ATE529413T1 - Verfahren zur synthese von aryloxydiaminopyrimidinen - Google Patents
Verfahren zur synthese von aryloxydiaminopyrimidinenInfo
- Publication number
- ATE529413T1 ATE529413T1 AT06778311T AT06778311T ATE529413T1 AT E529413 T1 ATE529413 T1 AT E529413T1 AT 06778311 T AT06778311 T AT 06778311T AT 06778311 T AT06778311 T AT 06778311T AT E529413 T1 ATE529413 T1 AT E529413T1
- Authority
- AT
- Austria
- Prior art keywords
- aryloxydiaminopyrimidines
- synthesis
- compound
- formula
- treating
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 230000015572 biosynthetic process Effects 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 230000026045 iodination Effects 0.000 abstract 1
- 238000006192 iodination reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyrane Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US71328005P | 2005-09-01 | 2005-09-01 | |
| PCT/EP2006/065523 WO2007025898A1 (en) | 2005-09-01 | 2006-08-21 | Process for synthesis of aryloxy diaminopyrimidines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE529413T1 true ATE529413T1 (de) | 2011-11-15 |
Family
ID=37086108
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT06778311T ATE529413T1 (de) | 2005-09-01 | 2006-08-21 | Verfahren zur synthese von aryloxydiaminopyrimidinen |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US7741484B2 (de) |
| EP (1) | EP1926716B1 (de) |
| JP (1) | JP4820873B2 (de) |
| CN (1) | CN101253158B (de) |
| AT (1) | ATE529413T1 (de) |
| CA (1) | CA2620033C (de) |
| ES (1) | ES2374750T3 (de) |
| TW (1) | TW200738650A (de) |
| WO (1) | WO2007025898A1 (de) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2619898C (en) * | 2005-09-01 | 2014-03-18 | F. Hoffmann-La Roche Ag | Diaminopyrimidines as p2x3 and p2x2/3 modulators |
| EP2079713B1 (de) * | 2006-10-04 | 2014-04-16 | F. Hoffmann-La Roche AG | Verfahren zur synthese von phenoxy-diaminopyrimidin-derivaten |
| CN102351655A (zh) * | 2011-08-18 | 2012-02-15 | 杭州澳赛诺化工有限公司 | 一种4-异丙基间苯二酚的合成方法 |
| JP6546592B2 (ja) | 2013-08-23 | 2019-07-17 | アファレント ファーマシューティカルズ インコーポレイテッド | 急性、亜急性または慢性の咳を治療するためのジアミノピリミジンｐ２ｘ３およびｐ２ｘ２／３受容体モジュレーター |
| WO2016004358A1 (en) | 2014-07-03 | 2016-01-07 | Afferent Pharmaceuticals, Inc. | Methods and compositions for treating diseases and conditions |
| HUE061764T2 (hu) | 2015-09-29 | 2023-08-28 | Afferent Pharmaceuticals Inc | Diaminopirimidin-P2X3 és P2X2/3 receptor modulátorok felhasználásra köhögés kezelésében |
| CA3096505A1 (en) * | 2018-04-23 | 2019-10-31 | Merck Sharp & Dohme Corp. | Novel process for synthesis of a phenoxy diaminopyrimidine compound |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SK285728B6 (sk) | 1999-04-15 | 2007-07-06 | Basf Aktiengesellschaft | Spôsob prípravy substituovaných pyrimidínov |
| DK1725540T5 (da) * | 2004-03-05 | 2012-10-22 | Hoffmann La Roche | Diaminopyrimidiner som p2x3- og p2x2/3-antagonister |
| CA2619898C (en) * | 2005-09-01 | 2014-03-18 | F. Hoffmann-La Roche Ag | Diaminopyrimidines as p2x3 and p2x2/3 modulators |
-
2006
- 2006-08-21 WO PCT/EP2006/065523 patent/WO2007025898A1/en not_active Ceased
- 2006-08-21 ES ES06778311T patent/ES2374750T3/es active Active
- 2006-08-21 EP EP06778311A patent/EP1926716B1/de active Active
- 2006-08-21 JP JP2008528471A patent/JP4820873B2/ja not_active Expired - Fee Related
- 2006-08-21 AT AT06778311T patent/ATE529413T1/de not_active IP Right Cessation
- 2006-08-21 CA CA2620033A patent/CA2620033C/en not_active Expired - Fee Related
- 2006-08-21 CN CN2006800319877A patent/CN101253158B/zh not_active Expired - Fee Related
- 2006-08-25 US US11/510,208 patent/US7741484B2/en active Active
- 2006-08-29 TW TW095131819A patent/TW200738650A/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP1926716A1 (de) | 2008-06-04 |
| CA2620033A1 (en) | 2007-03-08 |
| TW200738650A (en) | 2007-10-16 |
| JP4820873B2 (ja) | 2011-11-24 |
| CN101253158A (zh) | 2008-08-27 |
| JP2009506997A (ja) | 2009-02-19 |
| US20070049751A1 (en) | 2007-03-01 |
| ES2374750T3 (es) | 2012-02-21 |
| US7741484B2 (en) | 2010-06-22 |
| EP1926716B1 (de) | 2011-10-19 |
| WO2007025898A1 (en) | 2007-03-08 |
| CN101253158B (zh) | 2013-07-10 |
| CA2620033C (en) | 2014-12-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |