EA201790630A1 - Способы получения рибозидов - Google Patents

Способы получения рибозидов

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Publication number
EA201790630A1
EA201790630A1 EA201790630A EA201790630A EA201790630A1 EA 201790630 A1 EA201790630 A1 EA 201790630A1 EA 201790630 A EA201790630 A EA 201790630A EA 201790630 A EA201790630 A EA 201790630A EA 201790630 A1 EA201790630 A1 EA 201790630A1
Authority
EA
Eurasian Patent Office
Prior art keywords
methods
ribosids
obtaining
virus
treatment
Prior art date
Application number
EA201790630A
Other languages
English (en)
Inventor
Стивен Дональд Акст
Павел Робертович Бадалов
Катриен Брак
Сильвио Кампана
Андрей Щемелинин
Эдвард Дорфлер
Морин Мэй Фрик
Дэтянь Гао
Ларс В. Хойманн
Бриттани Хоан
Виллард Лью
Роберт Рональд Милбёрн
Шон Тимоти Невилл
Брюс Росс
Эрик Руден
Роберт Уильям Скотт
Дастин Сигель
Эндрю К. Стивенс
Кларисса Тадеуш
Тьяго Виейра
Эндрю В. Уолтман
Сянхун Ван
Марк Чарльз Уиткомб
Лидия Вулф
Чиа-Юнь Юй
Original Assignee
Джилид Сайэнс, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=54557474&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201790630(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Джилид Сайэнс, Инк. filed Critical Джилид Сайэнс, Инк.
Publication of EA201790630A1 publication Critical patent/EA201790630A1/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
    • A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
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    • A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
    • A61K31/6615—Compounds having two or more esterified phosphorus acid groups, e.g. inositol triphosphate, phytic acid
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    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
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    • C07F9/22—Amides of acids of phosphorus
    • C07F9/24—Esteramides
    • C07F9/2404—Esteramides the ester moiety containing a substituent or a structure which is considered as characteristic
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    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
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    • C07F9/02—Phosphorus compounds
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    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
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    • C07H9/02—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical the hetero ring containing only oxygen as ring hetero atoms
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

Предложены способы получения соединений и фармацевтических композиций для лечения вирусных инфекцийПредложенные соединения, композиции и способы являются особенно подходящими для применения для лечения инфекций, вызываемых вирусом Марбург, вирусом Эбола и вирусом
EA201790630A 2014-10-29 2015-10-29 Способы получения рибозидов EA201790630A1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462072331P 2014-10-29 2014-10-29
US201562105619P 2015-01-20 2015-01-20
PCT/US2015/057932 WO2016069825A1 (en) 2014-10-29 2015-10-29 Methods for the preparation of ribosides

Publications (1)

Publication Number Publication Date
EA201790630A1 true EA201790630A1 (ru) 2017-11-30

Family

ID=54557474

Family Applications (2)

Application Number Title Priority Date Filing Date
EA201790597A EA032239B1 (ru) 2014-10-29 2015-10-29 Способы лечения вирусных инфекций filoviridae
EA201790630A EA201790630A1 (ru) 2014-10-29 2015-10-29 Способы получения рибозидов

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EA201790597A EA032239B1 (ru) 2014-10-29 2015-10-29 Способы лечения вирусных инфекций filoviridae

Country Status (45)

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US (8) US11344565B2 (ru)
EP (5) EP3212174B1 (ru)
JP (9) JP6220484B1 (ru)
KR (5) KR102453808B1 (ru)
CN (5) CN107073005B (ru)
AR (2) AR102467A1 (ru)
AU (8) AU2015339222B2 (ru)
BR (2) BR102015027413A2 (ru)
CA (3) CA2963907C (ru)
CL (2) CL2017001040A1 (ru)
CO (1) CO2017003960A2 (ru)
CR (2) CR20170483A (ru)
CU (2) CU20170145A7 (ru)
CY (2) CY1120893T1 (ru)
DK (2) DK3212174T3 (ru)
DO (1) DOP2017000103A (ru)
EA (2) EA032239B1 (ru)
EC (2) ECSP17025261A (ru)
ES (3) ES2785034T3 (ru)
HK (1) HK1258795A1 (ru)
HR (1) HRP20181130T1 (ru)
HU (2) HUE049192T2 (ru)
IL (2) IL251560A0 (ru)
LT (2) LT3212174T (ru)
MA (3) MA40872A (ru)
MD (1) MD20170046A2 (ru)
ME (1) ME03070B (ru)
MX (3) MX2017005250A (ru)
MY (1) MY195823A (ru)
NZ (3) NZ730803A (ru)
PE (2) PE20180202A1 (ru)
PH (2) PH12017500631A1 (ru)
PL (3) PL3212174T3 (ru)
PT (3) PT3212174T (ru)
RS (1) RS57425B1 (ru)
SA (1) SA517381419B1 (ru)
SG (3) SG10202008772UA (ru)
SI (3) SI3212175T1 (ru)
SV (2) SV2017005424A (ru)
TR (1) TR201809518T4 (ru)
TW (4) TWI687432B (ru)
UA (1) UA121485C2 (ru)
UY (2) UY36376A (ru)
WO (3) WO2016069827A1 (ru)
ZA (1) ZA201800414B (ru)

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