BRPI0513903A - derivados de cetolìdeos úteis como agentes antimicrobianos, seus processos de preparação e composições farmacêuticas compreendendo os mesmos - Google Patents
derivados de cetolìdeos úteis como agentes antimicrobianos, seus processos de preparação e composições farmacêuticas compreendendo os mesmosInfo
- Publication number
- BRPI0513903A BRPI0513903A BRPI0513903-1A BRPI0513903A BRPI0513903A BR PI0513903 A BRPI0513903 A BR PI0513903A BR PI0513903 A BRPI0513903 A BR PI0513903A BR PI0513903 A BRPI0513903 A BR PI0513903A
- Authority
- BR
- Brazil
- Prior art keywords
- pharmaceutical compositions
- ketolide derivatives
- same
- preparation processes
- antimicrobial agents
- Prior art date
Links
- 239000003835 ketolide antibiotic agent Substances 0.000 title abstract 4
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 3
- 238000002360 preparation method Methods 0.000 title abstract 2
- 239000004599 antimicrobial Substances 0.000 title 1
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 241000193830 Bacillus <bacterium> Species 0.000 abstract 1
- 208000035143 Bacterial infection Diseases 0.000 abstract 1
- 241000606125 Bacteroides Species 0.000 abstract 1
- 241000606161 Chlamydia Species 0.000 abstract 1
- 241000193403 Clostridium Species 0.000 abstract 1
- 241000186216 Corynebacterium Species 0.000 abstract 1
- 241000606790 Haemophilus Species 0.000 abstract 1
- 241000589989 Helicobacter Species 0.000 abstract 1
- 241000589248 Legionella Species 0.000 abstract 1
- 208000007764 Legionnaires' Disease Diseases 0.000 abstract 1
- 241000186359 Mycobacterium Species 0.000 abstract 1
- 241000295644 Staphylococcaceae Species 0.000 abstract 1
- 230000003515 anti-microbian Effects 0.000 abstract 1
- 230000001580 bacterial effect Effects 0.000 abstract 1
- 208000022362 bacterial infectious disease Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 241001148471 unidentified anaerobic bacterium Species 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Abstract
DERIVADOS DE CETOLìDEOS úTEIS COMO AGENTES ANTIMICROBIANOS, SEUS PROCESSOS DE PREPARAçãO E COMPOSIçõES FARMACêUTICAS COMPREENDENDO OS MESMOS. A presente invenção refere-se a derivados de cetolídeos, os quais podem ser usados como agentes bacterianos. Particularmente, os compostos aqui descritos podem ser usados no tratamento ou na prevenção de condições causadas ou influenciadas por bactérias Gram-positivas, Gram-negativas ou anaeróbicas, mais particularmente contra, por exemplo, Staphylococci, Streptococci, Enterococci, Haemophilus, Moraxalla spp., Chlamydia spp., Mycoplasm, Legionella spp., Mycobacterium, Helicobacter, Clostridium, Bacteroides, Corynebacterium, Bacillus ou Enterobactericeae. A presente invenção refere-se ainda a processos preparação dos referidos derivados de cetolídeos, composições farmacêuticas dos mesmos e a métodos tratamento de infecções bacterianas.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN1400DE2004 | 2004-07-28 | ||
IN1388DE2005 | 2005-05-30 | ||
PCT/US2005/027875 WO2006080954A1 (en) | 2004-07-28 | 2005-07-28 | Ketolide derivatives as antibacterial agents |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0513903A true BRPI0513903A (pt) | 2008-05-20 |
Family
ID=36480874
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0513903-1A BRPI0513903A (pt) | 2004-07-28 | 2005-07-28 | derivados de cetolìdeos úteis como agentes antimicrobianos, seus processos de preparação e composições farmacêuticas compreendendo os mesmos |
Country Status (6)
Country | Link |
---|---|
US (1) | US20080287376A1 (pt) |
EP (1) | EP1794171A2 (pt) |
JP (1) | JP2008508322A (pt) |
BR (1) | BRPI0513903A (pt) |
RU (1) | RU2397987C2 (pt) |
WO (1) | WO2006080954A1 (pt) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3738591A3 (en) | 2003-03-10 | 2021-03-24 | Merck Sharp & Dohme Corp. | Novel antibacterial agents |
DE602005019786D1 (de) | 2004-12-21 | 2010-04-15 | Pfizer Prod Inc | Makrolide |
EP1954294A2 (en) | 2005-11-23 | 2008-08-13 | Ranbaxy Laboratories Limited | Use of macrolide derivatives for treating acne |
WO2007060618A2 (en) * | 2005-11-23 | 2007-05-31 | Ranbaxy Laboratories Limited | Macrolides derivatives as antibacterial agents |
US8273720B2 (en) * | 2007-09-17 | 2012-09-25 | Enanta Pharmaceuticals, Inc. | 6,11-bicyclolides: bridged biaryl macrolide derivatives |
MX2010002932A (es) * | 2007-09-17 | 2010-05-27 | Enanta Pharm Inc | Macrolidos de biarilo con puente en 6, 11. |
AU2008316830B2 (en) | 2007-10-25 | 2016-03-17 | Cempra Pharmaceuticals, Inc. | Process for the preparation of macrolide antibacterial agents |
EP2362727B1 (en) | 2008-10-24 | 2018-04-11 | Cempra Pharmaceuticals, Inc. | Methods for treating resistant diseases using triazole containing macrolides |
WO2010096051A1 (en) * | 2009-02-18 | 2010-08-26 | Enanta Pharmaceuticals, Inc. | 6,11-bicyclolides: bridged biaryl amide macrolide derivatives |
US9937194B1 (en) | 2009-06-12 | 2018-04-10 | Cempra Pharmaceuticals, Inc. | Compounds and methods for treating inflammatory diseases |
CN102724874B (zh) | 2009-09-10 | 2018-06-01 | 森普拉制药公司 | 治疗疟疾、结核病和mac疾病的方法 |
MY162411A (en) | 2010-03-22 | 2017-06-15 | Cempra Pharmaceuticals Inc | Crystalline forms of a macrolide, and uses therefor |
SI2571506T1 (sl) | 2010-05-20 | 2017-12-29 | Cempra Pharmaceuticals, Inc. | Postopki za pripravo makrolidov in ketolidov ter njihovih intermediatov |
WO2012034058A1 (en) * | 2010-09-10 | 2012-03-15 | Cempra Pharmaceuticals, Inc. | Hydrogen bond forming fluoro ketolides for treating diseases |
JP6208742B2 (ja) | 2012-03-27 | 2017-10-04 | センプラ ファーマシューティカルズ,インコーポレイテッド | マクロライド抗生物質を投与するための非経口製剤 |
WO2014152326A1 (en) | 2013-03-14 | 2014-09-25 | Cempra Pharmaceuticals, Inc. | Methods for treating respiratory diseases and formulations therefor |
US9751908B2 (en) | 2013-03-15 | 2017-09-05 | Cempra Pharmaceuticals, Inc. | Convergent processes for preparing macrolide antibacterial agents |
JP6437523B2 (ja) | 2013-04-04 | 2018-12-12 | プレジデント アンド フェローズ オブ ハーバード カレッジ | マクロライドならびにそれらの調製および使用の方法 |
CN105524132B (zh) * | 2014-09-30 | 2019-07-02 | 中国医学科学院药物研究所 | 含有喹啉取代基的红霉素a酮内酯类抗生素衍生物、其制备方法及应用 |
US10633407B2 (en) * | 2014-10-08 | 2020-04-28 | President And Fellows Of Harvard College | 14-membered ketolides and methods of their preparation and use |
US10640528B2 (en) | 2015-03-25 | 2020-05-05 | President And Fellows Of Havard College | Macrolides with modified desosamine sugars and uses thereof |
CN106518939B (zh) * | 2015-09-14 | 2019-12-31 | 江苏奥赛康药业有限公司 | 一种制备Solithromycin化合物的方法 |
CN107129514B (zh) * | 2016-03-02 | 2019-12-13 | 中国医学科学院药物研究所 | 红霉素a酮内酯类抗生素衍生物、其制备方法及应用 |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3681325A (en) * | 1970-09-30 | 1972-08-01 | Abbott Lab | De(n-methyl)-n-substituted derivatives of erythromycin |
FR2719587B1 (fr) * | 1994-05-03 | 1996-07-12 | Roussel Uclaf | Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments. |
FR2727969B1 (fr) * | 1994-12-09 | 1997-01-17 | Roussel Uclaf | Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments |
FR2742757B1 (fr) * | 1995-12-22 | 1998-01-30 | Roussel Uclaf | Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments |
UA51730C2 (uk) * | 1996-09-04 | 2002-12-16 | Ебботт Лабораторіз | 6-o-заміщені кетоліди з антибактеріальною активністю, спосіб їх одержання (варіанти), фармацевтична композиція та спосіб регулювання бактеріальної інфекції у ссавців |
BR9812577A (pt) * | 1997-09-30 | 2000-10-17 | Abbott Lab | Composto, processo para preparar o mesmo, composição farmacêutica, e, processo para tratar infecções bacterianas |
JP4573925B2 (ja) * | 1998-07-09 | 2010-11-04 | アベンティス・ファーマ・ソシエテ・アノニム | 新規のエリスロマイシン誘導体、その製造方法及びその薬剤としての使用 |
FR2785612A1 (fr) * | 1998-11-10 | 2000-05-12 | Hoechst Marion Roussel Inc | Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments |
JP4043191B2 (ja) * | 1998-11-03 | 2008-02-06 | ファイザー・プロダクツ・インク | 新規なマクロライド抗生物質 |
FR2786188B1 (fr) * | 1998-11-24 | 2002-10-31 | Hoechst Marion Roussel Inc | Nouveaux derives de l'erythromycine, leur procede de preparation et leur applicaion comme medicaments |
ID30233A (id) * | 1999-01-27 | 2001-11-15 | Pfizer Prod Inc | Antibiotika ketolida |
FR2789392B1 (fr) * | 1999-02-04 | 2001-10-05 | Hoechst Marion Roussel Inc | Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments |
CN1373767A (zh) * | 1999-04-16 | 2002-10-09 | 奥索-麦克尼尔药品公司 | 酮式大环内酯抗菌剂 |
US6590083B1 (en) * | 1999-04-16 | 2003-07-08 | Ortho-Mcneil Pharmaceutical, Inc. | Ketolide antibacterials |
JP2001181294A (ja) * | 1999-12-27 | 2001-07-03 | Hokuriku Seiyaku Co Ltd | エリスロマイシン誘導体 |
US20020115621A1 (en) * | 2000-08-07 | 2002-08-22 | Wei-Gu Su | Macrolide antibiotics |
JP2002173498A (ja) * | 2000-09-27 | 2002-06-21 | Hokuriku Seiyaku Co Ltd | エリスロマイシン誘導体 |
US6472372B1 (en) * | 2000-12-06 | 2002-10-29 | Ortho-Mcneil Pharmaceuticals, Inc. | 6-O-Carbamoyl ketolide antibacterials |
JP2003073394A (ja) * | 2001-09-04 | 2003-03-12 | Hokuriku Seiyaku Co Ltd | エリスロマイシン誘導体 |
WO2004096822A2 (en) * | 2003-04-25 | 2004-11-11 | Chiron Corporation | Pyridyl substituted ketolide antibiotics |
US7271155B2 (en) * | 2005-01-07 | 2007-09-18 | Enanta Pharmaceuticals, Inc. | 9A, 11-2C-bicyclic 9a-azalide derivatives |
-
2005
- 2005-07-28 WO PCT/US2005/027875 patent/WO2006080954A1/en active Application Filing
- 2005-07-28 RU RU2007107340/04A patent/RU2397987C2/ru not_active IP Right Cessation
- 2005-07-28 JP JP2007523900A patent/JP2008508322A/ja active Pending
- 2005-07-28 US US11/572,619 patent/US20080287376A1/en not_active Abandoned
- 2005-07-28 BR BRPI0513903-1A patent/BRPI0513903A/pt not_active IP Right Cessation
- 2005-07-28 EP EP05856911A patent/EP1794171A2/en not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
US20080287376A1 (en) | 2008-11-20 |
RU2007107340A (ru) | 2008-09-10 |
EP1794171A2 (en) | 2007-06-13 |
RU2397987C2 (ru) | 2010-08-27 |
JP2008508322A (ja) | 2008-03-21 |
WO2006080954A1 (en) | 2006-08-03 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 8A ANUIDADE. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2260 DE 29/04/2014. |