EA201692473A1 - Способы получения замещенных нуклеотидных аналогов - Google Patents

Способы получения замещенных нуклеотидных аналогов

Info

Publication number
EA201692473A1
EA201692473A1 EA201692473A EA201692473A EA201692473A1 EA 201692473 A1 EA201692473 A1 EA 201692473A1 EA 201692473 A EA201692473 A EA 201692473A EA 201692473 A EA201692473 A EA 201692473A EA 201692473 A1 EA201692473 A1 EA 201692473A1
Authority
EA
Eurasian Patent Office
Prior art keywords
nucleotide analogs
methods
substituted nucleotide
obtaining substituted
obtaining
Prior art date
Application number
EA201692473A
Other languages
English (en)
Inventor
Владимир Серебряный
Леонид Бейгельман
Original Assignee
Элиос Биофарма, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Элиос Биофарма, Инк. filed Critical Элиос Биофарма, Инк.
Publication of EA201692473A1 publication Critical patent/EA201692473A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C07H1/02—Phosphorylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H23/00—Compounds containing boron, silicon, or a metal, e.g. chelates, vitamin B12

Abstract

В данном документе раскрыты способы получения фосфорамидатных нуклеотидных аналогов, которые полезны в лечении заболеваний и/или состояний, таких как вирусные инфекции.
EA201692473A 2014-06-24 2015-06-22 Способы получения замещенных нуклеотидных аналогов EA201692473A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462016229P 2014-06-24 2014-06-24
PCT/US2015/036989 WO2015200216A1 (en) 2014-06-24 2015-06-22 Methods of preparing substituted nucleotide analogs

Publications (1)

Publication Number Publication Date
EA201692473A1 true EA201692473A1 (ru) 2017-03-31

Family

ID=54869042

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201692473A EA201692473A1 (ru) 2014-06-24 2015-06-22 Способы получения замещенных нуклеотидных аналогов

Country Status (17)

Country Link
US (1) US20150368286A1 (ru)
EP (1) EP3160979A4 (ru)
JP (1) JP2017519779A (ru)
KR (1) KR20170026494A (ru)
CN (1) CN106661076A (ru)
AU (1) AU2015280245A1 (ru)
BR (1) BR112016029994A2 (ru)
CA (1) CA2952812A1 (ru)
CL (1) CL2016003277A1 (ru)
EA (1) EA201692473A1 (ru)
IL (1) IL249456A0 (ru)
MX (1) MX2016017382A (ru)
NZ (1) NZ727392A (ru)
PH (1) PH12016502555A1 (ru)
SG (1) SG11201610259SA (ru)
TW (1) TW201625659A (ru)
WO (1) WO2015200216A1 (ru)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3107640A1 (en) 2011-12-22 2013-06-27 Janssen Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof and their use in ameliorating or treating a disease or condition associated with viral infections
CA2860234A1 (en) 2011-12-22 2013-06-27 Alios Biopharma, Inc. Substituted phosphorothioate nucleotide analogs
NZ631601A (en) 2012-03-21 2016-06-24 Alios Biopharma Inc Solid forms of a thiophosphoramidate nucleotide prodrug
USRE48171E1 (en) 2012-03-21 2020-08-25 Janssen Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
US9441007B2 (en) 2012-03-21 2016-09-13 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
AU2013361193B2 (en) 2012-12-21 2018-05-24 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
US9504705B2 (en) 2013-04-05 2016-11-29 Alios Biopharma, Inc. Hepatitis C viral infection treatment using a combination of compounds
CA2913206C (en) 2013-06-26 2022-08-02 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
TWI655199B (zh) 2013-06-26 2019-04-01 美商艾洛斯生物製藥公司 經取代之核苷、核苷酸及其類似物
US9862743B2 (en) 2013-10-11 2018-01-09 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
AP2016009653A0 (en) 2014-06-24 2016-12-31 Alios Biopharma Inc Substituted nucleosides, nucleotides and analogs thereof
EA201692535A1 (ru) 2014-06-24 2017-05-31 Элиос Биофарма, Инк. Замещенные нуклеозиды, нуклеотиды и их аналоги
KR20170073649A (ko) 2014-10-28 2017-06-28 앨리오스 바이오파마 인크. 치환된 뉴클레오시드 유사체의 제조 방법
MA41441A (fr) 2014-12-19 2017-12-12 Alios Biopharma Inc Nucléosides substitués, nucléotides et analogues de ceux-ci
MA41213A (fr) 2014-12-19 2017-10-24 Alios Biopharma Inc Nucléosides substitués, nucléotides et analogues de ceux-ci
CN107531717B (zh) 2015-03-11 2021-07-27 詹森生物制药有限公司 氮杂-吡啶酮化合物及其用途
WO2019237297A1 (en) * 2018-06-14 2019-12-19 Janssen Pharmaceuticals, Inc. Processes for preparing compounds/intermediates useful in the treatment of viral infections

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3817978A (en) * 1971-06-16 1974-06-18 Syntex Inc 4-fluoro nucleosides and sugar intermediates, and methods of preparing
AP3913A (en) * 2012-05-22 2016-11-26 Idenix Pharamaceuticals Inc D-amino acid compounds for liver disease
US9243022B2 (en) * 2012-12-21 2016-01-26 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
KR102241198B1 (ko) * 2013-05-16 2021-04-15 리보사이언스 엘엘씨 4'-플루오로-2'-메틸 치환된 뉴클레오시드 유도체
CA2913206C (en) * 2013-06-26 2022-08-02 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
US9862743B2 (en) * 2013-10-11 2018-01-09 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
KR20170073649A (ko) * 2014-10-28 2017-06-28 앨리오스 바이오파마 인크. 치환된 뉴클레오시드 유사체의 제조 방법
MA41441A (fr) * 2014-12-19 2017-12-12 Alios Biopharma Inc Nucléosides substitués, nucléotides et analogues de ceux-ci

Also Published As

Publication number Publication date
BR112016029994A2 (pt) 2017-08-22
KR20170026494A (ko) 2017-03-08
MX2016017382A (es) 2017-04-27
EP3160979A4 (en) 2018-01-03
CL2016003277A1 (es) 2017-06-02
EP3160979A1 (en) 2017-05-03
TW201625659A (zh) 2016-07-16
CN106661076A (zh) 2017-05-10
IL249456A0 (en) 2017-02-28
NZ727392A (en) 2018-04-27
JP2017519779A (ja) 2017-07-20
PH12016502555A1 (en) 2017-04-10
WO2015200216A1 (en) 2015-12-30
US20150368286A1 (en) 2015-12-24
SG11201610259SA (en) 2017-01-27
AU2015280245A1 (en) 2017-01-05
CA2952812A1 (en) 2015-12-30

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