ATE532516T1 - Verfahren zur synthese von glyt-1-hemmern - Google Patents
Verfahren zur synthese von glyt-1-hemmernInfo
- Publication number
- ATE532516T1 ATE532516T1 AT08709206T AT08709206T ATE532516T1 AT E532516 T1 ATE532516 T1 AT E532516T1 AT 08709206 T AT08709206 T AT 08709206T AT 08709206 T AT08709206 T AT 08709206T AT E532516 T1 ATE532516 T1 AT E532516T1
- Authority
- AT
- Austria
- Prior art keywords
- compound
- formula
- glyt
- inhibitors
- synthesis
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07103485 | 2007-03-05 | ||
| PCT/EP2008/052244 WO2008107334A2 (en) | 2007-03-05 | 2008-02-25 | Process for the synthesis of glyt-1 inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE532516T1 true ATE532516T1 (de) | 2011-11-15 |
Family
ID=39469606
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT08709206T ATE532516T1 (de) | 2007-03-05 | 2008-02-25 | Verfahren zur synthese von glyt-1-hemmern |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US7812161B2 (de) |
| EP (1) | EP2131843B1 (de) |
| JP (1) | JP4745446B2 (de) |
| KR (1) | KR101143073B1 (de) |
| CN (1) | CN101622000B (de) |
| AT (1) | ATE532516T1 (de) |
| AU (1) | AU2008223915B2 (de) |
| BR (1) | BRPI0808570B8 (de) |
| CA (1) | CA2678630C (de) |
| ES (1) | ES2375585T3 (de) |
| IL (1) | IL200323A (de) |
| MX (1) | MX2009009065A (de) |
| WO (1) | WO2008107334A2 (de) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5656474B2 (ja) | 2010-06-28 | 2015-01-21 | 関東化学株式会社 | 脂肪族光学活性フルオロアルコールの製造方法 |
| CN104628679B (zh) * | 2013-11-08 | 2018-02-09 | 江苏恩华药业股份有限公司 | Bitopertin的合成方法及其中间体 |
| CN106397312B (zh) * | 2015-07-31 | 2020-03-24 | 广东东阳光药业有限公司 | 一种制备glyt-1抑制剂的方法 |
| CN115279372A (zh) | 2020-01-09 | 2022-11-01 | 迪斯克医药公司 | 用甘氨酸转运蛋白抑制剂治疗红细胞生成性原卟啉病、x连锁原卟啉病或先天性红细胞生成性卟啉病的方法 |
| MX2023004293A (es) | 2020-10-13 | 2023-05-03 | Boehringer Ingelheim Int | Proceso de reelaboracion. |
| EP4577540A1 (de) | 2022-08-24 | 2025-07-02 | Boehringer Ingelheim International GmbH | Skalierbares verfahren zur herstellung eines glyt-1-inhibitors |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3992441A (en) * | 1972-12-26 | 1976-11-16 | Pfizer Inc. | Sulfamylbenzoic acids |
| US4480102A (en) * | 1982-07-23 | 1984-10-30 | The Dow Chemical Company | 2,3-Difluoro-5-(trifluoromethyl)pyridine and methods of making and using the same |
| EP0370560B1 (de) * | 1988-11-24 | 1994-01-12 | Akzo Nobel N.V. | 1-[Mono- oder bis(trifluormethyl)-2-pyridinyl]piperazine enthaltende pharmazeutische Zusammensetzungen |
| DE4235155A1 (de) * | 1992-10-19 | 1994-04-21 | Basf Ag | Verfahren zur Herstellung von Methylsulfonylbenzoesäuren |
| DE69906059D1 (de) * | 1998-04-20 | 2003-04-24 | Fujisawa Pharmaceutical Co | Anthranilsäurederivate als inhibitoren der c-gmp-phosphodiesterase |
| DE10112040A1 (de) | 2001-03-14 | 2002-10-02 | Aventis Pharma Gmbh | Verbessertes Verfahren zur Herstellung von Sulfonylcarboxamidderivaten |
| GB0227240D0 (en) * | 2002-11-21 | 2002-12-31 | Glaxo Group Ltd | Compounds |
| DK1656361T3 (da) * | 2003-08-11 | 2008-05-05 | Hoffmann La Roche | Piperazin med OR-substitueret phenylgruppe og anvendelse deraf som GLYT1-inhibitorer |
| SI1828154T1 (sl) * | 2004-12-09 | 2009-08-31 | Hoffmann La Roche | Derivati fenil-piperazin metanona |
| CN101356163A (zh) * | 2005-01-06 | 2009-01-28 | 弗·哈夫曼-拉罗切有限公司 | 作为甘氨酸转运体1(GlyT-1)抑制剂用于治疗神经学和神经精神病学障碍的硫烷基取代的苯甲酮化合物 |
| DE602005022113D1 (de) * | 2005-01-07 | 2010-08-12 | Hoffmann La Roche | Phenyl)methanon-derivate als glycin-transporter 1 (glyt-1) hemmer zur behandlung von neurologischen und neuropsychiatrischen erkrankungen |
| JP4219976B2 (ja) * | 2005-07-08 | 2009-02-04 | エフ．ホフマン−ラ ロシュ アーゲー | １，１，１−トリフルオロアセトンの不斉還元 |
-
2008
- 2008-02-25 ES ES08709206T patent/ES2375585T3/es active Active
- 2008-02-25 CN CN200880006900XA patent/CN101622000B/zh active Active
- 2008-02-25 CA CA2678630A patent/CA2678630C/en active Active
- 2008-02-25 WO PCT/EP2008/052244 patent/WO2008107334A2/en not_active Ceased
- 2008-02-25 JP JP2009552166A patent/JP4745446B2/ja active Active
- 2008-02-25 AT AT08709206T patent/ATE532516T1/de active
- 2008-02-25 AU AU2008223915A patent/AU2008223915B2/en active Active
- 2008-02-25 BR BRPI0808570A patent/BRPI0808570B8/pt active IP Right Grant
- 2008-02-25 KR KR1020097018418A patent/KR101143073B1/ko active Active
- 2008-02-25 EP EP08709206A patent/EP2131843B1/de active Active
- 2008-02-25 MX MX2009009065A patent/MX2009009065A/es active IP Right Grant
- 2008-02-27 US US12/038,006 patent/US7812161B2/en active Active
-
2009
- 2009-08-10 IL IL200323A patent/IL200323A/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| WO2008107334A3 (en) | 2008-10-23 |
| WO2008107334A2 (en) | 2008-09-12 |
| CA2678630A1 (en) | 2008-09-12 |
| BRPI0808570B1 (pt) | 2020-09-15 |
| EP2131843A2 (de) | 2009-12-16 |
| EP2131843B1 (de) | 2011-11-09 |
| BRPI0808570A2 (pt) | 2014-09-02 |
| AU2008223915B2 (en) | 2013-05-02 |
| AU2008223915A1 (en) | 2008-09-12 |
| MX2009009065A (es) | 2009-08-31 |
| CA2678630C (en) | 2015-04-14 |
| IL200323A0 (en) | 2010-04-29 |
| US20080221327A1 (en) | 2008-09-11 |
| JP2010520251A (ja) | 2010-06-10 |
| BRPI0808570B8 (pt) | 2021-05-25 |
| US7812161B2 (en) | 2010-10-12 |
| CN101622000B (zh) | 2012-07-04 |
| CN101622000A (zh) | 2010-01-06 |
| KR101143073B1 (ko) | 2012-05-08 |
| IL200323A (en) | 2013-11-28 |
| ES2375585T3 (es) | 2012-03-02 |
| JP4745446B2 (ja) | 2011-08-10 |
| KR20090110368A (ko) | 2009-10-21 |
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