WO2009102377A3 - Antibiotic tetrahydro-beta-carboline derivatives - Google Patents

Antibiotic tetrahydro-beta-carboline derivatives Download PDF

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Publication number
WO2009102377A3
WO2009102377A3 PCT/US2008/084832 US2008084832W WO2009102377A3 WO 2009102377 A3 WO2009102377 A3 WO 2009102377A3 US 2008084832 W US2008084832 W US 2008084832W WO 2009102377 A3 WO2009102377 A3 WO 2009102377A3
Authority
WO
WIPO (PCT)
Prior art keywords
beta
carboline derivatives
ppat
formula
tetrahydro
Prior art date
Application number
PCT/US2008/084832
Other languages
French (fr)
Other versions
WO2009102377A2 (en
Inventor
Roger Frechette
Original Assignee
Maxthera Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Maxthera Inc. filed Critical Maxthera Inc.
Priority to JP2010536160A priority Critical patent/JP2011518108A/en
Priority to AU2008350293A priority patent/AU2008350293A1/en
Priority to CN2008801260206A priority patent/CN102007130A/en
Priority to EP08872407A priority patent/EP2240493A2/en
Priority to CA2707442A priority patent/CA2707442A1/en
Publication of WO2009102377A2 publication Critical patent/WO2009102377A2/en
Publication of WO2009102377A3 publication Critical patent/WO2009102377A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Disclosed are compounds of Formula (I), pharmaceutical compositions comprising Formula (I) and methods of treating bacterial infections. The disclosed compounds are inhibitors of PPAT (phosphopantetheine adenyl transferase), and are useful in the treatment and prevention of diseases caused by bacteria, particularly bacteria dependent on PPAT, for example, species such Escherichia coli, Helicobacter pylori, Staphyloccocus aureus, and the like.
PCT/US2008/084832 2007-11-30 2008-11-26 Antibiotic tetrahydro-beta-carboline derivatives WO2009102377A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
JP2010536160A JP2011518108A (en) 2007-11-30 2008-11-26 Antibacterial tetrahydro-β-carboline derivative
AU2008350293A AU2008350293A1 (en) 2007-11-30 2008-11-26 Antibiotic tetrahydro-beta-carboline derivatives
CN2008801260206A CN102007130A (en) 2007-11-30 2008-11-26 Antibiotic tetrahydro-beta-carboline derivatives
EP08872407A EP2240493A2 (en) 2007-11-30 2008-11-26 Antibiotic tetrahydro-beta-carboline derivatives
CA2707442A CA2707442A1 (en) 2007-11-30 2008-11-26 Antibiotic tetrahydro-beta-carboline derivatives

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US99152007P 2007-11-30 2007-11-30
US60/991,520 2007-11-30

Publications (2)

Publication Number Publication Date
WO2009102377A2 WO2009102377A2 (en) 2009-08-20
WO2009102377A3 true WO2009102377A3 (en) 2009-11-05

Family

ID=40957421

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/084832 WO2009102377A2 (en) 2007-11-30 2008-11-26 Antibiotic tetrahydro-beta-carboline derivatives

Country Status (6)

Country Link
EP (1) EP2240493A2 (en)
JP (1) JP2011518108A (en)
CN (1) CN102007130A (en)
AU (1) AU2008350293A1 (en)
CA (1) CA2707442A1 (en)
WO (1) WO2009102377A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009073534A2 (en) 2007-11-30 2009-06-11 Maxthera Inc. Bicyclic ppat inhibitors as antibacterial agents
EP2687531B1 (en) 2011-03-18 2016-07-13 ONO Pharmaceutical Co., Ltd. Tetrahydrocarboline derivative
CN111012779A (en) * 2011-10-25 2020-04-17 新疆华世丹药物研究有限责任公司 Application of harmine derivative in preparation of antibacterial drugs
CN114478525B (en) * 2022-03-28 2023-05-30 山东京博农化科技股份有限公司 Tetrahydro-beta-carboline pyrazole amide derivative and preparation method and application thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002062339A1 (en) * 2000-12-08 2002-08-15 Smithkline Beecham Corporation Antibacterial compounds
US20060273819A1 (en) * 2003-04-29 2006-12-07 Timothy Opperman Antibiotic tetrahydro-beta-carboline derivatives

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002062339A1 (en) * 2000-12-08 2002-08-15 Smithkline Beecham Corporation Antibacterial compounds
US20060273819A1 (en) * 2003-04-29 2006-12-07 Timothy Opperman Antibiotic tetrahydro-beta-carboline derivatives

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
SEEFELD, M. A. ET AL.: "Inhibitors of bacterial enoyl acyl carrier protein reductase (FabI): 2,9- disubstituted 1,2,3,4-tetrahydropyrido[3,4-b]indoles as potential antibacterial agents", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 11, no. 17, 2001, pages 2241 - 2244 *
WANG, HAISHAN ET AL.: "Synthesis and Evaluation of Tryprostatin B and Demethoxyfumitremorgin C Analogues", JOURNAL OF MEDICINAL CHEMISTRY, vol. 43, no. 8, 2000, pages 1577 - 1585 *

Also Published As

Publication number Publication date
AU2008350293A1 (en) 2009-08-20
CA2707442A1 (en) 2009-08-20
EP2240493A2 (en) 2010-10-20
JP2011518108A (en) 2011-06-23
WO2009102377A2 (en) 2009-08-20
CN102007130A (en) 2011-04-06

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