BR112022026321A2 - Análogos de 1'-ciano nucleosídeo e usos dos mesmos - Google Patents

Análogos de 1'-ciano nucleosídeo e usos dos mesmos

Info

Publication number
BR112022026321A2
BR112022026321A2 BR112022026321A BR112022026321A BR112022026321A2 BR 112022026321 A2 BR112022026321 A2 BR 112022026321A2 BR 112022026321 A BR112022026321 A BR 112022026321A BR 112022026321 A BR112022026321 A BR 112022026321A BR 112022026321 A2 BR112022026321 A2 BR 112022026321A2
Authority
BR
Brazil
Prior art keywords
nucleoside analogs
cyan
compounds
cyane
alone
Prior art date
Application number
BR112022026321A
Other languages
English (en)
Inventor
H Byun Daniel
Chun Byoung-Kwon
O Clarke Michael
Jansa Petr
V Kalla Rao
Koltun Dmitry
L Mackman Richard
D Perry Thao
S Siegel Dustin
P Simonovich Scott
Original Assignee
Gilead Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gilead Sciences Inc filed Critical Gilead Sciences Inc
Publication of BR112022026321A2 publication Critical patent/BR112022026321A2/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

ANÁLOGOS DE 1'-CIANO NUCLEOSÍDEO E USOS DOS MESMOS.. A presente invenção refere-se a compostos de Fórmula (I) e métodos de uso dos ditos compostos, isoladamente ou em combinação com agentes adicionais, e composições farmacêuticas dos ditos compostos para o tratamento de infecções virais.
BR112022026321A 2020-06-24 2021-06-23 Análogos de 1'-ciano nucleosídeo e usos dos mesmos BR112022026321A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063043349P 2020-06-24 2020-06-24
US202163139648P 2021-01-20 2021-01-20
PCT/US2021/038645 WO2021262826A2 (en) 2020-06-24 2021-06-23 1'-cyano nucleoside analogs and uses thereof

Publications (1)

Publication Number Publication Date
BR112022026321A2 true BR112022026321A2 (pt) 2023-01-17

Family

ID=76959096

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112022026321A BR112022026321A2 (pt) 2020-06-24 2021-06-23 Análogos de 1'-ciano nucleosídeo e usos dos mesmos

Country Status (17)

Country Link
US (1) US11939347B2 (pt)
EP (1) EP4172160A2 (pt)
JP (1) JP2023531524A (pt)
KR (1) KR20230028486A (pt)
CN (1) CN115996928A (pt)
AU (1) AU2021296841A1 (pt)
BR (1) BR112022026321A2 (pt)
CA (1) CA3187821A1 (pt)
CL (1) CL2022003733A1 (pt)
CO (1) CO2022018715A2 (pt)
CR (1) CR20220675A (pt)
DO (1) DOP2022000293A (pt)
IL (1) IL299202A (pt)
MX (1) MX2022016405A (pt)
PE (1) PE20230618A1 (pt)
TW (1) TWI819321B (pt)
WO (1) WO2021262826A2 (pt)

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JP2023512656A (ja) 2020-01-27 2023-03-28 ギリアード サイエンシーズ， インコーポレイテッド ＳＡＲＳ ＣｏＶ－２感染を治療するための方法
TWI785528B (zh) 2020-03-12 2022-12-01 美商基利科學股份有限公司 1’-氰基核苷之製備方法
EP4157272A1 (en) 2020-05-29 2023-04-05 Gilead Sciences, Inc. Remdesivir treatment methods
TWI819321B (zh) 2020-06-24 2023-10-21 美商基利科學股份有限公司 1'-氰基核苷類似物及其用途
TW202228722A (zh) 2020-08-27 2022-08-01 美商基利科學股份有限公司 用於治療病毒感染之化合物及方法
WO2022166581A1 (zh) * 2021-02-07 2022-08-11 石家庄迪斯凯威医药科技有限公司 一种核苷酸衍生物及其药物组合物和用途
EP4320128A1 (en) 2022-03-02 2024-02-14 Gilead Sciences, Inc. Compounds and methods for treatment of viral infections
CN118165034A (zh) * 2022-12-09 2024-06-11 深圳市塔吉瑞生物医药有限公司 核苷酸类化合物及其组合物及用途
CN116332996A (zh) * 2023-05-04 2023-06-27 南京颐媛生物医学研究院有限公司 抗冠状病毒化合物及其制备方法和应用
CN116284135A (zh) * 2023-05-04 2023-06-23 南京颐媛生物医学研究院有限公司 抗冠状病毒核苷类化合物的制备方法及其应用

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