CL2016003277A1 - Métodos para preparar análogos de nucleótido sustituidos - Google Patents

Métodos para preparar análogos de nucleótido sustituidos

Info

Publication number
CL2016003277A1
CL2016003277A1 CL2016003277A CL2016003277A CL2016003277A1 CL 2016003277 A1 CL2016003277 A1 CL 2016003277A1 CL 2016003277 A CL2016003277 A CL 2016003277A CL 2016003277 A CL2016003277 A CL 2016003277A CL 2016003277 A1 CL2016003277 A1 CL 2016003277A1
Authority
CL
Chile
Prior art keywords
methods
nucleotide analogs
preparing substituted
substituted nucleotide
preparing
Prior art date
Application number
CL2016003277A
Other languages
English (en)
Inventor
Leonid Beigelman
Vladimir Serebryany
Original Assignee
Alios Biopharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alios Biopharma Inc filed Critical Alios Biopharma Inc
Publication of CL2016003277A1 publication Critical patent/CL2016003277A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C07H1/02—Phosphorylation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H23/00—Compounds containing boron, silicon or a metal, e.g. chelates or vitamin B12

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

<p>SE DESCRIBEN AQUÍ MÉTODOS PARA PREPARAR UN ANÁLOGO DE NUCLEÓTIDO DE FOSFOROAMIDATO QUE SON ÚTILES AL TRATAR ENFERMEDADES Y/O CONDICIONES TAL COMO INFECCIONES VIRALES.</p>
CL2016003277A 2014-06-24 2016-12-21 Métodos para preparar análogos de nucleótido sustituidos CL2016003277A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201462016229P 2014-06-24 2014-06-24

Publications (1)

Publication Number Publication Date
CL2016003277A1 true CL2016003277A1 (es) 2017-06-02

Family

ID=54869042

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2016003277A CL2016003277A1 (es) 2014-06-24 2016-12-21 Métodos para preparar análogos de nucleótido sustituidos

Country Status (17)

Country Link
US (1) US20150368286A1 (es)
EP (1) EP3160979A4 (es)
JP (1) JP2017519779A (es)
KR (1) KR20170026494A (es)
CN (1) CN106661076A (es)
AU (1) AU2015280245A1 (es)
BR (1) BR112016029994A2 (es)
CA (1) CA2952812A1 (es)
CL (1) CL2016003277A1 (es)
EA (1) EA201692473A1 (es)
IL (1) IL249456A0 (es)
MX (1) MX2016017382A (es)
NZ (1) NZ727392A (es)
PH (1) PH12016502555A1 (es)
SG (1) SG11201610259SA (es)
TW (1) TW201625659A (es)
WO (1) WO2015200216A1 (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG10201610936RA (en) 2011-12-22 2017-02-27 Alios Biopharma Inc Substituted nucleosides, nucleotides and analogs thereof
US8980865B2 (en) 2011-12-22 2015-03-17 Alios Biopharma, Inc. Substituted nucleotide analogs
USRE48171E1 (en) 2012-03-21 2020-08-25 Janssen Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
US8916538B2 (en) 2012-03-21 2014-12-23 Vertex Pharmaceuticals Incorporated Solid forms of a thiophosphoramidate nucleotide prodrug
US9441007B2 (en) 2012-03-21 2016-09-13 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
WO2014100498A1 (en) 2012-12-21 2014-06-26 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
WO2014165704A1 (en) 2013-04-05 2014-10-09 Vertex Pharmaceuticals, Inc. Hepatitis c viral infection treatment using a combination of compounds
US9815864B2 (en) 2013-06-26 2017-11-14 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
EP3424938B1 (en) 2013-06-26 2020-07-22 Janssen BioPharma, Inc. 4'-azidoalkyl-substituted nucleosides, nucleotides and analogs thereof
AU2014331863C1 (en) 2013-10-11 2019-05-16 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
AU2015280234B2 (en) 2014-06-24 2021-04-01 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
CN117379452A (zh) 2014-06-24 2024-01-12 艾丽奥斯生物制药有限公司 取代的核苷、核苷酸和其类似物
US9908914B2 (en) 2014-10-28 2018-03-06 Alios Biopharma, Inc. Methods of preparing substituted nucleoside analogs
MA41213A (fr) 2014-12-19 2017-10-24 Alios Biopharma Inc Nucléosides substitués, nucléotides et analogues de ceux-ci
MA41441A (fr) 2014-12-19 2017-12-12 Alios Biopharma Inc Nucléosides substitués, nucléotides et analogues de ceux-ci
MX383931B (es) 2015-03-11 2025-03-14 Janssen Biopharma Inc Compuestos de aza-piridona y usos de estos.
WO2019237297A1 (en) * 2018-06-14 2019-12-19 Janssen Pharmaceuticals, Inc. Processes for preparing compounds/intermediates useful in the treatment of viral infections

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3817978A (en) * 1971-06-16 1974-06-18 Syntex Inc 4-fluoro nucleosides and sugar intermediates, and methods of preparing
GEP20176800B (en) * 2012-05-22 2018-01-10 Idenix Pharmaceuticals Llk D-amino acid compounds for liver disease
CN110684067A (zh) * 2012-12-21 2020-01-14 艾丽奥斯生物制药有限公司 取代的核苷和核苷酸
MY186547A (en) * 2013-05-16 2021-07-26 Riboscience Llc 4?-fluoro-2?-methyl substituted nucleoside derivatives
US9815864B2 (en) * 2013-06-26 2017-11-14 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
AU2014331863C1 (en) * 2013-10-11 2019-05-16 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
US9908914B2 (en) * 2014-10-28 2018-03-06 Alios Biopharma, Inc. Methods of preparing substituted nucleoside analogs
MA41441A (fr) * 2014-12-19 2017-12-12 Alios Biopharma Inc Nucléosides substitués, nucléotides et analogues de ceux-ci

Also Published As

Publication number Publication date
PH12016502555A1 (en) 2017-04-10
TW201625659A (zh) 2016-07-16
CA2952812A1 (en) 2015-12-30
JP2017519779A (ja) 2017-07-20
EP3160979A1 (en) 2017-05-03
CN106661076A (zh) 2017-05-10
US20150368286A1 (en) 2015-12-24
BR112016029994A2 (pt) 2017-08-22
IL249456A0 (en) 2017-02-28
EA201692473A1 (ru) 2017-03-31
SG11201610259SA (en) 2017-01-27
MX2016017382A (es) 2017-04-27
KR20170026494A (ko) 2017-03-08
NZ727392A (en) 2018-04-27
EP3160979A4 (en) 2018-01-03
WO2015200216A1 (en) 2015-12-30
AU2015280245A1 (en) 2017-01-05

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