ATE455758T1 - Pyrrolidin-derivatie als prostaglandin- modulatoren - Google Patents

Pyrrolidin-derivatie als prostaglandin- modulatoren

Info

Publication number
ATE455758T1
ATE455758T1 AT02793091T AT02793091T ATE455758T1 AT E455758 T1 ATE455758 T1 AT E455758T1 AT 02793091 T AT02793091 T AT 02793091T AT 02793091 T AT02793091 T AT 02793091T AT E455758 T1 ATE455758 T1 AT E455758T1
Authority
AT
Austria
Prior art keywords
compounds
disorder
substituted pyrrolidine
pyrrolidine derivatives
prostaglandin
Prior art date
Application number
AT02793091T
Other languages
English (en)
Inventor
Yihua Liao
Zhong Zhao
Gian Araldi
Original Assignee
Merck Serono Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Serono Sa filed Critical Merck Serono Sa
Application granted granted Critical
Publication of ATE455758T1 publication Critical patent/ATE455758T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/06—Antiabortive agents; Labour repressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36—Oxygen or sulfur atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Reproductive Health (AREA)
  • Hematology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pulmonology (AREA)
  • Endocrinology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pregnancy & Childbirth (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT02793091T 2001-12-20 2002-12-19 Pyrrolidin-derivatie als prostaglandin- modulatoren ATE455758T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US34262001P 2001-12-20 2001-12-20
PCT/EP2002/014593 WO2003053923A2 (en) 2001-12-20 2002-12-19 Pyrrolidine derivatives as prostaglandin modulators

Publications (1)

Publication Number Publication Date
ATE455758T1 true ATE455758T1 (de) 2010-02-15

Family

ID=23342570

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02793091T ATE455758T1 (de) 2001-12-20 2002-12-19 Pyrrolidin-derivatie als prostaglandin- modulatoren

Country Status (10)

Country Link
US (3) US7335680B2 (de)
EP (1) EP1458679B1 (de)
JP (1) JP4554931B2 (de)
AT (1) ATE455758T1 (de)
AU (2) AU2002358772B2 (de)
CA (1) CA2469075C (de)
DE (1) DE60235198D1 (de)
ES (1) ES2337887T3 (de)
IL (2) IL162602A0 (de)
WO (1) WO2003053923A2 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1458679B1 (de) * 2001-12-20 2010-01-20 Merck Serono SA Pyrrolidin-derivatie als prostaglandin-modulatoren
TW200413000A (en) 2002-10-10 2004-08-01 Ono Pharmaceutical Co Intrinsic repair factor producing accelerator
KR100843244B1 (ko) 2007-04-19 2008-07-02 삼성전자주식회사 반도체 소자 및 그 제조 방법
US7547685B2 (en) 2004-11-08 2009-06-16 Allergan, Inc. Therapeutic substituted pyrrolidone compounds
US7893107B2 (en) 2005-11-30 2011-02-22 Allergan, Inc. Therapeutic methods using prostaglandin EP4 agonist components
US7557095B2 (en) * 2006-05-12 2009-07-07 Allergan, Inc. Therapeutic compounds
US7550448B2 (en) * 2006-05-24 2009-06-23 Allergan, Inc. Therapeutic compounds
AU2008246579A1 (en) 2007-05-08 2008-11-13 National University Corporation, Hamamatsu University School Of Medicine Cytotoxic T cell activator comprising EP4 agonist
WO2008144623A1 (en) * 2007-05-23 2008-11-27 Allergan, Inc. Cyclic lactams for the treatment of glaucoma or elevated intraocular pressure
US7964596B2 (en) 2008-03-07 2011-06-21 Allergan, Inc. Therapeutic compounds
EP2149552A1 (de) 2008-07-30 2010-02-03 Bayer Schering Pharma AG 5,6 substituierte Benzamid-Derivate als Modulatoren des EP2-Rezeptors
EP2149554A1 (de) 2008-07-30 2010-02-03 Bayer Schering Pharma Aktiengesellschaft Indolylamide als Modulatoren des EP2-Rezeptors
EP2149551A1 (de) 2008-07-30 2010-02-03 Bayer Schering Pharma AG N-(Indol-3-ylalkyl)-(hetero)arylamidderivate als Modulatoren des EP2-Rezeptors
EP2364296A1 (de) * 2008-11-10 2011-09-14 Pfizer Limited Pyrrolidine
WO2010087425A1 (ja) 2009-01-30 2010-08-05 国立大学法人京都大学 前立腺癌の進行抑制剤および進行抑制方法
TW201326154A (zh) 2011-11-28 2013-07-01 拜耳知識產權公司 作為ｅｐ２受體拮抗劑之新穎２ｈ－吲唑
JP6400479B2 (ja) 2012-10-29 2018-10-03 株式会社カルディオ 肺疾患特異的治療剤
US9968716B2 (en) 2013-10-15 2018-05-15 Ono Pharmaceutical Co., Ltd. Drug-eluting stent graft

Family Cites Families (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3873566A (en) 1973-02-28 1975-03-25 Du Pont 3-Pyrazolidinones and pyrazolidines
DE2451160A1 (de) * 1973-10-30 1975-05-07 Du Pont 3-pyrazolidinone und pyrazolidine
US3976660A (en) * 1974-08-15 1976-08-24 E. R. Squibb & Sons, Inc. Pyrrolidine derivatives
DE2527989A1 (de) 1975-06-24 1977-01-27 Hoechst Ag Pyrrolidone und verfahren zu ihrer herstellung
US4033989A (en) 1975-09-17 1977-07-05 The Upjohn Company 9-Deoxy-PGF2 Analogs
US4003911A (en) * 1975-09-26 1977-01-18 E. I. Du Pont De Nemours And Company Selected 3-pyrrolidinones and 2,4-pyrrolidindiones
US4090019A (en) 1976-05-10 1978-05-16 Minnesota Mining And Manufacturing Company Geminal prostaglandin analogs
US4211876A (en) * 1979-06-13 1980-07-08 E. I. Du Pont De Nemours And Company 3-Pyrazolidinone carboxamides
US4753945A (en) 1986-02-19 1988-06-28 Eye Research Institute Of Retina Foundation Stimulation of tear secretion with phosphodiesterase inhibitors
US5091431A (en) 1988-02-08 1992-02-25 Schering Corporation Phosphodiesterase inhibitors
US5010086A (en) 1990-02-28 1991-04-23 Sterling Drug Inc. Imidazopyridines, compositions and use
GB9013750D0 (en) 1990-06-20 1990-08-08 Pfizer Ltd Therapeutic agents
GB9119704D0 (en) 1991-09-14 1991-10-30 Pfizer Ltd Therapeutic agents
GB9121028D0 (en) 1991-10-03 1991-11-13 Pfizer Ltd Therapeutic agents
GB9126260D0 (en) 1991-12-11 1992-02-12 Pfizer Ltd Therapeutic agents
GB9213623D0 (en) 1992-06-26 1992-08-12 Pfizer Ltd Therapeutic agents
GB9218322D0 (en) 1992-08-28 1992-10-14 Pfizer Ltd Therapeutic agents
US5605814A (en) 1993-08-31 1997-02-25 Merck Frosst Canada Inc. DNA encoding human prostaglandin receptor EP2
GB9514465D0 (en) 1995-07-14 1995-09-13 Glaxo Lab Sa Chemical compounds
US6143746A (en) 1994-01-21 2000-11-07 Icos Corporation Tetracyclic cyclic GMP-specific phosphodiesterase inhibitors, process of preparation and use
GB9514160D0 (en) 1994-07-25 1995-09-13 Zeneca Ltd Aromatic compounds
GB9417532D0 (en) 1994-08-31 1994-10-19 Zeneca Ltd Aromatic compounds
GB9423911D0 (en) 1994-11-26 1995-01-11 Pfizer Ltd Therapeutic agents
TW502026B (en) 1995-06-20 2002-09-11 Zeneca Ltd Aromatic compounds useful as antagonists of e-type prostaglandins, processes for the preparation thereof, pharmaceutical compositions comprising the compounds, and intermediates
TW434240B (en) 1995-06-20 2001-05-16 Zeneca Ltd Aromatic compounds, preparation thereof and pharmaceutical composition comprising same
DE69635254T2 (de) 1995-07-07 2006-07-13 Astrazeneca Ab Ortho-substituierte aromatische Verbindungen, die drei (Het)aryl-Ringe enthalten, deren Herstellung und deren Verwendung als Prostaglandin-E2-(PGE2)-Antagonisten
GB9514473D0 (en) 1995-07-14 1995-09-13 Glaxo Lab Sa Chemical compounds
GB9514464D0 (en) 1995-07-14 1995-09-13 Glaxo Lab Sa Medicaments
BR9709230A (pt) 1996-05-10 1999-08-10 Icos Corp Composto
EP0941221B1 (de) 1996-11-20 2003-02-26 ALTANA Pharma AG Substituierte dihydrobenzofurane als pde-hemmstoffe
UA59384C2 (uk) 1996-12-20 2003-09-15 Пфайзер, Інк. Похідні сульфонамідів та амідів як агоністи простагландину, фармацевтична композиція та способи лікування на їх основі
AT404730B (de) * 1997-04-07 1999-02-25 Holderchem Ag Acryl-copolymere und polymerzusammensetzungen sowie deren verwendung als additive oder beimischungen zur verbesserung der eigenschaften von dispersionen und baustoffen
US6043252A (en) 1997-05-05 2000-03-28 Icos Corporation Carboline derivatives
WO1999005113A1 (en) 1997-07-25 1999-02-04 Byk Gulden Lomberg Chemische Fabrik Gmbh Substituted 6-phenylphenanthridines
US6006735A (en) 1997-09-12 1999-12-28 Park Industries, Inc. Automated stoneworking system and method
US6127363A (en) 1997-10-28 2000-10-03 Vivus, Inc. Local administration of Type IV phosphodiesterase inhibitors for the treatment of erectile dysfunction
US6156753A (en) 1997-10-28 2000-12-05 Vivus, Inc. Local administration of type III phosphodiesterase inhibitors for the treatment of erectile dysfunction
GB9725953D0 (en) 1997-12-08 1998-02-04 Pfizer Ltd Compounds useful in therapy
US6211197B1 (en) 1998-10-07 2001-04-03 Merck Frosst Canada & Co. Prostaglandin receptor ligands
GB9822238D0 (en) 1998-10-12 1998-12-09 Pfizer Ltd Process for preparation of pyrazolo[4,3-D]pyrimidin-7-ones and intermediates thereof
OA12117A (en) 1999-12-22 2006-05-04 Pfizer Prod Inc EP4 receptor selective agonists in the treatment of osteoporosis.
BR0211201A (pt) * 2001-07-16 2004-07-13 Hoffmann La Roche Composto, processo para a preparação desse composto, sua utilização, composição farmacêutica que compreende o mesmo e método para o tratamento de uma enfermidade em um mamìfero
EP1458679B1 (de) * 2001-12-20 2010-01-20 Merck Serono SA Pyrrolidin-derivatie als prostaglandin-modulatoren

Also Published As

Publication number Publication date
US8058305B2 (en) 2011-11-15
CA2469075C (en) 2011-09-13
US20050176800A1 (en) 2005-08-11
JP2005517665A (ja) 2005-06-16
JP4554931B2 (ja) 2010-09-29
US20090292000A1 (en) 2009-11-26
AU2002358772B2 (en) 2008-11-20
US7635713B2 (en) 2009-12-22
EP1458679A2 (de) 2004-09-22
AU2009200663B2 (en) 2011-09-15
IL162602A0 (en) 2005-11-20
US7335680B2 (en) 2008-02-26
IL162602A (en) 2011-07-31
US20080114051A1 (en) 2008-05-15
WO2003053923A2 (en) 2003-07-03
DE60235198D1 (de) 2010-03-11
ES2337887T3 (es) 2010-04-30
AU2009200663A1 (en) 2009-03-12
WO2003053923A3 (en) 2004-01-29
EP1458679B1 (de) 2010-01-20
AU2002358772A1 (en) 2003-07-09
CA2469075A1 (en) 2003-07-03

Similar Documents

Publication Publication Date Title
ATE455758T1 (de) Pyrrolidin-derivatie als prostaglandin- modulatoren
IL161581A (en) Pyrazolidinone derivatives and their use
MA27556A1 (fr) Derives de phenylalanine comme inhibiteurs de la dipeptidyl peptidase pour le traitement ou la prevention du diabete
ATE451376T1 (de) Zusammensetzungen, die sich als inhibitoren von proteinkinasen eignen
NO20055863L (no) W-karboksyarylsubstituerte difenylureaforbindelser som raf-kinaseinhibitorer
DE60314603D1 (de) Zusammensetzungen brauchbar als protein-kinase- inhibitoren
ATE433973T1 (de) Azolylaminoazine als inhibitoren von proteinkinasen
NO20030895D0 (no) Ny anvendelse av dipeptidyl peptidase IV inhibitorer
DE60332433D1 (de) Azolylaminoazine als proteinkinasehemmer
DE60332604D1 (de) Azolylaminoazine als proteinkinasehemmer
MA27548A1 (fr) Inhibiteurs heterocycliques beta-amines de la dipeptidyl peptidase pour le traitement ou la prevention du diabete.
ATE482213T1 (de) Als inhibitoren von proteinkinasen geeignete pyrazoloä1,5-aüpyrimidine
EP1408986A4 (de) Proteomimetische verbindungen und verfahren
ATE463492T1 (de) Kondensierte indole als dipeptidyl-peptidase- hemmer zur behandlung oder prävention von diabetes
DE60333387D1 (de) Triazolopyridazine als proteinkinase-inhibitoren
DE69729125D1 (de) Troponin untereinheiten und fragmente zur verwendung als inhibitoren der angiogenese
NO20040331L (no) Legemidler for sykdommer med benmassetap som har Eragonist som den aktive bestanddel
DE60330485D1 (de) Zur behandlung von diabetes
NO20045677L (no) Inhibitorer av JAK- og CDK2-proteinkinaser
ATE450530T1 (de) Zusammensetzungen zur verwendung als protein- kinase-inhibitoren
WO2003103604A3 (en) GAMMA LACTAMES USED AS PROSTAGLANDIN AGONISTS AND THEIR USE
WO2001054681A8 (en) Composition for treatment of stress
ATE389651T1 (de) Als inhibitoren von c-met geeignete pyrrolzusammensetzungen
DK1456380T3 (da) SMAD7-inhibitorer til behandling af CNS-sygdomme
EE9900275A (et) CD40L-vastaste ühendite terapeutilise manustamise meetodid

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties