DE602007008126D1 - Verfahren zur herstellung von (s)-4-fluormethyldihydrofuran-2-on - Google Patents
Verfahren zur herstellung von (s)-4-fluormethyldihydrofuran-2-onInfo
- Publication number
- DE602007008126D1 DE602007008126D1 DE602007008126T DE602007008126T DE602007008126D1 DE 602007008126 D1 DE602007008126 D1 DE 602007008126D1 DE 602007008126 T DE602007008126 T DE 602007008126T DE 602007008126 T DE602007008126 T DE 602007008126T DE 602007008126 D1 DE602007008126 D1 DE 602007008126D1
- Authority
- DE
- Germany
- Prior art keywords
- fluoromethyldihydrofuran
- preparing
- formula
- dialkylmalonate
- dpp
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/32—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Furan Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP06123512 | 2006-11-06 | ||
PCT/EP2007/061676 WO2008055814A2 (en) | 2006-11-06 | 2007-10-30 | Process for the preparation of (s)-4-fluoromethyl-dihydro-furan-2-one |
Publications (1)
Publication Number | Publication Date |
---|---|
DE602007008126D1 true DE602007008126D1 (de) | 2010-09-09 |
Family
ID=39322581
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE602007008126T Active DE602007008126D1 (de) | 2006-11-06 | 2007-10-30 | Verfahren zur herstellung von (s)-4-fluormethyldihydrofuran-2-on |
Country Status (9)
Country | Link |
---|---|
US (1) | US7956201B2 (de) |
EP (1) | EP2079721B1 (de) |
JP (1) | JP5172849B2 (de) |
CN (1) | CN101528721B (de) |
AT (1) | ATE475655T1 (de) |
CA (1) | CA2667679C (de) |
DE (1) | DE602007008126D1 (de) |
ES (1) | ES2347987T3 (de) |
WO (1) | WO2008055814A2 (de) |
Families Citing this family (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7407955B2 (en) | 2002-08-21 | 2008-08-05 | Boehringer Ingelheim Pharma Gmbh & Co., Kg | 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions |
US7501426B2 (en) | 2004-02-18 | 2009-03-10 | Boehringer Ingelheim International Gmbh | 8-[3-amino-piperidin-1-yl]-xanthines, their preparation and their use as pharmaceutical compositions |
DE102004054054A1 (de) | 2004-11-05 | 2006-05-11 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verfahren zur Herstellung chiraler 8-(3-Amino-piperidin-1-yl)-xanthine |
DE102005035891A1 (de) | 2005-07-30 | 2007-02-08 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | 8-(3-Amino-piperidin-1-yl)-xanthine, deren Herstellung und deren Verwendung als Arzneimittel |
PE20110235A1 (es) | 2006-05-04 | 2011-04-14 | Boehringer Ingelheim Int | Combinaciones farmaceuticas que comprenden linagliptina y metmorfina |
EP1852108A1 (de) | 2006-05-04 | 2007-11-07 | Boehringer Ingelheim Pharma GmbH & Co.KG | Zusammensetzungen von DPP-IV-Inhibitoren |
CA2810839A1 (en) | 2006-05-04 | 2007-11-15 | Boehringer Ingelheim International Gmbh | A polymorphic form of 1-[(4-methyl-quinazolin-2-yl)methyl]-3-methyl-7-(2-butyn-1-yl)-8-(3-(r)-amino-piperidin-1-yl)-xanthine |
WO2008031750A2 (en) * | 2006-09-15 | 2008-03-20 | F. Hoffmann-La Roche Ag | Process for the preparation of pyrido[2,1-a]isoquinoline derivatives by catalytic asymmetric hydrogenation of an enamine |
CL2008002427A1 (es) | 2007-08-16 | 2009-09-11 | Boehringer Ingelheim Int | Composicion farmaceutica que comprende 1-cloro-4-(b-d-glucopiranos-1-il)-2-[4-((s)-tetrahidrofurano-3-iloxi)bencil]-benceno combinado con 1-[(4-metilquinazolin-2-il)metil]-3-metil-7-(2-butin-1-il)-8-(3-(r)-aminopiperidin-1-il)xantina; y su uso para tratar diabetes mellitus tipo 2. |
US20090105480A1 (en) * | 2007-08-30 | 2009-04-23 | Ulrike Bromberger | Process for the preparation of a dpp-iv inhibitor |
PE20091730A1 (es) | 2008-04-03 | 2009-12-10 | Boehringer Ingelheim Int | Formulaciones que comprenden un inhibidor de dpp4 |
UY32030A (es) | 2008-08-06 | 2010-03-26 | Boehringer Ingelheim Int | "tratamiento para diabetes en pacientes inapropiados para terapia con metformina" |
BRPI0916997A2 (pt) | 2008-08-06 | 2020-12-15 | Boehringer Ingelheim International Gmbh | Inibidor de dpp-4 e seu uso |
MX2011001525A (es) * | 2008-08-15 | 2011-03-29 | Boehringer Ingelheim Int | Derivados de purina para su uso en el tratamiento de enfermedades relacionadas con fab. |
CN102149407A (zh) | 2008-09-10 | 2011-08-10 | 贝林格尔.英格海姆国际有限公司 | 治疗糖尿病和相关病症的组合疗法 |
US20200155558A1 (en) | 2018-11-20 | 2020-05-21 | Boehringer Ingelheim International Gmbh | Treatment for diabetes in patients with insufficient glycemic control despite therapy with an oral antidiabetic drug |
BRPI0923121A2 (pt) | 2008-12-23 | 2015-08-11 | Boehringer Ingelheim Int | Formas salinas de compostos orgânico |
AR074990A1 (es) | 2009-01-07 | 2011-03-02 | Boehringer Ingelheim Int | Tratamiento de diabetes en pacientes con un control glucemico inadecuado a pesar de la terapia con metformina |
TWI466672B (zh) | 2009-01-29 | 2015-01-01 | Boehringer Ingelheim Int | 小兒科病人糖尿病之治療 |
EP2395983B1 (de) | 2009-02-13 | 2020-04-08 | Boehringer Ingelheim International GmbH | Pharmazeutische zusammensetzung mit einem sglt2-inhibitor, einem dpp-iv-inhibitor und optional einem weiteren antidiabetischen mittel und ihre verwendung |
EP2395988A2 (de) | 2009-02-13 | 2011-12-21 | Boehringer Ingelheim International GmbH | Antidiabetische medikamente mit einem dpp-4-inhibitor (linagliptin) optional in kombination mit anderen antidiabetika |
CN107115530A (zh) | 2009-11-27 | 2017-09-01 | 勃林格殷格翰国际有限公司 | 基因型糖尿病患者利用dpp‑iv抑制剂例如利拉利汀的治疗 |
EP2547339A1 (de) | 2010-03-18 | 2013-01-23 | Boehringer Ingelheim International GmbH | Kombination eines gpr119-agonisten und des dpp-iv-hemmers linagliptin zur verwendung bei der behandlung von diabetes und zugehöriger erkrankungen |
KR101927068B1 (ko) | 2010-05-05 | 2018-12-10 | 베링거 인겔하임 인터내셔날 게엠베하 | 체중 감소 치료에 후속하는 dpp-4 억제제에 의한 순차적 병용 요법 |
CN102971005A (zh) | 2010-06-24 | 2013-03-13 | 贝林格尔.英格海姆国际有限公司 | 糖尿病治疗 |
US9034883B2 (en) | 2010-11-15 | 2015-05-19 | Boehringer Ingelheim International Gmbh | Vasoprotective and cardioprotective antidiabetic therapy |
AR085689A1 (es) | 2011-03-07 | 2013-10-23 | Boehringer Ingelheim Int | Composiciones farmaceuticas de metformina, linagliptina y un inhibidor de sglt-2 |
EP3517539B1 (de) | 2011-07-15 | 2022-12-14 | Boehringer Ingelheim International GmbH | Substituiertes dimeres chinazolinderivat, dessen herstellung und dessen verwendung in pharmazeutischen zusammensetzungen zur behandlung von diabetes typ i und ii |
US9555001B2 (en) | 2012-03-07 | 2017-01-31 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition and uses thereof |
US20130303462A1 (en) | 2012-05-14 | 2013-11-14 | Boehringer Ingelheim International Gmbh | Use of a dpp-4 inhibitor in podocytes related disorders and/or nephrotic syndrome |
WO2013174767A1 (en) | 2012-05-24 | 2013-11-28 | Boehringer Ingelheim International Gmbh | A xanthine derivative as dpp -4 inhibitor for use in modifying food intake and regulating food preference |
JP6615109B2 (ja) | 2014-02-28 | 2019-12-04 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Dpp−4阻害薬の医学的使用 |
CN106365986B (zh) * | 2015-07-21 | 2019-01-08 | 苏州鹏旭医药科技有限公司 | 化合物及其制备方法和在合成布瓦西坦中的用途 |
CN105801530A (zh) * | 2016-04-13 | 2016-07-27 | 成都拿盛科技有限公司 | 一种4位取代的手性γ-丁内酯的合成方法 |
CA3022202A1 (en) | 2016-06-10 | 2017-12-14 | Boehringer Ingelheim International Gmbh | Combinations of linagliptin and metformin |
WO2020168510A1 (zh) * | 2019-02-21 | 2020-08-27 | 上海博璞诺科技发展有限公司 | 一种手性丁内酯的制备方法 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9225257D0 (en) * | 1992-12-03 | 1993-01-27 | Wyeth John & Brother Ltd | Lactone |
KR100730867B1 (ko) | 2003-06-20 | 2007-06-20 | 에프. 호프만-라 로슈 아게 | Dpp-ⅳ 억제제로서의 피리도[2,1-a]이소퀴놀린 유도체 |
ES2313672T3 (es) | 2005-05-24 | 2009-03-01 | F. Hoffmann-La Roche Ag | Praparacion de (s)-4-fluorometil-dihidro-furan-2-ona. |
-
2007
- 2007-10-16 US US11/873,072 patent/US7956201B2/en not_active Expired - Fee Related
- 2007-10-30 JP JP2009535070A patent/JP5172849B2/ja not_active Expired - Fee Related
- 2007-10-30 DE DE602007008126T patent/DE602007008126D1/de active Active
- 2007-10-30 WO PCT/EP2007/061676 patent/WO2008055814A2/en active Application Filing
- 2007-10-30 EP EP07822030A patent/EP2079721B1/de not_active Not-in-force
- 2007-10-30 CN CN2007800399289A patent/CN101528721B/zh not_active Expired - Fee Related
- 2007-10-30 AT AT07822030T patent/ATE475655T1/de not_active IP Right Cessation
- 2007-10-30 CA CA2667679A patent/CA2667679C/en not_active Expired - Fee Related
- 2007-10-30 ES ES07822030T patent/ES2347987T3/es active Active
Also Published As
Publication number | Publication date |
---|---|
ES2347987T3 (es) | 2010-11-26 |
US20080108816A1 (en) | 2008-05-08 |
CN101528721B (zh) | 2013-01-02 |
WO2008055814A3 (en) | 2008-07-03 |
JP5172849B2 (ja) | 2013-03-27 |
ATE475655T1 (de) | 2010-08-15 |
EP2079721B1 (de) | 2010-07-28 |
WO2008055814A2 (en) | 2008-05-15 |
CA2667679A1 (en) | 2008-05-15 |
CA2667679C (en) | 2015-08-11 |
CN101528721A (zh) | 2009-09-09 |
JP2010508327A (ja) | 2010-03-18 |
EP2079721A2 (de) | 2009-07-22 |
US7956201B2 (en) | 2011-06-07 |
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