ATE478084T1 - Verfahren zur herstellung von 4'- azidocytidinderivaten - Google Patents
Verfahren zur herstellung von 4'- azidocytidinderivatenInfo
- Publication number
- ATE478084T1 ATE478084T1 AT07847643T AT07847643T ATE478084T1 AT E478084 T1 ATE478084 T1 AT E478084T1 AT 07847643 T AT07847643 T AT 07847643T AT 07847643 T AT07847643 T AT 07847643T AT E478084 T1 ATE478084 T1 AT E478084T1
- Authority
- AT
- Austria
- Prior art keywords
- azidocytidine
- derivatives
- producing
- mediated diseases
- treating
- Prior art date
Links
- ODLGMSQBFONGNG-JVZYCSMKSA-N 4-amino-1-[(2r,3r,4s,5r)-5-azido-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one Chemical class O=C1N=C(N)C=CN1[C@H]1[C@H](O)[C@H](O)[C@](CO)(N=[N+]=[N-])O1 ODLGMSQBFONGNG-JVZYCSMKSA-N 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 230000001404 mediated effect Effects 0.000 abstract 2
- 241000700605 Viruses Species 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/067—Pyrimidine radicals with ribosyl as the saccharide radical
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Virology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06125768 | 2006-12-11 | ||
| PCT/EP2007/063132 WO2008071571A1 (en) | 2006-12-11 | 2007-12-03 | Process for preparation of 4'-azido cytidine derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE478084T1 true ATE478084T1 (de) | 2010-09-15 |
Family
ID=39111615
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT07847643T ATE478084T1 (de) | 2006-12-11 | 2007-12-03 | Verfahren zur herstellung von 4'- azidocytidinderivaten |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US7632940B2 (de) |
| EP (1) | EP2102221B1 (de) |
| JP (1) | JP2010512365A (de) |
| CN (1) | CN101541818B (de) |
| AT (1) | ATE478084T1 (de) |
| CA (1) | CA2671306C (de) |
| DE (1) | DE602007008616D1 (de) |
| ES (1) | ES2348687T3 (de) |
| WO (1) | WO2008071571A1 (de) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2011305652B2 (en) | 2010-09-22 | 2016-10-20 | Janssen Biopharma, Inc. | Azido nucleosides and nucleotide analogs |
| EP2691409B1 (de) | 2011-03-31 | 2018-02-21 | Idenix Pharmaceuticals LLC. | Verbindungen und zusammensetzungen zur behandlung von virusinfektionen |
| AR088441A1 (es) | 2011-09-12 | 2014-06-11 | Idenix Pharmaceuticals Inc | Compuestos de carboniloximetilfosforamidato sustituido y composiciones farmaceuticas para el tratamiento de infecciones virales |
| CN102286047A (zh) * | 2011-09-14 | 2011-12-21 | 郑州大学 | 2’-脱氧-2’-氟-4’-三氮唑取代-β-D胞苷类似物、其制备方法及其应用 |
| EP2768838A1 (de) | 2011-10-14 | 2014-08-27 | IDENIX Pharmaceuticals, Inc. | Substituierte 3 ', 5 '-cyclophosphate von purin-nukleotid-verbindungen und pharmazeutische zusammensetzungen für die behandlung von virusinfektionen |
| EA024297B1 (ru) * | 2011-12-20 | 2016-09-30 | Рибосайенс Ллк | 2',4'-дифтор-2'-метилзамещенные нуклеозидные производные в качестве ингибиторов репликации рнк вируса гепатита с |
| US9109001B2 (en) | 2012-05-22 | 2015-08-18 | Idenix Pharmaceuticals, Inc. | 3′,5′-cyclic phosphoramidate prodrugs for HCV infection |
| GEP20176800B (en) | 2012-05-22 | 2018-01-10 | Idenix Pharmaceuticals Llk | D-amino acid compounds for liver disease |
| WO2013177195A1 (en) | 2012-05-22 | 2013-11-28 | Idenix Pharmaceuticals, Inc. | 3',5'-cyclic phosphate prodrugs for hcv infection |
| WO2013174962A1 (en) | 2012-05-25 | 2013-11-28 | Janssen R&D Ireland | Uracyl spirooxetane nucleosides |
| EP2900682A1 (de) | 2012-09-27 | 2015-08-05 | IDENIX Pharmaceuticals, Inc. | Ester und malonate aus sate-prodrugs |
| CN111848711A (zh) | 2012-10-08 | 2020-10-30 | 埃迪尼克斯医药有限责任公司 | 用于hcv感染的2′-氯核苷类似物 |
| US10723754B2 (en) | 2012-10-22 | 2020-07-28 | Idenix Pharmaceuticals Llc | 2′,4′-bridged nucleosides for HCV infection |
| US9211300B2 (en) | 2012-12-19 | 2015-12-15 | Idenix Pharmaceuticals Llc | 4′-fluoro nucleosides for the treatment of HCV |
| US9339541B2 (en) | 2013-03-04 | 2016-05-17 | Merck Sharp & Dohme Corp. | Thiophosphate nucleosides for the treatment of HCV |
| EP2970358B1 (de) | 2013-03-04 | 2021-06-30 | Idenix Pharmaceuticals LLC | 3'-deoxy-nukleoside zur behandlung von hcv |
| US20140271547A1 (en) | 2013-03-13 | 2014-09-18 | Idenix Pharmaceuticals, Inc. | Amino acid phosphoramidate pronucleotides of 2'-cyano, azido and amino nucleosides for the treatment of hcv |
| US9187515B2 (en) | 2013-04-01 | 2015-11-17 | Idenix Pharmaceuticals Llc | 2′,4′-fluoro nucleosides for the treatment of HCV |
| WO2014197578A1 (en) | 2013-06-05 | 2014-12-11 | Idenix Pharmaceuticals, Inc. | 1',4'-thio nucleosides for the treatment of hcv |
| EP3027636B1 (de) | 2013-08-01 | 2022-01-05 | Idenix Pharmaceuticals LLC | D-amino acid phosphoramidate pronucleotide of halogenierte pyrimidine verbindungen für leber krankheiten |
| WO2015161137A1 (en) | 2014-04-16 | 2015-10-22 | Idenix Pharmaceuticals, Inc. | 3'-substituted methyl or alkynyl nucleosides for the treatment of hcv |
| CN115215914B (zh) * | 2021-04-15 | 2024-05-28 | 中国科学院上海药物研究所 | 核苷类似物及其用途 |
| CN114656512B (zh) * | 2022-03-07 | 2022-12-06 | 安徽瑞拜药业有限公司 | 一种规模化寡核酸生产用氨解装置 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH07103149B2 (ja) * | 1987-11-30 | 1995-11-08 | ヤマサ醤油株式会社 | シトシン誘導体の製造法 |
| GB0114286D0 (en) * | 2001-06-12 | 2001-08-01 | Hoffmann La Roche | Nucleoside Derivatives |
| SG174624A1 (en) * | 2002-08-01 | 2011-10-28 | Pharmasset Inc | Compounds with the bicyclo[4.2.1]nonane system for the treatment of flaviviridae infections |
| TWI332507B (en) * | 2002-11-19 | 2010-11-01 | Hoffmann La Roche | Antiviral nucleoside derivatives |
| MXPA05013452A (es) * | 2003-06-19 | 2006-03-09 | Hoffmann La Roche | Proceso para preparar derivados de 4'-azidonucleosido. |
-
2007
- 2007-12-03 ES ES07847643T patent/ES2348687T3/es active Active
- 2007-12-03 EP EP07847643A patent/EP2102221B1/de not_active Not-in-force
- 2007-12-03 JP JP2009540706A patent/JP2010512365A/ja active Pending
- 2007-12-03 CN CN200780044240XA patent/CN101541818B/zh not_active Expired - Fee Related
- 2007-12-03 CA CA2671306A patent/CA2671306C/en not_active Expired - Fee Related
- 2007-12-03 WO PCT/EP2007/063132 patent/WO2008071571A1/en not_active Ceased
- 2007-12-03 AT AT07847643T patent/ATE478084T1/de not_active IP Right Cessation
- 2007-12-03 DE DE602007008616T patent/DE602007008616D1/de active Active
- 2007-12-07 US US11/999,926 patent/US7632940B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US20080161550A1 (en) | 2008-07-03 |
| US7632940B2 (en) | 2009-12-15 |
| EP2102221B1 (de) | 2010-08-18 |
| CN101541818A (zh) | 2009-09-23 |
| EP2102221A1 (de) | 2009-09-23 |
| CA2671306A1 (en) | 2008-06-19 |
| JP2010512365A (ja) | 2010-04-22 |
| DE602007008616D1 (de) | 2010-09-30 |
| ES2348687T3 (es) | 2010-12-10 |
| CA2671306C (en) | 2011-04-19 |
| CN101541818B (zh) | 2012-03-21 |
| WO2008071571A1 (en) | 2008-06-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |