BR112015028538A2 - derivados de sulfamoiltiofenamida e o uso dos mesmos como medicamentos para o tratamento da hepatite b - Google Patents
derivados de sulfamoiltiofenamida e o uso dos mesmos como medicamentos para o tratamento da hepatite bInfo
- Publication number
- BR112015028538A2 BR112015028538A2 BR112015028538A BR112015028538A BR112015028538A2 BR 112015028538 A2 BR112015028538 A2 BR 112015028538A2 BR 112015028538 A BR112015028538 A BR 112015028538A BR 112015028538 A BR112015028538 A BR 112015028538A BR 112015028538 A2 BR112015028538 A2 BR 112015028538A2
- Authority
- BR
- Brazil
- Prior art keywords
- sulfamoylthiophenamide
- hepatitis
- derivatives
- treatment
- medicines
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
resumo patente de invenção: "derivados de sulfamoiltiofenamida e o uso dos mesmos como medicamentos para o tratamento da hepatite b". a presente invenção refere-se a inibidores da replicação do hbv da fórmula (i) incluindo formas estereoquimicamente isoméricas, e sais, hidratos, solvatos dos mesmos, em que x e r1 a r8 têm o significado como definido aqui. a presente invenção se relaciona também a processos para preparação dos ditos compostos, composições farmacêuticas contendo os mesmos e seu uso, sozinhos ou em combinação com outros inibidores do hbv, em terapia contra o hbv.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13168295 | 2013-05-17 | ||
| EP13185227 | 2013-09-19 | ||
| EP14157917 | 2014-03-05 | ||
| PCT/EP2014/060132 WO2014184365A1 (en) | 2013-05-17 | 2014-05-16 | Sulphamoylthiophenamide derivatives and the use thereof as medicaments for the treatment of hepatitis b |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112015028538A2 true BR112015028538A2 (pt) | 2017-07-25 |
Family
ID=50729521
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112015028538A BR112015028538A2 (pt) | 2013-05-17 | 2014-05-16 | derivados de sulfamoiltiofenamida e o uso dos mesmos como medicamentos para o tratamento da hepatite b |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US10160743B2 (pt) |
| EP (1) | EP2997019B1 (pt) |
| JP (1) | JP6441315B2 (pt) |
| CN (1) | CN105960400B (pt) |
| AU (1) | AU2014267235B2 (pt) |
| BR (1) | BR112015028538A2 (pt) |
| CA (1) | CA2909742C (pt) |
| CY (1) | CY1122337T1 (pt) |
| DK (1) | DK2997019T3 (pt) |
| EA (1) | EA035500B1 (pt) |
| ES (1) | ES2695182T3 (pt) |
| HK (1) | HK1225387A1 (pt) |
| HR (1) | HRP20181863T1 (pt) |
| HU (1) | HUE040446T2 (pt) |
| IL (1) | IL242141B (pt) |
| LT (1) | LT2997019T (pt) |
| MX (1) | MX366787B (pt) |
| PL (1) | PL2997019T3 (pt) |
| PT (1) | PT2997019T (pt) |
| RS (1) | RS57999B1 (pt) |
| SI (1) | SI2997019T1 (pt) |
| WO (1) | WO2014184365A1 (pt) |
Families Citing this family (116)
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| EA027068B1 (ru) | 2013-04-03 | 2017-06-30 | Янссен Сайенсиз Айрлэнд Юси | Производные n-фенилкарбоксамида и их применение в качестве лекарственных препаратов для лечения гепатита b |
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2014
- 2014-05-16 WO PCT/EP2014/060132 patent/WO2014184365A1/en active Application Filing
- 2014-05-16 EP EP14724109.5A patent/EP2997019B1/en active Active
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- 2014-05-16 HU HUE14724109A patent/HUE040446T2/hu unknown
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- 2014-05-16 PT PT14724109T patent/PT2997019T/pt unknown
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- 2014-05-16 BR BR112015028538A patent/BR112015028538A2/pt not_active Application Discontinuation
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- 2014-05-16 AU AU2014267235A patent/AU2014267235B2/en not_active Ceased
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2015
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2016
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- 2018-11-08 CY CY20181101182T patent/CY1122337T1/el unknown
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| AU2014267235B2 (en) | 2017-10-05 |
| US20160115149A1 (en) | 2016-04-28 |
| EP2997019A1 (en) | 2016-03-23 |
| EA035500B1 (ru) | 2020-06-25 |
| LT2997019T (lt) | 2018-11-26 |
| IL242141B (en) | 2019-09-26 |
| ES2695182T3 (es) | 2019-01-02 |
| CN105960400A (zh) | 2016-09-21 |
| CN105960400B (zh) | 2019-05-31 |
| JP6441315B2 (ja) | 2018-12-19 |
| EA201592198A1 (ru) | 2016-03-31 |
| AU2014267235A8 (en) | 2015-12-10 |
| DK2997019T3 (en) | 2018-12-03 |
| RS57999B1 (sr) | 2019-01-31 |
| WO2014184365A1 (en) | 2014-11-20 |
| EP2997019B1 (en) | 2018-08-08 |
| MX2015015771A (es) | 2016-03-15 |
| CY1122337T1 (el) | 2020-07-31 |
| AU2014267235A1 (en) | 2015-11-12 |
| HRP20181863T1 (hr) | 2018-12-28 |
| SI2997019T1 (sl) | 2018-12-31 |
| HUE040446T2 (hu) | 2019-03-28 |
| PT2997019T (pt) | 2018-11-21 |
| CA2909742A1 (en) | 2014-11-20 |
| JP2016518437A (ja) | 2016-06-23 |
| HK1225387A1 (zh) | 2017-09-08 |
| MX366787B (es) | 2019-07-23 |
| CA2909742C (en) | 2020-08-04 |
| US10160743B2 (en) | 2018-12-25 |
| PL2997019T3 (pl) | 2019-03-29 |
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