DE60112766D1 - Verwendung von derivaten der valproinsäureamide und 2-valproinsäureamid zur behandlung und prävention von schmerzen und/oder kopfschmerzen - Google Patents
Verwendung von derivaten der valproinsäureamide und 2-valproinsäureamid zur behandlung und prävention von schmerzen und/oder kopfschmerzenInfo
- Publication number
- DE60112766D1 DE60112766D1 DE60112766T DE60112766T DE60112766D1 DE 60112766 D1 DE60112766 D1 DE 60112766D1 DE 60112766 T DE60112766 T DE 60112766T DE 60112766 T DE60112766 T DE 60112766T DE 60112766 D1 DE60112766 D1 DE 60112766D1
- Authority
- DE
- Germany
- Prior art keywords
- valproic acid
- pain
- prevention
- derivatives
- treatment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US22597300P | 2000-08-17 | 2000-08-17 | |
US22597700P | 2000-08-17 | 2000-08-17 | |
US225973P | 2000-08-17 | ||
US225977P | 2000-08-17 | ||
PCT/US2001/025919 WO2002013766A2 (en) | 2000-08-17 | 2001-08-17 | Valproic acid derivatives for the treatment of pain |
Publications (2)
Publication Number | Publication Date |
---|---|
DE60112766D1 true DE60112766D1 (de) | 2005-09-22 |
DE60112766T2 DE60112766T2 (de) | 2006-03-30 |
Family
ID=26920105
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60112766T Expired - Lifetime DE60112766T2 (de) | 2000-08-17 | 2001-08-17 | Verwendung von Derivaten der Valproinsäureamide und 2-Valproinsäureamide zur Behandlung und Prävention von Schmerzen und/oder Kopfschmerzen |
Country Status (21)
Country | Link |
---|---|
US (3) | US20020052418A1 (de) |
EP (1) | EP1311256B1 (de) |
JP (1) | JP2004505999A (de) |
KR (1) | KR100851955B1 (de) |
CN (1) | CN100462069C (de) |
AT (1) | ATE301995T1 (de) |
AU (1) | AU8830801A (de) |
CA (1) | CA2418455A1 (de) |
CZ (1) | CZ2004362A3 (de) |
DE (1) | DE60112766T2 (de) |
DK (1) | DK1311256T3 (de) |
ES (1) | ES2245377T3 (de) |
HU (1) | HUP0401867A2 (de) |
IL (2) | IL154470A0 (de) |
MX (1) | MXPA03001458A (de) |
NO (1) | NO20030724L (de) |
NZ (1) | NZ524687A (de) |
PL (1) | PL363041A1 (de) |
SI (1) | SI1311256T1 (de) |
WO (1) | WO2002013766A2 (de) |
ZA (1) | ZA200301427B (de) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1243262B1 (de) * | 2001-03-20 | 2006-05-31 | Schwarz Pharma Ag | Neue Verwendung von Peptidverbindungen bei der Behandlung von nicht-neuropathischem Entzündungsschmerz |
EP1243263B1 (de) * | 2001-03-21 | 2002-11-27 | Schwarz Pharma Ag | Neue Verwendung einer Klasse von Peptidverbindungen zur Behandlung von Allodynie oder andere Arten von chronischen oder Phantomschmerzen |
WO2004071424A2 (en) * | 2003-02-05 | 2004-08-26 | Teva Pharmaceutical Industries, Ltd. | Immediate release formulation of n-(2-propylpentanoyl)glycinamide |
EP1626707A4 (de) * | 2003-02-05 | 2009-07-01 | Yissum Res Dev Co | Formulierung von n-(2-propylpentanoyl)-glycinamid mit verzögerter freisetzung und verwandten verbindungen |
IL157751A0 (en) * | 2003-02-28 | 2004-03-28 | Yissum Res Dev Co | New amide derivatives of 2,2,3,3-tetramethylcyclopropane carboxylic acid, a method for their synthesis and pharmaceutical compositions containing them |
EP1491188A1 (de) * | 2003-06-25 | 2004-12-29 | G2M Cancer Drugs AG | Topische Verwendung von Valproinsäure zur Behandlung von Hauterkrankungen |
US20060004098A1 (en) * | 2003-07-28 | 2006-01-05 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Compounds useful for treating neurological disorders |
PL1689378T3 (pl) | 2003-12-02 | 2009-09-30 | Sanol Arznei Schwarz Gmbh | Nowe zastosowanie związków peptydowych do leczenia ośrodkowego bólu neuropatycznego |
US20060009384A1 (en) * | 2003-12-05 | 2006-01-12 | David Rudd | Novel use of peptide compounds for treating status epilepticus or related conditions |
US20100256179A1 (en) * | 2004-03-26 | 2010-10-07 | Ucb Pharma Gmbh | Combination therapy for pain in painful diabetic neuropathy |
EP1579858A1 (de) * | 2004-03-26 | 2005-09-28 | Schwarz Pharma Ag | Neue Verwendung von Peptidverbindungen zur Behandlung von diabetishen Neuropathie |
US20070042969A1 (en) * | 2004-03-26 | 2007-02-22 | Srz Properties, Inc. | Combination therapy for pain in painful diabetic neuropathy |
NZ550482A (en) * | 2004-04-16 | 2010-08-27 | Sanol Arznei Schwarz Gmbh | Use of peptidic compounds for the prophylaxis and treatment of chronic headache |
EP1604655A1 (de) * | 2004-06-09 | 2005-12-14 | Schwarz Pharma Ag | Neue Verwendung von Peptidverbindungen zur Behandlung von Trigeminusneuralgie |
US7427601B2 (en) * | 2004-06-24 | 2008-09-23 | Schwarz Pharma Ag | Method for treating tremor |
WO2006012603A2 (en) * | 2004-07-22 | 2006-02-02 | Nps Pharmaceuticals, Inc. | Analogs of isovaleramide, a pharmaceutical composition including the same, and a method of treating central nervous system conditions or diseases |
BRPI0514721A (pt) * | 2004-08-27 | 2008-06-24 | Sanol Arznei Schwarz Gmbh | uso de compostos de peptìdeos para tratar dor de cáncer ósseo, dor induzida por quimioterapia e nucleosìdeo |
EP1642889A1 (de) * | 2004-10-02 | 2006-04-05 | Schwarz Pharma Ag | Verbessertes Syntheseschema für Lacosamid |
US20060252749A1 (en) * | 2005-01-28 | 2006-11-09 | Srz Properties, Inc. | Lacosamide for add-on therapy of psychosis |
EP1754476A1 (de) * | 2005-08-18 | 2007-02-21 | Schwarz Pharma Ag | Lacosamid (SPM 927) zur Behandlung von Myalgien, z.B. Fibromyalgie |
US20070043120A1 (en) * | 2005-08-18 | 2007-02-22 | Bettina Beyreuther | Therapeutic combination for painful medical conditions |
EP1873527A1 (de) * | 2006-06-30 | 2008-01-02 | Schwarz Pharma Ag | Verfahren zur Identifizierung von CRMP-Modulatoren |
CN101466390B (zh) | 2006-06-15 | 2014-03-12 | 优时比制药有限公司 | 用于治疗难治性癫痫持续状态的肽类化合物 |
US8735356B2 (en) | 2006-06-15 | 2014-05-27 | Ucb Pharma Gmbh | Anticonvulsant combination therapy |
ES2326355B1 (es) * | 2008-02-25 | 2010-08-10 | Centro Atlantico Del Medicamento, S.A. | Acido 1-(di-n-propilacetilaminometil)-ciclohexilacetico. |
KR101733189B1 (ko) * | 2010-10-06 | 2017-05-08 | (주)아모레퍼시픽 | 손톱 또는 발톱 성장 촉진용 조성물 |
EP2468261A1 (de) | 2010-12-02 | 2012-06-27 | UCB Pharma GmbH | Formulierung von Lacosamid |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3050800C2 (de) * | 1979-03-22 | 1989-06-22 | Continental Pharma Inc., Bruessel/Bruxelles, Be | |
US4301176A (en) * | 1980-08-18 | 1981-11-17 | Warner-Lambert Company | Method of administering calcium valproate |
LU83729A1 (fr) * | 1981-11-04 | 1983-09-01 | Galephar | Sels d'acide valproique,leur preparation et leur utilisation |
US4913906B1 (en) * | 1985-02-28 | 2000-06-06 | Yissum Res Dev Co | Controlled release dosage form of valproic acid |
US5169642A (en) * | 1988-06-24 | 1992-12-08 | Abbott Laboratories | Sustained-release drug dosage units |
US6287598B1 (en) * | 1993-05-28 | 2001-09-11 | Alza Corporation | Method for providing sustained antiepileptic therapy |
US5585358A (en) * | 1993-07-06 | 1996-12-17 | Yissum Research Development Corporation Of The Hebrew University Of Jerusalem | Derivatives of valproic acid amides and 2-valproenoic acid amides, method of making and use thereof as anticonvulsant agents |
EA000976B1 (ru) * | 1996-03-25 | 2000-08-28 | Эли Лилли Энд Компани | Композиция для снятия боли и способ снятия боли |
CN1152677C (zh) * | 1996-08-30 | 2004-06-09 | Nps药物有限公司 | 用异戊酸衍生物类cns抑制剂治疗强直、惊厥 |
IL121268A0 (en) * | 1997-07-09 | 1998-01-04 | Dpharm Ltd | Branched chain fatty acids their derivatives and use in the treatment of central nervous system disorders |
US5760007A (en) * | 1997-07-16 | 1998-06-02 | Ortho Pharmaceutical Corporation | Anticonvulsant derivatives useful in treating neuropathic pain |
US6268396B1 (en) * | 1998-06-22 | 2001-07-31 | American Biogenetic Sciences, Inc. | Use of valproic acid analog for the treatment and prevention of migraine and affective illness |
AU771388B2 (en) * | 1999-01-19 | 2004-03-18 | Ortho-Mcneil Pharmaceutical, Inc. | Anticonvulsant derivatives useful in treating cluster headaches |
-
2001
- 2001-08-17 AT AT01968030T patent/ATE301995T1/de not_active IP Right Cessation
- 2001-08-17 CA CA002418455A patent/CA2418455A1/en not_active Abandoned
- 2001-08-17 CN CNB018171346A patent/CN100462069C/zh not_active Expired - Fee Related
- 2001-08-17 KR KR1020037002061A patent/KR100851955B1/ko not_active IP Right Cessation
- 2001-08-17 ES ES01968030T patent/ES2245377T3/es not_active Expired - Lifetime
- 2001-08-17 SI SI200130418T patent/SI1311256T1/sl unknown
- 2001-08-17 AU AU8830801A patent/AU8830801A/xx not_active Withdrawn
- 2001-08-17 WO PCT/US2001/025919 patent/WO2002013766A2/en active IP Right Grant
- 2001-08-17 DK DK01968030T patent/DK1311256T3/da active
- 2001-08-17 EP EP01968030A patent/EP1311256B1/de not_active Expired - Lifetime
- 2001-08-17 DE DE60112766T patent/DE60112766T2/de not_active Expired - Lifetime
- 2001-08-17 PL PL01363041A patent/PL363041A1/xx not_active Application Discontinuation
- 2001-08-17 HU HU0401867A patent/HUP0401867A2/hu unknown
- 2001-08-17 NZ NZ524687A patent/NZ524687A/en unknown
- 2001-08-17 IL IL15447001A patent/IL154470A0/xx unknown
- 2001-08-17 JP JP2002518914A patent/JP2004505999A/ja active Pending
- 2001-08-17 MX MXPA03001458A patent/MXPA03001458A/es active IP Right Grant
- 2001-08-17 CZ CZ2004362A patent/CZ2004362A3/cs unknown
- 2001-08-17 US US09/932,370 patent/US20020052418A1/en not_active Abandoned
-
2003
- 2003-02-14 NO NO20030724A patent/NO20030724L/no not_active Application Discontinuation
- 2003-02-14 IL IL154470A patent/IL154470A/en not_active IP Right Cessation
- 2003-02-21 ZA ZA200301427A patent/ZA200301427B/en unknown
-
2004
- 2004-04-16 US US10/826,904 patent/US20040204495A1/en not_active Abandoned
-
2009
- 2009-06-24 US US12/457,875 patent/US8288442B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
MXPA03001458A (es) | 2004-05-04 |
IL154470A (en) | 2010-11-30 |
HUP0401867A2 (hu) | 2004-12-28 |
US20040204495A1 (en) | 2004-10-14 |
IL154470A0 (en) | 2003-09-17 |
DK1311256T3 (da) | 2005-11-28 |
US20090281045A1 (en) | 2009-11-12 |
CN100462069C (zh) | 2009-02-18 |
KR20030036691A (ko) | 2003-05-09 |
EP1311256B1 (de) | 2005-08-17 |
CZ2004362A3 (cs) | 2005-01-12 |
SI1311256T1 (sl) | 2005-12-31 |
CN1551762A (zh) | 2004-12-01 |
AU8830801A (en) | 2002-02-25 |
NO20030724D0 (no) | 2003-02-14 |
ES2245377T3 (es) | 2006-01-01 |
WO2002013766A3 (en) | 2002-06-20 |
NO20030724L (no) | 2003-02-14 |
KR100851955B1 (ko) | 2008-08-12 |
JP2004505999A (ja) | 2004-02-26 |
ZA200301427B (en) | 2004-02-23 |
NZ524687A (en) | 2005-01-28 |
US8288442B2 (en) | 2012-10-16 |
EP1311256A4 (de) | 2004-03-24 |
ATE301995T1 (de) | 2005-09-15 |
PL363041A1 (en) | 2004-11-15 |
EP1311256A2 (de) | 2003-05-21 |
CA2418455A1 (en) | 2002-02-21 |
DE60112766T2 (de) | 2006-03-30 |
US20020052418A1 (en) | 2002-05-02 |
WO2002013766A2 (en) | 2002-02-21 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8327 | Change in the person/name/address of the patent owner |
Owner name: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEB, IL |