CU20140026A7 - Péptidos horquilla beta con propiedades antivirales contra el virus dengue - Google Patents
Péptidos horquilla beta con propiedades antivirales contra el virus dengueInfo
- Publication number
- CU20140026A7 CU20140026A7 CUP2014000026A CU20140026A CU20140026A7 CU 20140026 A7 CU20140026 A7 CU 20140026A7 CU P2014000026 A CUP2014000026 A CU P2014000026A CU 20140026 A CU20140026 A CU 20140026A CU 20140026 A7 CU20140026 A7 CU 20140026A7
- Authority
- CU
- Cuba
- Prior art keywords
- peptides
- properties against
- antiviral properties
- against virus
- virus dengue
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/10—Peptides having 12 to 20 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
- A61K47/6927—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores
- A61K47/6929—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
- C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24111—Flavivirus, e.g. yellow fever virus, dengue, JEV
- C12N2770/24122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24111—Flavivirus, e.g. yellow fever virus, dengue, JEV
- C12N2770/24133—Use of viral protein as therapeutic agent other than vaccine, e.g. apoptosis inducing or anti-inflammatory
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
La presente invención está relacionada con péptidos sintéticos, estructuralmente constreñidos, que han sido optimizados para la formación de estructura horquilla beta. Dichos péptidos son capaces de inhibir o atenuar la infección por el virus Dengue (DENV). La invención incluye también composiciones farmacéuticas que contienen estos péptidos sintéticos, las que son útiles para la prevención y/o el tratamiento de las infecciones causadas por DENV. De igual forma, la invención provee un método de tratamiento de las infecciones causadas por este virus.
Priority Applications (15)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CUP2014000026A CU20140026A7 (es) | 2014-03-03 | 2014-03-03 | Péptidos horquilla beta con propiedades antivirales contra el virus dengue |
ARP150100549A AR099563A1 (es) | 2014-03-03 | 2015-02-24 | PÉPTIDOS HORQUILLA b CON PROPIEDADES ANTIVIRALES CONTRA EL VIRUS DENGUE |
EP15718758.4A EP3115056B1 (en) | 2014-03-03 | 2015-02-26 | Beta-hairpin peptides having anti-viral properties against the dengue virus |
CA2940078A CA2940078C (en) | 2014-03-03 | 2015-02-26 | Beta hairpin peptides having anti-viral properties against the dengue virus |
JP2016555504A JP6854644B2 (ja) | 2014-03-03 | 2015-02-26 | デングウイルスに対する抗ウイルス特性を有するベータヘアピンペプチド |
US15/119,058 US9896482B2 (en) | 2014-03-03 | 2015-02-26 | Beta hairpin peptides having antiviral properties against Dengue virus |
PCT/CU2015/000002 WO2015131858A2 (es) | 2014-03-03 | 2015-02-26 | Péptidos horquilla beta con propiedades antivirales contra el virus dengue |
MYPI2016703158A MY181033A (en) | 2014-03-03 | 2015-02-26 | Beta hairpin peptides having antiviral properties against dengue virus |
BR112016019672-4A BR112016019672B1 (pt) | 2014-03-03 | 2015-02-26 | Peptídeos de grampo beta com propriedades antivirais contra o vírus da dengue, composição farmacêutica e seus usos |
AU2015226580A AU2015226580B2 (en) | 2014-03-03 | 2015-02-26 | Beta-hairpin peptides having anti-viral properties against the dengue virus |
MX2016011420A MX363745B (es) | 2014-03-03 | 2015-02-26 | Peptidos horquilla beta con propiedades antivirales contra el virus dengue. |
CN201580011814.8A CN106132981B (zh) | 2014-03-03 | 2015-02-26 | 具有针对登革病毒的抗病毒特性的β-发夹肽 |
KR1020167026665A KR102325400B1 (ko) | 2014-03-03 | 2015-02-26 | 뎅기열 바이러스에 대한 항바이러스 속성을 가진 베타 헤어핀 펩타이드 |
ES15718758T ES2733648T3 (es) | 2014-03-03 | 2015-02-26 | Péptidos de horquilla beta que tienen propiedades antivirales contra el virus del Dengue |
PH12016501715A PH12016501715A1 (en) | 2014-03-03 | 2016-08-31 | Beta hairpin peptides having antiviral properties against dengue virus |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CUP2014000026A CU20140026A7 (es) | 2014-03-03 | 2014-03-03 | Péptidos horquilla beta con propiedades antivirales contra el virus dengue |
Publications (1)
Publication Number | Publication Date |
---|---|
CU20140026A7 true CU20140026A7 (es) | 2015-11-27 |
Family
ID=53008223
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CUP2014000026A CU20140026A7 (es) | 2014-03-03 | 2014-03-03 | Péptidos horquilla beta con propiedades antivirales contra el virus dengue |
Country Status (14)
Country | Link |
---|---|
US (1) | US9896482B2 (es) |
EP (1) | EP3115056B1 (es) |
JP (1) | JP6854644B2 (es) |
KR (1) | KR102325400B1 (es) |
CN (1) | CN106132981B (es) |
AR (1) | AR099563A1 (es) |
AU (1) | AU2015226580B2 (es) |
CA (1) | CA2940078C (es) |
CU (1) | CU20140026A7 (es) |
ES (1) | ES2733648T3 (es) |
MX (1) | MX363745B (es) |
MY (1) | MY181033A (es) |
PH (1) | PH12016501715A1 (es) |
WO (1) | WO2015131858A2 (es) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3448415A4 (en) | 2016-04-29 | 2019-11-06 | Araim Pharmaceuticals, Inc. | TISSUE PROTECTIVE PEPTIDES FOR PREVENTING AND TREATING DISEASES AND DISORDERS ASSOCIATED WITH TISSUE INJURY |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CU23586A1 (es) * | 2005-11-22 | 2010-10-30 | Ct Ingenieria Genetica Biotech | Métodos y proteínas para el tratamiento profiláctico y/o terapéutico de los cuatro serotipos del virus de dengue y otros flavivirus |
CU23632A1 (es) * | 2006-04-28 | 2011-02-24 | Ct Ingenieria Genetica Biotech | Métodos para la identificación de candidatos terapéuticos contra enfermedades causadas por flavivirus y moléculas antivirales. |
CU23630A1 (es) * | 2006-10-30 | 2011-02-24 | Ct Ingenieria Genetica Biotech | Moléculas peptídicas quiméricas con propiedades antivirales contra los virus de la familia flaviviridae |
CU20080028A6 (es) * | 2008-02-29 | 2011-02-24 | Ct Ingenieria Genetica Biotech | Compuestos químicos obtenidos in silico para la preparación de composiciones farmacéuticas para atenuar o inhibir la infección por virus dengue y otros flavivirus |
-
2014
- 2014-03-03 CU CUP2014000026A patent/CU20140026A7/es unknown
-
2015
- 2015-02-24 AR ARP150100549A patent/AR099563A1/es unknown
- 2015-02-26 CA CA2940078A patent/CA2940078C/en active Active
- 2015-02-26 MX MX2016011420A patent/MX363745B/es active IP Right Grant
- 2015-02-26 MY MYPI2016703158A patent/MY181033A/en unknown
- 2015-02-26 CN CN201580011814.8A patent/CN106132981B/zh active Active
- 2015-02-26 WO PCT/CU2015/000002 patent/WO2015131858A2/es active Application Filing
- 2015-02-26 US US15/119,058 patent/US9896482B2/en active Active
- 2015-02-26 KR KR1020167026665A patent/KR102325400B1/ko active IP Right Grant
- 2015-02-26 ES ES15718758T patent/ES2733648T3/es active Active
- 2015-02-26 EP EP15718758.4A patent/EP3115056B1/en active Active
- 2015-02-26 JP JP2016555504A patent/JP6854644B2/ja active Active
- 2015-02-26 AU AU2015226580A patent/AU2015226580B2/en active Active
-
2016
- 2016-08-31 PH PH12016501715A patent/PH12016501715A1/en unknown
Also Published As
Publication number | Publication date |
---|---|
PH12016501715B1 (en) | 2016-12-19 |
AU2015226580A1 (en) | 2016-09-15 |
JP6854644B2 (ja) | 2021-04-07 |
CN106132981A (zh) | 2016-11-16 |
AU2015226580B2 (en) | 2018-11-08 |
ES2733648T3 (es) | 2019-12-02 |
BR112016019672A2 (pt) | 2017-10-24 |
MY181033A (en) | 2020-12-16 |
EP3115056B1 (en) | 2019-04-03 |
EP3115056A2 (en) | 2017-01-11 |
WO2015131858A2 (es) | 2015-09-11 |
PH12016501715A1 (en) | 2016-12-19 |
CN106132981B (zh) | 2019-11-12 |
CA2940078C (en) | 2020-11-17 |
KR20160127097A (ko) | 2016-11-02 |
MX2016011420A (es) | 2016-11-16 |
CA2940078A1 (en) | 2015-09-11 |
AR099563A1 (es) | 2016-08-03 |
WO2015131858A3 (es) | 2015-10-29 |
JP2017509619A (ja) | 2017-04-06 |
US9896482B2 (en) | 2018-02-20 |
US20170152290A1 (en) | 2017-06-01 |
KR102325400B1 (ko) | 2021-11-12 |
MX363745B (es) | 2019-04-01 |
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