SG11202111493WA - Novel oxalyl piperazines active against the hepatitis b virus (hbv) - Google Patents
Novel oxalyl piperazines active against the hepatitis b virus (hbv)Info
- Publication number
- SG11202111493WA SG11202111493WA SG11202111493WA SG11202111493WA SG11202111493WA SG 11202111493W A SG11202111493W A SG 11202111493WA SG 11202111493W A SG11202111493W A SG 11202111493WA SG 11202111493W A SG11202111493W A SG 11202111493WA SG 11202111493W A SG11202111493W A SG 11202111493WA
- Authority
- SG
- Singapore
- Prior art keywords
- piperazines
- hbv
- oxalyl
- hepatitis
- virus
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP19172008 | 2019-04-30 | ||
EP19172402 | 2019-05-02 | ||
PCT/EP2020/061920 WO2020221811A1 (en) | 2019-04-30 | 2020-04-29 | Novel oxalyl piperazines active against the hepatitis b virus (hbv) |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11202111493WA true SG11202111493WA (en) | 2021-11-29 |
Family
ID=70456795
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11202111493WA SG11202111493WA (en) | 2019-04-30 | 2020-04-29 | Novel oxalyl piperazines active against the hepatitis b virus (hbv) |
Country Status (16)
Country | Link |
---|---|
US (1) | US20220227737A1 (en) |
EP (1) | EP3962909B1 (en) |
JP (1) | JP2022533008A (en) |
KR (1) | KR20220003023A (en) |
CN (1) | CN113748111A (en) |
AU (1) | AU2020266258A1 (en) |
CA (1) | CA3138380A1 (en) |
CL (1) | CL2021002798A1 (en) |
CU (1) | CU20210090A7 (en) |
EC (1) | ECSP21080338A (en) |
IL (1) | IL287269A (en) |
MX (1) | MX2021013105A (en) |
SG (1) | SG11202111493WA (en) |
TW (1) | TWI753418B (en) |
UY (1) | UY38684A (en) |
WO (1) | WO2020221811A1 (en) |
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AU4289100A (en) | 1999-03-25 | 2000-10-16 | Bayer Aktiengesellschaft | Dihydropyrimidines and their use in the treatment of hepatitis |
ATE354942T1 (en) | 1999-04-23 | 2006-03-15 | Extenday Ip Ltd | FOIL FIXING AND ANCHORING PART |
AU3009801A (en) | 1999-12-22 | 2001-07-03 | Bayer Aktiengesellschaft | Combinations of medicaments for treating viral diseases |
WO2006033995A2 (en) | 2004-09-16 | 2006-03-30 | Valeant Research And Development | Thiazolidin-4-ones having anti-hepatitis b activity |
EP2222675B1 (en) * | 2007-12-19 | 2013-09-11 | Genentech, Inc. | 5-anilinoimidazopyridines and methods of use |
JP5977347B2 (en) | 2011-07-01 | 2016-08-24 | バルーク エス.ブルームバーグ インスティテュート | Sulfamoylbenzamide derivatives as antiviral agents against HBV infection |
TWI519515B (en) | 2011-12-21 | 2016-02-01 | 諾維拉治療公司 | Hepatitis b antiviral agents |
US9233933B2 (en) | 2012-01-06 | 2016-01-12 | Janssen Sciences Ireland Uc | 4,4-disubstituted-1,4-dihydropyrimidines and the use thereof as medicaments for the treatment of hepatitis B |
CA2881057C (en) | 2012-08-28 | 2020-10-27 | Janssen Sciences Ireland Uc | Sulfamoyl-arylamides and the use thereof as medicaments for the treatment of hepatitis b |
CA2881045C (en) | 2012-08-28 | 2020-10-13 | Janssen Sciences Ireland Uc | Fused bicyclic sulfamoyl derivatives and the use thereof as medicaments for the treatment of hepatitis b. |
US8993771B2 (en) | 2013-03-12 | 2015-03-31 | Novira Therapeutics, Inc. | Hepatitis B antiviral agents |
AU2014267198A1 (en) | 2013-05-17 | 2015-11-05 | F. Hoffmann-La Roche Ag | 6-bridged heteroaryldihydropyrimidines for the treatment and prophylaxis of Hepatitis B virus infection |
HUE040446T2 (en) | 2013-05-17 | 2019-03-28 | Janssen Sciences Ireland Uc | Sulphamoylthiophenamide derivatives and the use thereof as medicaments for the treatment of hepatitis b |
LT3024819T (en) | 2013-07-25 | 2018-06-11 | Janssen Sciences Ireland Uc | Glyoxamide substituted pyrrolamide derivatives and the use thereof as medicaments for the treatment of hepatitis b |
US10220034B2 (en) | 2013-10-18 | 2019-03-05 | Indiana University Research And Technology Corporation | Hepatitis B viral assembly effectors |
ES2777248T3 (en) | 2013-11-14 | 2020-08-04 | Novira Therapeutics Inc | Azepane derivatives and methods of treating hepatitis B infections |
US9169212B2 (en) | 2014-01-16 | 2015-10-27 | Novira Therapeutics, Inc. | Azepane derivatives and methods of treating hepatitis B infections |
BR112016020566B1 (en) | 2014-03-07 | 2022-11-29 | F. Hoffmann-La Roche Ag | NOVEL HETEROARYL-DIHYDRO-PYRIMIDINES FUSED IN POSITION 6 FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION |
DK3116316T3 (en) | 2014-03-13 | 2019-08-19 | Univ Indiana Res & Tech Corp | ALLOSTERIC MODULATORS OF HEPATITIS B CORE PROTEIN |
US9771358B2 (en) | 2014-03-28 | 2017-09-26 | Sunshine Lake Pharma Co., Ltd. | Dihydropyrimidine compounds and their application in pharmaceuticals |
AU2015255656A1 (en) | 2014-05-09 | 2016-11-10 | Assembly Biosciences, Inc. | Methods and compositions for treating hepatitis B virus infections |
EP3180319B1 (en) | 2014-08-14 | 2018-10-03 | F.Hoffmann-La Roche Ag | Novel pyridazones and triazinones for the treatment and prophylaxis of hepatitis b virus infection |
JP2018504373A (en) | 2014-12-02 | 2018-02-15 | ノヴィラ・セラピューティクス・インコーポレイテッド | Sulfide alkyl and pyridyl reverse sulfonamide compounds for the treatment of HBV |
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-
2020
- 2020-04-29 KR KR1020217038550A patent/KR20220003023A/en unknown
- 2020-04-29 WO PCT/EP2020/061920 patent/WO2020221811A1/en unknown
- 2020-04-29 CA CA3138380A patent/CA3138380A1/en active Pending
- 2020-04-29 CN CN202080032036.1A patent/CN113748111A/en active Pending
- 2020-04-29 EP EP20721247.3A patent/EP3962909B1/en active Active
- 2020-04-29 JP JP2021564290A patent/JP2022533008A/en active Pending
- 2020-04-29 MX MX2021013105A patent/MX2021013105A/en unknown
- 2020-04-29 CU CU2021000090A patent/CU20210090A7/en unknown
- 2020-04-29 AU AU2020266258A patent/AU2020266258A1/en not_active Abandoned
- 2020-04-29 SG SG11202111493WA patent/SG11202111493WA/en unknown
- 2020-04-29 US US17/607,430 patent/US20220227737A1/en active Pending
- 2020-04-30 TW TW109114651A patent/TWI753418B/en active
- 2020-05-04 UY UY0001038684A patent/UY38684A/en unknown
-
2021
- 2021-10-14 IL IL287269A patent/IL287269A/en unknown
- 2021-10-25 CL CL2021002798A patent/CL2021002798A1/en unknown
- 2021-11-12 EC ECSENADI202180338A patent/ECSP21080338A/en unknown
Also Published As
Publication number | Publication date |
---|---|
CA3138380A1 (en) | 2020-11-05 |
AU2020266258A2 (en) | 2022-05-05 |
TWI753418B (en) | 2022-01-21 |
JP2022533008A (en) | 2022-07-21 |
UY38684A (en) | 2020-11-30 |
IL287269A (en) | 2021-12-01 |
ECSP21080338A (en) | 2021-12-30 |
CU20210090A7 (en) | 2022-06-06 |
TW202106678A (en) | 2021-02-16 |
EP3962909A1 (en) | 2022-03-09 |
WO2020221811A1 (en) | 2020-11-05 |
KR20220003023A (en) | 2022-01-07 |
US20220227737A1 (en) | 2022-07-21 |
CN113748111A (en) | 2021-12-03 |
MX2021013105A (en) | 2021-11-17 |
EP3962909B1 (en) | 2023-10-04 |
AU2020266258A1 (en) | 2021-12-23 |
CL2021002798A1 (en) | 2022-06-10 |
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