ES2133324T3 - Compuestos de dibenzoxazepina sustituidos, composiciones farmaceuticas y metodos de uso. - Google Patents
Compuestos de dibenzoxazepina sustituidos, composiciones farmaceuticas y metodos de uso.Info
- Publication number
- ES2133324T3 ES2133324T3 ES92914560T ES92914560T ES2133324T3 ES 2133324 T3 ES2133324 T3 ES 2133324T3 ES 92914560 T ES92914560 T ES 92914560T ES 92914560 T ES92914560 T ES 92914560T ES 2133324 T3 ES2133324 T3 ES 2133324T3
- Authority
- ES
- Spain
- Prior art keywords
- pharmaceutical compositions
- methods
- formula
- dibenzoxazepine compounds
- substituted dibenzoxazepine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Abstract
Un procedimiento para preparar un compuesto que tiene la estructura **fórmula** o una sal farmacéuticamente aceptable del mismo; en donde: R1 es: halégeno; X es: -CH=CH-, -CF2-, -CHF-, -(CH2)n- o -(CH2)p-CH=CH-; en donde p y n son números enteros de 1 a 6; Y es: **fórmula**, azufre, **fórmula** u oxígeno; R3 es: hidrógeno o t-butiloxicarbonilo; Het es: piridilo, tienilo o furanilo; en donde m es un número enterode0 a 6; en donde q es el número entero 0 ó 1; caracterizado porque A) un aminoderivado de la fórmula **fórmula** en la que R1 es como se define anteriormente, se hace reaccionar con un cloruro de ácido dela fórmula Het-(CH2)m-(Y)(X)q-COCl en la que m, Y, X, q y Het son como se definen anteriormente, en presencia de una base o B) un aminoderivado de la fórmula **fórmula** en la que R1 es como se define anteriormente, se hace reaccionar con un éster de la fórmula Het-(CH2)m-Y-(X)q-COOMe/Et con m, Y, X, q y Het como se definen anteriormente, en presencia de un catalizador, o C) un aminoderivado de la fórmula **fórmula** en la que R1 es como se define anteriormente, se hace reaccionar con un ácido de la fórmula Het-(CH2)m-Y-(X)q-COOH con Het, m, Y, X, q como se definen anteriormente, en presencia de una amina, o D) un compuesto acetilado de la fórmula **fórmula** con R1 como se define anteriormente, se hace reaccionar con un aminocompuesto de la fórmula Het-(CH2)m-Y-(X)q-CONHNH2 con Het, m, Y, X, q como se definen anteriormente, en presencia de una base dando así los compuestos deseados que pueden convertirse de una manera conocida en compuestos en los que Y es SO o SO2 a través de la oxidación de un compuesto en el que Y = S, o en los enantiómeros respectivos, o las sales farmacéuticamente aceptables, de una manera conocida de por sí.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US69565491A | 1991-05-03 | 1991-05-03 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2133324T3 true ES2133324T3 (es) | 1999-09-16 |
Family
ID=24793923
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES95116871T Expired - Lifetime ES2149305T3 (es) | 1991-05-03 | 1992-04-16 | Compuestos de dibenzoxazepina sustituidos, composiciones farmaceuticas y procedimientos de uso. |
ES92914560T Expired - Lifetime ES2133324T3 (es) | 1991-05-03 | 1992-04-16 | Compuestos de dibenzoxazepina sustituidos, composiciones farmaceuticas y metodos de uso. |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES95116871T Expired - Lifetime ES2149305T3 (es) | 1991-05-03 | 1992-04-16 | Compuestos de dibenzoxazepina sustituidos, composiciones farmaceuticas y procedimientos de uso. |
Country Status (12)
Country | Link |
---|---|
EP (5) | EP0583421B1 (es) |
JP (1) | JP3222891B2 (es) |
AT (2) | ATE194987T1 (es) |
AU (1) | AU2246292A (es) |
CA (1) | CA2108903C (es) |
DE (2) | DE69229442T2 (es) |
DK (2) | DK0694545T3 (es) |
ES (2) | ES2149305T3 (es) |
GR (2) | GR3030992T3 (es) |
IE (2) | IE921410A1 (es) |
PT (2) | PT911331E (es) |
WO (1) | WO1992019617A2 (es) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5182272A (en) * | 1991-05-03 | 1993-01-26 | G. D. Searle & Co. | 8-substituted-dibenz[b,f][1,4]oxazepine-10(11)-carboxylic acid, substituted hydrazides, pharmaceutical compositions, and methods for treating pain |
US5180720A (en) * | 1991-05-03 | 1993-01-19 | G. D. Searle & Co. | 2- and 3-alkoxy or hydroxy-8-substituted-dibenz[b,f]-[1,4]oxazepine-10(11H)-carboxylic acid, substituted hydrazides and methods for treating pain |
US5378840A (en) * | 1992-04-16 | 1995-01-03 | G. D. Searle & Co. | Substituted dibenzoxazepine compounds |
US5212169A (en) * | 1991-10-31 | 1993-05-18 | G. D. Searle & Co. | Substituted dibenzoxazepine compounds, pharmaceutical compositions and methods for treating pain |
US5304644A (en) * | 1992-04-15 | 1994-04-19 | G. D. Searle & Co. | 1-,2-,3-,4-,5-,6-,7-,8- and/or 9 substituted dibenzoxazepine compounds, pharmaceutical compositions and methods for treating pain |
CA2113787A1 (en) * | 1993-01-29 | 1994-07-30 | Nobuyuki Hamanaka | Carbocyclic sulfonamides |
US5395932A (en) * | 1993-04-30 | 1995-03-07 | G. D. Searle & Co. | 2,3-,4-,5-,6-,7-,8-,9- and/or 10-substituted dibenzoxazepine compounds, pharmaceutical compositions and methods of use |
US5354746A (en) * | 1993-06-01 | 1994-10-11 | G. D. Searle & Co. | Squaric acid derivatives of substituted dibenzoxazepine compounds, pharmaceutical compositions and methods of use |
US5354747A (en) * | 1993-06-16 | 1994-10-11 | G. D. Searle & Co. | 2-, 3-, 4-, 5-, 6-, 7-, 8-, 9- and/or 10-substituted dibenzoxazepine and dibenzthiazepine compounds, pharmaceutical compositions and methods of use |
US5461047A (en) * | 1993-06-16 | 1995-10-24 | G. D. Searle & Co. | 2-,3-,4-,5-,6-,7-,8-,9- and/or 10-substituted dibenzoxazepine and dibenzthiazepine compounds, pharmaceutical compositions and methods of use |
US5420270A (en) * | 1993-10-07 | 1995-05-30 | G. D. Searle & Co. | Aryl substituted dibenzoxazepine compounds, pharmaceutical compositions and methods of use |
US5424424A (en) * | 1993-10-07 | 1995-06-13 | G. D. Searle & Co. | Tartaric acid derivatives of substituted dibenzoxazepine compounds, pharmaceutical compositions and methods of use |
US5488046A (en) * | 1993-11-03 | 1996-01-30 | G. D. Searle & Co. | Carbamic acid derivatives of substituted dibenzoxazepine compounds, pharmaceutical compositions and methods of use |
US5449675A (en) * | 1994-06-09 | 1995-09-12 | G. D. Searle & Co. | Substituted dibenzoxazepine and dibenzthiazepine urea compounds, pharmaceutical compositions and methods of use |
US5441950A (en) * | 1994-06-09 | 1995-08-15 | G. D. Searle & Co. | Substituted dibenzoxazepine and dibenzthiazepine carbamate compounds, pharmaceutical compositions and methods of use |
GB9720270D0 (en) | 1997-09-25 | 1997-11-26 | Pharmagene Lab Limited | Medicaments for the treatment of migraine |
JP4175113B2 (ja) * | 2001-03-14 | 2008-11-05 | 小野薬品工業株式会社 | Ep1アンタゴニストを有効成分として含有するうつ病の治療剤 |
US20060100195A1 (en) * | 2001-11-19 | 2006-05-11 | Takayuki Maruyama | Remedies for urinary frequency |
US8598219B2 (en) | 2003-01-30 | 2013-12-03 | Helsinn Healthcare Sa | Liquid pharmaceutical formulations of palonosetron |
JO2735B1 (en) | 2003-01-30 | 2013-09-15 | هيلسين هيلث كير أس ايه. | Liquid pharmaceutical formations of balloonosterone |
US8710045B2 (en) | 2004-01-22 | 2014-04-29 | The Trustees Of Columbia University In The City Of New York | Agents for preventing and treating disorders involving modulation of the ryanodine receptors |
US9181187B2 (en) | 2007-02-16 | 2015-11-10 | Ono Pharmaceutical Co., Ltd. | Therapeutic agent for urinary excretion disorder |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3624104A (en) * | 1969-10-27 | 1971-11-30 | Searle & Co | Aralkanoyl derivatives of dibenzoxazepine-n-carboxylic acid hydrazides |
US3917649A (en) * | 1971-03-23 | 1975-11-04 | Searle & Co | Dibenzoxazepine N-carboxylic acid hydrazides and derivatives |
GB1522003A (en) * | 1975-10-17 | 1978-08-23 | Searle & Co | 1-acyl-2-(8-chloro-10,11-dihydrodibenz-(b,f)(1,4)-oxazepine-10-carbonyl)hydrazines |
US4045442A (en) * | 1976-01-05 | 1977-08-30 | G. D. Searle & Co. | 1-(Substituted amino)alkanoyl-2-(dibenzoxazepine-10-carbonyl)hydrazines and derivatives thereof |
US4704386A (en) * | 1985-08-29 | 1987-11-03 | G. D. Searle & Co. | 8-chlorodibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid, 2-[(phenylsulfinyl-, and phenylsulfonyl)alkanoyl]hydrazides |
-
1992
- 1992-04-16 WO PCT/US1992/003028 patent/WO1992019617A2/en active IP Right Grant
- 1992-04-16 ES ES95116871T patent/ES2149305T3/es not_active Expired - Lifetime
- 1992-04-16 CA CA002108903A patent/CA2108903C/en not_active Expired - Fee Related
- 1992-04-16 DE DE69229442T patent/DE69229442T2/de not_active Expired - Fee Related
- 1992-04-16 EP EP92914560A patent/EP0583421B1/en not_active Expired - Lifetime
- 1992-04-16 AU AU22462/92A patent/AU2246292A/en not_active Abandoned
- 1992-04-16 AT AT95116871T patent/ATE194987T1/de not_active IP Right Cessation
- 1992-04-16 EP EP95116871A patent/EP0694545B1/en not_active Expired - Lifetime
- 1992-04-16 DE DE69231298T patent/DE69231298T2/de not_active Expired - Fee Related
- 1992-04-16 DK DK95116871T patent/DK0694545T3/da active
- 1992-04-16 ES ES92914560T patent/ES2133324T3/es not_active Expired - Lifetime
- 1992-04-16 DK DK92914560T patent/DK0583421T3/da active
- 1992-04-16 JP JP51183892A patent/JP3222891B2/ja not_active Expired - Fee Related
- 1992-04-16 AT AT92914560T patent/ATE181329T1/de not_active IP Right Cessation
- 1992-04-29 PT PT99101029T patent/PT911331E/pt unknown
- 1992-04-29 PT PT95116872T patent/PT694546E/pt unknown
- 1992-04-29 EP EP99101029A patent/EP0911331B1/en not_active Expired - Lifetime
- 1992-04-29 EP EP95116872A patent/EP0694546B1/en not_active Expired - Lifetime
- 1992-04-29 EP EP92107328A patent/EP0512400B1/en not_active Expired - Lifetime
- 1992-07-01 IE IE141092A patent/IE921410A1/en not_active IP Right Cessation
- 1992-07-01 IE IE20000774A patent/IE20000774A1/en not_active IP Right Cessation
-
1999
- 1999-08-18 GR GR990402070T patent/GR3030992T3/el unknown
-
2000
- 2000-10-20 GR GR20000402337T patent/GR3034650T3/el not_active IP Right Cessation
Also Published As
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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