AR046202A1 - Compuestos nucleosidicos para el tratamiento de infecciones virales - Google Patents
Compuestos nucleosidicos para el tratamiento de infecciones viralesInfo
- Publication number
- AR046202A1 AR046202A1 ARP040103897A ARP040103897A AR046202A1 AR 046202 A1 AR046202 A1 AR 046202A1 AR P040103897 A ARP040103897 A AR P040103897A AR P040103897 A ARP040103897 A AR P040103897A AR 046202 A1 AR046202 A1 AR 046202A1
- Authority
- AR
- Argentina
- Prior art keywords
- treatment
- viral infections
- nucleosidic compounds
- nucleosidic
- compounds
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 208000036142 Viral infection Diseases 0.000 title 1
- 150000003839 salts Chemical class 0.000 abstract 2
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/14—Pyrrolo-pyrimidine radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Genetics & Genomics (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Virology (AREA)
- Biochemistry (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Reivindicaciones 1: Un compuesto caracterizado porque es de la fórmula (1) donde Y se selecciona del grupo formado por un enlace, -CH2- o -O-; cada uno de W, W1 y W2 se selecciona independientemente del grupo formado por H y una prodroga aceptable para uso farmacéutico, y sales o sales parciales aceptables para uso farmacéutico de la misma.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US51515303P | 2003-10-27 | 2003-10-27 | |
US10/861,090 US7202223B2 (en) | 2003-10-27 | 2004-06-04 | Nucleoside compounds for treating viral infections |
US60281504P | 2004-08-18 | 2004-08-18 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR046202A1 true AR046202A1 (es) | 2005-11-30 |
Family
ID=34557362
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP040103897A AR046202A1 (es) | 2003-10-27 | 2004-10-26 | Compuestos nucleosidicos para el tratamiento de infecciones virales |
Country Status (15)
Country | Link |
---|---|
US (1) | US7157434B2 (es) |
EP (1) | EP1680436A1 (es) |
JP (1) | JP2007509939A (es) |
KR (1) | KR20060096487A (es) |
AR (1) | AR046202A1 (es) |
AU (1) | AU2004285923A1 (es) |
BR (1) | BRPI0415883A (es) |
CA (1) | CA2542776A1 (es) |
IL (1) | IL174685A0 (es) |
MX (1) | MXPA06004680A (es) |
NO (1) | NO20062146L (es) |
SV (1) | SV2005001920A (es) |
TW (3) | TW200524587A (es) |
UY (1) | UY28581A1 (es) |
WO (1) | WO2005042556A1 (es) |
Families Citing this family (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MY164523A (en) * | 2000-05-23 | 2017-12-29 | Univ Degli Studi Cagliari | Methods and compositions for treating hepatitis c virus |
JP5230052B2 (ja) * | 2000-05-26 | 2013-07-10 | イデニクス(ケイマン)リミテツド | フラビウイルスおよびペスチウイルス治療のための方法および組成物 |
WO2004002422A2 (en) * | 2002-06-28 | 2004-01-08 | Idenix (Cayman) Limited | 2’-c-methyl-3’-o-l-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections |
NZ537662A (en) * | 2002-06-28 | 2007-10-26 | Idenix Cayman Ltd | 2'-C-methyl-3'-O-L-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections |
US7608600B2 (en) * | 2002-06-28 | 2009-10-27 | Idenix Pharmaceuticals, Inc. | Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections |
CA2506129C (en) * | 2002-11-15 | 2015-02-17 | Idenix (Cayman) Limited | 2'-branched nucleosides and flaviviridae mutation |
AU2003300901A1 (en) * | 2002-12-12 | 2004-06-30 | Idenix (Cayman) Limited | Process for the production of 2'-branched nucleosides |
WO2005051298A2 (en) | 2003-11-19 | 2005-06-09 | Metabasis Therapeutics, Inc. | Novel phosphorus-containing thyromimetics |
US20050182252A1 (en) * | 2004-02-13 | 2005-08-18 | Reddy K. R. | Novel 2'-C-methyl nucleoside derivatives |
WO2006121468A1 (en) | 2004-11-22 | 2006-11-16 | Genelabs Technologies, Inc. | 5-nitro-nucleoside compounds for treating viral infections |
WO2006093986A1 (en) | 2005-02-28 | 2006-09-08 | Genelabs Technologies, Inc. | Tricyclic-nucleoside prodrugs for treating viral infections |
WO2006102594A1 (en) * | 2005-03-23 | 2006-09-28 | Genelabs Technologies, Inc. | Nucleoside prodrugs for treating viral infections |
WO2007084157A2 (en) * | 2005-03-23 | 2007-07-26 | Genelabs Technologies, Inc. | Nucleoside prodrugs for treating viral infections |
WO2006116557A1 (en) * | 2005-04-25 | 2006-11-02 | Genelabs Technologies, Inc. | Nucleoside compounds for treating viral infections |
US20090232879A1 (en) | 2005-05-26 | 2009-09-17 | Metabasis Therapeutics, Inc. | Thyromimetics for the Treatment of Fatty Liver Diseases |
PT2397156T (pt) | 2005-06-08 | 2016-12-23 | The President And Fellows Of Harvard College | Métodos e composições para tratamento de infeções persistentes e cancro através da inibição da via de morte celular programada 1 (pd-1) |
US8067571B2 (en) | 2005-07-13 | 2011-11-29 | Avi Biopharma, Inc. | Antibacterial antisense oligonucleotide and method |
WO2007075876A2 (en) * | 2005-12-23 | 2007-07-05 | Idenix Pharmaceuticals, Inc. | Process for preparing a synthetic intermediate for preparation of branched nucleosides |
JP2010515680A (ja) * | 2007-01-05 | 2010-05-13 | メルク・シャープ・エンド・ドーム・コーポレイション | Rna依存性rnaウイルス感染症の治療用としてのヌクレオシドアリールホスホロアミデート |
TW200838550A (en) * | 2007-02-09 | 2008-10-01 | Novartis Ag | Organic compounds |
US7964580B2 (en) * | 2007-03-30 | 2011-06-21 | Pharmasset, Inc. | Nucleoside phosphoramidate prodrugs |
GB0709791D0 (en) * | 2007-05-22 | 2007-06-27 | Angeletti P Ist Richerche Bio | Antiviral agents |
WO2010015637A1 (en) * | 2008-08-06 | 2010-02-11 | Novartis Ag | New antiviral modified nucleosides |
KR101721707B1 (ko) | 2008-11-28 | 2017-03-30 | 에모리 유니버시티 | 감염 및 종양 치료 방법 |
SG172363A1 (en) | 2008-12-23 | 2011-07-28 | Pharmasset Inc | Synthesis of purine nucleosides |
GB0900914D0 (en) | 2009-01-20 | 2009-03-04 | Angeletti P Ist Richerche Bio | Antiviral agents |
SI2421879T1 (sl) * | 2009-04-22 | 2014-01-31 | Institute Of Organic Chemistry And Biochemistry As Cr | Novi 7-deazapurinski nukleozidi za terapevtske uporabe |
TWI620756B (zh) | 2010-05-28 | 2018-04-11 | 薩羅塔治療公司 | 具有經修飾之單元間連結及/或末端基團之寡核苷酸類似物 |
WO2012031243A2 (en) | 2010-09-03 | 2012-03-08 | Avi Biopharma, Inc. | dsRNA MOLECULES COMPRISING OLIGONUCLEOTIDE ANALOGS HAVING MODIFIED INTERSUBUNIT LINKAGES AND/OR TERMINAL GROUPS |
CN103209987B (zh) | 2010-09-22 | 2017-06-06 | 艾丽奥斯生物制药有限公司 | 取代的核苷酸类似物 |
CA2854907C (en) * | 2011-11-18 | 2020-03-10 | Sarepta Therapeutics, Inc. | Functionally-modified oligonucleotides and subunits thereof |
CN105377868A (zh) | 2013-04-12 | 2016-03-02 | 艾其林医药公司 | 用于治疗hcv的高活性核苷衍生物 |
PT3023100T (pt) | 2013-07-18 | 2019-05-29 | Taiho Pharmaceutical Co Ltd | Fármaco antitumoral para administração intermitente de inibidor de fgfr |
JP6035423B2 (ja) | 2013-08-12 | 2016-11-30 | 大鵬薬品工業株式会社 | 新規な縮合ピリミジン化合物又はその塩 |
EP3105238A4 (en) | 2014-02-13 | 2017-11-08 | Ligand Pharmaceuticals, Inc. | Prodrug compounds and their uses |
WO2016003812A1 (en) | 2014-07-02 | 2016-01-07 | Ligand Pharmaceuticals, Inc. | Prodrug compounds and uses therof |
WO2016196897A1 (en) | 2015-06-04 | 2016-12-08 | Sarepta Therapeutics, Inc. | Methods and compounds for treatment of lymphocyte-related diseases and conditions |
CN110198719A (zh) | 2016-11-21 | 2019-09-03 | 维京治疗公司 | 治疗糖原贮积病的方法 |
AU2018280118B2 (en) | 2017-06-05 | 2021-07-15 | Viking Therapeutics, Inc. | Compositions for the treatment of fibrosis |
CN111788196A (zh) | 2018-01-09 | 2020-10-16 | 配体药物公司 | 缩醛化合物及其治疗用途 |
CA3094167A1 (en) | 2018-03-22 | 2019-09-26 | Viking Therapeutics, Inc. | Crystalline forms and methods of producing crystalline forms of a compound |
JP2022510691A (ja) | 2018-12-05 | 2022-01-27 | バイキング・セラピューティクス・インコーポレイテッド | 線維症及び炎症の処置のための組成物 |
Family Cites Families (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4140851A (en) | 1977-11-21 | 1979-02-20 | The United States Of America As Represented By The Department Of Health, Education And Welfare | Synthesis and antitumor activity of 2,4,5-trisubstituted-pyrrolo2,3-d]-pyrimidine nucleosides |
JPS61229897A (ja) | 1985-04-05 | 1986-10-14 | Nippon Zoki Pharmaceut Co Ltd | 新規ヌクレオシド化合物 |
US6211158B1 (en) | 1987-04-10 | 2001-04-03 | Roche Diagnostics Gmbh | Desazapurine-nucleotide derivatives, processes for the preparation thereof, pharmaceutical compositions containing them and the use thereof for nucleic acid sequencing and as antiviral agents |
US4892865A (en) | 1987-12-01 | 1990-01-09 | The Regents Of The University Of Michigan | Pyrrolo[2,3-d]pyrimidine nucleosides as antiviral agents |
US4968686A (en) | 1988-04-08 | 1990-11-06 | The Regents Of The University Of Michigan | Acyclic pyrrolo [2,3-d]pyrimidine analogs as antiviral agents |
US4927830A (en) | 1988-04-08 | 1990-05-22 | The Regents Of The University Of Michigan | Acyclic pyrrolo[2,3-D]pyrimidine analogs as antiviral agents |
US5824796A (en) | 1988-09-28 | 1998-10-20 | Epoch Pharmaceuticals, Inc. | Cross-linking oligonucleotides |
US5763597A (en) | 1989-09-15 | 1998-06-09 | Metabasis Therapeutics, Inc. | Orally active adenosine kinase inhibitors |
EP0604409B1 (en) | 1990-01-11 | 2004-07-14 | Isis Pharmaceuticals, Inc. | Oligonucleotide analogs for detecting and modulating rna activity and gene expression |
US5681941A (en) | 1990-01-11 | 1997-10-28 | Isis Pharmaceuticals, Inc. | Substituted purines and oligonucleotide cross-linking |
EP0684953A4 (en) | 1993-02-03 | 1999-12-22 | Gensia Inc | ADENOSINE KINASE INHIBITORS COMPRISING LYXOFURANOSYL DERIVATIVES. |
AU6632094A (en) | 1993-04-19 | 1994-11-08 | Gilead Sciences, Inc. | Enhanced triple-helix and double-helix formation with oligomers containing modified purines |
EP0719274A1 (en) | 1993-09-17 | 1996-07-03 | Gilead Sciences, Inc. | Method for dosing therapeutic compounds |
US5798340A (en) | 1993-09-17 | 1998-08-25 | Gilead Sciences, Inc. | Nucleotide analogs |
US6150510A (en) | 1995-11-06 | 2000-11-21 | Aventis Pharma Deutschland Gmbh | Modified oligonucleotides, their preparation and their use |
DE4438918A1 (de) | 1994-11-04 | 1996-05-09 | Hoechst Ag | Modifizierte Oligonukleotide, deren Herstellung sowie deren Verwendung |
US6004939A (en) | 1995-07-06 | 1999-12-21 | Ctrc Research Foundation Board Of Regents | Methods for modulation and inhibition of telomerase |
US6054442A (en) | 1995-07-06 | 2000-04-25 | Board Of Regents, University Of Texas System | Methods and compositions for modulation and inhibition of telomerase in vitro |
FR2750435B1 (fr) | 1996-06-27 | 1998-08-28 | Appligene Oncor | Procede de formation de complexes d'hybridation dont la stabilite depend peu de la composition en base des deux molecules d'acides nucleiques hybridees |
US6831069B2 (en) | 1999-08-27 | 2004-12-14 | Ribapharm Inc. | Pyrrolo[2,3-d]pyrimidine nucleoside analogs |
EP1138689A1 (en) | 2000-03-28 | 2001-10-04 | Roche Diagnostics GmbH | N8- and C8-linked purine bases as universal nucleosides used for oligonucleotide hybridization |
MY164523A (en) | 2000-05-23 | 2017-12-29 | Univ Degli Studi Cagliari | Methods and compositions for treating hepatitis c virus |
US20030008841A1 (en) | 2000-08-30 | 2003-01-09 | Rene Devos | Anti-HCV nucleoside derivatives |
EP1539188B1 (en) | 2001-01-22 | 2015-01-07 | Merck Sharp & Dohme Corp. | Nucleoside derivatives as inhibitors of rna-dependent rna viral polymerase |
AU2002353165A1 (en) | 2001-12-17 | 2003-06-30 | Ribapharm Inc. | Deazapurine nucleoside libraries and compounds |
CA2470521A1 (en) | 2001-12-21 | 2003-07-10 | Micrologix Biotech Inc. | Anti-viral 7-deaza l-nucleosides |
WO2003062256A1 (en) | 2002-01-17 | 2003-07-31 | Ribapharm Inc. | 2'-beta-modified-6-substituted adenosine analogs and their use as antiviral agents |
AU2003209045B2 (en) * | 2002-02-13 | 2006-12-14 | Isis Pharmaceuticals, Inc. | Methods of inhibiting orthopoxvirus replication with nucleoside compounds |
US20040014108A1 (en) | 2002-05-24 | 2004-01-22 | Eldrup Anne B. | Oligonucleotides having modified nucleoside units |
AU2003237249A1 (en) | 2002-05-24 | 2003-12-12 | Isis Pharmaceuticals, Inc. | Oligonucleotides having modified nucleoside units |
AU2003269902A1 (en) | 2002-07-16 | 2004-02-02 | Isis Pharmaceuticals, Inc. | Nucleoside derivatives as inhibitors of rna-dependent rna viral polymerase |
AU2003254657A1 (en) | 2002-07-25 | 2004-02-16 | Micrologix Biotech Inc. | Anti-viral 7-deaza d-nucleosides and uses thereof |
WO2004028481A2 (en) | 2002-09-30 | 2004-04-08 | Genelabs Technologies, Inc. | Nucleoside derivatives for treating hepatitis c virus infection |
US7094768B2 (en) * | 2002-09-30 | 2006-08-22 | Genelabs Technologies, Inc. | Nucleoside derivatives for treating hepatitis C virus infection |
WO2004044140A2 (en) | 2002-11-05 | 2004-05-27 | Isis Pharmaceticals, Inc. | 2’-substituted oligomeric compounds and compositions for use in gene modulations |
-
2004
- 2004-10-20 KR KR1020067008060A patent/KR20060096487A/ko not_active Application Discontinuation
- 2004-10-20 AU AU2004285923A patent/AU2004285923A1/en not_active Abandoned
- 2004-10-20 US US10/970,321 patent/US7157434B2/en not_active Expired - Fee Related
- 2004-10-20 JP JP2006538116A patent/JP2007509939A/ja active Pending
- 2004-10-20 CA CA002542776A patent/CA2542776A1/en not_active Abandoned
- 2004-10-20 WO PCT/US2004/034955 patent/WO2005042556A1/en not_active Application Discontinuation
- 2004-10-20 BR BRPI0415883-0A patent/BRPI0415883A/pt not_active Application Discontinuation
- 2004-10-20 MX MXPA06004680A patent/MXPA06004680A/es unknown
- 2004-10-20 EP EP04810014A patent/EP1680436A1/en not_active Withdrawn
- 2004-10-26 AR ARP040103897A patent/AR046202A1/es unknown
- 2004-10-26 TW TW093132438A patent/TW200524587A/zh unknown
- 2004-10-26 UY UY28581A patent/UY28581A1/es not_active Application Discontinuation
- 2004-10-26 TW TW093132415A patent/TW200524606A/zh unknown
- 2004-10-26 TW TW093132412A patent/TW200528466A/zh unknown
- 2004-10-27 SV SV2004001920A patent/SV2005001920A/es not_active Application Discontinuation
-
2006
- 2006-03-30 IL IL174685A patent/IL174685A0/en unknown
- 2006-05-12 NO NO20062146A patent/NO20062146L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
SV2005001920A (es) | 2005-08-18 |
UY28581A1 (es) | 2005-05-31 |
TW200524587A (en) | 2005-08-01 |
AU2004285923A1 (en) | 2005-05-12 |
WO2005042556A1 (en) | 2005-05-12 |
KR20060096487A (ko) | 2006-09-11 |
US7157434B2 (en) | 2007-01-02 |
BRPI0415883A (pt) | 2007-01-09 |
TW200524606A (en) | 2005-08-01 |
IL174685A0 (en) | 2006-08-20 |
JP2007509939A (ja) | 2007-04-19 |
EP1680436A1 (en) | 2006-07-19 |
TW200528466A (en) | 2005-09-01 |
NO20062146L (no) | 2006-07-21 |
MXPA06004680A (es) | 2007-04-17 |
CA2542776A1 (en) | 2005-05-12 |
US20050107312A1 (en) | 2005-05-19 |
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FB | Suspension of granting procedure |