BR9609503A - Composto, uso de um composto, processo de tratamento de condições onde a inibição de pde especìfico para cgmp é de benefìcio terapêutico, em corpo de animal humano ou não humano, composição farmacêutica, e processos para preparar a mesma e um composto - Google Patents

Composto, uso de um composto, processo de tratamento de condições onde a inibição de pde especìfico para cgmp é de benefìcio terapêutico, em corpo de animal humano ou não humano, composição farmacêutica, e processos para preparar a mesma e um composto

Info

Publication number
BR9609503A
BR9609503A BR9609503-2A BR9609503A BR9609503A BR 9609503 A BR9609503 A BR 9609503A BR 9609503 A BR9609503 A BR 9609503A BR 9609503 A BR9609503 A BR 9609503A
Authority
BR
Brazil
Prior art keywords
compound
human
pgmp
inhibition
prepare
Prior art date
Application number
BR9609503-2A
Other languages
English (en)
Inventor
Alain Claude-Marie Daugan
Richard Frederic Labaudiniere
Original Assignee
Icos Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Icos Corp filed Critical Icos Corp
Publication of BR9609503A publication Critical patent/BR9609503A/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pulmonology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Obesity (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Otolaryngology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

"COMPOSTO, USO DE UM COMPOSTO, PROCESSO DE TRATAMENTO DE CONDIçõES ONDE A INIBIçãO DE PDE ESPECìFICO PARA CGMP é DE BENEFìCIO TERAPêUTICO, EM UM CORPO DE ANIMAL HUMANO OU NãO HUMANO, COMPOSIçãO FARMACêUTICA, E, PROCESSOS PARA PREPARAR A MESMA E UM COMPOSTO". Um composto de fórmula (I): e sais e solvatos dos mesmos, em que: R° representa hidrogênio, halogênio ou alquila C~ 1-6~; R^ 1^ é selecionado dentre o grupo consistindo de: (a) hidrogênio; (b) alquila C~ 1-6~ opcionalmente substituída por um ou mais substituintes selecionados dentre fenila, halogênio, -CO~ 2~R^ a^ e -NR^ a^R^ b^; (c) cicloalquila C~ 3-6~; (d) fenila; e (e) um anel heterocíclico de 5- ou 6- membros contendo pelo menos um heteroátomo selecionado dentre oxigênio, nitrogênio e enxofre, e sendo opcionalmente substituído por uma ou mais alquila C~ 1-6~, e opcionalmente ligado ao átomo de nitrogênio que R^ 1^ é fixado via alquila C~ 1-6~; R^ 2^ é selecionado dentre o grupo consistindo de: (f) cicloalquila C~ 3-6~; (g) fenila opcionalmente substituída por um ou mais substituintes selecionados dentre -OR^ a^, -NR^ a^R^ b^, halogênio, hidroxi, trifluorometila, ciano e nitro; (h) um anel heterocíclico com 5- ou 6- membros contendo pelo menos um heteroátomo selecionado dentre oxigênio, nitrogênio e enxofre; e (i) um anel bicíclico (1) fixado no resto de uma via de molécula de átomos de carbono do anel benzeno e A é um anel heterocíclico com 5- ou 6- membros como definidos no ponto (h); e R^ a^ e R^ b^ independentemente representam hidrogênio ou alquila C~ 1-6~. Um composto da presente invenção é um inibidor potente e seletivo de PDE específico para cGMP tendo utilidade em várias áreas terapêuticas onde esta inibição é benéfica.
BR9609503-2A 1995-07-14 1996-07-11 Composto, uso de um composto, processo de tratamento de condições onde a inibição de pde especìfico para cgmp é de benefìcio terapêutico, em corpo de animal humano ou não humano, composição farmacêutica, e processos para preparar a mesma e um composto BR9609503A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9514473.9A GB9514473D0 (en) 1995-07-14 1995-07-14 Chemical compounds
PCT/EP1996/003023 WO1996032003A2 (en) 1995-07-14 1996-07-11 Tetrahydroimidazopyridoindolediones and their use as medicaments

Publications (1)

Publication Number Publication Date
BR9609503A true BR9609503A (pt) 2000-03-08

Family

ID=10777704

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9609503-2A BR9609503A (pt) 1995-07-14 1996-07-11 Composto, uso de um composto, processo de tratamento de condições onde a inibição de pde especìfico para cgmp é de benefìcio terapêutico, em corpo de animal humano ou não humano, composição farmacêutica, e processos para preparar a mesma e um composto

Country Status (13)

Country Link
US (3) US6001847A (pt)
EP (1) EP0859778B1 (pt)
JP (1) JP4012246B2 (pt)
CN (1) CN1095841C (pt)
AT (1) ATE211139T1 (pt)
AU (1) AU702548B2 (pt)
BR (1) BR9609503A (pt)
CA (1) CA2226759A1 (pt)
DE (1) DE69618231T2 (pt)
ES (1) ES2170252T3 (pt)
GB (1) GB9514473D0 (pt)
MX (1) MX9800415A (pt)
WO (1) WO1996032003A2 (pt)

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Also Published As

Publication number Publication date
MX9800415A (es) 1998-04-30
JP4012246B2 (ja) 2007-11-21
ATE211139T1 (de) 2002-01-15
EP0859778B1 (en) 2001-12-19
WO1996032003A3 (en) 1997-01-03
WO1996032003A2 (en) 1996-10-17
GB9514473D0 (en) 1995-09-13
CN1095841C (zh) 2002-12-11
US6001847A (en) 1999-12-14
AU702548B2 (en) 1999-02-25
EP0859778A2 (en) 1998-08-26
CN1195350A (zh) 1998-10-07
JPH11509517A (ja) 1999-08-24
DE69618231D1 (de) 2002-01-31
US6218400B1 (en) 2001-04-17
ES2170252T3 (es) 2002-08-01
DE69618231T2 (de) 2002-08-22
CA2226759A1 (en) 1996-10-17
AU6613896A (en) 1996-10-30
US6143757A (en) 2000-11-07

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