GB1454171A - Tetracyclic compounds - Google Patents

Tetracyclic compounds

Info

Publication number
GB1454171A
GB1454171A GB4400273A GB4400273A GB1454171A GB 1454171 A GB1454171 A GB 1454171A GB 4400273 A GB4400273 A GB 4400273A GB 4400273 A GB4400273 A GB 4400273A GB 1454171 A GB1454171 A GB 1454171A
Authority
GB
United Kingdom
Prior art keywords
xr
compounds
ia
sp
reacting
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB4400273A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Council of Scientific and Industrial Research (CSIR)
Original Assignee
Council of Scientific and Industrial Research (CSIR)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Council of Scientific and Industrial Research (CSIR) filed Critical Council of Scientific and Industrial Research (CSIR)
Priority to GB4400273A priority Critical patent/GB1454171A/en
Publication of GB1454171A publication Critical patent/GB1454171A/en
Application status is Expired legal-status Critical

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14Ortho-condensed systems

Abstract

1454171 Pyrazinopyridoindoles COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH 19 Oct 1973 44002/73 Heading C2C The invention comprises compounds of formula and their pharmaceutically acceptable acid addition and quaternary ammonium salts, wherein X is alkylene, oxoalkylene or hydroxyalkylene and R is H, C 1-6 alkyl, aryl, aryloxy, CN, carboalkoxy, dialkylamino, benzodioxanyl or 4-pyridyl, or XR is H; R<SP>1</SP> is H or C 1-6 alkyl; and either Y=Z=H 2 or O, or Y=O and Z=H 2 . The diones are prepared by reacting haloacetyl compound (V) with R-X-NH 2 , and the mono-ones (XR=H; Ia) by reacting (II) with ethyleneimine. The compounds where Y=Z=H 2 are prepared by reducing (Ia) with LiAlH 4 and introducing the group XR (#H) by known reactions Therapeutic compositions having tranquillizing and hypotensive activity comprise the above compounds.
GB4400273A 1973-10-19 1973-10-19 Tetracyclic compounds Expired GB1454171A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB4400273A GB1454171A (en) 1973-10-19 1973-10-19 Tetracyclic compounds

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB4400273A GB1454171A (en) 1973-10-19 1973-10-19 Tetracyclic compounds

Publications (1)

Publication Number Publication Date
GB1454171A true GB1454171A (en) 1976-10-27

Family

ID=10431319

Family Applications (1)

Application Number Title Priority Date Filing Date
GB4400273A Expired GB1454171A (en) 1973-10-19 1973-10-19 Tetracyclic compounds

Country Status (1)

Country Link
GB (1) GB1454171A (en)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997003985A1 (en) * 1995-07-14 1997-02-06 Icos Corporation Cyclic gmp-specific phosphodiesterase inhibitors
US5859006A (en) * 1994-01-21 1999-01-12 Icos Corporation Tetracyclic derivatives; process of preparation and use
US6001847A (en) * 1995-07-14 1999-12-14 Icos Corporation Chemical compounds
US6117881A (en) * 1996-05-10 2000-09-12 Icos Corporation N-cinnamoyl derivatives of (β) carbolines
US6140329A (en) * 1995-07-14 2000-10-31 Icos Corporation Use of cGMP-phosphodiesterase inhibitors in methods and compositions to treat impotence
US6143746A (en) * 1994-01-21 2000-11-07 Icos Corporation Tetracyclic cyclic GMP-specific phosphodiesterase inhibitors, process of preparation and use
FR2916200A1 (en) * 2007-05-18 2008-11-21 Fourtillan Snc New 1,2,3,4,6,7,12,12a-octahydro-pyrazino(1',2':1,6)pyrido(3,4-b)indole compounds are 5-hydroxy tryptamine-2 receptor antagonist useful to treat e.g. depression, anxiety, Parkinson's disease, Alzheimer's disease and cancer

Cited By (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6127542A (en) * 1994-01-21 2000-10-03 Icos Corporation Tetracyclic derivatives, process of preparation and use
US5859006A (en) * 1994-01-21 1999-01-12 Icos Corporation Tetracyclic derivatives; process of preparation and use
US6369059B1 (en) 1994-01-21 2002-04-09 Icos Corporation Tetracyclic derivatives, process of preparation and use
US6143746A (en) * 1994-01-21 2000-11-07 Icos Corporation Tetracyclic cyclic GMP-specific phosphodiesterase inhibitors, process of preparation and use
US6025494A (en) * 1994-01-21 2000-02-15 Icos Corporation Tetracyclic derivatives, process of preparation and use
US6784179B2 (en) 1994-01-21 2004-08-31 Icos Corporation Tetracyclic derivatives, process of preparation and use
WO1997003985A1 (en) * 1995-07-14 1997-02-06 Icos Corporation Cyclic gmp-specific phosphodiesterase inhibitors
US6140329A (en) * 1995-07-14 2000-10-31 Icos Corporation Use of cGMP-phosphodiesterase inhibitors in methods and compositions to treat impotence
US6143757A (en) * 1995-07-14 2000-11-07 Icos Corporation Chemical compounds
US6001847A (en) * 1995-07-14 1999-12-14 Icos Corporation Chemical compounds
US6218400B1 (en) 1995-07-14 2001-04-17 Icos Corporation Treatment method using a cGMP-Specific PDE inhibitor
US6608065B1 (en) 1995-07-14 2003-08-19 Icos Corporation Use of cGMP phosphodiesterase inhibitors in methods to treat female sexual dysfunction
US5981527A (en) * 1995-07-14 1999-11-09 Icos Corporation Cyclic GMP-specific phosphodiesterase inhibitors
US6306870B1 (en) 1996-05-10 2001-10-23 Icos Corporation N-cinnamoyl derivatives of beta-carboline
US6117881A (en) * 1996-05-10 2000-09-12 Icos Corporation N-cinnamoyl derivatives of (β) carbolines
FR2916200A1 (en) * 2007-05-18 2008-11-21 Fourtillan Snc New 1,2,3,4,6,7,12,12a-octahydro-pyrazino(1',2':1,6)pyrido(3,4-b)indole compounds are 5-hydroxy tryptamine-2 receptor antagonist useful to treat e.g. depression, anxiety, Parkinson's disease, Alzheimer's disease and cancer

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee