CU20080028A6 - Compuestos químicos obtenidos in silico para la preparación de composiciones farmacéuticas para atenuar o inhibir la infección por virus dengue y otros flavivirus - Google Patents
Compuestos químicos obtenidos in silico para la preparación de composiciones farmacéuticas para atenuar o inhibir la infección por virus dengue y otros flavivirusInfo
- Publication number
- CU20080028A6 CU20080028A6 CU20080028A CU20080028A CU20080028A6 CU 20080028 A6 CU20080028 A6 CU 20080028A6 CU 20080028 A CU20080028 A CU 20080028A CU 20080028 A CU20080028 A CU 20080028A CU 20080028 A6 CU20080028 A6 CU 20080028A6
- Authority
- CU
- Cuba
- Prior art keywords
- silico
- preparation
- pharmaceutical compositions
- compounds obtained
- chemical compounds
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/18—Sulfonamides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/428—Thiazoles condensed with carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Furan Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Peptides Or Proteins (AREA)
Abstract
Compuestos químicos obtenidos in silico que contienen dos subestructuras funcionalmente distintivas de acuerdo a la fórmula [C]-[A] donde [A] es definida como ancla y corresponde a una subestructura química capaz de unirse a la proteína E del Virus Dengue; y [C] definida como cabeza, se corresponde a una subestructura química unida covalentemente a la subestructura [A], donde dicha subestructura aporta o favorece la capacidad de las moléculas de la presente invención de inhibir la infección por virus Dengue afectando, o modulando una o más de las interacciones intermoleculares que involucran a la proteína E, para la preparación de composiciones farmacéuticas.
Priority Applications (11)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CU20080028A CU20080028A6 (es) | 2008-02-29 | 2008-02-29 | Compuestos químicos obtenidos in silico para la preparación de composiciones farmacéuticas para atenuar o inhibir la infección por virus dengue y otros flavivirus |
US12/919,416 US8722742B2 (en) | 2008-02-29 | 2009-02-27 | Chemical compounds having antiviral activity against Dengue virus and other Flaviviruses |
CN200980113787XA CN102006865B (zh) | 2008-02-29 | 2009-02-27 | 化学化合物在制备用于减弱或抑制黄病毒属病毒感染的药物组合物中的用途 |
JP2010547941A JP5400067B2 (ja) | 2008-02-29 | 2009-02-27 | デングウイルス及びその他のフラビウイルスに対して抗ウイルス活性を有する化合物 |
ES09714439.8T ES2647506T3 (es) | 2008-02-29 | 2009-02-27 | Compuestos químicos que tienen actividad antiviral contra el virus dengue y otros flavivirus |
BRPI0908489-4A BRPI0908489A2 (pt) | 2008-02-29 | 2009-02-27 | uso de compostos químicos e método para desenhar compostos químicos que atenuam ou inibem a infecção pelo vírus da dengue |
MX2010009563A MX2010009563A (es) | 2008-02-29 | 2009-02-27 | Compuestos quimicos con accion antiviral contra virus de dengue y otros flavivirus. |
AU2009218960A AU2009218960B2 (en) | 2008-02-29 | 2009-02-27 | Chemical compounds having antiviral activity against dengue virus and other flaviviruses |
CA2716971A CA2716971C (en) | 2008-02-29 | 2009-02-27 | Chemical compounds having antiviral activity against dengue virus and other flaviviruses |
EP09714439.8A EP2258356B1 (en) | 2008-02-29 | 2009-02-27 | Chemical compounds having antiviral activity against dengue virus and other flaviviruses |
PCT/CU2009/000002 WO2009106019A2 (es) | 2008-02-29 | 2009-02-27 | Compuestos quimicos con accion antiviral contra virus dengue y otros flavivirus |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CU20080028A CU20080028A6 (es) | 2008-02-29 | 2008-02-29 | Compuestos químicos obtenidos in silico para la preparación de composiciones farmacéuticas para atenuar o inhibir la infección por virus dengue y otros flavivirus |
Publications (1)
Publication Number | Publication Date |
---|---|
CU20080028A6 true CU20080028A6 (es) | 2011-02-24 |
Family
ID=40972816
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CU20080028A CU20080028A6 (es) | 2008-02-29 | 2008-02-29 | Compuestos químicos obtenidos in silico para la preparación de composiciones farmacéuticas para atenuar o inhibir la infección por virus dengue y otros flavivirus |
Country Status (11)
Country | Link |
---|---|
US (1) | US8722742B2 (es) |
EP (1) | EP2258356B1 (es) |
JP (1) | JP5400067B2 (es) |
CN (1) | CN102006865B (es) |
AU (1) | AU2009218960B2 (es) |
BR (1) | BRPI0908489A2 (es) |
CA (1) | CA2716971C (es) |
CU (1) | CU20080028A6 (es) |
ES (1) | ES2647506T3 (es) |
MX (1) | MX2010009563A (es) |
WO (1) | WO2009106019A2 (es) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2010528051A (ja) | 2007-05-23 | 2010-08-19 | シガ・テクノロジーズ・インコーポレーテッド | デング感染症の治療または予防のための抗ウイルス薬 |
CN102731394A (zh) * | 2011-04-12 | 2012-10-17 | 中国科学院上海药物研究所 | 取代的喹啉-2-甲醛-苯腙类化合物及其制备方法和用途 |
WO2013096744A1 (en) | 2011-12-21 | 2013-06-27 | Novira Therapeutics, Inc. | Hepatitis b antiviral agents |
CN103183631B (zh) * | 2011-12-28 | 2016-08-24 | 天津市国际生物医药联合研究院 | 靛红-5-磺酰胺类衍生物及其在制备治疗非典型性肺炎的药物中的应用 |
WO2013192165A2 (en) | 2012-06-20 | 2013-12-27 | University Of Kansas | Compounds and methods for activating the apoptotic arm of the unfolded protein response |
DK2888010T3 (da) | 2012-08-22 | 2021-06-28 | Univ Cornell | Fremgangsmåder til at hæmme fascin |
JP2015533782A (ja) * | 2012-08-28 | 2015-11-26 | ヤンセン・サイエンシズ・アイルランド・ユーシー | スルファモイル−アリールアミド及びb型肝炎の治療のための薬剤としてのその使用 |
CU24188B1 (es) * | 2012-12-27 | 2016-07-29 | Ct De Ingeniería Genética Y Biotecnología | Composición vacunal contra el virus dengue |
HUE034820T2 (en) | 2013-02-28 | 2018-02-28 | Janssen Sciences Ireland Uc | Sulphamoyl arylamides and their use as medicaments for the treatment of hepatitis B |
HUE033542T2 (en) | 2013-04-03 | 2017-12-28 | Janssen Sciences Ireland Uc | Their use as medicaments for the treatment of N-phenylcarboxamide derivatives and hepatitis B |
JO3603B1 (ar) | 2013-05-17 | 2020-07-05 | Janssen Sciences Ireland Uc | مشتقات سلفامويل بيرولاميد واستخدامها كادوية لمعالجة التهاب الكبد نوع بي |
PT2997019T (pt) | 2013-05-17 | 2018-11-21 | Janssen Sciences Ireland Uc | Derivados de sulfamoíltiofenamida e o seu uso como medicamentos para o tratamento da hepatite b |
PL3024819T3 (pl) | 2013-07-25 | 2018-08-31 | Janssen Sciences Ireland Uc | Pochodne piroloamidowe podstawione glioksamidem i ich zastosowanie jako leków do leczenia wirusowego zapalenia wątroby typu B |
ES2655518T3 (es) | 2013-10-23 | 2018-02-20 | Janssen Sciences Ireland Uc | Derivados de carboxamida y su uso como medicamentos para el tratamiento de la hepatitis B |
US10392349B2 (en) | 2014-01-16 | 2019-08-27 | Novira Therapeutics, Inc. | Azepane derivatives and methods of treating hepatitis B infections |
ES2792848T3 (es) | 2014-02-05 | 2020-11-12 | Novira Therapeutics Inc | Politerapia para el tratamiento de infecciones por VHB |
EA035848B1 (ru) | 2014-02-06 | 2020-08-20 | Янссен Сайенсиз Айрлэнд Юси | Производные сульфамоилпирроламида и их применение в качестве медикаментов для лечения гепатита b |
JP6691869B2 (ja) | 2014-02-20 | 2020-05-13 | コーネル ユニヴァーシティー | ファシンを阻害するための化合物及び方法 |
CU20140026A7 (es) * | 2014-03-03 | 2015-11-27 | Ct De Ingeniería Genética Y Biotecnología Biocubafarma | Péptidos horquilla beta con propiedades antivirales contra el virus dengue |
RU2016149804A (ru) * | 2014-05-23 | 2018-06-26 | Ф. Хоффманн-Ля Рош Аг | Производные бензолсульфонамида и их применение в качестве модуляторов орфанного рецептора y, связанного с ретиноевой кислотой |
US10487120B2 (en) * | 2015-02-09 | 2019-11-26 | Academia Sinica | Epitope-substituted vaccine for use in improving safety and immunogenicity against dengue viruses |
US10875876B2 (en) | 2015-07-02 | 2020-12-29 | Janssen Sciences Ireland Uc | Cyclized sulfamoylarylamide derivatives and the use thereof as medicaments for the treatment of hepatitis B |
EP3848026A1 (en) | 2016-04-15 | 2021-07-14 | Novira Therapeutics Inc. | Combinations and methods comprising a capsid assembly inhibitor |
PT3518948T (pt) * | 2016-10-03 | 2023-07-17 | Ottawa Hospital Res Inst | Composições e métodos para melhorar o crescimento, a propagração e a eficácia imunoterapêutica de oncolítica de vírus de rna oncolíticos |
CN109384727B (zh) * | 2017-08-10 | 2023-07-28 | 中国科学院上海药物研究所 | 酞嗪酮类化合物、其制备方法、药物组合物及用途 |
CN108299280A (zh) * | 2018-01-19 | 2018-07-20 | 天津国际生物医药联合研究院 | 对混合谱系白血病关键蛋白具有抑制作用的靛红-5-磺酰胺类抑制剂 |
EA202092171A1 (ru) | 2018-03-14 | 2020-12-01 | Янссен Сайенсиз Айрлэнд Анлимитед Компани | Схема дозирования модулятора сборки капсида |
JP7357934B2 (ja) | 2018-04-12 | 2023-10-10 | パーデュー・リサーチ・ファウンデーション | ベンズアミド抗菌剤 |
CN113454077A (zh) | 2019-02-22 | 2021-09-28 | 爱尔兰詹森科学公司 | 用于治疗hbv感染或hbv诱发的疾病的酰胺衍生物 |
KR20220005549A (ko) | 2019-05-06 | 2022-01-13 | 얀센 사이언시즈 아일랜드 언리미티드 컴퍼니 | Hbv 감염 또는 hbv-유도성 질환의 치료에 유용한 아미드 유도체 |
CN111346079B (zh) * | 2020-02-24 | 2023-06-20 | 南方医科大学 | 细菌dna促旋酶抑制剂brd7716作为治疗和/或预防登革病毒感染的药物及其制药用途 |
WO2023158708A1 (en) * | 2022-02-16 | 2023-08-24 | Denali Therapeutics Inc. | Compounds, compositions, and methods |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CU22683A1 (es) * | 1997-01-15 | 2001-07-20 | Inst De Medicina Tropical Pedro Kouri | Epítopes de la proteína pre-m/m del virus del dengue, péptidos sintéticos, proteínas quiméricas y sus usos |
CU23245A1 (es) * | 2001-07-16 | 2007-10-17 | Inst De Medicina Tropical Pedr | CADENAS QUIMéRICAS CODIFICANTES PARA PROTEINAS INDUCTORAS DE EFECTOS CONTRA VIRUS. PREPARADOS UTILIZANDO PROTEINAS QUIMéRICAS |
WO2005002501A2 (en) * | 2003-04-22 | 2005-01-13 | Children's Medical Center Corporation | Novel druggable regions in the dengue virus envelope glycoprotein and methods of using the same |
CU23586A1 (es) | 2005-11-22 | 2010-10-30 | Ct Ingenieria Genetica Biotech | Métodos y proteínas para el tratamiento profiláctico y/o terapéutico de los cuatro serotipos del virus de dengue y otros flavivirus |
CU23632A1 (es) | 2006-04-28 | 2011-02-24 | Ct Ingenieria Genetica Biotech | Métodos para la identificación de candidatos terapéuticos contra enfermedades causadas por flavivirus y moléculas antivirales. |
EP2200428A4 (en) | 2007-09-07 | 2013-06-05 | Mevlabs Inc | FORMULATIONS AND DEVICES FOR THE ADMINISTRATION OF ARTHROPOD COMPOUNDS AND MICROORGANISMS WITHIN ARTHROPODS |
-
2008
- 2008-02-29 CU CU20080028A patent/CU20080028A6/es unknown
-
2009
- 2009-02-27 BR BRPI0908489-4A patent/BRPI0908489A2/pt not_active IP Right Cessation
- 2009-02-27 CN CN200980113787XA patent/CN102006865B/zh not_active Expired - Fee Related
- 2009-02-27 JP JP2010547941A patent/JP5400067B2/ja not_active Expired - Fee Related
- 2009-02-27 EP EP09714439.8A patent/EP2258356B1/en active Active
- 2009-02-27 WO PCT/CU2009/000002 patent/WO2009106019A2/es active Application Filing
- 2009-02-27 MX MX2010009563A patent/MX2010009563A/es active IP Right Grant
- 2009-02-27 ES ES09714439.8T patent/ES2647506T3/es active Active
- 2009-02-27 CA CA2716971A patent/CA2716971C/en not_active Expired - Fee Related
- 2009-02-27 US US12/919,416 patent/US8722742B2/en not_active Expired - Fee Related
- 2009-02-27 AU AU2009218960A patent/AU2009218960B2/en not_active Ceased
Also Published As
Publication number | Publication date |
---|---|
CN102006865A (zh) | 2011-04-06 |
AU2009218960B2 (en) | 2013-06-27 |
CA2716971C (en) | 2016-05-10 |
ES2647506T3 (es) | 2017-12-21 |
JP2011513250A (ja) | 2011-04-28 |
WO2009106019A2 (es) | 2009-09-03 |
CA2716971A1 (en) | 2009-09-03 |
EP2258356A2 (en) | 2010-12-08 |
EP2258356B1 (en) | 2017-09-27 |
AU2009218960A1 (en) | 2009-09-03 |
US20110065686A1 (en) | 2011-03-17 |
JP5400067B2 (ja) | 2014-01-29 |
BRPI0908489A2 (pt) | 2018-03-27 |
MX2010009563A (es) | 2010-09-24 |
CN102006865B (zh) | 2013-04-24 |
WO2009106019A3 (es) | 2010-01-28 |
US8722742B2 (en) | 2014-05-13 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CU20080028A6 (es) | Compuestos químicos obtenidos in silico para la preparación de composiciones farmacéuticas para atenuar o inhibir la infección por virus dengue y otros flavivirus | |
AR084237A1 (es) | Metodos para tratar virus de hepatitis c (hcv), composicion | |
CY1122291T1 (el) | Αναστολeις ιικου αναδιπλασιασμου | |
BRPI0919447B8 (pt) | compostos derivados de ácido 1-amino-2- ciclobutiletilborônico, composição farmacêutica e uso dos mesmos para tratar câncer | |
BRPI0916286B8 (pt) | amidofenóxi-indazóis úteis como inibidores de c-met, seus usos, e composição farmacêutica | |
BR112014006324B8 (pt) | composição e seu uso para o tratamento de hcv | |
CY1119056T1 (el) | Παραγωγα 2',4',-διφθορο-2'-μεθυλ υποκατεστημενου νουκλεοσιδιου ως αναστολεις αντιγραφης hcv rna | |
CY1112999T1 (el) | Αναστολεις ιου ηπατιτιδας c | |
BR112012011100A2 (pt) | compostos inibidores do vírus da hepatite, composição e uso dos mesmos | |
CO6561788A2 (es) | Inhibidores del virus de la hepatitis c | |
BR112013020042A2 (pt) | inibidores de vírus da hepatite c | |
MA32257B1 (fr) | Hydroxymethyl pyrrolidines comme agonistes des recepteurs beta-3- adrenergiques. | |
BR112012004696B8 (pt) | composto modulador da atividade de tlr, seu uso, composição farmacêutica, medicamento, kit e combinação | |
UY33445A (es) | Un régimen de dosificación, métodos para tratar el virus de la hepatitis c, composición farmacéutica, compuesta, compuestos anti-hcv y kit | |
EA201692506A3 (ru) | Ингибиторы репликации вирусов гриппа | |
EA201290089A1 (ru) | Химические соединения | |
UY31952A (es) | 5-metilideno-1,3-tiazolidina-2,4-dionas sustituidas como inhibidores de quinasa pim | |
MX2010009738A (es) | Compuestos y composiciones como moduladores de la actividad de tlr. | |
EA201001275A1 (ru) | Конформационно-ограниченные бифенильные производные для применения в качестве ингибиторов вируса гепатита с | |
BRPI0814252B8 (pt) | composição farmacêutica aquosa estável compreendendo natalizumabe, dose unitária, e seringa pré-cheia | |
BRPI1009637A2 (pt) | composto, composição e uso de um composto | |
EA200870216A1 (ru) | Амидо соединения и их применение в качестве лекарственных средств | |
BRPI0908421B8 (pt) | solução estável de um composto farmacêutico | |
BRPI0920655A2 (pt) | conjugados e hpma-docetaxel ou gencitabina e usos dos mesmos | |
EA201001205A1 (ru) | Соединения, содержащие циклобутоксигруппу |