BR112018005048B8 - uso de um composto antiviral ou sal do mesmo para o tratamento de uma infecção por coronaviridae - Google Patents

uso de um composto antiviral ou sal do mesmo para o tratamento de uma infecção por coronaviridae

Info

Publication number
BR112018005048B8
BR112018005048B8 BR112018005048A BR112018005048A BR112018005048B8 BR 112018005048 B8 BR112018005048 B8 BR 112018005048B8 BR 112018005048 A BR112018005048 A BR 112018005048A BR 112018005048 A BR112018005048 A BR 112018005048A BR 112018005048 B8 BR112018005048 B8 BR 112018005048B8
Authority
BR
Brazil
Prior art keywords
treatment
salt
antiviral compound
coronaviridae infection
coronaviridae
Prior art date
Application number
BR112018005048A
Other languages
English (en)
Other versions
BR112018005048B1 (pt
Inventor
S Ray Adrian
Siegel Dustin
Yang Feng Joy
O'neil Hanrahan Clarke Michael
L Mackman Richard
Jordan Robert
Original Assignee
Gilead Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gilead Sciences Inc filed Critical Gilead Sciences Inc
Priority to BR122020020217-3A priority Critical patent/BR122020020217B1/pt
Publication of BR112018005048B1 publication Critical patent/BR112018005048B1/pt
Publication of BR112018005048B8 publication Critical patent/BR112018005048B8/pt

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/664—Amides of phosphorus acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)

Abstract

são fornecidos métodos para o tratamento de infecções pelos vírus arenaviridae e coronaviridae administrado nucleosídeos e pró-fármacos dos mesmos, de fórmula i: , em que a posição 1' do açúcar de nucleosídeo é substituído. os compostos, composições e métodos fornecidos são particularmente úteis para o tratamento de infecções pelo vírus lassa e vírus junin.
BR112018005048A 2015-09-16 2016-09-16 uso de um composto antiviral ou sal do mesmo para o tratamento de uma infecção por coronaviridae BR112018005048B8 (pt)

Priority Applications (1)

Application Number Priority Date Filing Date Title
BR122020020217-3A BR122020020217B1 (pt) 2015-09-16 2016-09-16 Uso de um composto antiviral ou sal do mesmo para o tratamento de uma infecção por arenaviridae

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201562219302P 2015-09-16 2015-09-16
US62/219,302 2015-09-16
US201562239696P 2015-10-09 2015-10-09
US62/239,696 2015-10-09
PCT/US2016/052092 WO2017049060A1 (en) 2015-09-16 2016-09-16 Methods for treating arenaviridae and coronaviridae virus infections

Publications (2)

Publication Number Publication Date
BR112018005048B1 BR112018005048B1 (pt) 2021-02-23
BR112018005048B8 true BR112018005048B8 (pt) 2021-03-23

Family

ID=56997582

Family Applications (2)

Application Number Title Priority Date Filing Date
BR112018005048A BR112018005048B8 (pt) 2015-09-16 2016-09-16 uso de um composto antiviral ou sal do mesmo para o tratamento de uma infecção por coronaviridae
BR122020020217-3A BR122020020217B1 (pt) 2015-09-16 2016-09-16 Uso de um composto antiviral ou sal do mesmo para o tratamento de uma infecção por arenaviridae

Family Applications After (1)

Application Number Title Priority Date Filing Date
BR122020020217-3A BR122020020217B1 (pt) 2015-09-16 2016-09-16 Uso de um composto antiviral ou sal do mesmo para o tratamento de uma infecção por arenaviridae

Country Status (24)

Country Link
US (5) US10251904B2 (pt)
EP (3) EP4088718A1 (pt)
JP (5) JP6742403B2 (pt)
KR (1) KR20180050742A (pt)
CN (5) CN108348526A (pt)
AU (3) AU2016323604B2 (pt)
BR (2) BR112018005048B8 (pt)
CA (1) CA2998189C (pt)
CY (1) CY1125089T1 (pt)
DK (2) DK3349758T3 (pt)
EA (1) EA038141B1 (pt)
ES (2) ES2918585T3 (pt)
HK (3) HK1255732A1 (pt)
HR (2) HRP20220740T1 (pt)
HU (2) HUE058737T2 (pt)
LT (2) LT3785717T (pt)
MA (2) MA52371A (pt)
MX (2) MX2021005087A (pt)
PL (2) PL3349758T3 (pt)
PT (2) PT3785717T (pt)
SG (2) SG10202109869XA (pt)
SI (2) SI3785717T1 (pt)
TW (1) TW201733595A (pt)
WO (1) WO2017049060A1 (pt)

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