EA200970375A1 - Соединения и способы лечения вируса гепатита с - Google Patents

Соединения и способы лечения вируса гепатита с

Info

Publication number
EA200970375A1
EA200970375A1 EA200970375A EA200970375A EA200970375A1 EA 200970375 A1 EA200970375 A1 EA 200970375A1 EA 200970375 A EA200970375 A EA 200970375A EA 200970375 A EA200970375 A EA 200970375A EA 200970375 A1 EA200970375 A1 EA 200970375A1
Authority
EA
Eurasian Patent Office
Prior art keywords
methods
hepatitis
virus
connections
treatment
Prior art date
Application number
EA200970375A
Other languages
English (en)
Inventor
Голинь Ли
Реза Фатхи
Чжэнь Ян
Юнь Ляо
Цян Чжу
Анджела Лэм
Энтони Сандрасагра
Кеннет Навошик
Хиун-Дзоон Чо
Цзе Цао
У Жоцю
К. Ричард Уоббе
Original Assignee
Президио Фармасьютикалз, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Президио Фармасьютикалз, Инк. filed Critical Президио Фармасьютикалз, Инк.
Publication of EA200970375A1 publication Critical patent/EA200970375A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Настоящее изобретение относится к арилзамещенным производным пиразола, а также способам их получения. Изобретение также относится к композициям и способам лечения HCV путем введения соединения согласно настоящему изобретению, индивидуально или в комбинации с дополнительными антивирусными агентами, в терапевтически эффективном количестве.
EA200970375A 2006-10-13 2007-10-15 Соединения и способы лечения вируса гепатита с EA200970375A1 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US85164306P 2006-10-13 2006-10-13
US92552807P 2007-04-20 2007-04-20
US93356507P 2007-06-06 2007-06-06
PCT/US2007/022055 WO2008048589A2 (en) 2006-10-13 2007-10-15 Compounds and methods for treatment of hcv

Publications (1)

Publication Number Publication Date
EA200970375A1 true EA200970375A1 (ru) 2009-10-30

Family

ID=39314638

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200970375A EA200970375A1 (ru) 2006-10-13 2007-10-15 Соединения и способы лечения вируса гепатита с

Country Status (8)

Country Link
US (1) US7923004B2 (ru)
EP (1) EP2076264A2 (ru)
JP (1) JP2010506843A (ru)
AP (1) AP2009004840A0 (ru)
AU (1) AU2007313250A1 (ru)
CA (1) CA2680507A1 (ru)
EA (1) EA200970375A1 (ru)
WO (1) WO2008048589A2 (ru)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8329703B2 (en) * 2005-02-15 2012-12-11 Xtl Biopharmaceuticals Ltd. Pyrazole compounds
BRPI1007836A2 (pt) 2009-02-27 2015-09-01 Enanta Phamaceuticals Inc Inibidores do vírus c da hepatite
WO2011015658A1 (en) 2009-08-07 2011-02-10 Tibotec Pharmaceuticals Bis-benzimidazole derivatives as hepatitis c virus inhibitors
EP2462136A1 (en) * 2009-08-07 2012-06-13 Janssen R&D Ireland Phenyl ethynyl derivatives as hepatitis c virus inhibitors
BR112012004969A2 (pt) 2009-09-03 2019-09-24 Tibotec Pharm Ltd derivados de bis-benzimidazol
UA108211C2 (ru) 2009-11-04 2015-04-10 Янссен Рід Айрленд Бензимидазолимидазольные производные
EP2512480A4 (en) 2009-12-14 2013-05-15 Enanta Pharm Inc HEPATITIS C-VIRUS HEMMER
US20130296311A1 (en) * 2010-05-28 2013-11-07 Presidio Pharmaceuticals, Inc. Inhibitors of hcv ns5a
CA2802067A1 (en) * 2010-06-09 2011-12-15 Presidio Pharmaceuticals, Inc. Inhibitors of hcv ns5a protein
BR112013002122A2 (pt) 2010-07-26 2016-09-20 Janssen R&D Ireland derivados hetero-bicíclicos como inibidores de hcv
WO2013030750A1 (en) 2011-09-01 2013-03-07 Lupin Limited Antiviral compounds
RU2621734C1 (ru) 2011-12-28 2017-06-07 Янссен Сайенсиз Айрлэнд Юси Гетеробициклические производные в качестве ингибиторов hcv
BR112014016007A8 (pt) 2011-12-28 2017-07-04 Janssen R&D Ireland derivados de quinazolinona como inibidores de vhc
IN2014MN01547A (ru) 2012-02-10 2015-05-08 Lupin Ltd
KR20210098504A (ko) 2018-12-04 2021-08-10 브리스톨-마이어스 스큅 컴퍼니 다중 동위원소체 반응 모니터링에 의한 샘플내 보정 곡선을 사용한 분석 방법
KR20200089219A (ko) * 2019-01-15 2020-07-24 보로노이 주식회사 아릴 또는 헤테로아릴 유도체, 및 이를 유효성분으로 포함하는 키나아제 관련 질환 치료용 약학적 조성물

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3832570A1 (de) * 1988-09-24 1990-03-29 Hoechst Ag 7-substituierte derivate der 3,5-dihydroxyhept-6-insaeure, verfahren zur ihrer herstellung, ihre verwendung als arzneimittel, sowie zwischenprodukte
HU9301218D0 (en) * 1992-05-13 1993-08-30 Sandoz Ag Method for producing new pyrazole derivatives
KR100770419B1 (ko) * 1999-09-24 2007-10-26 니혼노야쿠가부시키가이샤 살충, 살진드기제
DE10064823A1 (de) 2000-12-22 2002-06-27 Knoll Ag Integrinrezeptorliganden
US20020183366A1 (en) * 2001-03-23 2002-12-05 Garvey David S. Cyclooxygenase-2 inhibitors, compositions and methods of use
CH697574B1 (de) * 2003-01-07 2008-12-15 Lanxess Deutschland Gmbh Pyrazolylarylalkine.
CH697663B1 (de) * 2003-01-07 2009-01-15 Lanxess Deutschland Gmbh Pyrazolylalkine.
EA011808B1 (ru) * 2003-01-08 2009-06-30 Новартис Вэксинес Энд Дайэгностикс, Инк. Антибактериальные агенты
EP1522541A1 (en) 2003-10-07 2005-04-13 Lipideon Biotechnology AG Novel hypocholesterolemic compounds
EP1755607A2 (en) 2004-04-29 2007-02-28 Pharmix Corporation Compositions and treatments for inhibiting kinase and/or hmg-coa reductase
BRPI0511834A (pt) * 2004-07-14 2008-01-08 Ptc Therapeutics Inc métodos por tratar hepatite c
JP2006089485A (ja) * 2004-08-24 2006-04-06 Santen Pharmaceut Co Ltd ジヒドロオロテートデヒドロゲナーゼ阻害活性を有する新規複素環アミド誘導体
US8329703B2 (en) * 2005-02-15 2012-12-11 Xtl Biopharmaceuticals Ltd. Pyrazole compounds

Also Published As

Publication number Publication date
AU2007313250A1 (en) 2008-04-24
US20090041723A1 (en) 2009-02-12
WO2008048589A2 (en) 2008-04-24
US7923004B2 (en) 2011-04-12
JP2010506843A (ja) 2010-03-04
WO2008048589A3 (en) 2008-12-04
CA2680507A1 (en) 2008-04-24
EP2076264A2 (en) 2009-07-08
AP2009004840A0 (en) 2009-04-30

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