GB1454171A - Tetracyclic compounds - Google Patents
Tetracyclic compoundsInfo
- Publication number
- GB1454171A GB1454171A GB4400273A GB4400273A GB1454171A GB 1454171 A GB1454171 A GB 1454171A GB 4400273 A GB4400273 A GB 4400273A GB 4400273 A GB4400273 A GB 4400273A GB 1454171 A GB1454171 A GB 1454171A
- Authority
- GB
- United Kingdom
- Prior art keywords
- compounds
- reacting
- alkyl
- prepared
- tetracyclic compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
1454171 Pyrazinopyridoindoles COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH 19 Oct 1973 44002/73 Heading C2C The invention comprises compounds of formula and their pharmaceutically acceptable acid addition and quaternary ammonium salts, wherein X is alkylene, oxoalkylene or hydroxyalkylene and R is H, C 1-6 alkyl, aryl, aryloxy, CN, carboalkoxy, dialkylamino, benzodioxanyl or 4-pyridyl, or XR is H; R<SP>1</SP> is H or C 1-6 alkyl; and either Y=Z=H 2 or O, or Y=O and Z=H 2 . The diones are prepared by reacting haloacetyl compound (V) with R-X-NH 2 , and the mono-ones (XR=H; Ia) by reacting (II) with ethyleneimine. The compounds where Y=Z=H 2 are prepared by reducing (Ia) with LiAlH 4 and introducing the group XR (#H) by known reactions Therapeutic compositions having tranquillizing and hypotensive activity comprise the above compounds.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB4400273A GB1454171A (en) | 1973-10-19 | 1973-10-19 | Tetracyclic compounds |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB4400273A GB1454171A (en) | 1973-10-19 | 1973-10-19 | Tetracyclic compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1454171A true GB1454171A (en) | 1976-10-27 |
Family
ID=10431319
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB4400273A Expired GB1454171A (en) | 1973-10-19 | 1973-10-19 | Tetracyclic compounds |
Country Status (1)
Country | Link |
---|---|
GB (1) | GB1454171A (en) |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1997003985A1 (en) * | 1995-07-14 | 1997-02-06 | Icos Corporation | Cyclic gmp-specific phosphodiesterase inhibitors |
US5859006A (en) * | 1994-01-21 | 1999-01-12 | Icos Corporation | Tetracyclic derivatives; process of preparation and use |
US6001847A (en) * | 1995-07-14 | 1999-12-14 | Icos Corporation | Chemical compounds |
US6117881A (en) * | 1996-05-10 | 2000-09-12 | Icos Corporation | N-cinnamoyl derivatives of (β) carbolines |
US6140329A (en) * | 1995-07-14 | 2000-10-31 | Icos Corporation | Use of cGMP-phosphodiesterase inhibitors in methods and compositions to treat impotence |
US6143746A (en) * | 1994-01-21 | 2000-11-07 | Icos Corporation | Tetracyclic cyclic GMP-specific phosphodiesterase inhibitors, process of preparation and use |
FR2916200A1 (en) * | 2007-05-18 | 2008-11-21 | Fourtillan Snc | New 1,2,3,4,6,7,12,12a-octahydro-pyrazino(1',2':1,6)pyrido(3,4-b)indole compounds are 5-hydroxy tryptamine-2 receptor antagonist useful to treat e.g. depression, anxiety, Parkinson's disease, Alzheimer's disease and cancer |
-
1973
- 1973-10-19 GB GB4400273A patent/GB1454171A/en not_active Expired
Cited By (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6369059B1 (en) | 1994-01-21 | 2002-04-09 | Icos Corporation | Tetracyclic derivatives, process of preparation and use |
US5859006A (en) * | 1994-01-21 | 1999-01-12 | Icos Corporation | Tetracyclic derivatives; process of preparation and use |
US6784179B2 (en) | 1994-01-21 | 2004-08-31 | Icos Corporation | Tetracyclic derivatives, process of preparation and use |
US6143746A (en) * | 1994-01-21 | 2000-11-07 | Icos Corporation | Tetracyclic cyclic GMP-specific phosphodiesterase inhibitors, process of preparation and use |
US6025494A (en) * | 1994-01-21 | 2000-02-15 | Icos Corporation | Tetracyclic derivatives, process of preparation and use |
US6127542A (en) * | 1994-01-21 | 2000-10-03 | Icos Corporation | Tetracyclic derivatives, process of preparation and use |
US6143757A (en) * | 1995-07-14 | 2000-11-07 | Icos Corporation | Chemical compounds |
US6140329A (en) * | 1995-07-14 | 2000-10-31 | Icos Corporation | Use of cGMP-phosphodiesterase inhibitors in methods and compositions to treat impotence |
US6001847A (en) * | 1995-07-14 | 1999-12-14 | Icos Corporation | Chemical compounds |
US6218400B1 (en) | 1995-07-14 | 2001-04-17 | Icos Corporation | Treatment method using a cGMP-Specific PDE inhibitor |
WO1997003985A1 (en) * | 1995-07-14 | 1997-02-06 | Icos Corporation | Cyclic gmp-specific phosphodiesterase inhibitors |
US6608065B1 (en) | 1995-07-14 | 2003-08-19 | Icos Corporation | Use of cGMP phosphodiesterase inhibitors in methods to treat female sexual dysfunction |
US5981527A (en) * | 1995-07-14 | 1999-11-09 | Icos Corporation | Cyclic GMP-specific phosphodiesterase inhibitors |
US6117881A (en) * | 1996-05-10 | 2000-09-12 | Icos Corporation | N-cinnamoyl derivatives of (β) carbolines |
US6306870B1 (en) | 1996-05-10 | 2001-10-23 | Icos Corporation | N-cinnamoyl derivatives of beta-carboline |
FR2916200A1 (en) * | 2007-05-18 | 2008-11-21 | Fourtillan Snc | New 1,2,3,4,6,7,12,12a-octahydro-pyrazino(1',2':1,6)pyrido(3,4-b)indole compounds are 5-hydroxy tryptamine-2 receptor antagonist useful to treat e.g. depression, anxiety, Parkinson's disease, Alzheimer's disease and cancer |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PS | Patent sealed | ||
PCNP | Patent ceased through non-payment of renewal fee |