WO2008020229A3 - Antibacterial pyrrolecarboxamides - Google Patents

Antibacterial pyrrolecarboxamides Download PDF

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Publication number
WO2008020229A3
WO2008020229A3 PCT/GB2007/003146 GB2007003146W WO2008020229A3 WO 2008020229 A3 WO2008020229 A3 WO 2008020229A3 GB 2007003146 W GB2007003146 W GB 2007003146W WO 2008020229 A3 WO2008020229 A3 WO 2008020229A3
Authority
WO
WIPO (PCT)
Prior art keywords
pyrrolecarboxamides
antibacterial
formula
medicaments
compounds
Prior art date
Application number
PCT/GB2007/003146
Other languages
French (fr)
Other versions
WO2008020229A2 (en
Inventor
Michael Barry Gravestock
Kenneth Gregory Hull
Paul Robert Fleming
Original Assignee
Astrazeneca Ab
Astrazeneca Uk Ltd
Michael Barry Gravestock
Kenneth Gregory Hull
Paul Robert Fleming
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab, Astrazeneca Uk Ltd, Michael Barry Gravestock, Kenneth Gregory Hull, Paul Robert Fleming filed Critical Astrazeneca Ab
Publication of WO2008020229A2 publication Critical patent/WO2008020229A2/en
Publication of WO2008020229A3 publication Critical patent/WO2008020229A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Abstract

Compounds of formula (I) and their pharmaceutically acceptable salts are described. Formula (I) Processes for their preparation, pharmaceutical compositions containing them, their use as medicaments and their use in the treatment of bacterial infections are also described.
PCT/GB2007/003146 2006-08-17 2007-08-16 Antibacterial pyrrolecarboxamides WO2008020229A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US82274806P 2006-08-17 2006-08-17
US60/822,748 2006-08-17

Publications (2)

Publication Number Publication Date
WO2008020229A2 WO2008020229A2 (en) 2008-02-21
WO2008020229A3 true WO2008020229A3 (en) 2008-04-03

Family

ID=38969995

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2007/003146 WO2008020229A2 (en) 2006-08-17 2007-08-16 Antibacterial pyrrolecarboxamides

Country Status (1)

Country Link
WO (1) WO2008020229A2 (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2280959B1 (en) 2008-06-05 2012-04-04 Glaxo Group Limited 4-amino-indazoles
ES2526966T3 (en) 2008-06-05 2015-01-19 Glaxo Group Limited Novel compounds
ES2445199T3 (en) 2008-06-05 2014-02-28 Glaxo Group Limited Benzpyrazole derivatives as PI3-kinase inhibitors
EP2326640A1 (en) * 2008-07-30 2011-06-01 Ranbaxy Laboratories Limited Pyrrole carboxylic acid derivatives as antibacterial agents
ES2542551T3 (en) 2009-03-09 2015-08-06 Glaxo Group Limited 4-Oxadiazol-2-yl-indazoles as inhibitors of PI3 kinases
EA021056B1 (en) 2009-04-30 2015-03-31 Глаксо Груп Лимитед Oxazole substituted indazoles as pi3-kinase inhibitors, pharmaceutical composition comprising same and use thereof in treatment of disorders mediated by inappropriate pi3-kinase activity
UY32856A (en) 2009-08-26 2011-03-31 Astrazeneca Ab UREA HETEROCYCLIC DERIVATIVES AND METHODS OF USE OF THE SAME
GB201018124D0 (en) 2010-10-27 2010-12-08 Glaxo Group Ltd Polymorphs and salts
BR112015012366A8 (en) * 2012-11-29 2019-10-01 Chemocentryx Inc cxcr7 antagonists, their use, pharmaceutical composition, as well as methods for detecting high levels of cxcr7 in a sample and for imaging a tumor, organ, or tissue
US10399968B2 (en) 2015-09-30 2019-09-03 Daiichi Sankyo Company, Limited Hydroxyalkyl thiadiazole derivatives
CA3056571C (en) 2017-03-14 2021-11-23 Daiichi Sankyo Company, Limited N-phosphonoxymethyl prodrugs of hydroxyalkyl thiadiazole derivatives
KR20190133667A (en) 2017-03-24 2019-12-03 다이쇼 세이야꾸 가부시끼가이샤 2 (1H) -quinolinone derivative
US20210323957A1 (en) 2018-09-03 2021-10-21 Univerza V Ljubljani New class of dna gyrase and/or topoisomerase iv inhibitors with activity against gram-positive and gram-negative bacteria
KR20210102338A (en) 2018-12-12 2021-08-19 케모센트릭스, 인크. CXCR7 inhibitors for the treatment of cancer
EP4263503A1 (en) 2020-12-17 2023-10-25 Univerza V Ljubljani New n-phenylpyrrolamide inhibitors of dna gyrase and topoisomerase iv with antibacterial activity

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050026991A1 (en) * 2003-07-31 2005-02-03 Cholody Wieslaw M. Derivatives of 3-hydroxy-pyrrole-2,4-dicarboxylic acid and uses thereof
WO2005026149A1 (en) * 2003-09-13 2005-03-24 Astrazeneca Ab Pyrrol derivatives with antibacterial activity
WO2006087543A1 (en) * 2005-02-18 2006-08-24 Astrazeneca Ab Antibacterial piperidine derivatives

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050026991A1 (en) * 2003-07-31 2005-02-03 Cholody Wieslaw M. Derivatives of 3-hydroxy-pyrrole-2,4-dicarboxylic acid and uses thereof
WO2005026149A1 (en) * 2003-09-13 2005-03-24 Astrazeneca Ab Pyrrol derivatives with antibacterial activity
WO2006087543A1 (en) * 2005-02-18 2006-08-24 Astrazeneca Ab Antibacterial piperidine derivatives

Also Published As

Publication number Publication date
WO2008020229A2 (en) 2008-02-21

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