US6420536B1 (en) 2002-07-16
SK168399A3 (en) 2000-11-07
JP3315704B2 (ja) 2002-08-19
CN1259136A (zh) 2000-07-05
CN1172947C (zh) 2004-10-27
DE69818665D1 (de) 2003-11-06
AP1231A (en) 2003-12-11
IS5252A (is) 1999-11-16
EA199901015A1 (ru) 2000-06-26
DE122004000018I2 (de) 2011-01-13
CN1243766C (zh) 2006-03-01
EA002441B1 (ru) 2002-04-25
HRP980314B1 (en) 2004-04-30
PT988310E (pt) 2003-12-31
EG24081A (en) 2008-05-11
HUP0002209A2 (hu) 2000-12-28
HK1068893A1 (en) 2005-07-29
UA67744C2 (uk) 2004-07-15
DK0988310T3 (da) 2003-12-15
HUP0002209A3 (en) 2003-05-28
WO1998056802A1 (en) 1998-12-17
EP0988310A1 (en) 2000-03-29
CA2293823C (en) 2004-02-17
CN1793155A (zh) 2006-06-28
TNSN98082A1 (fr) 2005-03-15
CN1566129A (zh) 2005-01-19
ME00876B (me) 2012-06-20
CN1793155B (zh) 2010-05-12
AR013086A1 (es) 2000-12-13
HRP980314A2 (en) 1999-04-30
CZ442199A3 (cs) 2000-07-12
HN1998000086A (es) 1999-03-08
IL132809A0 (en) 2001-03-19
KR100396168B1 (ko) 2003-08-27
IS1998B (is) 2005-03-15
US6936592B2 (en) 2005-08-30
DE122004000018I1 (de) 2004-09-30
NO996106L (no) 2000-02-10
NL300150I1 (nl) 2004-08-02
US20020061858A1 (en) 2002-05-23
ID22992A (id) 1999-12-23
CA2293823A1 (en) 1998-12-17
AP9801255A0 (en) 1998-06-30
MY123354A (en) 2006-05-31
BRPI9810519B1 (pt) 2012-02-22
UY25040A1 (es) 2000-09-29
PL191601B1 (pl) 2006-06-30
EP0988310B1 (en) 2003-10-01
US6777393B2 (en) 2004-08-17

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