BRPI0415883A - compostos e composições de nucleosìdeo para o tratamento de infecções virais - Google Patents
compostos e composições de nucleosìdeo para o tratamento de infecções viraisInfo
- Publication number
- BRPI0415883A BRPI0415883A BRPI0415883-0A BRPI0415883A BRPI0415883A BR PI0415883 A BRPI0415883 A BR PI0415883A BR PI0415883 A BRPI0415883 A BR PI0415883A BR PI0415883 A BRPI0415883 A BR PI0415883A
- Authority
- BR
- Brazil
- Prior art keywords
- compositions
- viral infections
- treatment
- nucleoside compounds
- compounds
- Prior art date
Links
- 208000036142 Viral infection Diseases 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 title abstract 3
- 239000002777 nucleoside Substances 0.000 title abstract 2
- -1 nucleoside compounds Chemical class 0.000 title abstract 2
- 230000009385 viral infection Effects 0.000 title abstract 2
- 241000710781 Flaviviridae Species 0.000 abstract 1
- 241000711549 Hepacivirus C Species 0.000 abstract 1
- 241000700605 Viruses Species 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/14—Pyrrolo-pyrimidine radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Biotechnology (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Genetics & Genomics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
"COMPOSTOS E COMPOSIçõES DE NUCLEOSìDEO PARA O TRATAMENTO DE INFECçõES VIRAIS". São divulgados compostos, composições e métodos para o tratamento de infecções virais causadas por um vírus da família flaviviridae, tal como vírus da hepatite C.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US51515303P | 2003-10-27 | 2003-10-27 | |
US10/861,090 US7202223B2 (en) | 2003-10-27 | 2004-06-04 | Nucleoside compounds for treating viral infections |
US60281504P | 2004-08-18 | 2004-08-18 | |
PCT/US2004/034955 WO2005042556A1 (en) | 2003-10-27 | 2004-10-20 | Nucleoside compounds for treating viral infections |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0415883A true BRPI0415883A (pt) | 2007-01-09 |
Family
ID=34557362
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0415883-0A BRPI0415883A (pt) | 2003-10-27 | 2004-10-20 | compostos e composições de nucleosìdeo para o tratamento de infecções virais |
Country Status (15)
Country | Link |
---|---|
US (1) | US7157434B2 (pt) |
EP (1) | EP1680436A1 (pt) |
JP (1) | JP2007509939A (pt) |
KR (1) | KR20060096487A (pt) |
AR (1) | AR046202A1 (pt) |
AU (1) | AU2004285923A1 (pt) |
BR (1) | BRPI0415883A (pt) |
CA (1) | CA2542776A1 (pt) |
IL (1) | IL174685A0 (pt) |
MX (1) | MXPA06004680A (pt) |
NO (1) | NO20062146L (pt) |
SV (1) | SV2005001920A (pt) |
TW (3) | TW200524587A (pt) |
UY (1) | UY28581A1 (pt) |
WO (1) | WO2005042556A1 (pt) |
Families Citing this family (41)
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MY164523A (en) | 2000-05-23 | 2017-12-29 | Univ Degli Studi Cagliari | Methods and compositions for treating hepatitis c virus |
KR20030036189A (ko) | 2000-05-26 | 2003-05-09 | 이데닉스(케이만)리미티드 | 플라비바이러스 및 페스티바이러스의 치료방법 및 조성물 |
CN101172993A (zh) * | 2002-06-28 | 2008-05-07 | 埃迪尼克斯(开曼)有限公司 | 用于治疗黄病毒感染的2′-c-甲基-3′-o-l-缬氨酸酯核糖呋喃基胞苷 |
AU2003248748A1 (en) * | 2002-06-28 | 2004-01-19 | Idenix (Cayman) Limited | 2'-c-methyl-3'-o-l-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections |
US7608600B2 (en) | 2002-06-28 | 2009-10-27 | Idenix Pharmaceuticals, Inc. | Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections |
KR20050088079A (ko) | 2002-11-15 | 2005-09-01 | 이데닉스 (케이만) 리미티드 | 2'-분지형 뉴클레오시드 및 플라비비리다에 돌연변이 |
EP2319853B1 (en) * | 2002-12-12 | 2014-03-12 | IDENIX Pharmaceuticals, Inc. | Process for the production of 2'-branched nucleosides |
CN1882327A (zh) | 2003-11-19 | 2006-12-20 | 症变治疗公司 | 含磷的新的拟甲状腺素药 |
US20050182252A1 (en) * | 2004-02-13 | 2005-08-18 | Reddy K. R. | Novel 2'-C-methyl nucleoside derivatives |
WO2006121468A1 (en) | 2004-11-22 | 2006-11-16 | Genelabs Technologies, Inc. | 5-nitro-nucleoside compounds for treating viral infections |
WO2006093987A1 (en) * | 2005-02-28 | 2006-09-08 | Genelabs Technologies, Inc. | Tricyclic-nucleoside compounds for treating viral infections |
WO2006102594A1 (en) * | 2005-03-23 | 2006-09-28 | Genelabs Technologies, Inc. | Nucleoside prodrugs for treating viral infections |
WO2007084157A2 (en) * | 2005-03-23 | 2007-07-26 | Genelabs Technologies, Inc. | Nucleoside prodrugs for treating viral infections |
AR056327A1 (es) * | 2005-04-25 | 2007-10-03 | Genelabs Tech Inc | Compuestos de nucleosidos para el tratamiento de infecciones virales |
CA2606499C (en) | 2005-05-26 | 2017-06-13 | Metabasis Therapeutics, Inc. | Thyromimetics for the treatment of fatty liver diseases |
CA2981431C (en) | 2005-06-08 | 2021-04-13 | Dana-Farber Cancer Institute Inc. | Use of compounds that reduce activity or expression of programmed cell death-1 to treat lymphoma |
US8067571B2 (en) | 2005-07-13 | 2011-11-29 | Avi Biopharma, Inc. | Antibacterial antisense oligonucleotide and method |
US7781576B2 (en) * | 2005-12-23 | 2010-08-24 | Idenix Pharmaceuticals, Inc. | Process for preparing a synthetic intermediate for preparation of branched nucleosides |
AU2007342367B2 (en) * | 2007-01-05 | 2012-12-06 | Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. | Nucleoside aryl phosphoramidates for the treatment of RNA-dependent RNA viral infection |
TW200838550A (en) * | 2007-02-09 | 2008-10-01 | Novartis Ag | Organic compounds |
US7964580B2 (en) * | 2007-03-30 | 2011-06-21 | Pharmasset, Inc. | Nucleoside phosphoramidate prodrugs |
GB0709791D0 (en) * | 2007-05-22 | 2007-06-27 | Angeletti P Ist Richerche Bio | Antiviral agents |
WO2010015637A1 (en) * | 2008-08-06 | 2010-02-11 | Novartis Ag | New antiviral modified nucleosides |
HUE028582T2 (en) | 2008-11-28 | 2016-12-28 | Univ Emory | Method for determining the efficacy of PD-1 antagonists |
EA019295B1 (ru) * | 2008-12-23 | 2014-02-28 | Джилид Фармассет, Ллс. | Соединения пуриновых нуклеозидов и способ их получения |
GB0900914D0 (en) | 2009-01-20 | 2009-03-04 | Angeletti P Ist Richerche Bio | Antiviral agents |
EP2421879B1 (en) * | 2009-04-22 | 2013-09-04 | Institute Of Organic Chemistry And Biochemistry As CR, V.V.I. | Novel 7-deazapurine nucleosides for therapeutic uses |
US8779128B2 (en) | 2010-05-28 | 2014-07-15 | Sarepta Therapeutics, Inc. | Oligonucleotide analogues having modified intersubunit linkages and/or terminal groups |
WO2012031243A2 (en) | 2010-09-03 | 2012-03-08 | Avi Biopharma, Inc. | dsRNA MOLECULES COMPRISING OLIGONUCLEOTIDE ANALOGS HAVING MODIFIED INTERSUBUNIT LINKAGES AND/OR TERMINAL GROUPS |
BR112013005872A2 (pt) * | 2010-09-22 | 2019-09-24 | Alios Biopharma Inc | compostos, composição farmacêutica e respectivos usos |
JP2015500204A (ja) | 2011-11-18 | 2015-01-05 | サレプタ セラピューティクス, インコーポレイテッド | 機能的に修飾されたオリゴヌクレオチドおよびそのサブユニット |
RU2015148006A (ru) | 2013-04-12 | 2017-05-18 | Ачиллион Фармасютикалз, Инк. | Дейтерированные нуклеозидные пролекарства, применимые для лечения hcv |
TWI574691B (zh) | 2013-07-18 | 2017-03-21 | Taiho Pharmaceutical Co Ltd | Anti - tumor agents for intermittent administration of FGFR inhibitors |
TWI585089B (zh) | 2013-08-12 | 2017-06-01 | Taiho Pharmaceutical Co Ltd | Novel condensed pyrimidine compounds or salts thereof |
EP3105238A4 (en) | 2014-02-13 | 2017-11-08 | Ligand Pharmaceuticals, Inc. | Prodrug compounds and their uses |
EP3164136A4 (en) | 2014-07-02 | 2018-04-04 | Ligand Pharmaceuticals, Inc. | Prodrug compounds and uses therof |
EP3302489A4 (en) | 2015-06-04 | 2019-02-06 | Sarepta Therapeutics, Inc. | METHOD AND COMPOUNDS FOR THE TREATMENT OF DISEASES AND SUFFERING IN CONNECTION WITH LYMPHOCYTES |
CA3044059A1 (en) | 2016-11-21 | 2018-05-24 | Viking Therapeutics, Inc. | Method of treating glycogen storage disease |
BR112019025659A2 (pt) | 2017-06-05 | 2020-08-25 | Viking Therapeutics, Inc. | composições para o tratamento de fibrose |
CN111788196A (zh) | 2018-01-09 | 2020-10-16 | 配体药物公司 | 缩醛化合物及其治疗用途 |
AU2019238090A1 (en) | 2018-03-22 | 2020-10-08 | Viking Therapeutics, Inc. | Crystalline forms and methods of producing crystalline forms of a compound |
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US4140851A (en) * | 1977-11-21 | 1979-02-20 | The United States Of America As Represented By The Department Of Health, Education And Welfare | Synthesis and antitumor activity of 2,4,5-trisubstituted-pyrrolo2,3-d]-pyrimidine nucleosides |
JPS61229897A (ja) | 1985-04-05 | 1986-10-14 | Nippon Zoki Pharmaceut Co Ltd | 新規ヌクレオシド化合物 |
US6211158B1 (en) * | 1987-04-10 | 2001-04-03 | Roche Diagnostics Gmbh | Desazapurine-nucleotide derivatives, processes for the preparation thereof, pharmaceutical compositions containing them and the use thereof for nucleic acid sequencing and as antiviral agents |
US4892865A (en) * | 1987-12-01 | 1990-01-09 | The Regents Of The University Of Michigan | Pyrrolo[2,3-d]pyrimidine nucleosides as antiviral agents |
US4927830A (en) * | 1988-04-08 | 1990-05-22 | The Regents Of The University Of Michigan | Acyclic pyrrolo[2,3-D]pyrimidine analogs as antiviral agents |
US4968686A (en) * | 1988-04-08 | 1990-11-06 | The Regents Of The University Of Michigan | Acyclic pyrrolo [2,3-d]pyrimidine analogs as antiviral agents |
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US20040014957A1 (en) * | 2002-05-24 | 2004-01-22 | Anne Eldrup | Oligonucleotides having modified nucleoside units |
WO2003100017A2 (en) * | 2002-05-24 | 2003-12-04 | Isis Pharmaceuticals, Inc. | Oligonucleotides having modified nucleoside units |
US20060264389A1 (en) | 2002-07-16 | 2006-11-23 | Balkrishen Bhat | Nucleoside derivatives as inhibitors of rna-dependent rna viral polymerase |
CN1671727A (zh) | 2002-07-25 | 2005-09-21 | 麦克洛基克斯生物技术有限公司 | 抗病毒7-脱氮-d-核苷及其用途 |
US7094768B2 (en) * | 2002-09-30 | 2006-08-22 | Genelabs Technologies, Inc. | Nucleoside derivatives for treating hepatitis C virus infection |
MXPA05003400A (es) | 2002-09-30 | 2005-06-22 | Genelabs Tech Inc | Derivados de nucleosidos para tratar la infeccion por el virus de la hepatitis c. |
AU2003291682A1 (en) | 2002-11-05 | 2004-06-03 | Isis Pharmaceuticals, Inc. | 2'-methoxy substituted oligomeric compounds and compositions for use in gene modulations |
-
2004
- 2004-10-20 US US10/970,321 patent/US7157434B2/en not_active Expired - Fee Related
- 2004-10-20 BR BRPI0415883-0A patent/BRPI0415883A/pt not_active Application Discontinuation
- 2004-10-20 MX MXPA06004680A patent/MXPA06004680A/es unknown
- 2004-10-20 CA CA002542776A patent/CA2542776A1/en not_active Abandoned
- 2004-10-20 EP EP04810014A patent/EP1680436A1/en not_active Withdrawn
- 2004-10-20 WO PCT/US2004/034955 patent/WO2005042556A1/en not_active Application Discontinuation
- 2004-10-20 KR KR1020067008060A patent/KR20060096487A/ko not_active Application Discontinuation
- 2004-10-20 AU AU2004285923A patent/AU2004285923A1/en not_active Abandoned
- 2004-10-20 JP JP2006538116A patent/JP2007509939A/ja active Pending
- 2004-10-26 TW TW093132438A patent/TW200524587A/zh unknown
- 2004-10-26 UY UY28581A patent/UY28581A1/es not_active Application Discontinuation
- 2004-10-26 TW TW093132415A patent/TW200524606A/zh unknown
- 2004-10-26 AR ARP040103897A patent/AR046202A1/es unknown
- 2004-10-26 TW TW093132412A patent/TW200528466A/zh unknown
- 2004-10-27 SV SV2004001920A patent/SV2005001920A/es not_active Application Discontinuation
-
2006
- 2006-03-30 IL IL174685A patent/IL174685A0/en unknown
- 2006-05-12 NO NO20062146A patent/NO20062146L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
US20050107312A1 (en) | 2005-05-19 |
AR046202A1 (es) | 2005-11-30 |
MXPA06004680A (es) | 2007-04-17 |
JP2007509939A (ja) | 2007-04-19 |
WO2005042556A1 (en) | 2005-05-12 |
SV2005001920A (es) | 2005-08-18 |
NO20062146L (no) | 2006-07-21 |
CA2542776A1 (en) | 2005-05-12 |
EP1680436A1 (en) | 2006-07-19 |
TW200524606A (en) | 2005-08-01 |
UY28581A1 (es) | 2005-05-31 |
TW200524587A (en) | 2005-08-01 |
AU2004285923A1 (en) | 2005-05-12 |
IL174685A0 (en) | 2006-08-20 |
KR20060096487A (ko) | 2006-09-11 |
US7157434B2 (en) | 2007-01-02 |
TW200528466A (en) | 2005-09-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B11A | Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing | ||
B11Y | Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette] |