WO2009073545A3 - Tetrahydro-isoquinoline ppat inhibitors as antibacterial agents - Google Patents

Tetrahydro-isoquinoline ppat inhibitors as antibacterial agents Download PDF

Info

Publication number
WO2009073545A3
WO2009073545A3 PCT/US2008/084948 US2008084948W WO2009073545A3 WO 2009073545 A3 WO2009073545 A3 WO 2009073545A3 US 2008084948 W US2008084948 W US 2008084948W WO 2009073545 A3 WO2009073545 A3 WO 2009073545A3
Authority
WO
WIPO (PCT)
Prior art keywords
tetrahydro
ppat
isoquinoline
antibacterial agents
inhibitors
Prior art date
Application number
PCT/US2008/084948
Other languages
French (fr)
Other versions
WO2009073545A2 (en
Inventor
Roger Frechette
Original Assignee
Maxthera, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Maxthera, Inc. filed Critical Maxthera, Inc.
Priority to EP08857446A priority Critical patent/EP2225207A2/en
Priority to AU2008334075A priority patent/AU2008334075A1/en
Priority to CA2707445A priority patent/CA2707445A1/en
Priority to CN2008801260189A priority patent/CN102007101A/en
Priority to JP2010536184A priority patent/JP2011518109A/en
Publication of WO2009073545A2 publication Critical patent/WO2009073545A2/en
Publication of WO2009073545A3 publication Critical patent/WO2009073545A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/056—Ortho-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Disclosed are Tetrahydro-isoquinoline derivatives such as structural formula (I), pharmaceutical compositions comprising them and methods of treating bacterial infections. The disclosed compounds are inhibitors of PPAT (phosphopantetheine adenyl transferase), and are useful in the treatment and prevention of diseases caused by bacteria, particularly bacteria dependent on PPAT, for example, species such Escherichia coli, Helicobacter pylori, Staphyloccocus aureus, and the like. Description of the variables in structural formula (I) are provided herein.
PCT/US2008/084948 2007-11-30 2008-11-26 Tetrahydro-isoquinoline ppat inhibitors as antibacterial agents WO2009073545A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
EP08857446A EP2225207A2 (en) 2007-11-30 2008-11-26 Tetrahydro-isoquinoline ppat inhibitors as antibacterial agents
AU2008334075A AU2008334075A1 (en) 2007-11-30 2008-11-26 Tetrahydro-isoquinoline PPAT inhibitors as antibacterial agents
CA2707445A CA2707445A1 (en) 2007-11-30 2008-11-26 Tetrahydro-isoquinoline ppat inhibitors as antibacterial agents
CN2008801260189A CN102007101A (en) 2007-11-30 2008-11-26 Tetrahydro-isoquinoline ppat inhibitors as antibacterial agents
JP2010536184A JP2011518109A (en) 2007-11-30 2008-11-26 Tetrahydro-isoquinoline PPAT inhibitors as antibacterial agents

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US99152507P 2007-11-30 2007-11-30
US60/991,525 2007-11-30

Publications (2)

Publication Number Publication Date
WO2009073545A2 WO2009073545A2 (en) 2009-06-11
WO2009073545A3 true WO2009073545A3 (en) 2009-09-11

Family

ID=40718459

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/084948 WO2009073545A2 (en) 2007-11-30 2008-11-26 Tetrahydro-isoquinoline ppat inhibitors as antibacterial agents

Country Status (6)

Country Link
EP (1) EP2225207A2 (en)
JP (1) JP2011518109A (en)
CN (1) CN102007101A (en)
AU (1) AU2008334075A1 (en)
CA (1) CA2707445A1 (en)
WO (1) WO2009073545A2 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8124616B2 (en) 2007-11-30 2012-02-28 Biota Scientific Management Pty Ltd Bicyclic PPAT inhibitors as antibacterial agents
FR2986002B1 (en) 2012-01-24 2014-02-21 Servier Lab NOVEL INDOLIZINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
CN102603755B (en) * 2012-02-08 2015-09-09 中国人民解放军第二军医大学 One class has the compound of collaborative fluconazole overriding resistance fungi effect
FR3008976A1 (en) 2013-07-23 2015-01-30 Servier Lab "NOVEL INDOLIZINE DERIVATIVES, PROCESS FOR PREPARING THEM AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM"
FR3008977A1 (en) 2013-07-23 2015-01-30 Servier Lab NOVEL ISOINDOLINE OR ISOQUINOLINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME
FR3008975A1 (en) 2013-07-23 2015-01-30 Servier Lab NOVEL PYRROLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
ES2838573T3 (en) 2014-08-21 2021-07-02 Bristol Myers Squibb Co Benzamide derivatives linked as potent ROCK inhibitors
WO2017025509A1 (en) * 2015-08-12 2017-02-16 Syngenta Participations Ag Microbiocidal heterobicyclic derivatives
CN113461699B (en) * 2021-04-14 2022-06-21 宁波大学 Tetracycipylliole alkaloid compound and preparation method and application thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000058307A2 (en) * 1999-03-11 2000-10-05 Neurogen Corporation Aryl fused 2,4-disubstituted pyridines: nk3 receptor ligands
US20050070570A1 (en) * 2003-06-18 2005-03-31 4Sc Ag Novel potassium channels modulators
US20060069102A1 (en) * 2004-09-20 2006-03-30 4 Sc Ag Novel heterocyclic NF-kB inhibitors
WO2007104557A2 (en) * 2006-03-15 2007-09-20 4Sc Ag Novel heterocyclic nf-kb inhibitors

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000058307A2 (en) * 1999-03-11 2000-10-05 Neurogen Corporation Aryl fused 2,4-disubstituted pyridines: nk3 receptor ligands
US20050070570A1 (en) * 2003-06-18 2005-03-31 4Sc Ag Novel potassium channels modulators
US20060069102A1 (en) * 2004-09-20 2006-03-30 4 Sc Ag Novel heterocyclic NF-kB inhibitors
WO2007104557A2 (en) * 2006-03-15 2007-09-20 4Sc Ag Novel heterocyclic nf-kb inhibitors

Also Published As

Publication number Publication date
CN102007101A (en) 2011-04-06
AU2008334075A1 (en) 2009-06-11
EP2225207A2 (en) 2010-09-08
WO2009073545A2 (en) 2009-06-11
JP2011518109A (en) 2011-06-23
CA2707445A1 (en) 2009-06-11

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