WO2008111020A3 - Macrolide derivatives as antibacterial agents - Google Patents

Macrolide derivatives as antibacterial agents Download PDF

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Publication number
WO2008111020A3
WO2008111020A3 PCT/IB2008/050979 IB2008050979W WO2008111020A3 WO 2008111020 A3 WO2008111020 A3 WO 2008111020A3 IB 2008050979 W IB2008050979 W IB 2008050979W WO 2008111020 A3 WO2008111020 A3 WO 2008111020A3
Authority
WO
WIPO (PCT)
Prior art keywords
compounds disclosed
antibacterial agents
spp
macrolide derivatives
treating
Prior art date
Application number
PCT/IB2008/050979
Other languages
French (fr)
Other versions
WO2008111020A2 (en
Inventor
Anjan Chakrabarti
Yogesh Baban Surase
Jitendra Sambhaji Jadhav
Biswajit Das
Dilip Upadhyay
Original Assignee
Ranbaxy Lab Ltd
Anjan Chakrabarti
Yogesh Baban Surase
Jitendra Sambhaji Jadhav
Biswajit Das
Dilip Upadhyay
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ranbaxy Lab Ltd, Anjan Chakrabarti, Yogesh Baban Surase, Jitendra Sambhaji Jadhav, Biswajit Das, Dilip Upadhyay filed Critical Ranbaxy Lab Ltd
Publication of WO2008111020A2 publication Critical patent/WO2008111020A2/en
Publication of WO2008111020A3 publication Critical patent/WO2008111020A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

The present invention provides macrolide derivatives, which can be used as antibacterial agents. Compounds disclosed herein can be used for treating or preventing conditions caused by or contributed to by gram positive, gram negative or anaerobic bacteria, more particularly against, for example, Staphylococci, Streptococci, Enterococci, Haemophilus, Moraxalla spp., Chlamydia spp., Mycoplasm, Legionella spp., Mycobacterium, Helicobacter, Clostridium, Bacteroides, Corynebacterium, Bacillus, Enterobactericeae or any combination thereof. Also provided, are the processes for preparing the compounds disclosed herein, pharmaceutical compositions containing compounds disclosed herein, and methods of treating bacterial infections.
PCT/IB2008/050979 2007-03-14 2008-03-14 Macrolide derivatives as antibacterial agents WO2008111020A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN551DE2007 2007-03-14
IN551/DEL/2007 2007-03-14

Publications (2)

Publication Number Publication Date
WO2008111020A2 WO2008111020A2 (en) 2008-09-18
WO2008111020A3 true WO2008111020A3 (en) 2008-11-13

Family

ID=39730790

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2008/050979 WO2008111020A2 (en) 2007-03-14 2008-03-14 Macrolide derivatives as antibacterial agents

Country Status (1)

Country Link
WO (1) WO2008111020A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104610402A (en) * 2014-12-30 2015-05-13 晋江市托美汀生物科技有限公司 Preparation method of macrolide impurity

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104558069B (en) * 2014-12-31 2017-01-04 广东东阳光药业有限公司 The synthetic method of macrolide impurity
CN108727445B (en) * 2018-06-29 2021-06-11 宜昌东阳光生化制药有限公司 Synthesis method of azithromycin impurity F

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999016779A1 (en) * 1997-09-30 1999-04-08 Abbott Laboratories 3'-n-modified 6-o-substituted erythromycin ketolide derivatives having antibacterial activity
WO2000012521A1 (en) * 1998-08-26 2000-03-09 Abbott Laboratories 3', 3'-n-bis-desmethyl-3'-n-cycloalkyl erythromycin derivatives as lhrh antagonists
WO2007129646A1 (en) * 2006-05-01 2007-11-15 Taisho Pharmaceutical Co., Ltd. Macrolide derivative

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999016779A1 (en) * 1997-09-30 1999-04-08 Abbott Laboratories 3'-n-modified 6-o-substituted erythromycin ketolide derivatives having antibacterial activity
WO2000012521A1 (en) * 1998-08-26 2000-03-09 Abbott Laboratories 3', 3'-n-bis-desmethyl-3'-n-cycloalkyl erythromycin derivatives as lhrh antagonists
WO2007129646A1 (en) * 2006-05-01 2007-11-15 Taisho Pharmaceutical Co., Ltd. Macrolide derivative

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
"The Merck Index", 2001, MERCK & CO., WHITEHOUSE STATION, NJ, XP002495203 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104610402A (en) * 2014-12-30 2015-05-13 晋江市托美汀生物科技有限公司 Preparation method of macrolide impurity
CN104610402B (en) * 2014-12-30 2017-01-25 晋江市托美汀生物科技有限公司 Preparation method of macrolide impurity

Also Published As

Publication number Publication date
WO2008111020A2 (en) 2008-09-18

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