RS49675B - 4"supstituisani-9-deokso-9a-aza-9a- homoeritromicin a derivati - Google Patents
4"supstituisani-9-deokso-9a-aza-9a- homoeritromicin a derivatiInfo
- Publication number
- RS49675B RS49675B YUP-586/99A YU58699A RS49675B RS 49675 B RS49675 B RS 49675B YU 58699 A YU58699 A YU 58699A RS 49675 B RS49675 B RS 49675B
- Authority
- RS
- Serbia
- Prior art keywords
- groups
- integer
- membered heteroaryl
- carbon
- optionally substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Communicable Diseases (AREA)
- Tropical Medicine & Parasitology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US4934897P | 1997-06-11 | 1997-06-11 | |
PCT/IB1998/000839 WO1998056802A1 (en) | 1997-06-11 | 1998-05-29 | 4'-substituted-9-deoxo-9a-aza-9a-homoerythromycin a derivatives |
Publications (2)
Publication Number | Publication Date |
---|---|
YU58699A YU58699A (sr) | 2002-08-12 |
RS49675B true RS49675B (sr) | 2007-11-15 |
Family
ID=21959336
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
YUP-586/99A RS49675B (sr) | 1997-06-11 | 1998-05-29 | 4"supstituisani-9-deokso-9a-aza-9a- homoeritromicin a derivati |
Country Status (50)
Families Citing this family (54)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HN1998000086A (es) | 1997-06-11 | 1999-03-08 | Pfizer Prod Inc | Derivados de 9 - desofo - 9 aza - 9a - homoeritromicina a - c - 4 sustituidos. |
EP1011689B8 (en) * | 1997-09-10 | 2007-05-09 | Merial Ltd. | USE OF 9a-AZALIDES AS VETERINARY ANTIMICROBIAL AGENTS |
US6339063B1 (en) | 1997-09-10 | 2002-01-15 | Merck & Co., Inc. | 9a-azalides as veterinary antimicrobial agents |
EP1779853A3 (en) * | 1997-09-10 | 2010-01-27 | Merial Ltd. | 9a-azalides as veterinary antimicrobial agents |
AP9801420A0 (en) * | 1998-01-02 | 1998-12-31 | Pfizer Prod Inc | Novel macrolides. |
US6043227A (en) * | 1998-08-19 | 2000-03-28 | Pfizer Inc. | C11 carbamates of macrolide antibacterials |
EP1437360A3 (en) * | 1998-08-19 | 2005-04-06 | Pfizer Products Inc. | C11 Carbamates of macrolide antibacterials |
US6100240A (en) * | 1998-10-09 | 2000-08-08 | Pfizer Inc | Macrolide derivatives |
CA2292359C (en) * | 1999-01-28 | 2004-09-28 | Pfizer Products Inc. | Novel azalides and methods of making same |
OA11876A (en) * | 1999-05-18 | 2006-03-27 | Pfizer Prod Inc | Novel crystalline forms of a macrolide antibiotic. |
AU3832100A (en) * | 1999-05-24 | 2000-12-12 | Pfizer Products Inc. | 13-methyl-erythromycin derivatives |
US6465437B1 (en) * | 1999-06-30 | 2002-10-15 | Pfizer Inc. | Diphosphate salt of a 4″-substituted-9-deoxo-9A-AZA-9A- homoerythromycin derivative and its pharmaceutical composition |
US6764996B1 (en) | 1999-08-24 | 2004-07-20 | Abbott Laboratories | 9a-azalides with antibacterial activity |
PT1206476E (pt) * | 1999-08-24 | 2006-05-31 | Abbott Lab | 9a-azalidos com actividade antibacteriana |
US6608033B1 (en) | 1999-08-27 | 2003-08-19 | Pfizer Inc. | Treatment or prevention of coccidiosis |
ATE243703T1 (de) | 2000-01-27 | 2003-07-15 | Pfizer Prod Inc | Antibiotische azalid-zusammensetzungen |
PL359861A1 (en) * | 2000-04-27 | 2004-09-06 | Pfizer Products Inc. | The use of azalide antibiotic compositions for treating or preventing a bacterial or protozoal infection in mammals |
RU2263117C2 (ru) * | 2001-04-27 | 2005-10-27 | Пфайзер Продактс Инк. | Способ получения 4"-замещенных производных 9-деоксо-9а-аза-9а-гомоэритромицина а |
AU2002317415A1 (en) * | 2001-08-01 | 2003-02-17 | Pfizer Products Inc. | Azalide antibiotic compositions |
CA2801100A1 (en) | 2003-03-10 | 2004-09-23 | Optimer Pharmaceuticals, Inc. | Macrolides and processes for their preparation |
US7276487B2 (en) | 2003-09-23 | 2007-10-02 | Enanta Pharmaceuticals, Inc. | 9a, 11-3C-bicyclic 9a-azalide derivatives |
CA2546195A1 (en) * | 2003-11-21 | 2005-06-02 | Pfizer Products Inc. | The use of anti biotics as vaccine adjuvants |
CA2557801C (en) * | 2004-03-16 | 2013-06-25 | Boehringer Ingelheim International Gmbh | Glucopyranosyl-substituted benzol derivatives, drugs containing said compounds, the use thereof and method for the production thereof |
US20060116336A1 (en) * | 2004-03-17 | 2006-06-01 | American Pharmaceutical Partners, Inc. | Lyophilized azithromycin formulation |
US7468428B2 (en) * | 2004-03-17 | 2008-12-23 | App Pharmaceuticals, Llc | Lyophilized azithromycin formulation |
US7402568B2 (en) | 2004-09-29 | 2008-07-22 | Enanta Pharmaceuticals, Inc. | Bicyclic 9a-azalide derivatives |
US7767797B1 (en) * | 2004-09-30 | 2010-08-03 | Synovo Gmbh | Macrocyclic compounds and methods of use thereof |
US7271155B2 (en) | 2005-01-07 | 2007-09-18 | Enanta Pharmaceuticals, Inc. | 9A, 11-2C-bicyclic 9a-azalide derivatives |
ATE429921T1 (de) * | 2005-01-14 | 2009-05-15 | Glaxosmithkline Zagreb | 9a-carbamoyl- und thiocarbamoylazalide mit antimalariawirkung |
CN105732745A (zh) | 2007-10-25 | 2016-07-06 | 森普拉制药公司 | 大环内酯类抗菌剂的制备方法 |
CN107854477A (zh) | 2008-10-24 | 2018-03-30 | 森普拉制药公司 | 使用含三唑的大环内酯治疗抗性疾病的方法 |
US9937194B1 (en) * | 2009-06-12 | 2018-04-10 | Cempra Pharmaceuticals, Inc. | Compounds and methods for treating inflammatory diseases |
WO2011032052A1 (en) | 2009-09-10 | 2011-03-17 | Cempra Pharmaceuticals, Inc. | Methods for treating malaria, tuberculosis and mac diseases |
EP2550286B1 (en) | 2010-03-22 | 2015-12-09 | Cempra Pharmaceuticals, Inc. | Crystalline forms of a macrolide, and uses therefor |
PL2571506T3 (pl) | 2010-05-20 | 2017-10-31 | Cempra Pharmaceuticals Inc | Sposoby sporządzania makrolidów i ketolidów oraz ich produktów pośrednich |
KR20180110181A (ko) | 2010-09-10 | 2018-10-08 | 셈프라 파마슈티컬스, 인크. | 질환을 치료하기 위한 수소결합 형성 플루오로 케토라이드 |
JP5908479B2 (ja) * | 2010-09-20 | 2016-04-26 | ノバルティス ティーアゲズントハイト アーゲー | クラジノース環のC−4”をエポキシド基で修飾した9−デオキソ−9a−アザ−9a−ホモエリスロマイシンAの新規製造方法 |
EP2625185A4 (en) * | 2010-10-10 | 2014-03-26 | Synovo Gmbh | INFLAMMATORY MAKROLIDE |
CN102993250B (zh) * | 2011-07-06 | 2016-02-10 | 洛阳惠中兽药有限公司 | C-3取代的-9-脱氧-9a-氮杂-9a-高红霉素a衍生物 |
CN102260306B (zh) * | 2011-07-22 | 2012-07-18 | 山东鲁抗舍里乐药业有限公司 | 一种制备泰拉霉素的方法 |
EP2736915A1 (en) | 2011-07-27 | 2014-06-04 | Farma GRS, d.o.o. | New crystalline forms of tulathromycin |
IN2014DN08939A (sr) | 2012-03-27 | 2015-05-22 | Cempra Pharmaceuticals Inc | |
CN102786569B (zh) * | 2012-09-07 | 2016-12-07 | 安徽中升药业有限公司 | 泰拉霉素中间体及其制备方法与泰拉霉素的制备方法 |
AU2014239959A1 (en) | 2013-03-14 | 2015-10-01 | Cempra Pharmaceuticals, Inc. | Methods for treating respiratory diseases and formulations therefor |
EP2968384A4 (en) | 2013-03-15 | 2017-02-15 | Cempra Pharmaceuticals, Inc. | Convergent processes for preparing macrolide antibacterial agents |
SI3027634T1 (sl) * | 2013-07-31 | 2018-10-30 | Farma Grs, D.O.O. | Proces za pripravo tulatromicina |
CN103497227B (zh) * | 2013-09-13 | 2015-09-30 | 青岛科技大学 | 一种泰拉菌素中间体的制备方法 |
CN104725446B (zh) * | 2015-03-26 | 2017-10-27 | 宁夏泰瑞制药股份有限公司 | 一种从泰拉霉素粗品中分离泰拉霉素a和泰拉霉素b的方法 |
CN104861018A (zh) * | 2015-06-17 | 2015-08-26 | 瑞普(天津)生物药业有限公司 | 一种泰拉菌素的制备方法 |
CN105646617A (zh) * | 2016-01-21 | 2016-06-08 | 杭州海尔希畜牧科技有限公司 | 一种制备泰拉霉素的方法 |
FR3048612B1 (fr) * | 2016-03-14 | 2020-10-02 | Septeos | Tulathromycine potentialisee |
CN106046077B (zh) * | 2016-08-04 | 2019-07-26 | 湖北美天生物科技股份有限公司 | 一种泰拉霉素a的合成方法 |
CN108003207B (zh) * | 2017-12-19 | 2019-05-10 | 海门慧聚药业有限公司 | 制备泰拉霉素的方法 |
CN111087433B (zh) * | 2018-10-23 | 2023-03-21 | 湖北美天生物科技股份有限公司 | 一种泰拉霉素中间体的制备方法 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SI8110592A8 (en) * | 1981-03-06 | 1996-06-30 | Pliva Pharm & Chem Works | Process for preparing of n-methyl-11-aza-10-deoxo-10-dihydroerythromycine a and derivatives thereof |
US4474768A (en) * | 1982-07-19 | 1984-10-02 | Pfizer Inc. | N-Methyl 11-aza-10-deoxo-10-dihydro-erytromycin A, intermediates therefor |
US4512982A (en) * | 1984-04-13 | 1985-04-23 | Pfizer Inc. | 9α-Aza-9α-homoerythromycin compounds, pharmaceutical composition and therapeutic method |
CA2064634C (en) * | 1991-04-04 | 1998-08-04 | James V. Heck | 9-deoxo-8a-aza-8a-homoerythromycin a derivatives modified at the 4"- and8a-positions |
US5226958A (en) * | 1991-04-11 | 1993-07-13 | Pacemark, Inc. | Sealant for pneumatic inner tubes and tubeless tires |
EP0549040A1 (en) * | 1991-12-20 | 1993-06-30 | Merck & Co. Inc. | Methods of making 4" derivatives of 9-deoxo-8a-aza-8a-alkyl-8a-homoerythromycin A |
US5441939A (en) * | 1994-03-04 | 1995-08-15 | Pfizer Inc. | 3"-desmethoxy derivatives of erythromycin and azithromycin |
HN1998000086A (es) * | 1997-06-11 | 1999-03-08 | Pfizer Prod Inc | Derivados de 9 - desofo - 9 aza - 9a - homoeritromicina a - c - 4 sustituidos. |
UA70972C2 (uk) | 1998-11-20 | 2004-11-15 | Пфайзер Продактс Інк. | 13-членні азаліди і їх застосування як антибіотиків |
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1998
- 1998-05-03 HN HN1998000086A patent/HN1998000086A/es unknown
- 1998-05-27 PA PA19988452201A patent/PA8452201A1/es unknown
- 1998-05-29 NZ NZ514871A patent/NZ514871A/en not_active IP Right Cessation
- 1998-05-29 RS YUP-586/99A patent/RS49675B/sr unknown
- 1998-05-29 CN CN200910145318A patent/CN101691390A/zh active Pending
- 1998-05-29 CN CN2006100513455A patent/CN1793155B/zh not_active Expired - Lifetime
- 1998-05-29 DE DE122004000018C patent/DE122004000018I2/de active Active
- 1998-05-29 PT PT98920693T patent/PT988310E/pt unknown
- 1998-05-29 CN CNB988059223A patent/CN1172947C/zh not_active Expired - Lifetime
- 1998-05-29 ID IDW991569A patent/ID22992A/id unknown
- 1998-05-29 NZ NZ500660A patent/NZ500660A/en not_active IP Right Cessation
- 1998-05-29 ES ES98920693T patent/ES2205487T3/es not_active Expired - Lifetime
- 1998-05-29 CA CA002293823A patent/CA2293823C/en not_active Expired - Lifetime
- 1998-05-29 DK DK98920693T patent/DK0988310T3/da active
- 1998-05-29 JP JP50193599A patent/JP3315704B2/ja not_active Expired - Lifetime
- 1998-05-29 EP EP98920693A patent/EP0988310B9/en not_active Expired - Lifetime
- 1998-05-29 EA EA199901015A patent/EA002441B1/ru not_active IP Right Cessation
- 1998-05-29 CN CNB2004100491122A patent/CN1243766C/zh not_active Expired - Lifetime
- 1998-05-29 DE DE69818665T patent/DE69818665T2/de not_active Expired - Lifetime
- 1998-05-29 ME MEP-1999-586A patent/ME00876B/me unknown
- 1998-05-29 IL IL13280998A patent/IL132809A0/xx not_active IP Right Cessation
- 1998-05-29 HU HU0002209A patent/HU228005B1/hu active Protection Beyond IP Right Term
- 1998-05-29 CZ CZ0442199A patent/CZ298556B6/cs not_active IP Right Cessation
- 1998-05-29 UA UA99126736A patent/UA67744C2/uk unknown
- 1998-05-29 WO PCT/IB1998/000839 patent/WO1998056802A1/en active IP Right Grant
- 1998-05-29 KR KR10-1999-7011642A patent/KR100396168B1/ko not_active IP Right Cessation
- 1998-05-29 SI SI9830572T patent/SI0988310T1/xx unknown
- 1998-05-29 US US09/424,104 patent/US6420536B1/en not_active Expired - Lifetime
- 1998-05-29 AT AT98920693T patent/ATE251173T1/de active
- 1998-05-29 BR BRPI9810519A patent/BRPI9810519B8/pt not_active IP Right Cessation
- 1998-05-29 PL PL337505A patent/PL191601B1/pl unknown
- 1998-05-29 AU AU73475/98A patent/AU749816B2/en not_active Expired
- 1998-05-29 SK SK1683-99A patent/SK284171B6/sk not_active IP Right Cessation
- 1998-06-04 AP APAP/P/1998/001255A patent/AP1231A/en active
- 1998-06-08 PE PE1998000471A patent/PE79699A1/es not_active Application Discontinuation
- 1998-06-09 MY MYPI98002575A patent/MY123354A/en unknown
- 1998-06-09 EG EG64098A patent/EG24081A/xx active
- 1998-06-09 AR ARP980102706A patent/AR013086A1/es active IP Right Grant
- 1998-06-10 TN TNTNSN98082A patent/TNSN98082A1/fr unknown
- 1998-06-10 DZ DZ980124A patent/DZ2514A1/xx active
- 1998-06-10 MA MA25107A patent/MA24564A1/fr unknown
- 1998-06-10 CO CO98033232A patent/CO4950611A1/es unknown
- 1998-06-10 ZA ZA9805017A patent/ZA985017B/xx unknown
- 1998-06-10 GT GT199800077A patent/GT199800077A/es unknown
- 1998-06-11 UY UY25040A patent/UY25040A1/es not_active IP Right Cessation
- 1998-06-11 HR HR980314A patent/HRP980314B1/xx not_active IP Right Cessation
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1999
- 1999-02-26 TW TW087109077A patent/TW472060B/zh not_active IP Right Cessation
- 1999-11-16 IS IS5252A patent/IS1998B/is unknown
- 1999-12-03 OA OA9900268A patent/OA11224A/en unknown
- 1999-12-03 BG BG103945A patent/BG64391B1/bg unknown
- 1999-12-10 NO NO996106A patent/NO316911B1/no not_active IP Right Cessation
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2000
- 2000-11-17 HK HK00107338A patent/HK1028048A1/xx not_active IP Right Cessation
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2001
- 2001-11-21 US US09/989,936 patent/US20020061858A1/en not_active Abandoned
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2002
- 2002-03-13 JP JP2002068432A patent/JP2002316933A/ja active Pending
- 2002-10-18 US US10/273,879 patent/US6777393B2/en not_active Expired - Lifetime
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2004
- 2004-03-26 US US10/810,922 patent/US6936592B2/en not_active Expired - Lifetime
- 2004-05-04 FR FR04C0013C patent/FR04C0013I2/fr active Active
- 2004-05-05 LU LU91076C patent/LU91076I9/fr unknown
- 2004-05-10 NL NL300150C patent/NL300150I2/nl unknown
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2005
- 2005-02-16 HK HK05101261A patent/HK1068893A1/xx not_active IP Right Cessation
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2006
- 2006-07-28 HK HK06108418.1A patent/HK1088014A1/xx not_active IP Right Cessation
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2012
- 2012-11-26 HU HUS1200028C patent/HUS1200028I1/hu unknown
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