ATE373009T1 - Verfahren zur vorbereitung von telithromycin - Google Patents
Verfahren zur vorbereitung von telithromycinInfo
- Publication number
- ATE373009T1 ATE373009T1 AT05775551T AT05775551T ATE373009T1 AT E373009 T1 ATE373009 T1 AT E373009T1 AT 05775551 T AT05775551 T AT 05775551T AT 05775551 T AT05775551 T AT 05775551T AT E373009 T1 ATE373009 T1 AT E373009T1
- Authority
- AT
- Austria
- Prior art keywords
- formula
- xiia
- benzoyl
- deoxy
- imidazol
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- LJVAJPDWBABPEJ-PNUFFHFMSA-N telithromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)[C@@H](C)C(=O)O[C@@H]([C@]2(OC(=O)N(CCCCN3C=C(N=C3)C=3C=NC=CC=3)[C@@H]2[C@@H](C)C(=O)[C@H](C)C[C@@]1(C)OC)C)CC)[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O LJVAJPDWBABPEJ-PNUFFHFMSA-N 0.000 title 1
- 229960003250 telithromycin Drugs 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical compound NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 abstract 3
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 abstract 3
- 125000002962 imidazol-1-yl group Chemical group [*]N1C([H])=NC([H])=C1[H] 0.000 abstract 3
- 229960002626 clarithromycin Drugs 0.000 abstract 2
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN491MU2004 | 2004-04-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE373009T1 true ATE373009T1 (de) | 2007-09-15 |
Family
ID=35159987
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05775551T ATE373009T1 (de) | 2004-04-28 | 2005-04-25 | Verfahren zur vorbereitung von telithromycin |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20070260066A1 (de) |
| EP (1) | EP1742957B1 (de) |
| AT (1) | ATE373009T1 (de) |
| AU (1) | AU2005238313A1 (de) |
| CA (1) | CA2559281A1 (de) |
| DE (1) | DE602005002475T2 (de) |
| ES (1) | ES2294733T3 (de) |
| PL (1) | PL1742957T3 (de) |
| SI (1) | SI1742957T1 (de) |
| WO (1) | WO2005105821A2 (de) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3738591A3 (de) | 2003-03-10 | 2021-03-24 | Merck Sharp & Dohme Corp. | Neuartige antibakterielle wirkstoffe |
| WO2007039914A2 (en) * | 2005-10-06 | 2007-04-12 | Alembic Limited | Novel polymorphs of telithromycin |
| WO2007049296A2 (en) * | 2005-10-28 | 2007-05-03 | Alembic Limited | Amorphous form of telithromycin |
| WO2007059307A2 (en) * | 2005-11-15 | 2007-05-24 | Teva Pharmaceutical Industries Ltd. | Crystalline and amorphous forms of telithromycin |
| WO2007069264A2 (en) * | 2005-12-15 | 2007-06-21 | Alembic Limited | Reference standards for determining the purity of telithromycin and processes therefor |
| GB0600238D0 (en) * | 2006-01-06 | 2006-02-15 | Sandoz Ag | Organic compounds |
| WO2008007388A1 (en) * | 2006-07-12 | 2008-01-17 | Alembic Limited | Novel process for the preparation of telithromycin |
| WO2008023383A1 (en) * | 2006-08-25 | 2008-02-28 | Alembic Limited | Novel process for the preparation of telithromycin |
| ES2306590B1 (es) * | 2006-12-15 | 2009-08-07 | Ercros Industrial,S .A. | Formas cristalinas i y ii de telitromicina. |
| ES2310121B1 (es) * | 2007-04-19 | 2009-09-11 | Ercros Industrial, S.A. | Nuevo proceso de sintesis de telitromicina. |
| EP2220104A1 (de) * | 2007-10-25 | 2010-08-25 | Sandoz AG | Verfahren zur herstellung von telithromycin |
| CN101917850B (zh) | 2007-10-25 | 2016-01-13 | 森普拉制药公司 | 大环内酯类抗菌剂的制备方法 |
| DK2358379T3 (en) | 2008-10-24 | 2016-03-07 | Cempra Pharmaceuticals Inc | BIOFORSVAR USING TRIAZOLHOLDIGE macrolides |
| US9937194B1 (en) | 2009-06-12 | 2018-04-10 | Cempra Pharmaceuticals, Inc. | Compounds and methods for treating inflammatory diseases |
| EP2475253B1 (de) | 2009-09-10 | 2016-10-26 | Cempra Pharmaceuticals, Inc. | Verfahren zur behandlung von malaria, tuberkulose und mac-erkrankungen |
| BR112012023950A2 (pt) | 2010-03-22 | 2016-07-05 | Cempra Pharmaceuticals Inc | formas cristalinas de um macrolídeo, e usos dos mesmos |
| PL2571506T3 (pl) | 2010-05-20 | 2017-10-31 | Cempra Pharmaceuticals Inc | Sposoby sporządzania makrolidów i ketolidów oraz ich produktów pośrednich |
| US9815863B2 (en) | 2010-09-10 | 2017-11-14 | Cempra Pharmaceuticals, Inc. | Hydrogen bond forming fluoro ketolides for treating diseases |
| MX2014011537A (es) | 2012-03-27 | 2015-02-10 | Cempra Pharmaceuticals Inc | Formulaciones parenterales para la administracion de antibioticos macrolidos. |
| WO2014152326A1 (en) | 2013-03-14 | 2014-09-25 | Cempra Pharmaceuticals, Inc. | Methods for treating respiratory diseases and formulations therefor |
| BR112015023670A2 (pt) | 2013-03-15 | 2017-07-18 | Cempra Pharmaceuticals Inc | processo para preparar um composto |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL99995A (en) * | 1990-11-21 | 1997-11-20 | Roussel Uclaf | Erythromycin derivatives, their preparation and pharmaceutical compositions containing them |
| FR2719587B1 (fr) * | 1994-05-03 | 1996-07-12 | Roussel Uclaf | Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments. |
| FR2732684B1 (fr) * | 1995-04-06 | 1997-04-30 | Roussel Uclaf | Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments |
-
2005
- 2005-04-25 AT AT05775551T patent/ATE373009T1/de not_active IP Right Cessation
- 2005-04-25 WO PCT/IN2005/000125 patent/WO2005105821A2/en not_active Ceased
- 2005-04-25 AU AU2005238313A patent/AU2005238313A1/en not_active Abandoned
- 2005-04-25 SI SI200530112T patent/SI1742957T1/sl unknown
- 2005-04-25 DE DE602005002475T patent/DE602005002475T2/de not_active Expired - Fee Related
- 2005-04-25 EP EP05775551A patent/EP1742957B1/de not_active Expired - Lifetime
- 2005-04-25 ES ES05775551T patent/ES2294733T3/es not_active Expired - Lifetime
- 2005-04-25 CA CA002559281A patent/CA2559281A1/en not_active Abandoned
- 2005-04-25 US US10/591,889 patent/US20070260066A1/en not_active Abandoned
- 2005-04-25 PL PL05775551T patent/PL1742957T3/pl unknown
Also Published As
| Publication number | Publication date |
|---|---|
| SI1742957T1 (sl) | 2008-04-30 |
| US20070260066A1 (en) | 2007-11-08 |
| EP1742957B1 (de) | 2007-09-12 |
| DE602005002475T2 (de) | 2008-05-29 |
| AU2005238313A1 (en) | 2005-11-10 |
| CA2559281A1 (en) | 2005-11-10 |
| WO2005105821A2 (en) | 2005-11-10 |
| PL1742957T3 (pl) | 2008-05-30 |
| EP1742957A2 (de) | 2007-01-17 |
| ES2294733T3 (es) | 2008-04-01 |
| WO2005105821A3 (en) | 2006-04-27 |
| DE602005002475D1 (de) | 2007-10-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |