ES2170252T3 - Tetrahidroimidazopiridoindoldionas como inhibidores de cgmp especifico pde. - Google Patents

Tetrahidroimidazopiridoindoldionas como inhibidores de cgmp especifico pde.

Info

Publication number
ES2170252T3
ES2170252T3 ES96925709T ES96925709T ES2170252T3 ES 2170252 T3 ES2170252 T3 ES 2170252T3 ES 96925709 T ES96925709 T ES 96925709T ES 96925709 T ES96925709 T ES 96925709T ES 2170252 T3 ES2170252 T3 ES 2170252T3
Authority
ES
Spain
Prior art keywords
tetrahydroimidazopiridoindoldionas
inhibitors
cgmp pde
specific cgmp
specific
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96925709T
Other languages
English (en)
Inventor
Alain Claude-Marie Lab Daugan
Richard Frederic Labaudiniere
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Icos Corp
Original Assignee
Icos Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Icos Corp filed Critical Icos Corp
Application granted granted Critical
Publication of ES2170252T3 publication Critical patent/ES2170252T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Reproductive Health (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

COMPUESTO DE FORMULA (I) Y SALES Y SOLVATOS DEL MISMO, EN LOS QUE R 0 REPRESENTA UN ATOMO DE HIDROGENO, HALOGENO O UN GRUPO C 1-6 ALQUILO; R 1 SE SELECCIONA A PARTIR DEL GRUPO FORMADO POR: A) UN ATOMO DE HIDROGENO; B) UN GRUPO C SUB,16 ALQUILO SUSTITUIDO OPCIONALMENTE POR UNO O MAS SUSTITUYENTES SELECCIONADOS ENTRE UN GRUPO FENILO, UN ATOMO HALOGENO, CO2 R A - Y - NR A R B -; C) UN GRUPO C 3 6 CICLOALQUILO; D) UN GRUPO FENILO; Y E) UN ANILLO HETEROCICLICO DE 5 O 6 ELEMENTOS QUE CONTIENE AL MENOS UN HETEROATOMO SELECCIONADO ENTRE OXIGENO, NITROGENO Y AZUFRE, PUDIENDO SUSTITUIRSE OPCIONALMENTE POR UNO O MAS GRUPOS C 1-6 ALQUILO, UNIE NDOSE OPCIONALMENTE AL ATOMO DE NITROGENO AL QUE SE UNE R 1 A TRAVES DEL GRUPO C 1-6 ALQUILO; R 2 SE SELECCIONA A PARTIR DEL GRUPO FORMADO POR: F) UN GRUPO C 36 CICLOALQUILO; G) UN GRUPO FENILO SUSTITUIDO OPCIONALMENTE POR UNO O MAS SUSTITUYENTES SELECCIONADOS A PARTIR DE - OR A , NR AR B , UN ATOMO HALOGENO, UN GRUPO HIDROXILO, TRIFLUOROMET ILO, CIANO Y NITRO; H) UN ANILLO HETEROCICLICO DE 5 O 6 ELEMENTOS QUE CONTIENE AL MENOS UN HETEROATOMO SELECCIONADO ENTRE OXIGENO, NITROGENO Y AZUFRE; E I) UN ANILLO BICICLICO (1) UNIDO AL RESTO DE LA MOLECULA A TRAVES DE UNO DE LOS ATOMOS DE CARBONO DEL ANILLO BENCENICO, SIENDO A UN ANILLO HETEROCICLICO DE 5 O 6 ELEMENTOS SEGUN LO DEFINIDO EN EL PUNTO H); Y R A Y RB REPRESENTAN INDEPENDIENTEMENTE UN ATOMO DE HIDROGENO O UN GRUPO C 1-6 ALQUILO. UN COMPUESTO DE LA PRESENTE INVENCION ES UN INHIBIDOR POTENTE Y SELECTIVO DE PDE ESPECIFICO DE GMPC CON UTILIDAD EN DIVERSAS AREAS TERAPEUTICAS DONDE DICHA INHIBICION ES BENEFICIOSA.
ES96925709T 1995-07-14 1996-07-11 Tetrahidroimidazopiridoindoldionas como inhibidores de cgmp especifico pde. Expired - Lifetime ES2170252T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9514473.9A GB9514473D0 (en) 1995-07-14 1995-07-14 Chemical compounds

Publications (1)

Publication Number Publication Date
ES2170252T3 true ES2170252T3 (es) 2002-08-01

Family

ID=10777704

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96925709T Expired - Lifetime ES2170252T3 (es) 1995-07-14 1996-07-11 Tetrahidroimidazopiridoindoldionas como inhibidores de cgmp especifico pde.

Country Status (13)

Country Link
US (3) US6001847A (es)
EP (1) EP0859778B1 (es)
JP (1) JP4012246B2 (es)
CN (1) CN1095841C (es)
AT (1) ATE211139T1 (es)
AU (1) AU702548B2 (es)
BR (1) BR9609503A (es)
CA (1) CA2226759A1 (es)
DE (1) DE69618231T2 (es)
ES (1) ES2170252T3 (es)
GB (1) GB9514473D0 (es)
MX (1) MX9800415A (es)
WO (1) WO1996032003A2 (es)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69833254T2 (de) 1997-06-23 2006-11-02 Cellegy Pharmaceuticals, Inc., Brisbane Microdosistherapie von gefässbedingten erscheinungen durch no-donoren
US6403597B1 (en) 1997-10-28 2002-06-11 Vivus, Inc. Administration of phosphodiesterase inhibitors for the treatment of premature ejaculation
US6548490B1 (en) * 1997-10-28 2003-04-15 Vivus, Inc. Transmucosal administration of phosphodiesterase inhibitors for the treatment of erectile dysfunction
CA2339630C (en) * 1998-09-16 2006-05-23 Icos Corporation Carboline derivatives as cgmp phosphodiesterase inhibitors
US6451807B1 (en) * 1999-04-30 2002-09-17 Lilly Icos, Llc. Methods of treating sexual dysfunction in an individual suffering from a retinal disease, class 1 congestive heart failure, or myocardial infarction using a PDE5 inhibitor
HUP0001632A3 (en) 1999-04-30 2001-12-28 Lilly Icos Llc Wilmington Pharmaceutical compositions comprising selective phosphodiestherase inhibitors
US20010036959A1 (en) * 2000-04-03 2001-11-01 Gabel Rolf Dieter Carvedilol-hydrophilic solutions
AU2001255849B8 (en) 2000-04-19 2006-04-27 Lilly Icos, Llc. PDE-V inhibitors for treatment of Parkinson's Disease
JP2004501920A (ja) * 2000-06-23 2004-01-22 リリー　アイコス　リミテッド　ライアビリティ　カンパニー 環状ｇｍｐ特異的ホスホジエステラーゼ阻害剤
AU2002213419A1 (en) 2000-10-02 2002-04-15 Lilly Icos Llc Condensed pyridoindole derivatives
EP1335923B1 (en) * 2000-10-03 2006-07-12 Lilly Icos LLC Condensed pyridoindole derivatives
JP4179784B2 (ja) * 2001-02-15 2008-11-12 田辺三菱製薬株式会社 口腔内速崩壊性錠
DE10118306A1 (de) 2001-04-12 2002-10-17 Bayer Ag Imidazotriazinonhaltige Zusammensetzungen zur nasalen Applikation
CA2441792C (en) 2001-04-25 2010-08-03 Lilly Icos Llc Carboline derivatives as inhibitors of phosphodiesterase 5 (pdes) for the treatment of cardiovascular diseases and erectile dysfunction
WO2002098875A1 (en) * 2001-06-05 2002-12-12 Lilly Icos Llc Carboline derivatives as pde-5 inhibitors
CA2469075C (en) * 2001-12-20 2011-09-13 Applied Research Systems Ars Holding N.V. Pyrrolidine derivatives as prostaglandin modulators
MY140561A (en) * 2002-02-20 2009-12-31 Nycomed Gmbh Dosage form containing pde 4 inhibitor as active ingredient
US7208516B2 (en) * 2002-03-20 2007-04-24 Celgene Corporation Methods of the treatment of psoriatic arthritis using (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione
US7276529B2 (en) * 2002-03-20 2007-10-02 Celgene Corporation Methods of the treatment or prevention of exercise-induced asthma using (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione
US7893101B2 (en) 2002-03-20 2011-02-22 Celgene Corporation Solid forms comprising (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione, compositions thereof, and uses thereof
US6962940B2 (en) 2002-03-20 2005-11-08 Celgene Corporation (+)-2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione: methods of using and compositions thereof
ES2211295B1 (es) * 2002-07-19 2005-12-01 Consejo Sup. De Investig. Cientificas Tetrahidro-beta-carbolinas fenolicas como antioxidantes.
CN100430395C (zh) * 2002-07-31 2008-11-05 利利艾科斯有限公司 改进的皮克特-施彭格勒反应和由该反应制备得到的产物
US20050048573A1 (en) * 2003-02-03 2005-03-03 Plexxikon, Inc. PDE5A crystal structure and uses
SI1606261T1 (sl) 2003-03-10 2010-03-31 Nycomed Gmbh Novi postopek za pripravo roflumilasta
JP2007501866A (ja) 2003-06-13 2007-02-01 マイクロバイア インコーポレイテッド 胃腸疾患の治療のための方法および組成物
DE10348022A1 (de) * 2003-10-15 2005-05-25 Imtm Gmbh Neue Dipeptidylpeptidase IV-Inhibitoren zur funktionellen Beeinflussung unterschiedlicher Zellen und zur Behandlung immunologischer, entzündlicher, neuronaler und anderer Erkrankungen
US7767689B2 (en) 2004-03-15 2010-08-03 Ptc Therapeutics, Inc. Carboline derivatives useful in the treatment of cancer
ZA200608176B (en) 2004-03-15 2008-05-28 Ptc Therapeutics Inc Carboline derivatives useful in the inhibition of angiogenesis
US8076353B2 (en) 2004-03-15 2011-12-13 Ptc Therapeutics, Inc. Inhibition of VEGF translation
US8076352B2 (en) 2004-03-15 2011-12-13 Ptc Therapeutics, Inc. Administration of carboline derivatives useful in the treatment of cancer and other diseases
EP1732543B1 (en) * 2004-03-15 2017-05-10 PTC Therapeutics, Inc. Tetracyclic carboline deratives for inhibiting angiogenesis
US7718665B2 (en) 2004-08-18 2010-05-18 4Sc Ag Benzothienopyridines for use as inhibitors of Eg5 kinesin
US8663694B2 (en) * 2005-03-16 2014-03-04 Takeda Gmbh Taste masked dosage form containing roflumilast
US20070155791A1 (en) * 2005-12-29 2007-07-05 Zeldis Jerome B Methods for treating cutaneous lupus using aminoisoindoline compounds
JP5349056B2 (ja) 2006-02-22 2013-11-20 ４エスツェー アクチェンゲゼルシャフト Ｅｇ５キネシンモジュレーターとしてのインドロピリジン類
WO2007113243A2 (en) * 2006-03-31 2007-10-11 Investigación Y Clínica Andrológicas S.L. Use of pde 5 inhibitors for the treatment of overactive bladder
FR2912405A1 (fr) * 2007-02-08 2008-08-15 Fourtillan Snc Derives des imidazo[1',5':1,6]pyrido[3,4-b]indoles et leur utilisation en therapeutique
AU2007358076A1 (en) * 2007-08-22 2009-02-26 4Sc Ag Indolopyridines as inhibitors of the kinesin spindle protein (Eg5 )
EP2098524A1 (en) * 2008-03-05 2009-09-09 4Sc Ag Process for preparing enantiomerically pure indolopyrinidines
EP2268279A1 (en) * 2008-03-24 2011-01-05 Celgene Corporation Treatment of psoriasis or psoriatic arthritis using cyclopropyl-n-{2-{(1s)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl¨-3-oxoisoindoline-4-yl}carboxamide
EP3878848A1 (en) 2013-11-22 2021-09-15 Sabre Therapeutics LLC Autotaxin inhibiting indole compounds
EA201690880A1 (ru) * 2013-11-22 2016-12-30 Фармакеа, Инк. Тетрациклические ингибиторы аутотаксина
WO2015089105A1 (en) 2013-12-09 2015-06-18 Respira Therapeutics, Inc. Pde5 inhibitor powder formulations and methods relating thereto
JP6687550B2 (ja) 2014-06-23 2020-04-22 セルジーン コーポレイション 肝疾患又は肝機能異常を治療するためのアプレミラスト
EP4026549A1 (en) 2015-05-27 2022-07-13 Sabre Therapeutics LLC Autotaxin inhibitors and uses thereof
WO2017168174A1 (en) 2016-04-02 2017-10-05 N4 Pharma Uk Limited New pharmaceutical forms of sildenafil

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3644384A (en) * 1969-06-09 1972-02-22 Sterling Drug Inc Certain 2-(alpha-haloacetyl) - 1 2 3 4-tetrahydro - 9h - pyrido(3 4-b)indole-3-carboxylates and derivatives
US3717638A (en) * 1971-03-11 1973-02-20 Sterling Drug Inc 1,2,3,4,6,7,12,12A-OCTAHYDRO-2-PHENYLPYRAZINO[2',1':6,1]PYRIDO[3,4-b]INDOLES AND INTERMEDIATES THEREFOR
US3917599A (en) * 1973-03-30 1975-11-04 Council Scient Ind Res 2-Substituted-1,2,3,4,6,7,12,12A-octahydropyrazino(2{40 ,1{40 :6,1)pyrido(3,4-B)indoles
GB1454171A (en) * 1973-10-19 1976-10-27 Council Scient Ind Res Tetracyclic compounds
US4188390A (en) * 1977-11-05 1980-02-12 Pfizer Inc. Antihypertensive 4-amino-2-[4-(1,4-benzodioxan-2-carbonyl) piperazin-1-yl or homopiperazin-1-yl]quinazolines
US4656174A (en) * 1982-07-24 1987-04-07 Pfizer Inc. Quinoline therapeutic agents
US4801587A (en) * 1987-03-02 1989-01-31 Gene Voss Impotence ointment
IT1217190B (it) * 1988-04-22 1990-03-14 Recordati Chem Pharm Composti utili per il trattamento e diagnosi di disfunzioni frettili
EP0357122A3 (en) * 1988-08-29 1991-10-23 Duphar International Research B.V Use of beta-carbolines, their bio-isosteric benzofuran and benzothiophene analogues for the manufacture of a medicament having cytostatic properties
DE3830096A1 (de) * 1988-09-03 1990-03-15 Hoechst Ag Piperazindione mit psychotroper wirkung
FR2649613B1 (fr) * 1989-07-11 1991-09-27 Virag Ronald Medicament vaso-actif
JPH0344324A (ja) * 1989-07-13 1991-02-26 Kazuoki Tsuchiya 性機能賦活剤
ATE113839T1 (de) * 1990-05-31 1994-11-15 Pfizer Arzneimittel gegen impotenz.
US5270323A (en) * 1990-05-31 1993-12-14 Pfizer Inc. Method of treating impotence
GB9013750D0 (en) * 1990-06-20 1990-08-08 Pfizer Ltd Therapeutic agents
GB9114760D0 (en) * 1991-07-09 1991-08-28 Pfizer Ltd Therapeutic agents
GB9218322D0 (en) * 1992-08-28 1992-10-14 Pfizer Ltd Therapeutic agents
GB9311920D0 (en) * 1993-06-09 1993-07-28 Pfizer Ltd Therapeutic agents
GB9514465D0 (en) * 1995-07-14 1995-09-13 Glaxo Lab Sa Chemical compounds
GB9401090D0 (en) * 1994-01-21 1994-03-16 Glaxo Lab Sa Chemical compounds
ES2143049T3 (es) * 1994-04-22 2000-05-01 Pentech Pharmaceuticals Inc Formas sublinguales de dosificacion que contienen apomorfina y su uso para el tratamiento de la disfuncion erectil.
US5874437A (en) * 1996-11-01 1999-02-23 Nitromed, Inc. Nitrosated and nitrosylated phosphodiesterase inhibitor compounds, compositions and their uses

Also Published As

Publication number Publication date
JPH11509517A (ja) 1999-08-24
US6001847A (en) 1999-12-14
DE69618231D1 (de) 2002-01-31
AU702548B2 (en) 1999-02-25
JP4012246B2 (ja) 2007-11-21
US6143757A (en) 2000-11-07
CA2226759A1 (en) 1996-10-17
BR9609503A (pt) 2000-03-08
CN1095841C (zh) 2002-12-11
EP0859778B1 (en) 2001-12-19
GB9514473D0 (en) 1995-09-13
WO1996032003A2 (en) 1996-10-17
MX9800415A (es) 1998-04-30
WO1996032003A3 (en) 1997-01-03
EP0859778A2 (en) 1998-08-26
DE69618231T2 (de) 2002-08-22
ATE211139T1 (de) 2002-01-15
CN1195350A (zh) 1998-10-07
AU6613896A (en) 1996-10-30
US6218400B1 (en) 2001-04-17

Similar Documents

Publication Publication Date Title
ES2170252T3 (es) Tetrahidroimidazopiridoindoldionas como inhibidores de cgmp especifico pde.
ATE302775T1 (de) Carbolinderivate
TR200201505T2 (tr) Terapötik maddeler olarak pirazolopirimidinler
EA200200208A1 (ru) Синергитическая композиция
ATE346067T1 (de) Carbolinderivate
ATE332903T1 (de) Kondensierte pyridoindolderivate
DE60112306D1 (de) Kondensierte pyrazindionderivate als pde5 inhibitore
MXPA02012076A (es) Compuestos quimicos.
IT1285770B1 (it) Composti corticoidei
MXPA02012470A (es) Inhibidores de fosfodiesterasa especificos para gmp ciclico.
ATE302776T1 (de) Kondensierte pyridoindolderivate
ATE330958T1 (de) Pyrazino 1'2':1,6öpyrido 3,4-böindolderivate
DE60122559D1 (de) Indolderivate als pde5-inhibitoren
MXPA03004023A (es) Compuestos quimicos.
DE60213798D1 (de) Carbolinderivate als pdev inhibitoren
MXPA03000887A (es) Derivados heterociclicos fusionados como inhibidores de fosfodiesterasa.
DE60219788D1 (de) Tetrazyklische verbindungen als pde5-inhibitoren
DK0937075T3 (da) Hidtil ukendte imidazo- og oxazolopyridiner som phosphodiesteraseinhibitorer

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 859778

Country of ref document: ES