DE602007008616D1 - Verfahren zur herstellung von 4'-azidocytidinderivaten - Google Patents

Verfahren zur herstellung von 4'-azidocytidinderivaten

Info

Publication number
DE602007008616D1
DE602007008616D1 DE602007008616T DE602007008616T DE602007008616D1 DE 602007008616 D1 DE602007008616 D1 DE 602007008616D1 DE 602007008616 T DE602007008616 T DE 602007008616T DE 602007008616 T DE602007008616 T DE 602007008616T DE 602007008616 D1 DE602007008616 D1 DE 602007008616D1
Authority
DE
Germany
Prior art keywords
preparation
azidocytidine
derivatives
mediated diseases
treating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602007008616T
Other languages
English (en)
Inventor
Peter John Harrington
Stefan Hildbrand
Keshab Sarma
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of DE602007008616D1 publication Critical patent/DE602007008616D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/067—Pyrimidine radicals with ribosyl as the saccharide radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
DE602007008616T 2006-12-11 2007-12-03 Verfahren zur herstellung von 4'-azidocytidinderivaten Active DE602007008616D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06125768 2006-12-11
PCT/EP2007/063132 WO2008071571A1 (en) 2006-12-11 2007-12-03 Process for preparation of 4'-azido cytidine derivatives

Publications (1)

Publication Number Publication Date
DE602007008616D1 true DE602007008616D1 (de) 2010-09-30

Family

ID=39111615

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602007008616T Active DE602007008616D1 (de) 2006-12-11 2007-12-03 Verfahren zur herstellung von 4'-azidocytidinderivaten

Country Status (9)

Country Link
US (1) US7632940B2 (de)
EP (1) EP2102221B1 (de)
JP (1) JP2010512365A (de)
CN (1) CN101541818B (de)
AT (1) ATE478084T1 (de)
CA (1) CA2671306C (de)
DE (1) DE602007008616D1 (de)
ES (1) ES2348687T3 (de)
WO (1) WO2008071571A1 (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012040124A1 (en) 2010-09-22 2012-03-29 Alios Biopharma, Inc. Azido nucleosides and nucleotide analogs
JP2014514295A (ja) 2011-03-31 2014-06-19 アイディニックス ファーマシューティカルズ インコーポレイテッド ウイルス感染の治療のための化合物および薬学的組成物
EP2755983B1 (de) 2011-09-12 2017-03-15 Idenix Pharmaceuticals LLC. Substituierte carbonyloxymethylphosphoramidatverbindungen und pharmazeutische zusammensetzungen zur behandlung von virusinfektionen
CN102286047A (zh) * 2011-09-14 2011-12-21 郑州大学 2’-脱氧-2’-氟-4’-三氮唑取代-β-D胞苷类似物、其制备方法及其应用
EP2768838A1 (de) 2011-10-14 2014-08-27 IDENIX Pharmaceuticals, Inc. Substituierte 3 ', 5 '-cyclophosphate von purin-nukleotid-verbindungen und pharmazeutische zusammensetzungen für die behandlung von virusinfektionen
CN104011061B (zh) * 2011-12-20 2017-06-13 里博科学有限责任公司 作为hcv rna复制抑制剂的2‘,4’‑二氟‑2‘‑甲基取代的核苷衍生物
EP2852605B1 (de) 2012-05-22 2018-01-31 Idenix Pharmaceuticals LLC 3',5'-cyclische phosphat-prodrugs für hcv-infektion
SG11201407674TA (en) 2012-05-22 2014-12-30 Idenix Pharmaceuticals Inc D-amino acid compounds for liver disease
WO2013177188A1 (en) 2012-05-22 2013-11-28 Idenix Pharmaceuticals, Inc. 3',5'-cyclic phosphoramidate prodrugs for hcv infection
PL2861611T3 (pl) 2012-05-25 2017-08-31 Janssen Sciences Ireland Uc Nukleozydy uracylowe spirooksetanu
WO2014052638A1 (en) 2012-09-27 2014-04-03 Idenix Pharmaceuticals, Inc. Esters and malonates of sate prodrugs
TR201809048T4 (tr) 2012-10-08 2018-07-23 Centre Nat Rech Scient Hcv enfeksiyonu için 2'-kloro nükleosit analogları.
US10723754B2 (en) 2012-10-22 2020-07-28 Idenix Pharmaceuticals Llc 2′,4′-bridged nucleosides for HCV infection
WO2014099941A1 (en) 2012-12-19 2014-06-26 Idenix Pharmaceuticals, Inc. 4'-fluoro nucleosides for the treatment of hcv
US9339541B2 (en) 2013-03-04 2016-05-17 Merck Sharp & Dohme Corp. Thiophosphate nucleosides for the treatment of HCV
EP2970358B1 (de) 2013-03-04 2021-06-30 Idenix Pharmaceuticals LLC 3'-deoxy-nukleoside zur behandlung von hcv
EP2970357A1 (de) 2013-03-13 2016-01-20 IDENIX Pharmaceuticals, Inc. Aminosäure-phosphoramidat-pronukleotide von 2'-cyano-, azido- und aminonukleosiden zur behandlung von hcv
US9187515B2 (en) 2013-04-01 2015-11-17 Idenix Pharmaceuticals Llc 2′,4′-fluoro nucleosides for the treatment of HCV
WO2014197578A1 (en) 2013-06-05 2014-12-11 Idenix Pharmaceuticals, Inc. 1',4'-thio nucleosides for the treatment of hcv
US20150037282A1 (en) 2013-08-01 2015-02-05 Idenix Pharmaceuticals, Inc. D-amino acid phosphoramidate pronucleotides of halogeno pyrimidine compounds for liver disease
EP3131914B1 (de) 2014-04-16 2023-05-10 Idenix Pharmaceuticals LLC 3'-substituierte methyl- oder alkynylnukleoside zur behandlung von hcv
US20240166680A1 (en) * 2021-04-15 2024-05-23 Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences Nucleoside analog and use thereof
CN114656512B (zh) * 2022-03-07 2022-12-06 安徽瑞拜药业有限公司 一种规模化寡核酸生产用氨解装置

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07103149B2 (ja) * 1987-11-30 1995-11-08 ヤマサ醤油株式会社 シトシン誘導体の製造法
GB0114286D0 (en) * 2001-06-12 2001-08-01 Hoffmann La Roche Nucleoside Derivatives
SG174624A1 (en) * 2002-08-01 2011-10-28 Pharmasset Inc Compounds with the bicyclo[4.2.1]nonane system for the treatment of flaviviridae infections
TWI332507B (en) * 2002-11-19 2010-11-01 Hoffmann La Roche Antiviral nucleoside derivatives
EP1644395B1 (de) * 2003-06-19 2006-11-22 F. Hoffmann-La Roche Ag Verfahren zur herstellung von 4'-azidonukleosidderivaten

Also Published As

Publication number Publication date
EP2102221A1 (de) 2009-09-23
CA2671306C (en) 2011-04-19
ES2348687T3 (es) 2010-12-10
CN101541818A (zh) 2009-09-23
ATE478084T1 (de) 2010-09-15
CN101541818B (zh) 2012-03-21
WO2008071571A1 (en) 2008-06-19
CA2671306A1 (en) 2008-06-19
US7632940B2 (en) 2009-12-15
EP2102221B1 (de) 2010-08-18
US20080161550A1 (en) 2008-07-03
JP2010512365A (ja) 2010-04-22

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