ES2106531T3 - Compuestos de dibenzoxazepina substituidos en 2, 3, 4, 5, 6, 7, 8, 9 y/o 10, composiciones farmaceuticas y metodos de uso. - Google Patents

Compuestos de dibenzoxazepina substituidos en 2, 3, 4, 5, 6, 7, 8, 9 y/o 10, composiciones farmaceuticas y metodos de uso.

Info

Publication number
ES2106531T3
ES2106531T3 ES94914743T ES94914743T ES2106531T3 ES 2106531 T3 ES2106531 T3 ES 2106531T3 ES 94914743 T ES94914743 T ES 94914743T ES 94914743 T ES94914743 T ES 94914743T ES 2106531 T3 ES2106531 T3 ES 2106531T3
Authority
ES
Spain
Prior art keywords
sulfur
oxygen
formula
pharmaceutical compositions
animal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94914743T
Other languages
English (en)
Inventor
Nizal Samuel Chandrakumar
Timothy Joseph Hagen
Barnett Sylvain Pitzele
Sofya Tsymbalov
E Ann Hallinan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GD Searle LLC
Original Assignee
GD Searle LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GD Searle LLC filed Critical GD Searle LLC
Application granted granted Critical
Publication of ES2106531T3 publication Critical patent/ES2106531T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Abstract

LA PRESENTE INVENCION PROPORCIONA COMPUESTOS DE DIBENZOXAZEPINA SUSTITUIDA DE FORMULA (I), QUE SON UTILES COMO AGENTES ANALGESICOS PARA EL TRATAMIENTO DE DOLOR, Y COMO ANTAGONISTAS DE PROSTAGLANDINA-E{SUB, 2} PARA EL TRATAMIENTO DE ENFERMEDADES EN LAS QUE INTERVIENE LA PROSTAGLANDINA-E{SUB, 2}, COMPOSICIONES FARMACEUTICAS QUE COMPRENDEN UNA CANTIDAD TERAPEUTICAMENTE EFECTIVA DE UN COMPUESTO DE FORMULA (I) EN COMBINACION CON UN PORTADOR FARMACEUTICAMENTE ACEPTABLE, UN METODO PARA ELIMINAR O MEJORAR DOLOR EN UN ANIMAL, Y UN METODO PARA EL TRATAMIENTO DE ENFERMEDADES EN LAS QUE INTERVENGA LA PROSTAGLANDINA-E{SUB, 2} EN UN ANIMAL, QUE COMPRENDE LA ADMINISTRACION DE UNA CANTIDAD TERAPEUTICAMENTE EFECTIVA DE UN COMPUESTO DE FORMULA (I) AL ANIMAL.
ES94914743T 1993-04-30 1994-04-07 Compuestos de dibenzoxazepina substituidos en 2, 3, 4, 5, 6, 7, 8, 9 y/o 10, composiciones farmaceuticas y metodos de uso. Expired - Lifetime ES2106531T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/056,704 US5395932A (en) 1993-04-30 1993-04-30 2,3-,4-,5-,6-,7-,8-,9- and/or 10-substituted dibenzoxazepine compounds, pharmaceutical compositions and methods of use

Publications (1)

Publication Number Publication Date
ES2106531T3 true ES2106531T3 (es) 1997-11-01

Family

ID=22006101

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94914743T Expired - Lifetime ES2106531T3 (es) 1993-04-30 1994-04-07 Compuestos de dibenzoxazepina substituidos en 2, 3, 4, 5, 6, 7, 8, 9 y/o 10, composiciones farmaceuticas y metodos de uso.

Country Status (11)

Country Link
US (2) US5395932A (es)
EP (1) EP0696283B1 (es)
JP (2) JP3540317B2 (es)
AT (1) ATE158292T1 (es)
AU (1) AU6698894A (es)
CA (1) CA2159990A1 (es)
DE (1) DE69405726T2 (es)
DK (1) DK0696283T3 (es)
ES (1) ES2106531T3 (es)
GR (1) GR3025022T3 (es)
WO (1) WO1994025456A1 (es)

Families Citing this family (17)

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US5395932A (en) * 1993-04-30 1995-03-07 G. D. Searle & Co. 2,3-,4-,5-,6-,7-,8-,9- and/or 10-substituted dibenzoxazepine compounds, pharmaceutical compositions and methods of use
US5488046A (en) * 1993-11-03 1996-01-30 G. D. Searle & Co. Carbamic acid derivatives of substituted dibenzoxazepine compounds, pharmaceutical compositions and methods of use
US5449675A (en) * 1994-06-09 1995-09-12 G. D. Searle & Co. Substituted dibenzoxazepine and dibenzthiazepine urea compounds, pharmaceutical compositions and methods of use
GB9720270D0 (en) 1997-09-25 1997-11-26 Pharmagene Lab Limited Medicaments for the treatment of migraine
KR20010108316A (ko) 1999-03-05 2001-12-07 데이비드 엠 모이어 Ｃ16 불포화된 ｆｐ-선택적 프로스타글란딘 유사체
GB9905418D0 (en) * 1999-03-09 1999-05-05 Glaxo Group Ltd Process
US7015212B1 (en) 1999-05-12 2006-03-21 The United States Of America As Represented By The Department Of Health And Human Services Thiazepine inhibitors of HIV-1 integrase
US6894175B1 (en) 1999-08-04 2005-05-17 The Procter & Gamble Company 2-Decarboxy-2-phosphinico prostaglandin derivatives and methods for their preparation and use
US20020037914A1 (en) * 2000-03-31 2002-03-28 Delong Mitchell Anthony Compositions and methods for treating hair loss using C16-C20 aromatic tetrahydro prostaglandins
US20020172693A1 (en) * 2000-03-31 2002-11-21 Delong Michell Anthony Compositions and methods for treating hair loss using non-naturally occurring prostaglandins
US20020013294A1 (en) * 2000-03-31 2002-01-31 Delong Mitchell Anthony Cosmetic and pharmaceutical compositions and methods using 2-decarboxy-2-phosphinico derivatives
US20020146439A1 (en) * 2000-03-31 2002-10-10 Delong Mitchell Anthony Compositions and methods for treating hair loss using oximyl and hydroxylamino prostaglandins
MX2008013400A (es) 2006-04-19 2008-11-10 Astellas Pharma Inc Derivado de azolcarboxamida.
MX2010004499A (es) 2007-10-24 2010-05-20 Astellas Pharma Inc Compuesto de azolcarboxamida o sal de el.
US8722739B2 (en) 2008-10-29 2014-05-13 Novaer Holdings, Inc. Amino acid salts of prostaglandins
US8623918B2 (en) * 2008-10-29 2014-01-07 Novaer Holdings, Inc. Amino acid salts of prostaglandins
EP3309556B1 (en) 2009-06-25 2020-04-08 Prometheus Biosciences, Inc. Methods for diagnosing irritable bowel syndrome

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BE632563A (es) * 1963-03-26
US3357998A (en) * 1964-11-06 1967-12-12 Searle & Co Complex amides of dihydrodibenzo [b, f] [1, 4] oxazepine-10-carboxylic acids
NL127795C (es) * 1966-01-28
US3534019A (en) * 1967-10-30 1970-10-13 Searle & Co Dibenzoxazepine - n - carboxylic acid hydrazides and related compounds
US3624104A (en) * 1969-10-27 1971-11-30 Searle & Co Aralkanoyl derivatives of dibenzoxazepine-n-carboxylic acid hydrazides
DE2213809A1 (de) * 1971-03-23 1972-10-12 G.D. Searle & Co., Skokie, 111. (V. St. A.) Dibenzoxazepin-N-carbonsäurehydrazide und deren Derivate
US3917649A (en) * 1971-03-23 1975-11-04 Searle & Co Dibenzoxazepine N-carboxylic acid hydrazides and derivatives
US3989719A (en) * 1971-03-23 1976-11-02 G. D. Searle & Co. Dibenzoxazepine N-carboxylic acid hydrazides and derivatives
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GB1522003A (en) * 1975-10-17 1978-08-23 Searle & Co 1-acyl-2-(8-chloro-10,11-dihydrodibenz-(b,f)(1,4)-oxazepine-10-carbonyl)hydrazines
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US4170593A (en) * 1976-01-05 1979-10-09 G. D. Searle & Co. 1-(Substituted amino)alkanoyl-2-(dibenzoxapine-10-carbonyl)hydrazines and derivatives thereof
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GB9021813D0 (en) * 1990-10-08 1990-11-21 Ici Plc Tricyclic heterocycles
EP0524270B1 (de) * 1990-10-12 1996-04-17 Fa. Proglas Veredelungsvorrichtung zum geissfussveredeln
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GB9120640D0 (en) * 1991-09-27 1991-11-06 Ici Plc Tricyclic heterocycles
WO1993007132A1 (en) * 1991-10-01 1993-04-15 G.D. Searle & Co. 10-acyl-dibenz(b,f)(1,4)-oxazepines and their thiazepines and diazepines analogues useful as prostaglandin antagonists
US5212169A (en) * 1991-10-31 1993-05-18 G. D. Searle & Co. Substituted dibenzoxazepine compounds, pharmaceutical compositions and methods for treating pain
EP0613472A1 (en) * 1991-11-05 1994-09-07 G.D. Searle & Co. 10-acyl-dibenz(b,f) (1,4)-oxazepines and their thiazepines analo gues useful as prostaglandin antagonists
US5354863A (en) * 1992-01-21 1994-10-11 G. D. Searle & Co. Opioid agonist compounds
US5225417A (en) * 1992-01-21 1993-07-06 G. D. Searle & Co. Opioid agonist compounds
US5304644A (en) * 1992-04-15 1994-04-19 G. D. Searle & Co. 1-,2-,3-,4-,5-,6-,7-,8- and/or 9 substituted dibenzoxazepine compounds, pharmaceutical compositions and methods for treating pain
US5395932A (en) * 1993-04-30 1995-03-07 G. D. Searle & Co. 2,3-,4-,5-,6-,7-,8-,9- and/or 10-substituted dibenzoxazepine compounds, pharmaceutical compositions and methods of use

Also Published As

Publication number Publication date
EP0696283B1 (en) 1997-09-17
CA2159990A1 (en) 1994-11-10
GR3025022T3 (en) 1998-01-30
JPH08509497A (ja) 1996-10-08
DE69405726D1 (de) 1997-10-23
EP0696283A1 (en) 1996-02-14
AU6698894A (en) 1994-11-21
US5395932A (en) 1995-03-07
US5719140A (en) 1998-02-17
WO1994025456A1 (en) 1994-11-10
JP3540317B2 (ja) 2004-07-07
DK0696283T3 (da) 1998-04-27
ATE158292T1 (de) 1997-10-15
JP2003277378A (ja) 2003-10-02
DE69405726T2 (de) 1998-02-19

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