PL2571506T3 - Sposoby sporządzania makrolidów i ketolidów oraz ich produktów pośrednich - Google Patents

Sposoby sporządzania makrolidów i ketolidów oraz ich produktów pośrednich

Info

Publication number
PL2571506T3
PL2571506T3 PL11784318T PL11784318T PL2571506T3 PL 2571506 T3 PL2571506 T3 PL 2571506T3 PL 11784318 T PL11784318 T PL 11784318T PL 11784318 T PL11784318 T PL 11784318T PL 2571506 T3 PL2571506 T3 PL 2571506T3
Authority
PL
Poland
Prior art keywords
ketolides
processes
intermediates therefor
macrolides
preparing
Prior art date
Application number
PL11784318T
Other languages
English (en)
Inventor
David E Pereira
Original Assignee
Cempra Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cempra Pharmaceuticals Inc filed Critical Cempra Pharmaceuticals Inc
Publication of PL2571506T3 publication Critical patent/PL2571506T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
PL11784318T 2010-05-20 2011-05-20 Sposoby sporządzania makrolidów i ketolidów oraz ich produktów pośrednich PL2571506T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US34666410P 2010-05-20 2010-05-20
EP11784318.5A EP2571506B1 (en) 2010-05-20 2011-05-20 Processes for preparing macrolides and ketolides and intermediates therefor
PCT/US2011/037330 WO2011146829A1 (en) 2010-05-20 2011-05-20 Processes for preparing macrolides and ketolides and intermediates therefor

Publications (1)

Publication Number Publication Date
PL2571506T3 true PL2571506T3 (pl) 2017-10-31

Family

ID=44992076

Family Applications (1)

Application Number Title Priority Date Filing Date
PL11784318T PL2571506T3 (pl) 2010-05-20 2011-05-20 Sposoby sporządzania makrolidów i ketolidów oraz ich produktów pośrednich

Country Status (15)

Country Link
US (4) US9051346B2 (pl)
EP (1) EP2571506B1 (pl)
JP (1) JP6184319B2 (pl)
KR (1) KR101945324B1 (pl)
CN (2) CN105198944B (pl)
AU (1) AU2011255464C1 (pl)
BR (1) BR112012029586A2 (pl)
CA (1) CA2799937A1 (pl)
DK (1) DK2571506T3 (pl)
ES (1) ES2636948T3 (pl)
IL (1) IL223161A0 (pl)
PL (1) PL2571506T3 (pl)
RU (1) RU2608390C2 (pl)
SI (1) SI2571506T1 (pl)
WO (1) WO2011146829A1 (pl)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3738591A3 (en) 2003-03-10 2021-03-24 Merck Sharp & Dohme Corp. Novel antibacterial agents
US8563573B2 (en) 2007-11-02 2013-10-22 Vertex Pharmaceuticals Incorporated Azaindole derivatives as CFTR modulators
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DK2358379T3 (en) 2008-10-24 2016-03-07 Cempra Pharmaceuticals Inc BIOFORSVAR USING TRIAZOLHOLDIGE macrolides
US9937194B1 (en) 2009-06-12 2018-04-10 Cempra Pharmaceuticals, Inc. Compounds and methods for treating inflammatory diseases
EP2475253B1 (en) 2009-09-10 2016-10-26 Cempra Pharmaceuticals, Inc. Methods for treating malaria, tuberculosis and mac diseases
US8802868B2 (en) 2010-03-25 2014-08-12 Vertex Pharmaceuticals Incorporated Solid forms of (R)-1(2,2-difluorobenzo[D][1,3]dioxo1-5-yl)-N-(1-(2,3-dihydroxypropyl-6-fluoro-2-(1-hydroxy-2-methylpropan2-yl)-1H-Indol-5-yl)-Cyclopropanecarboxamide
RU2745977C2 (ru) 2010-04-22 2021-04-05 Вертекс Фармасьютикалз Инкорпорейтед Способ получения циклоалкилкарбоксамидо-индольных соединений
PL2571506T3 (pl) * 2010-05-20 2017-10-31 Cempra Pharmaceuticals Inc Sposoby sporządzania makrolidów i ketolidów oraz ich produktów pośrednich
US9815863B2 (en) 2010-09-10 2017-11-14 Cempra Pharmaceuticals, Inc. Hydrogen bond forming fluoro ketolides for treating diseases
MX2014011537A (es) 2012-03-27 2015-02-10 Cempra Pharmaceuticals Inc Formulaciones parenterales para la administracion de antibioticos macrolidos.
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WO2014152326A1 (en) 2013-03-14 2014-09-25 Cempra Pharmaceuticals, Inc. Methods for treating respiratory diseases and formulations therefor
BR112015023670A2 (pt) 2013-03-15 2017-07-18 Cempra Pharmaceuticals Inc processo para preparar um composto
BR112015025159A2 (pt) 2013-04-04 2017-07-18 Harvard College macrolídeos e métodos de sua preparação e uso
SG10201913575VA (en) 2014-04-15 2020-02-27 Vertex Pharma Pharmaceutical compositions for the treatment of cystic fibrosis transmembrane conductance regulator mediated diseases
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CN104311611B (zh) * 2014-08-13 2017-01-18 广东东阳光药业有限公司 一种制备固态大环内酯的方法
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Also Published As

Publication number Publication date
EP2571506A4 (en) 2014-04-02
ES2636948T3 (es) 2017-10-10
JP6184319B2 (ja) 2017-08-23
CN105198944B (zh) 2018-06-01
AU2011255464A1 (en) 2012-12-13
IL223161A0 (en) 2013-02-03
AU2011255464B2 (en) 2016-06-16
BR112012029586A2 (pt) 2016-08-02
US20200087335A1 (en) 2020-03-19
JP2013527187A (ja) 2013-06-27
EP2571506A1 (en) 2013-03-27
CN105198944A (zh) 2015-12-30
US20150232500A1 (en) 2015-08-20
US9051346B2 (en) 2015-06-09
US20130066056A1 (en) 2013-03-14
RU2608390C2 (ru) 2017-01-18
SI2571506T1 (sl) 2017-12-29
KR20130120374A (ko) 2013-11-04
DK2571506T3 (en) 2017-08-28
US20190048035A1 (en) 2019-02-14
CN102917708A (zh) 2013-02-06
KR101945324B1 (ko) 2019-02-07
HK1218919A1 (zh) 2017-03-17
AU2011255464C1 (en) 2017-02-23
RU2012150753A (ru) 2014-06-27
HK1181672A1 (zh) 2013-11-15
CN102917708B (zh) 2015-11-25
EP2571506B1 (en) 2017-05-10
WO2011146829A1 (en) 2011-11-24
CA2799937A1 (en) 2011-11-24

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