PE20230618A1 - Analogos de nucleosido de 1'-ciano y usos de los mismos - Google Patents

Analogos de nucleosido de 1'-ciano y usos de los mismos

Info

Publication number
PE20230618A1
PE20230618A1 PE2022003018A PE2022003018A PE20230618A1 PE 20230618 A1 PE20230618 A1 PE 20230618A1 PE 2022003018 A PE2022003018 A PE 2022003018A PE 2022003018 A PE2022003018 A PE 2022003018A PE 20230618 A1 PE20230618 A1 PE 20230618A1
Authority
PE
Peru
Prior art keywords
alkyl
compounds
c6alkyl
cycloalkyl
optionally substituted
Prior art date
Application number
PE2022003018A
Other languages
English (en)
Inventor
Daniel H Byun
Byoung-Kwon Chun
Michael O Clarke
Petr Jansa
Rao V Kalla
Dmitry Koltun
Richard L Mackman
Thao D Perry
Dustin S Siegel
Scott P Simonovich
Original Assignee
Gilead Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gilead Sciences Inc filed Critical Gilead Sciences Inc
Publication of PE20230618A1 publication Critical patent/PE20230618A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicinal Preparation (AREA)

Abstract

La presente invencion se refiere a un compuesto de formula I, donde: cada R1 y R2 son independientemente H, -(CO)alquilo C1-C6 o -(CO)OalquiloC1-C6, donde el alquilo y Oalquilo estan opcionalmente sustituido con un grupo NH2; o R1 y R2 se combinan para formar -CO, -CO-CO-, entre otros; R3A es H o alquilo C1-C6, en donde el alquilo esta opcionalmente sustituido con -OH o fenilo; R3B es H o alquilo C1-C3; R4 es alquilo C1-C8, cicloalquilo C3-C10, entre otros; la base es i), ii) o ii), donde R6 es -NHR6A y R6A, R7A y R7B son H o CH2OPO(OH)2; Ar es arilo C6-C10 o heteroarilo de 5 a 10 miembros que contiene uno a tres heteroatomos seleccionados de O, N y S; n es 0 a 3; R5 es halo, ciano, alquilo C1-C6, entre otros, o dos grupos R5 se unen con los atomos de carbono adyacentes para formar un cicloalquilo C5-C6. Son compuestos especificos los compuestos seleccionados del grupo que consiste en a), b), c), d), entre otros. Tambien se refiere a una composicion farmaceutica. Dichos compuestos son utiles en el tratamiento de infecciones virales, tal como una infeccion por virus de la influenza, virus del ebola, sarampion, paperas, entre otros.
PE2022003018A 2020-06-24 2021-06-23 Analogos de nucleosido de 1'-ciano y usos de los mismos PE20230618A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063043349P 2020-06-24 2020-06-24
US202163139648P 2021-01-20 2021-01-20
PCT/US2021/038645 WO2021262826A2 (en) 2020-06-24 2021-06-23 1'-cyano nucleoside analogs and uses thereof

Publications (1)

Publication Number Publication Date
PE20230618A1 true PE20230618A1 (es) 2023-04-14

Family

ID=76959096

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2022003018A PE20230618A1 (es) 2020-06-24 2021-06-23 Analogos de nucleosido de 1'-ciano y usos de los mismos

Country Status (17)

Country Link
US (1) US11939347B2 (es)
EP (1) EP4172160A2 (es)
JP (1) JP2023531524A (es)
KR (1) KR20230028486A (es)
CN (1) CN115996928A (es)
AU (1) AU2021296841A1 (es)
BR (1) BR112022026321A2 (es)
CA (1) CA3187821A1 (es)
CL (1) CL2022003733A1 (es)
CO (1) CO2022018715A2 (es)
CR (1) CR20220675A (es)
DO (1) DOP2022000293A (es)
IL (1) IL299202A (es)
MX (1) MX2022016405A (es)
PE (1) PE20230618A1 (es)
TW (1) TWI819321B (es)
WO (1) WO2021262826A2 (es)

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EP4157272A1 (en) 2020-05-29 2023-04-05 Gilead Sciences, Inc. Remdesivir treatment methods
BR112022026321A2 (pt) 2020-06-24 2023-01-17 Gilead Sciences Inc Análogos de 1'-ciano nucleosídeo e usos dos mesmos
US11926645B2 (en) 2020-08-27 2024-03-12 Gilead Sciences, Inc. Compounds and methods for treatment of viral infections
WO2022166581A1 (zh) * 2021-02-07 2022-08-11 石家庄迪斯凯威医药科技有限公司 一种核苷酸衍生物及其药物组合物和用途
TW202400185A (zh) 2022-03-02 2024-01-01 美商基利科學股份有限公司 用於治療病毒感染的化合物及方法
CN116284135A (zh) * 2023-05-04 2023-06-23 南京颐媛生物医学研究院有限公司 抗冠状病毒核苷类化合物的制备方法及其应用
CN116332996A (zh) * 2023-05-04 2023-06-27 南京颐媛生物医学研究院有限公司 抗冠状病毒化合物及其制备方法和应用

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