DE69729125D1 - Troponin untereinheiten und fragmente zur verwendung als inhibitoren der angiogenese - Google Patents

Troponin untereinheiten und fragmente zur verwendung als inhibitoren der angiogenese

Info

Publication number
DE69729125D1
DE69729125D1 DE69729125T DE69729125T DE69729125D1 DE 69729125 D1 DE69729125 D1 DE 69729125D1 DE 69729125 T DE69729125 T DE 69729125T DE 69729125 T DE69729125 T DE 69729125T DE 69729125 D1 DE69729125 D1 DE 69729125D1
Authority
DE
Germany
Prior art keywords
fragments
angiogenesis
inhibitors
units
troponin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69729125T
Other languages
English (en)
Other versions
DE69729125T2 (de
Inventor
A Moses
S Langer
G Wiederschain
Inmin Wu
Arthur Sytkowski
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Childrens Medical Center Corp
Original Assignee
Childrens Medical Center Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Childrens Medical Center Corp filed Critical Childrens Medical Center Corp
Publication of DE69729125D1 publication Critical patent/DE69729125D1/de
Application granted granted Critical
Publication of DE69729125T2 publication Critical patent/DE69729125T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4716—Muscle proteins, e.g. myosin, actin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE69729125T 1996-02-16 1997-02-14 Troponin untereinheiten und fragmente zur verwendung als inhibitoren der angiogenese Expired - Lifetime DE69729125T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US602941 1996-02-16
US08/602,941 US5837680A (en) 1996-02-16 1996-02-16 Pharmaceutical compositions comprising troponin subunits, fragments and analogs thereof and methods of their use to inhibit angiogenesis
PCT/US1997/002439 WO1997030085A1 (en) 1996-02-16 1997-02-14 Troponin subunits and fragments useful as angiogenesis inhibitors

Publications (2)

Publication Number Publication Date
DE69729125D1 true DE69729125D1 (de) 2004-06-17
DE69729125T2 DE69729125T2 (de) 2005-05-12

Family

ID=24413387

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69729125T Expired - Lifetime DE69729125T2 (de) 1996-02-16 1997-02-14 Troponin untereinheiten und fragmente zur verwendung als inhibitoren der angiogenese

Country Status (8)

Country Link
US (4) US5837680A (de)
EP (1) EP1007556B1 (de)
JP (1) JP3990456B2 (de)
AT (1) ATE266675T1 (de)
AU (1) AU707262B2 (de)
CA (1) CA2247247C (de)
DE (1) DE69729125T2 (de)
WO (1) WO1997030085A1 (de)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6586401B1 (en) 1996-02-16 2003-07-01 Children's Medical Center Corporation Troponin subunit I fragment and homologs thereof
US6589936B1 (en) * 1996-02-16 2003-07-08 Children's Medical Center Corporation Pharmaceutical compositions comprising recombinant troponin subunits
US6465431B1 (en) 1999-11-17 2002-10-15 Boston Life Sciences, Inc. Pharmaceutical compositions comprising troponin subunits, fragments and homologs thereof and methods of their use to inhibit angiogenesis
US5837680A (en) 1996-02-16 1998-11-17 Children's Medical Center Corporation Pharmaceutical compositions comprising troponin subunits, fragments and analogs thereof and methods of their use to inhibit angiogenesis
US7220557B2 (en) * 1997-04-24 2007-05-22 Human Genome Sciences, Inc. METH1 polynucleotides
US20030166065A1 (en) * 1997-04-24 2003-09-04 Human Genome Sciences, Inc. Novel integrin ligand ITGL-TSP
US6248869B1 (en) * 1997-05-29 2001-06-19 Medical Analysis Systems, Inc. Troponin I forms and use of the same
US6468519B1 (en) * 1997-09-10 2002-10-22 Rutgers, The State University Of New Jersey Polyanhydrides with biologically active degradation products
JP2001518304A (ja) * 1997-10-01 2001-10-16 ジー・ディー・サール・アンド・カンパニー アンギオスタチン成分を含む融合タンパク質及び抗腫瘍療法におけるその使用
KR100335397B1 (ko) * 1998-05-25 2002-09-05 주식회사 하이닉스반도체 센스앰프순차구동장치
EP1098971B1 (de) 1998-07-17 2006-08-30 Licentia Ltd. Myotilin, ein actin-organisierendes protein
US6378526B1 (en) * 1998-08-03 2002-04-30 Insite Vision, Incorporated Methods of ophthalmic administration
AU6117099A (en) * 1998-10-21 2000-05-08 Spectral Diagnostics Inc. Cardiac troponin i polypeptide fragments and uses in diagnostics
EP1165059A4 (de) * 1999-03-15 2003-03-05 Boston Life Sciences Inc Pharmazeutische zusammensetzungen die untereinheiten von troponin, fragmente davon und deren homologe enthalten und methoden zu ihrer verwendung zur inhibition von angiogenese
KR20030000011A (ko) * 1999-05-25 2003-01-03 휴먼 게놈 사이언시즈, 인크. Ｍｅｔｈ－１ 및 ｍｅｔｈ－２ 폴리뉴클레오티드 및폴리펩티드
US20020142982A1 (en) * 1999-09-02 2002-10-03 Timothy Hla Method for regulating angiogenesis
AU2002218786A1 (en) 2000-07-12 2002-01-21 Agensys, Inc. Novel tumor antigen useful in diagnosis and therapy of bladder, ovary, lung and kidney cancers
US20030236188A1 (en) * 2001-05-03 2003-12-25 Spytek Kimberly A. Novel human proteins, polynucleotides encoding them and methods of using the same
US20050163807A1 (en) * 2002-02-04 2005-07-28 Xiaoyan Liu Anticancer agents using vero toxin variants
US8623822B2 (en) * 2002-03-01 2014-01-07 Bracco Suisse Sa KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy
US7794693B2 (en) * 2002-03-01 2010-09-14 Bracco International B.V. Targeting vector-phospholipid conjugates
US20050100963A1 (en) 2002-03-01 2005-05-12 Dyax Corporation KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy
US7211240B2 (en) * 2002-03-01 2007-05-01 Bracco International B.V. Multivalent constructs for therapeutic and diagnostic applications
US7261876B2 (en) 2002-03-01 2007-08-28 Bracco International Bv Multivalent constructs for therapeutic and diagnostic applications
EP1572724A4 (de) 2002-03-01 2007-03-14 Dyax Corp Kdr und vegf/kdr bindungspeptide und ihre verwendung bei der diagnose und therapie
US7491389B2 (en) 2002-03-21 2009-02-17 University Of Florida Reasearch Foundation, Inc. Modulating angiogenesis
WO2004028559A1 (en) * 2002-09-26 2004-04-08 The Board Of Trustees Of The University Of Illinois Anti-angiogenic fragments of pigment epithelium-derived factor (pedf)
AU2004217894B2 (en) 2003-03-03 2010-07-15 Bracco International B.V. Peptides that specifically bind HGF receptor (cMet) and uses thereof
CN1294987C (zh) * 2003-04-15 2007-01-17 刘凤鸣 心肌肌钙蛋白i在制备抑制肿瘤药物中的应用
CA2820537C (en) * 2003-04-23 2015-10-20 Valeritas, Inc. Hydraulically actuated pump for fluid administration
WO2006014425A1 (en) 2004-07-02 2006-02-09 Biovalve Technologies, Inc. Methods and devices for delivering glp-1 and uses thereof
US8697139B2 (en) 2004-09-21 2014-04-15 Frank M. Phillips Method of intervertebral disc treatment using articular chondrocyte cells
US7265248B1 (en) 2005-04-29 2007-09-04 Technology Innovations, Llc Compositions and methods for the treatment of malaria
US20070130009A1 (en) * 2005-06-01 2007-06-07 Chad Steelberg System and method for media play pricing
WO2007067611A2 (en) * 2005-12-07 2007-06-14 The Brigham And Women's Hospital, Inc. Methods of treating cardiac reperfusion disease
CN101460216B (zh) 2006-03-30 2013-06-19 瓦莱里塔斯公司 多筒式流体递送器械
US8468561B2 (en) 2006-08-09 2013-06-18 Google Inc. Preemptible station inventory

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69122956T2 (de) * 1990-01-25 1997-05-22 Childrens Hosp Medical Center Verfahren und zusammensetzungen zur hemmung der angiogenese
FR2701954B1 (fr) * 1993-02-23 1995-07-07 Pasteur Sanofi Diagnostics Composition stabilisée de troponine pour immunoessais et procédé de stabilisation de troponine pour immunoessais.
US5837680A (en) 1996-02-16 1998-11-17 Children's Medical Center Corporation Pharmaceutical compositions comprising troponin subunits, fragments and analogs thereof and methods of their use to inhibit angiogenesis

Also Published As

Publication number Publication date
AU707262B2 (en) 1999-07-08
EP1007556B1 (de) 2004-05-12
ATE266675T1 (de) 2004-05-15
US6025331A (en) 2000-02-15
JP2000506523A (ja) 2000-05-30
CA2247247A1 (en) 1997-08-21
US5837680A (en) 1998-11-17
EP1007556A2 (de) 2000-06-14
CA2247247C (en) 2010-08-03
JP3990456B2 (ja) 2007-10-10
WO1997030085A1 (en) 1997-08-21
EP1007556A4 (de) 2000-06-14
US6653283B1 (en) 2003-11-25
AU2275397A (en) 1997-09-02
DE69729125T2 (de) 2005-05-12
US6403558B1 (en) 2002-06-11

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