EA201700097A1 - Пептид для лечения сахарного диабета 2-го типа и его осложнений - Google Patents

Пептид для лечения сахарного диабета 2-го типа и его осложнений

Info

Publication number
EA201700097A1
EA201700097A1 EA201700097A EA201700097A EA201700097A1 EA 201700097 A1 EA201700097 A1 EA 201700097A1 EA 201700097 A EA201700097 A EA 201700097A EA 201700097 A EA201700097 A EA 201700097A EA 201700097 A1 EA201700097 A1 EA 201700097A1
Authority
EA
Eurasian Patent Office
Prior art keywords
arg
gly
glu
ser
diabetes
Prior art date
Application number
EA201700097A
Other languages
English (en)
Inventor
Михаил Иванович Титов
Иван Иванович Елисеев
Валерий Геннадьевич МАКАРОВ
Марина Николаевна МАКАРОВА
Елена Васильевна Шекунова
Владимир Александрович Кашкин
Original Assignee
Дафот Энтерпрайсис Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Дафот Энтерпрайсис Лимитед filed Critical Дафот Энтерпрайсис Лимитед
Publication of EA201700097A1 publication Critical patent/EA201700097A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/605—Glucagons
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/57563—Vasoactive intestinal peptide [VIP]; Related peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/15—Corynebacterium

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Neurology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Obesity (AREA)

Abstract

Изобретение относится к биотехнологии. Представлен аналог эксенатида формулы H-His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Gly-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-D-Arg-D-Arg-D-Arg-D-Arg-D-Arg-D-Arg-D-Arg-D-Arg-Gly-OH. Изобретение позволяет лечить и проводить профилактику сахарного диабета, а также лечить и проводить профилактику осложнений сахарного диабета 2-го типа, таких как диабетическая нейропатия, мышечная дистрофия и эндотелиопатия.
EA201700097A 2014-08-21 2015-08-04 Пептид для лечения сахарного диабета 2-го типа и его осложнений EA201700097A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
RU2014134341/10A RU2573933C1 (ru) 2014-08-21 2014-08-21 Пептид для лечения сахарного диабета 2-го типа и его осложнений
PCT/IB2015/001614 WO2016027157A1 (en) 2014-08-21 2015-08-04 Peptide for treatment of type 2 diabetes mellitus and its complications

Publications (1)

Publication Number Publication Date
EA201700097A1 true EA201700097A1 (ru) 2017-06-30

Family

ID=54292830

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201700097A EA201700097A1 (ru) 2014-08-21 2015-08-04 Пептид для лечения сахарного диабета 2-го типа и его осложнений

Country Status (12)

Country Link
US (1) US9868773B2 (ru)
EP (1) EP3183265B1 (ru)
JP (1) JP6442729B2 (ru)
KR (1) KR102003619B1 (ru)
CN (1) CN106574233A (ru)
AU (1) AU2015304934B2 (ru)
CA (1) CA2958795C (ru)
EA (1) EA201700097A1 (ru)
ES (1) ES2711841T3 (ru)
IL (1) IL250666B (ru)
RU (1) RU2573933C1 (ru)
WO (1) WO2016027157A1 (ru)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102408480B1 (ko) 2018-05-30 2022-06-10 이삼구 당뇨질환의 치료용 조성물
WO2024077149A2 (en) * 2022-10-05 2024-04-11 Eli Lilly And Company Peptides for incretin synthesis

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1986000337A1 (fr) * 1984-06-19 1986-01-16 Transgene S.A. DERIVES DE L'alpha1-ANTITRYPSINE HUMAINE ET PROCEDE POUR LEUR PREPARATION
CA1340265C (en) * 1985-01-18 1998-12-15 Kirston E. Koths Oxidation resistant muteins
US5424286A (en) 1993-05-24 1995-06-13 Eng; John Exendin-3 and exendin-4 polypeptides, and pharmaceutical compositions comprising same
US20040092443A1 (en) 1996-08-06 2004-05-13 Yeda Research And Development Co., Ltd Long-acting exendins and exendin agonists
AU4063697A (en) 1996-08-08 1998-02-25 Amylin Pharmaceuticals, Inc. Methods for regulating gastrointestinal motility
JP4798814B2 (ja) 1997-01-07 2011-10-19 アミリン・ファーマシューティカルズ，インコーポレイテッド 食物摂取低減用のエキセンジンおよびそのアゴニストの使用
WO1999007404A1 (en) 1997-08-08 1999-02-18 Amylin Pharmaceuticals, Inc. Novel exendin agonist compounds
US6703359B1 (en) 1998-02-13 2004-03-09 Amylin Pharmaceuticals, Inc. Inotropic and diuretic effects of exendin and GLP-1
WO1999040788A1 (en) 1998-02-13 1999-08-19 Amylin Pharmaceuticals, Inc. Inotropic and diuretic effects of exendin and glp-1
JP2002517469A (ja) 1998-06-12 2002-06-18 バイオネブラスカ，インコーポレイテッド グルカゴン様ペプチド−１は、耐糖能異常を有する対象におけるグルコースに対するβ細胞応答を改善する
DE69941510D1 (de) 1998-08-10 2009-11-19 Us Gov Nat Inst Health Differenzierung von nicht-insulin in insulin-produzierende zellen durch glp-1 und exendin-4 und dessen verwendung
RU2247575C9 (ru) 1999-01-14 2005-11-10 Амилин Фармасьютикалз, Инк. Способы подавления глюкагона
ATE460942T1 (de) * 1999-01-14 2010-04-15 Amylin Pharmaceuticals Inc Exendine zur glucagon suppression
US20030087820A1 (en) * 1999-01-14 2003-05-08 Young Andrew A. Novel exendin agonist formulations and methods of administration thereof
US6506724B1 (en) 1999-06-01 2003-01-14 Amylin Pharmaceuticals, Inc. Use of exendins and agonists thereof for the treatment of gestational diabetes mellitus
CA2396157A1 (en) 2000-01-10 2001-07-19 Amylin Pharmaceuticals, Inc. Use of exendins and agonists thereof for modulation of triglyceride levels and treatment of dyslipidemia
CN100480374C (zh) * 2001-09-28 2009-04-22 中国科学院上海生命科学研究院 制备重组人类胰高血糖素肽－1氨基酸7－37肽段的方法
US7105489B2 (en) 2002-01-22 2006-09-12 Amylin Pharmaceuticals, Inc. Methods and compositions for treating polycystic ovary syndrome
WO2004016747A2 (en) 2002-08-14 2004-02-26 University Of Florida Bone marrow cell differentiation
AU2003268693A1 (en) 2002-09-30 2004-04-19 Ajinomoto Co., Inc. Method of producing stable isotope-labeled protein
MXPA05003335A (es) 2002-10-02 2005-07-05 Zealand Pharma As Compuestos de exendina-4 estabilizados.
WO2004052390A1 (en) 2002-12-11 2004-06-24 Amylin Pharmaceuticals, Inc. Methods and compositions for treating polycystic ovary syndrome
US20040209803A1 (en) 2002-12-19 2004-10-21 Alain Baron Compositions for the treatment and prevention of nephropathy
JP2006514035A (ja) 2002-12-17 2006-04-27 アミリン・ファーマシューティカルズ，インコーポレイテッド 心不整脈の予防および治療
JP4233029B2 (ja) 2003-08-27 2009-03-04 白田 正樹 マイタケ由来の抽出物およびグリコプロテイン並びにその製造方法
CN1989238B (zh) 2004-05-20 2010-05-26 味之素株式会社 生产琥珀酸的细菌和生产琥珀酸的方法
US7442682B2 (en) * 2004-10-19 2008-10-28 Nitto Denko Corporation Transepithelial delivery of peptides with incretin hormone activities
JP4595506B2 (ja) * 2004-11-25 2010-12-08 味の素株式会社 Ｌ−アミノ酸生産菌及びｌ−アミノ酸の製造方法
PL3524261T3 (pl) * 2005-08-19 2024-04-15 Amylin Pharmaceuticals, Llc Eksendyna do stosowania w leczeniu cukrzycy i zmniejszania masy ciała
JP5252585B2 (ja) 2006-06-09 2013-07-31 ウェルスタット セラピューティクス コーポレイション 代謝障害の治療のための化合物
CN102827284B (zh) * 2006-11-14 2015-07-29 上海仁会生物制药股份有限公司 带有聚乙二醇基团的Exendin或其类似物及其制剂和用途
HUE027603T2 (en) * 2007-04-20 2016-10-28 Sigma-Tau Rare Disease Ltd Stable, recombinant adenosine deaminase
CN103285379A (zh) * 2013-06-09 2013-09-11 南方医科大学 Glp-1用于制备预防与治疗2型糖尿病大血管并发症的药物的用途
US9410225B2 (en) 2014-05-13 2016-08-09 Teck Resources Limited Process for recovery of copper from arsenic-bearing and/or antimony-bearing copper sulphide concentrates
CA2914090C (en) 2015-03-31 2023-08-01 Allen-Vanguard Corporation Frequency and time domain streaming receiver

Also Published As

Publication number Publication date
CN106574233A (zh) 2017-04-19
CA2958795A1 (en) 2016-02-25
ES2711841T3 (es) 2019-05-07
CA2958795C (en) 2021-01-12
IL250666A0 (en) 2017-04-30
JP2017525764A (ja) 2017-09-07
EP3183265B1 (en) 2018-09-26
RU2573933C1 (ru) 2016-01-27
US20170240610A1 (en) 2017-08-24
IL250666B (en) 2021-10-31
EP3183265A1 (en) 2017-06-28
AU2015304934A1 (en) 2017-03-09
WO2016027157A1 (en) 2016-02-25
AU2015304934B2 (en) 2018-05-10
KR102003619B1 (ko) 2019-07-24
KR20170041914A (ko) 2017-04-17
JP6442729B2 (ja) 2018-12-26
US9868773B2 (en) 2018-01-16

Similar Documents

Publication Publication Date Title
SA519401435B1 (ar) مركبات حلقية ثنائية النيوكليوتيد
EA201691261A1 (ru) Новые дигидрохинолизиноны для лечения и профилактики инфекции, вызванной вирусом гепатита b
EA201790806A1 (ru) Иммунорегулирующие средства
SA518391864B1 (ar) مشتقات باي بيرازوليل مفيدة لمعالجة أمراض المناعة الذاتية
EA201790413A1 (ru) Антитела против tigit
MX2022005253A (es) Anticuerpos neutralizantes de poliomavirus.
EA201692473A1 (ru) Способы получения замещенных нуклеотидных аналогов
BR112017008672A2 (pt) anticorpos de il-6 melhorados
MX2020006237A (es) Compuestos para el tratamiento de enfermedades relacionadas con la expresion de dux4.
EA201890185A1 (ru) Способы лечения опосредованных гепсидином нарушений
MX2022015248A (es) Un anticuerpo anti-il-23a para usarse en el tratamiento de la enfermedad de crohn.
EA201890572A1 (ru) Биофармацевтические композиции
EA201791249A1 (ru) Получаемые из cd44v6 циклические пептиды для лечения злокачественных опухолей и связанных с ангиогенезом заболеваний
EA201990400A1 (ru) Соединения и композиции и их применение
EA201790442A1 (ru) Трициклические азотсодержащие соединения для лечения инфекции, вызываемой neisseria gonorrhoeae
EA202090014A1 (ru) Гетероароматические соединения в качестве ингибиторов ванина
EA201790070A1 (ru) Бифениламиды, содержащие модифицированные простые эфирные группы, в качестве ингибиторов hsp90 и стимуляторов hsp70
TN2019000106A1 (en) Novel compounds for treating parasitic disease
EA201890543A1 (ru) Способы и материалы для генной терапии galgt2
PH12016501613B1 (en) Pyrazines modulators of gpr6
CY1122374T1 (el) Βιοτινη για την θεραπευτικη αντιμετωπιση απομυελινωτικων νευροπαθειων
EA201691498A1 (ru) Новая мишень для лечения и профилактики диабета
EA201700097A1 (ru) Пептид для лечения сахарного диабета 2-го типа и его осложнений
EA201692216A1 (ru) Пирролидиновые модуляторы gpr40 для лечения заболеваний, таких как диабет
EA202191758A1 (ru) Пептиды для лечения и профилактики диабета и связанных с ним заболеваний