ATE526312T1 - Verfahren zur herstellung von reinen 4- pyrrolidinophenylbenzyletherderivaten als maob- inhibitoren - Google Patents
Verfahren zur herstellung von reinen 4- pyrrolidinophenylbenzyletherderivaten als maob- inhibitorenInfo
- Publication number
- ATE526312T1 ATE526312T1 AT06707551T AT06707551T ATE526312T1 AT E526312 T1 ATE526312 T1 AT E526312T1 AT 06707551 T AT06707551 T AT 06707551T AT 06707551 T AT06707551 T AT 06707551T AT E526312 T1 ATE526312 T1 AT E526312T1
- Authority
- AT
- Austria
- Prior art keywords
- derivatives
- pyrrolidinophenylbenzylether
- producing pure
- maob inhibitors
- maob
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/402—1-aryl substituted, e.g. piretanide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
- C07D207/277—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP05102030 | 2005-03-15 | ||
PCT/EP2006/002314 WO2006097270A1 (en) | 2005-03-15 | 2006-03-14 | Method of preparation of pure 4-pyrrolidinophenylbenzyl ether derivatives as maob inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE526312T1 true ATE526312T1 (de) | 2011-10-15 |
Family
ID=36465154
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT06707551T ATE526312T1 (de) | 2005-03-15 | 2006-03-14 | Verfahren zur herstellung von reinen 4- pyrrolidinophenylbenzyletherderivaten als maob- inhibitoren |
Country Status (14)
Country | Link |
---|---|
US (2) | US7501528B2 (de) |
EP (1) | EP1861363B1 (de) |
JP (2) | JP5366192B2 (de) |
KR (1) | KR100915737B1 (de) |
CN (1) | CN101142182B (de) |
AT (1) | ATE526312T1 (de) |
AU (1) | AU2006224774B2 (de) |
BR (1) | BRPI0609061A2 (de) |
CA (1) | CA2600761C (de) |
ES (1) | ES2373738T3 (de) |
IL (1) | IL185545A (de) |
MX (1) | MX2007011155A (de) |
TW (1) | TW200714584A (de) |
WO (1) | WO2006097270A1 (de) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7501528B2 (en) * | 2005-03-15 | 2009-03-10 | Hoffmann-La Roche Inc. | Method for preparing enantiomerically pure 4-pyrrolidino phenylbenzyl ether derivatives |
ITMI20061297A1 (it) * | 2006-07-04 | 2008-01-05 | Laboratorio Chimico Int Spa | Procedimento per la preparazione della'acido (r)-(-)-3-(carbamoilmetil)-5-metilesanoico e del pregabalin e intermedi di sintesi |
CN105111105B (zh) * | 2012-03-07 | 2017-08-15 | 浙江九洲药业股份有限公司 | 一种n‑甲氧羰基‑l‑叔亮氨酸的制备方法 |
WO2014158916A1 (en) | 2013-03-14 | 2014-10-02 | Dart Neuroscience, Llc | Substituted naphthyridine and quinoline compounds as mao inhibitors |
RU2016118748A (ru) * | 2013-10-29 | 2017-12-05 | Ф. Хоффманн-Ля Рош Аг | Кристаллические формы производного пирролидона, полезные при лечении болезни альцгеймера, и их получение |
WO2016156124A1 (en) | 2015-03-27 | 2016-10-06 | F. Hoffmann-La Roche Ag | Pharmaceutical formulation comprising sembragiline |
MA50371A (fr) * | 2017-10-10 | 2021-03-31 | Biogen Inc | Procédé de préparation de dérivés spiro |
EP3762364B1 (de) | 2018-03-08 | 2023-08-23 | Sunshine Lake Pharma Co., Ltd. | Pyrrolidinamidderivate und verwendungen davon |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6012339B2 (ja) * | 1976-08-04 | 1985-04-01 | 日本化薬株式会社 | 光学活性マンデル酸・フエニルグリシノ−ル塩及びその製造法 |
US4348393A (en) * | 1978-06-09 | 1982-09-07 | Delalande S.A. | N-Aryl oxazolidinones, oxazolidinethiones, pyrrolidinones, pyrrolidines and thiazolidinones |
JPH0395138A (ja) * | 1989-09-07 | 1991-04-19 | Nissan Chem Ind Ltd | 3―メチルヘプタン酸の光学分割法 |
US5679715A (en) | 1995-06-07 | 1997-10-21 | Harris; Richard Y. | Method for treating multiple sclerosis |
JP3258027B2 (ja) | 1996-03-15 | 2002-02-18 | サマーセット・ファーマシューティカルズ・インコーポレイテッド | セレジリン投与による末梢ニューロパシーの予防および治療方法 |
AU1359801A (en) | 1999-11-05 | 2001-06-06 | Vela Pharmaceuticals Inc. | Methods and compositions for treating reward deficiency syndrome |
TW504694B (en) * | 2000-01-12 | 2002-10-01 | Hitachi Ltd | Non-volatile semiconductor memory device and semiconductor disk device |
MY134480A (en) * | 2002-09-20 | 2007-12-31 | Hoffmann La Roche | 4-pyrrolidino-phenyl-benzyl ether derivatives |
US7148362B2 (en) * | 2003-09-18 | 2006-12-12 | Hoffmann-La Roche Inc. | Process for the preparation of enantiopure pyrrolidin-2-one derivatives |
AU2005268894B2 (en) * | 2004-08-02 | 2010-12-16 | F. Hoffmann-La Roche Ag | Benzyloxy derivatives as MAOB inhibitors |
US7501528B2 (en) * | 2005-03-15 | 2009-03-10 | Hoffmann-La Roche Inc. | Method for preparing enantiomerically pure 4-pyrrolidino phenylbenzyl ether derivatives |
-
2006
- 2006-03-08 US US11/370,668 patent/US7501528B2/en not_active Expired - Fee Related
- 2006-03-13 TW TW095108434A patent/TW200714584A/zh unknown
- 2006-03-14 AU AU2006224774A patent/AU2006224774B2/en not_active Ceased
- 2006-03-14 EP EP06707551A patent/EP1861363B1/de not_active Not-in-force
- 2006-03-14 JP JP2008501217A patent/JP5366192B2/ja not_active Expired - Fee Related
- 2006-03-14 WO PCT/EP2006/002314 patent/WO2006097270A1/en not_active Application Discontinuation
- 2006-03-14 ES ES06707551T patent/ES2373738T3/es active Active
- 2006-03-14 MX MX2007011155A patent/MX2007011155A/es active IP Right Grant
- 2006-03-14 CA CA2600761A patent/CA2600761C/en not_active Expired - Fee Related
- 2006-03-14 CN CN2006800082838A patent/CN101142182B/zh not_active Expired - Fee Related
- 2006-03-14 BR BRPI0609061-3A patent/BRPI0609061A2/pt not_active Application Discontinuation
- 2006-03-14 KR KR1020077020985A patent/KR100915737B1/ko active IP Right Grant
- 2006-03-14 AT AT06707551T patent/ATE526312T1/de active
-
2007
- 2007-08-27 IL IL185545A patent/IL185545A/en not_active IP Right Cessation
-
2009
- 2009-01-26 US US12/359,356 patent/US8227505B2/en not_active Expired - Fee Related
-
2011
- 2011-11-18 JP JP2011252413A patent/JP2012067122A/ja not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
JP5366192B2 (ja) | 2013-12-11 |
AU2006224774B2 (en) | 2011-08-18 |
MX2007011155A (es) | 2007-10-23 |
KR100915737B1 (ko) | 2009-09-04 |
EP1861363B1 (de) | 2011-09-28 |
AU2006224774A1 (en) | 2006-09-21 |
CA2600761A1 (en) | 2006-09-21 |
JP2008533076A (ja) | 2008-08-21 |
IL185545A0 (en) | 2008-01-06 |
CN101142182B (zh) | 2012-06-06 |
CN101142182A (zh) | 2008-03-12 |
KR20070103497A (ko) | 2007-10-23 |
EP1861363A1 (de) | 2007-12-05 |
CA2600761C (en) | 2014-05-13 |
US20090171100A1 (en) | 2009-07-02 |
US7501528B2 (en) | 2009-03-10 |
US20060211868A1 (en) | 2006-09-21 |
BRPI0609061A2 (pt) | 2010-02-17 |
ES2373738T3 (es) | 2012-02-08 |
IL185545A (en) | 2011-11-30 |
TW200714584A (en) | 2007-04-16 |
US8227505B2 (en) | 2012-07-24 |
JP2012067122A (ja) | 2012-04-05 |
WO2006097270A1 (en) | 2006-09-21 |
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