MX2015005949A - Nucleosidos que contienen aza-azucar antiviral. - Google Patents

Nucleosidos que contienen aza-azucar antiviral.

Info

Publication number
MX2015005949A
MX2015005949A MX2015005949A MX2015005949A MX2015005949A MX 2015005949 A MX2015005949 A MX 2015005949A MX 2015005949 A MX2015005949 A MX 2015005949A MX 2015005949 A MX2015005949 A MX 2015005949A MX 2015005949 A MX2015005949 A MX 2015005949A
Authority
MX
Mexico
Prior art keywords
azasugar
compounds
viral
pharmaceutically acceptable
antiviral
Prior art date
Application number
MX2015005949A
Other languages
English (en)
Inventor
Shanta Bantia
Pravin L Kotian
Yarlagadda S Babu
Minwan Wu
V Satish Kumar
Original Assignee
Biocryst Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biocryst Pharm Inc filed Critical Biocryst Pharm Inc
Publication of MX2015005949A publication Critical patent/MX2015005949A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Pulmonology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La presente invención se refiere a compuestos que comprenden un aza-azúcar unido a una base heterocíclica, que incluyen sales de los mismos farmacéuticamente aceptables, adecuados para uso en la inhibición de la actividad de polimerasa del ARN o replicación viral, y tratar infecciones virales. Los compuestos son caracterizados, en parte, por farmacocinéticas favorables para el ingrediente farmacéutico activo, particularmente en conjunto con administración entérica, que incluye, en particular, administración oral. También se describen composiciones farmacéuticas que comprenden uno o más compuestos mencionados anteriormente, o sales de los mismos farmacéuticamente aceptables, así como también métodos para preparar los mismos. También se proporcionan métodos para inhibir la actividad de la polimerasa de ARN viral, replicación viral, y tratar infecciones virales.
MX2015005949A 2012-11-16 2013-11-18 Nucleosidos que contienen aza-azucar antiviral. MX2015005949A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261727468P 2012-11-16 2012-11-16
PCT/US2013/070537 WO2014078778A2 (en) 2012-11-16 2013-11-18 Antiviral azasugar-containing nucleosides

Publications (1)

Publication Number Publication Date
MX2015005949A true MX2015005949A (es) 2015-09-08

Family

ID=50731836

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2015005949A MX2015005949A (es) 2012-11-16 2013-11-18 Nucleosidos que contienen aza-azucar antiviral.

Country Status (9)

Country Link
US (2) US20150291596A1 (es)
EP (2) EP3251674A3 (es)
JP (1) JP2016504284A (es)
AU (1) AU2013344422A1 (es)
CA (1) CA2890905A1 (es)
HK (1) HK1212235A1 (es)
IL (1) IL238785A0 (es)
MX (1) MX2015005949A (es)
WO (1) WO2014078778A2 (es)

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CN111704619B (zh) * 2020-07-30 2021-10-19 四川大学 一种Forodesine的制备方法
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Also Published As

Publication number Publication date
US20170267681A1 (en) 2017-09-21
WO2014078778A2 (en) 2014-05-22
EP3251674A2 (en) 2017-12-06
EP3251674A3 (en) 2018-02-21
CA2890905A1 (en) 2014-05-22
IL238785A0 (en) 2015-06-30
WO2014078778A3 (en) 2014-10-09
US20150291596A1 (en) 2015-10-15
HK1212235A1 (en) 2016-06-10
EP2919785A2 (en) 2015-09-23
AU2013344422A1 (en) 2015-07-02
JP2016504284A (ja) 2016-02-12
EP2919785A4 (en) 2016-10-05

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