BR112014016007A8 - derivados de quinazolinona como inibidores de vhc - Google Patents
derivados de quinazolinona como inibidores de vhcInfo
- Publication number
- BR112014016007A8 BR112014016007A8 BR112014016007A BR112014016007A BR112014016007A8 BR 112014016007 A8 BR112014016007 A8 BR 112014016007A8 BR 112014016007 A BR112014016007 A BR 112014016007A BR 112014016007 A BR112014016007 A BR 112014016007A BR 112014016007 A8 BR112014016007 A8 BR 112014016007A8
- Authority
- BR
- Brazil
- Prior art keywords
- inhibitors
- vhc
- quinazolinone derivatives
- hcv
- relates
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/113—Spiro-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Peptides Or Proteins (AREA)
Abstract
resumo patente de invenção: "derivados de quinazolinona como inibidores de vhc". a presente invenção refere-se a inibidores da replicação de vhc de fórmula i (i) incluindo as formas estereoquimicamente isoméricas, sais e solvatos dos mesmos , em que r e r' têm o significado como aqui definido. a presente invenção também se refere a processos para a preparação dos referidos compostos, composições farmacêuticas que os contêm e ao seu uso, sozinho ou em combinação com outros inibidores de vhc, na terapia de vhc.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP11195841 | 2011-12-28 | ||
EP12152267 | 2012-01-24 | ||
PCT/EP2012/076942 WO2013098320A1 (en) | 2011-12-28 | 2012-12-27 | Quinazolinone derivatives as hcv inhibitors |
Publications (2)
Publication Number | Publication Date |
---|---|
BR112014016007A2 BR112014016007A2 (pt) | 2017-06-13 |
BR112014016007A8 true BR112014016007A8 (pt) | 2017-07-04 |
Family
ID=47505013
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112014016007A BR112014016007A8 (pt) | 2011-12-28 | 2012-12-27 | derivados de quinazolinona como inibidores de vhc |
Country Status (12)
Country | Link |
---|---|
US (1) | US9382261B2 (pt) |
EP (1) | EP2797913B1 (pt) |
JP (2) | JP6199891B2 (pt) |
CN (1) | CN104169271B (pt) |
AU (1) | AU2012360910B8 (pt) |
BR (1) | BR112014016007A8 (pt) |
CA (1) | CA2858646A1 (pt) |
ES (1) | ES2601461T3 (pt) |
IN (1) | IN2014MN01486A (pt) |
MX (1) | MX348127B (pt) |
RU (1) | RU2014131017A (pt) |
WO (1) | WO2013098320A1 (pt) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9326973B2 (en) | 2012-01-13 | 2016-05-03 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
US9717712B2 (en) | 2013-07-02 | 2017-08-01 | Bristol-Myers Squibb Company | Combinations comprising tricyclohexadecahexaene derivatives for use in the treatment of hepatitis C virus |
US20150023913A1 (en) | 2013-07-02 | 2015-01-22 | Bristol-Myers Squibb Company | Hepatitis C Virus Inhibitors |
CN105530933B (zh) | 2013-07-17 | 2018-12-11 | 百时美施贵宝公司 | 用于治疗hcv的包含联苯衍生物的组合产品 |
WO2017023631A1 (en) | 2015-08-06 | 2017-02-09 | Bristol-Myers Squibb Company | Hepatitis c virus inhibitors |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8143288B2 (en) | 2005-06-06 | 2012-03-27 | Bristol-Myers Squibb Company | Inhibitors of HCV replication |
US7659270B2 (en) * | 2006-08-11 | 2010-02-09 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
US8329159B2 (en) | 2006-08-11 | 2012-12-11 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
AP2009004840A0 (en) | 2006-10-13 | 2009-04-30 | Xtl Biopharmaceuticals Ltd | Compounds and methods for treatment of HCV |
TW200831084A (en) | 2006-11-21 | 2008-08-01 | Genelabs Tech Inc | Anti-viral compounds |
US7906655B2 (en) | 2008-08-07 | 2011-03-15 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
BRPI0922366B8 (pt) * | 2008-12-03 | 2021-05-25 | Presidio Pharmaceuticals Inc | composto, composição farmacêutica e uso de um composto |
US8865756B2 (en) | 2008-12-03 | 2014-10-21 | Presidio Pharmaceuticals, Inc. | Inhibitors of HCV NS5A |
WO2011004276A1 (en) * | 2009-07-06 | 2011-01-13 | Pfizer Limited | Hepatitis c virus inhibitors |
UA108211C2 (uk) | 2009-11-04 | 2015-04-10 | Янссен Рід Айрленд | Бензімідазолімідазольні похідні |
WO2011091446A1 (en) * | 2010-01-22 | 2011-07-28 | Glaxosmithkline Llc | Chemical compounds |
CA2791630A1 (en) * | 2010-03-04 | 2011-09-09 | Enanta Pharmaceuticals, Inc. | Combination pharmaceutical agents as inhibitors of hcv replication |
EP2598498B1 (en) | 2010-07-26 | 2014-07-09 | Janssen R&D Ireland | Hetero-bicyclic derivatives as hcv inhibitors |
US9126986B2 (en) * | 2011-12-28 | 2015-09-08 | Janssen Sciences Ireland Uc | Hetero-bicyclic derivatives as HCV inhibitors |
-
2012
- 2012-12-27 WO PCT/EP2012/076942 patent/WO2013098320A1/en active Application Filing
- 2012-12-27 CA CA2858646A patent/CA2858646A1/en not_active Abandoned
- 2012-12-27 CN CN201280065174.5A patent/CN104169271B/zh not_active Expired - Fee Related
- 2012-12-27 RU RU2014131017A patent/RU2014131017A/ru not_active Application Discontinuation
- 2012-12-27 BR BR112014016007A patent/BR112014016007A8/pt not_active IP Right Cessation
- 2012-12-27 AU AU2012360910A patent/AU2012360910B8/en not_active Ceased
- 2012-12-27 US US14/368,511 patent/US9382261B2/en not_active Expired - Fee Related
- 2012-12-27 EP EP12810312.4A patent/EP2797913B1/en not_active Not-in-force
- 2012-12-27 JP JP2014549464A patent/JP6199891B2/ja not_active Expired - Fee Related
- 2012-12-27 IN IN1486MUN2014 patent/IN2014MN01486A/en unknown
- 2012-12-27 MX MX2014008042A patent/MX348127B/es active IP Right Grant
- 2012-12-27 ES ES12810312.4T patent/ES2601461T3/es active Active
-
2017
- 2017-07-28 JP JP2017146186A patent/JP2018012699A/ja not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
AU2012360910B2 (en) | 2017-01-05 |
IN2014MN01486A (pt) | 2015-04-24 |
AU2012360910B8 (en) | 2017-02-02 |
EP2797913A1 (en) | 2014-11-05 |
ES2601461T3 (es) | 2017-02-15 |
BR112014016007A2 (pt) | 2017-06-13 |
US9382261B2 (en) | 2016-07-05 |
JP6199891B2 (ja) | 2017-09-20 |
US20140378485A1 (en) | 2014-12-25 |
CN104169271A (zh) | 2014-11-26 |
CA2858646A1 (en) | 2013-07-04 |
WO2013098320A1 (en) | 2013-07-04 |
RU2014131017A (ru) | 2016-02-20 |
CN104169271B (zh) | 2017-04-05 |
EP2797913B1 (en) | 2016-08-17 |
AU2012360910A8 (en) | 2017-02-02 |
JP2018012699A (ja) | 2018-01-25 |
JP2015503537A (ja) | 2015-02-02 |
AU2012360910A1 (en) | 2014-06-26 |
MX348127B (es) | 2017-05-26 |
MX2014008042A (es) | 2014-08-21 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B25A | Requested transfer of rights approved |
Owner name: JANSSEN SCIENCES IRELAND UC (IE) |
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B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B08F | Application fees: application dismissed [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 7A ANUIDADE. |
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B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2546 DE 22-10-2019 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |
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B350 | Update of information on the portal [chapter 15.35 patent gazette] |