CY1112733T1 - Ενωσεις ιμιδαζο [4,5-c]πυριδινης και μεθοδοι αντι-ιικης θεραπειας - Google Patents

Ενωσεις ιμιδαζο [4,5-c]πυριδινης και μεθοδοι αντι-ιικης θεραπειας

Info

Publication number
CY1112733T1
CY1112733T1 CY20121100329T CY121100329T CY1112733T1 CY 1112733 T1 CY1112733 T1 CY 1112733T1 CY 20121100329 T CY20121100329 T CY 20121100329T CY 121100329 T CY121100329 T CY 121100329T CY 1112733 T1 CY1112733 T1 CY 1112733T1
Authority
CY
Cyprus
Prior art keywords
imidazo
pyridine compounds
virtual methods
treatment
general formula
Prior art date
Application number
CY20121100329T
Other languages
English (en)
Inventor
Gerhard Puerstinger
Steven S Bondy
Eric Davis Dowdy
Choung U Kim
David A Oare
Johan Neyts
Vahid Zia
Original Assignee
K.U.Leuven Research & Development
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by K.U.Leuven Research & Development filed Critical K.U.Leuven Research & Development
Publication of CY1112733T1 publication Critical patent/CY1112733T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

Η παρούσα εφεύρεση αφορά σε φαρμακευτικές συνθέσεις για τη θεραπεία ή πρόληψη ιικών μολύνσεων που περιλαμβάνουν ως δραστικό συστατικό τουλάχιστον ένα προφάρμακο ιμιδαζο[4,5-c]πυριδίνης που έχει το γενικό Τύπο (Α), όπου οι υποκαταστάτες περιγράφονται στην περιγραφή. Η εφεύρεση επίσης αφορά σε μεθόδους για την παρασκευή και συστηματική εξέταση ενώσεων σύμφωνα προς την εφεύρεση που έχουν τον ανωτέρω αναφερθέντα γενικό Τύπο και χρήση αυτών στη θεραπεία ή την προφύλαξη ιικών μολύνσεων.
CY20121100329T 2003-12-22 2012-04-03 Ενωσεις ιμιδαζο [4,5-c]πυριδινης και μεθοδοι αντι-ιικης θεραπειας CY1112733T1 (el)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US53229203P 2003-12-22 2003-12-22
US53396304P 2004-01-02 2004-01-02
US59102404P 2004-07-26 2004-07-26
US59106904P 2004-07-26 2004-07-26
US59099004P 2004-07-26 2004-07-26
US59098904P 2004-07-26 2004-07-26
EP04815224A EP1706403B9 (en) 2003-12-22 2004-12-21 Imidazo[4,5-c]pyridine compounds and methods of antiviral treatment

Publications (1)

Publication Number Publication Date
CY1112733T1 true CY1112733T1 (el) 2016-02-10

Family

ID=34744004

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20121100329T CY1112733T1 (el) 2003-12-22 2012-04-03 Ενωσεις ιμιδαζο [4,5-c]πυριδινης και μεθοδοι αντι-ιικης θεραπειας

Country Status (18)

Country Link
US (3) US7648998B2 (el)
EP (3) EP2161273B1 (el)
JP (3) JP4970048B2 (el)
KR (1) KR101131589B1 (el)
AT (1) ATE544765T1 (el)
AU (2) AU2004309390B2 (el)
CA (1) CA2549606C (el)
CY (1) CY1112733T1 (el)
DK (2) DK2161273T3 (el)
ES (1) ES2381890T3 (el)
HK (1) HK1092793A1 (el)
IL (1) IL176298A (el)
NZ (2) NZ548074A (el)
PL (1) PL1706403T3 (el)
PT (1) PT1706403E (el)
SG (1) SG149067A1 (el)
SI (1) SI2161273T1 (el)
WO (1) WO2005063744A2 (el)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69932323T2 (de) 1998-03-02 2006-11-23 Anthony S. Ramona Ellsworth Fahrradaufhängungsvorrichtung und entsprechendes verfahren
GB0215293D0 (en) 2002-07-03 2002-08-14 Rega Foundation Viral inhibitors
US7648998B2 (en) * 2003-12-22 2010-01-19 K.U. Leuven Research & Development Imidazo 4,5-c pyridine compounds and methods of antiviral treatment
CA2574220C (en) * 2004-07-27 2014-09-16 Gilead Sciences, Inc. Imidazo[4,5-d]pyrimidines, their uses and methods of preparation
AU2005319167B2 (en) * 2004-12-21 2011-09-29 Gilead Sciences, Inc. Imidazo[4,5-C]pyridine compound and method of antiviral treatment
US20070128625A1 (en) * 2005-07-25 2007-06-07 Gilead Sciences, Llc Drug-resistant mutants of hepatitis C virus
WO2008005519A2 (en) * 2006-07-07 2008-01-10 Gilead Sciences, Inc. Novel pyridazine compound and use thereof
UA96296C2 (en) * 2006-07-07 2011-10-25 Гилиад Сайенсиз, Инк. Pyridazine compounds and use thereof
AU2011253901B2 (en) * 2006-07-07 2013-08-29 Gilead Sciences, Inc. Novel pyridazine compound and use thereof
CA2672298C (en) 2006-12-14 2015-02-03 K.U.Leuven Research & Development Fused pyridine compounds useful in the prophylaxis or treatment of viral infections
UA99466C2 (en) * 2007-07-06 2012-08-27 Гилиад Сайенсиз, Инк. Crystalline pyridazine compound
TW200920372A (en) * 2007-07-13 2009-05-16 Genelabs Tech Inc Anti-viral compounds, compositions, and methods of use
US20090197880A1 (en) * 2007-07-13 2009-08-06 Genelabs Technologies, Inc. Anti-viral compounds, compositions, and methods of use
UY31685A (es) * 2008-03-04 2009-11-10 Smithkline Beecham Corp Compuestos antivirales, composiciones y metodos para usarlos
KR101220182B1 (ko) * 2009-02-25 2013-01-11 에스케이바이오팜 주식회사 치환된 아졸 유도체 화합물, 이를 포함하는 약제학적 조성물 및 이를 이용한 파킨슨씨 병 치료방법
US8673954B2 (en) 2009-02-27 2014-03-18 Enanta Pharmaceuticals, Inc. Benzimidazole derivatives
WO2010099527A1 (en) 2009-02-27 2010-09-02 Enanta Pharmaceuticals, Inc. Hepatitis c virus inhibitors
US9765087B2 (en) 2009-02-27 2017-09-19 Enanta Pharmaceuticals, Inc. Benzimidazole derivatives
US10752611B2 (en) 2009-02-27 2020-08-25 Enanta Pharmaceuticals, Inc. Benzimidazole derivatives
US8101643B2 (en) * 2009-02-27 2012-01-24 Enanta Pharmaceuticals, Inc. Benzimidazole derivatives
CA2784646A1 (en) 2009-12-18 2011-06-23 Boehringer Ingelheim International Gmbh Hcv combination therapy
US8933110B2 (en) 2010-01-25 2015-01-13 Enanta Pharmaceuticals, Inc. Hepatitis C virus inhibitors
US8785487B2 (en) 2010-01-25 2014-07-22 Enanta Pharmaceuticals, Inc. Hepatitis C virus inhibitors
EP2555622A4 (en) 2010-04-09 2013-09-18 Enanta Pharm Inc HEPATITIS C-VIRUS HEMMER
KR101799429B1 (ko) * 2010-05-03 2017-11-21 에스케이바이오팜 주식회사 신경 세포 사멸 또는 신경 퇴화를 억제하기 위한 약학적 조성물
JP2013526581A (ja) * 2010-05-21 2013-06-24 ギリアード サイエンシーズ， インコーポレイテッド ヘテロ環式フラビウイルス科ウイルス阻害剤
US8778938B2 (en) 2010-06-04 2014-07-15 Enanta Pharmaceuticals, Inc. Hepatitis C virus inhibitors
WO2012021704A1 (en) 2010-08-12 2012-02-16 Enanta Pharmaceuticals, Inc. Hepatitis c virus inhibitors
EP2709455A4 (en) 2011-05-18 2014-11-05 Enanta Pharm Inc PROCESSES FOR THE PREPARATION OF 5-AZASPIRO [2.4] HEPTANE-6-CARBOXYLIC ACID AND ITS DERIVATIVES
US8492386B2 (en) 2011-10-21 2013-07-23 Abbvie Inc. Methods for treating HCV
ES2527544T1 (es) 2011-10-21 2015-01-26 Abbvie Inc. Tratamiento mono (PSI-7977) o de combinación con AAD para su uso en el tratamiento del VHC
US8466159B2 (en) 2011-10-21 2013-06-18 Abbvie Inc. Methods for treating HCV
AR088463A1 (es) 2011-10-21 2014-06-11 Abbvie Inc Metodos para el tratamiento de hcv
RS62434B1 (sr) 2014-12-26 2021-11-30 Univ Emory Antivirusni n4-hidroksicitidin derivati
WO2017189978A1 (en) 2016-04-28 2017-11-02 Emory University Alkyne containing nucleotide and nucleoside therapeutic compositions and uses related thereto
EP3455218A4 (en) 2016-05-10 2019-12-18 C4 Therapeutics, Inc. C3 CARBON-BASED GLUTARIMIDE DEGRONIMERS FOR TARGET PROTEIN REDUCTION
EP3454856B1 (en) 2016-05-10 2024-09-11 C4 Therapeutics, Inc. Heterocyclic degronimers for target protein degradation
WO2017197036A1 (en) 2016-05-10 2017-11-16 C4 Therapeutics, Inc. Spirocyclic degronimers for target protein degradation
CN111372592A (zh) 2017-12-07 2020-07-03 埃默里大学 N4-羟基胞苷及衍生物和与其相关的抗病毒用途
AU2021225333A1 (en) * 2020-02-24 2022-08-11 Katholieke Universiteit Leuven Pyrrolopyridine and imidazopyridine antiviral compounds

Family Cites Families (113)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US462009A (en) * 1891-10-27 Four-hundred-day clock
US232937A (en) * 1880-10-05 Pipe cutter and wrench
US605836A (en) * 1898-06-21 George ashley
US89588A (en) * 1869-05-04 Improved apparatus for making illuminating-gas from gasoline
US510260A (en) * 1893-12-05 Electric-arc-lighting system
US78019A (en) * 1868-05-19 Albert b
US300726A (en) * 1884-06-17 Benjamin franklin opp
US637615A (en) * 1899-07-31 1899-11-21 Dluarej Norwood Jerauld Fire-escape.
US658625A (en) * 1899-08-16 1900-09-25 John Eicher Cream-ripening apparatus.
US706795A (en) * 1902-03-24 1902-08-12 Internat Silver Co Tilting vessel.
US1048742A (en) * 1912-04-17 1912-12-31 Theodore Scherba Trolley.
US1162196A (en) * 1913-07-05 1915-11-30 Safety Car Heating & Lighting Dynamo-mounting.
US1400241A (en) * 1919-04-09 1921-12-13 Sholdebrand Henry Oliver Stovepipe-cleaner
US1386923A (en) * 1920-01-02 1921-08-09 Edward C Capper Automatic fire-alarm device
US2191978A (en) * 1935-10-10 1940-02-27 Ig Farbenindustrie Ag Quaternary nitrogen compounds and process of preparing them
US2264115A (en) * 1939-01-14 1941-11-25 T & T Vicars Ltd Method and apparatus for treating dough
US2411662A (en) * 1943-05-13 1946-11-26 Geigy Ag J R Imino-di-fatty acid amide
US2548863A (en) * 1946-05-29 1951-04-17 Wyeth Corp Substituted glycinamides
US2516674A (en) * 1948-10-29 1950-07-25 Wyeth Corp Substituted glycinamide
US3035207A (en) * 1959-01-14 1962-05-15 A E I Lamp And Lighting Compan Circuit arrangement for operating electric discharge lamp
US3985891A (en) * 1973-02-03 1976-10-12 Boehringer Ingelheim Gmbh 2-Phenyl-imidazo (4,5-b)pyridines and salts thereof
SU813921A1 (ru) 1979-10-26 1986-12-23 Институт физико-органической химии и углехимии АН УССР Стирильные производные имидазо(4,5- @ )пиридиний иодида,обладающие фунгицидной активностью
SU851940A1 (ru) 1980-03-20 1988-04-30 Институт физико-органической химии и углехимии АН УССР Четвертичные соли имидазо @ 4,5-с @ пиридини ,обладающие антимикробной и фунгистатической активностью
SU860463A1 (ru) 1980-04-09 1998-05-27 Институт физико-органической химии и углехимии АН Украинской ССР Производные 4-амино-1,3-диметилимидазо [4,5-с] пиридин-2-она, обладающие акарицидным действием
SU1048742A1 (ru) 1981-03-30 1986-12-23 Институт физико-органической химии и углехимии АН УССР 2,4-Дистирилпроизводные имидазо-(4,5- @ )пиридини ,обладающие бактериостатической и фунгистатической активностью
US4358387A (en) * 1981-08-10 1982-11-09 Texaco Inc. Cylinder lubricating oil composition
CA1183847A (en) * 1981-10-01 1985-03-12 Georges Van Daele N-(3-hydroxy-4-piperidinyl)benzamide derivatives
US5137896A (en) * 1981-10-01 1992-08-11 Janssen Pharmaceutica N.V. N-(3-hydroxy-4-piperidinyl)benzamide derivatives
FR2527608B1 (fr) * 1982-05-28 1986-10-10 Sandoz Sa Nouveaux composes heterocycliques, leur preparation et leur utilisation comme medicaments
GB2148289B (en) 1983-10-17 1987-09-23 Lilly Co Eli 3-bicyclicpyridinium-methyl cephalosporins
US4692443A (en) * 1983-10-17 1987-09-08 Eli Lilly And Company 3-bicyclicpyridinium-methyl cephalosporins
GB8501542D0 (en) * 1985-01-22 1985-02-20 Erba Farmitalia 4 5 6 7-tetrahydro-imidazo(4 5-clpyridine derivatives
GB8530602D0 (en) 1985-12-12 1986-01-22 Fujisawa Pharmaceutical Co Heterocyclic compounds
ES2052544T3 (es) 1986-02-03 1994-07-16 Janssen Pharmaceutica Nv Composiciones anti-histaminicas que contienen n-heterociclil-4-piperidinaminas.
US4804658A (en) * 1986-09-15 1989-02-14 G. D. Searle & Co. Imidazopyridine derivatives and pharmaceutical compositions
NZ225447A (en) 1987-07-20 1991-12-23 Merck & Co Inc Piperazinyl derivatives of purine and purine isosteres and pharmaceutical compositions
US5057517A (en) * 1987-07-20 1991-10-15 Merck & Co., Inc. Piperazinyl derivatives of purines and isosteres thereof as hypoglycemic agents
US5227384A (en) * 1988-03-14 1993-07-13 G. D. Searle & Co. 5-substituted [4,5-c] imidazopyridines and pharmaceutical use thereof
US4914108A (en) * 1988-03-14 1990-04-03 G. D. Searle & Co. 5-substituted(4,5-c)imidazopyridine compounds which have useful platelet activating factor antagonistic activity
US5019581A (en) * 1988-03-14 1991-05-28 G. D. Searle & Co. 5-substituted (4,5-c) imidazopyridine compounds which have useful platelet activating factor antagonistic activity
US5302601A (en) * 1988-03-14 1994-04-12 G. D. Searle & Co. 5-substituted imidazo[4,5-c]pyridines
US5332744A (en) * 1989-05-30 1994-07-26 Merck & Co., Inc. Substituted imidazo-fused 6-membered heterocycles as angiotensin II antagonists
US4988707A (en) 1989-09-13 1991-01-29 G. D. Searle & Co. Pharmacologically active phenylalkanoyl substituted imidazo (4,5-C) pyridines
US4990518A (en) * 1989-09-13 1991-02-05 G. D. Searle & Co. Pharmacologically active heteroaryl substituted imidazo (4,5-c) pyridines
US5095873A (en) 1989-09-13 1992-03-17 Yamaha Hatsudoki Kabushiki Kaisha Fuel injection system and method for engine
FR2663332B1 (fr) 1990-06-15 1997-11-07 Roussel Uclaf Nouvelles cephalosporines comportant en position 3 un radical propenyle substitue par un ammonium quaternaire, leur procede de preparation, leur application comme medicaments, les compositions les renfermant et les nouveaux intermediaires obtenus.
US5011832A (en) * 1990-06-26 1991-04-30 Merck & Co., Inc. 2-biphenyl-carbapenem antibacterial agents
US5372808A (en) * 1990-10-17 1994-12-13 Amgen Inc. Methods and compositions for the treatment of diseases with consensus interferon while reducing side effect
JPH04327587A (ja) 1991-04-26 1992-11-17 Asahi Chem Ind Co Ltd ６’−ｃ−アルキル−３−デアザネプラノシンａ誘導体、その製造法およびその用途
GB9116056D0 (en) * 1991-07-24 1991-09-11 British Bio Technology Compounds
US5587372A (en) * 1991-12-12 1996-12-24 Roussel Uclaf Cephalosporins
GB9200245D0 (en) 1992-01-07 1992-02-26 British Bio Technology Compounds
GB9202792D0 (en) 1992-02-11 1992-03-25 British Bio Technology Compounds
DE4211474A1 (de) 1992-04-06 1993-10-07 Merck Patent Gmbh Imidazopyridine
US5208242A (en) 1992-08-26 1993-05-04 G. D. Searle & Co. 5-substituted-4-phenyl-5H-imidazo[4,5-c]pyridine derivatives
DE4230464A1 (de) 1992-09-11 1994-03-17 Merck Patent Gmbh Imidazolderivate
DE4236026A1 (de) * 1992-10-24 1994-04-28 Merck Patent Gmbh Imidazopyridine
JP3115455B2 (ja) 1992-12-18 2000-12-04 明治製菓株式会社 新規セファロスポリン誘導体
US5374638A (en) 1993-03-19 1994-12-20 Merck & Co., Inc. Six membered ring fused imidazoles substituted with phenoxyphenylacetic acid derivatives used to treat asthma
DE4309969A1 (de) 1993-03-26 1994-09-29 Bayer Ag Substituierte heteroanellierte Imidazole
DE4318813A1 (de) 1993-06-07 1994-12-08 Merck Patent Gmbh Imidazopyridine
DE4324580A1 (de) * 1993-07-22 1995-01-26 Thomae Gmbh Dr K Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
US5486525A (en) * 1993-12-16 1996-01-23 Abbott Laboratories Platelet activating factor antagonists: imidazopyridine indoles
US5563143A (en) 1994-09-21 1996-10-08 Pfizer Inc. Catechol diether compounds as inhibitors of TNF release
US6506876B1 (en) * 1994-10-11 2003-01-14 G.D. Searle & Co. LTA4 hydrolase inhibitor pharmaceutical compositions and methods of use
US5585492A (en) * 1994-10-11 1996-12-17 G. D. Searle & Co. LTA4 Hydrolase inhibitors
US5635514A (en) * 1994-10-25 1997-06-03 G. D. Searle & Company Heteroaralkyl and heteroarylthioalkyl thiophenolic compounds as 5-lipoxgenase inhibitors
US5880140A (en) * 1996-04-03 1999-03-09 Merck & Co., Inc. Biheteroaryl inhibitors of farnesyl-protein transferase
US5854265A (en) * 1996-04-03 1998-12-29 Merck & Co., Inc. Biheteroaryl inhibitors of farnesyl-protein transferase
US5874452A (en) * 1996-04-03 1999-02-23 Merck & Co., Inc. Biheteroaryl inhibitors of farnesyl-protein transferase
US6080870A (en) * 1996-04-03 2000-06-27 Merck & Co., Inc. Biaryl substituted imidazole compounds useful as farnesyl-protein transferase inhibitors
US5872136A (en) * 1996-04-03 1999-02-16 Merck & Co., Inc. Arylheteroaryl inhibitors of farnesyl-protein transferase
US5883105A (en) * 1996-04-03 1999-03-16 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
US6063930A (en) * 1996-04-03 2000-05-16 Merck & Co., Inc. Substituted imidazole compounds useful as farnesyl-protein transferase inhibitors
US5859035A (en) * 1996-04-03 1999-01-12 Merck & Co., Inc. Arylheteroaryl inhibitors of farnesyl-protein transferase
US5939557A (en) * 1996-04-03 1999-08-17 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
US6015817A (en) * 1996-12-05 2000-01-18 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
NZ504800A (en) * 1997-11-28 2001-10-26 Sumitomo Pharma 6-Amino-9-benzyl-8-hydroxy-purine derivatives and interferon inducers, antiviral agents, anticancer agents and therapeutic agents for immunologic diseases thereof
DE19845153A1 (de) 1998-10-01 2000-04-06 Merck Patent Gmbh Imidazo[4,5]-pyridin-4-on-derivate
US6271380B1 (en) 1998-12-30 2001-08-07 Dupont Pharmaceuticals Company 1H-imidazo[4,5-d]pyridazin-7-ones, 3H-imidazo-[4,5-c]pyridin-4-ones and corresponding thiones as corticotropin releasing factor (CRF) receptor ligands
DE69932263T2 (de) * 1999-01-08 2007-06-06 Chisso Corp. Borderivate und organische elektrolumineszierende verbindungen
DE19900471A1 (de) 1999-01-08 2000-07-13 Merck Patent Gmbh Imidazo[4,5c]-pyridin-4-on-derivate
EP1182195A4 (en) * 1999-05-07 2003-03-26 Takeda Chemical Industries Ltd CYCLIC CONNECTIONS AND APPLICATIONS THEREOF
US6844367B1 (en) * 1999-09-17 2005-01-18 Millennium Pharmaceuticals, Inc. Benzamides and related inhibitors of factor Xa
CN1623984A (zh) 1999-12-27 2005-06-08 日本烟草产业株式会社 稠环化合物及其药物用途
US6770666B2 (en) * 1999-12-27 2004-08-03 Japan Tobacco Inc. Fused-ring compounds and use thereof as drugs
EP1259485B1 (en) * 2000-02-29 2005-11-30 Millennium Pharmaceuticals, Inc. BENZAMIDES AND RELATED INHIBITORS OF FACTOR Xa
EP1132381A1 (en) 2000-03-08 2001-09-12 Cermol S.A. Ester derivatives of dimethylpropionic acid and pharmaceutical compositions containing them
US6448281B1 (en) * 2000-07-06 2002-09-10 Boehringer Ingelheim (Canada) Ltd. Viral polymerase inhibitors
KR100892614B1 (ko) 2001-04-17 2009-04-09 다이닛본 스미토모 세이야꾸 가부시끼가이샤 신규 아데닌 유도체
AR035543A1 (es) * 2001-06-26 2004-06-16 Japan Tobacco Inc Agente terapeutico para la hepatitis c que comprende un compuesto de anillo condensado, compuesto de anillo condensado, composicion farmaceutica que lo comprende, compuestos de benzimidazol, tiazol y bifenilo utiles como intermediarios para producir dichos compuestos, uso del compuesto de anillo con
US20030073836A1 (en) * 2001-07-05 2003-04-17 Boehringer Ingelheim Pharma Kg Heteroarylcarboxylic acid amides, the preparation thereof and their use as pharmaceutical compositions
US6841566B2 (en) 2001-07-20 2005-01-11 Boehringer Ingelheim, Ltd. Viral polymerase inhibitors
EP2335700A1 (en) 2001-07-25 2011-06-22 Boehringer Ingelheim (Canada) Ltd. Hepatitis C virus polymerase inhibitors with a heterobicylic structure
US7294457B2 (en) * 2001-08-07 2007-11-13 Boehringer Ingelheim (Canada) Ltd. Direct binding assay for identifying inhibitors of HCV polymerase
DE10140246A1 (de) * 2001-08-09 2003-03-06 Forsch Pigmente Und Lacke E V Verfahren zur Behandlung von Oberflächen von Substraten
WO2003026587A2 (en) * 2001-09-26 2003-04-03 Bristol-Myers Squibb Company Compounds useful for treating hepatitus c virus
AU2003205570A1 (en) 2002-01-10 2003-07-24 Boehringer Ingelheim Pharma Gmbh And Co. Kg Combination of mtp inhibitors or apob secretion inhibitors with fibrates for use as drugs
GB0215293D0 (en) * 2002-07-03 2002-08-14 Rega Foundation Viral inhibitors
SI1532149T1 (sl) 2002-08-21 2010-05-31 Boehringer Ingelheim Pharma amino piperidin il ksantini njihova priprava in njihova uporaba kot zdravila
US20040097574A1 (en) 2002-08-29 2004-05-20 Boehringer Ingelheim Pharmaceuticals, Inc. Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
MXPA05006354A (es) * 2002-12-13 2005-08-26 Smithkline Beecham Corp Antagonistas ccr5 como agentes terapeuticos.
US7098231B2 (en) * 2003-01-22 2006-08-29 Boehringer Ingelheim International Gmbh Viral polymerase inhibitors
US7223785B2 (en) * 2003-01-22 2007-05-29 Boehringer Ingelheim International Gmbh Viral polymerase inhibitors
DE602004022633D1 (de) * 2003-01-30 2009-10-01 Boehringer Ingelheim Pharma 2,4-diaminopyrimidinderivate, die sich als inhibitoren von pkc-theta eignen
US7566707B2 (en) * 2003-06-18 2009-07-28 Boehringer Ingelheim International Gmbh Imidazopyridazinone and imidazopyridone derivatives, the preparation thereof and their use as pharmaceutical compositions
AU2004291262C1 (en) * 2003-11-05 2011-08-11 F. Hoffmann-La Roche Ag Phenyl derivatives as PPAR agonists
US7648998B2 (en) * 2003-12-22 2010-01-19 K.U. Leuven Research & Development Imidazo 4,5-c pyridine compounds and methods of antiviral treatment
CA2574220C (en) * 2004-07-27 2014-09-16 Gilead Sciences, Inc. Imidazo[4,5-d]pyrimidines, their uses and methods of preparation
CN101018843B (zh) 2004-09-13 2011-05-11 西巴特殊化学品控股有限公司 烷基氨基乙酰胺润滑添加剂
AU2005319167B2 (en) * 2004-12-21 2011-09-29 Gilead Sciences, Inc. Imidazo[4,5-C]pyridine compound and method of antiviral treatment
WO2008005519A2 (en) * 2006-07-07 2008-01-10 Gilead Sciences, Inc. Novel pyridazine compound and use thereof
UA99466C2 (en) 2007-07-06 2012-08-27 Гилиад Сайенсиз, Инк. Crystalline pyridazine compound

Also Published As

Publication number Publication date
ES2381890T3 (es) 2012-06-01
NZ548074A (en) 2010-08-27
EP1706403B1 (en) 2012-02-08
CA2549606C (en) 2015-10-06
AU2011202214B2 (en) 2012-12-20
EP2546254A1 (en) 2013-01-16
KR20060132850A (ko) 2006-12-22
EP2161273B1 (en) 2015-04-15
WO2005063744A2 (en) 2005-07-14
DK2161273T3 (en) 2015-07-20
KR101131589B1 (ko) 2012-04-13
DK1706403T3 (da) 2012-04-23
US20050222198A1 (en) 2005-10-06
PL1706403T3 (pl) 2012-07-31
WO2005063744A3 (en) 2005-09-01
AU2011202214A1 (en) 2011-06-16
JP2011148835A (ja) 2011-08-04
IL176298A (en) 2015-06-30
HK1092793A1 (en) 2007-02-16
US20070244148A1 (en) 2007-10-18
AU2004309390A1 (en) 2005-07-14
PT1706403E (pt) 2012-04-23
SG149067A1 (en) 2009-01-29
CA2549606A1 (en) 2005-07-14
AU2004309390B2 (en) 2011-06-02
US8329727B2 (en) 2012-12-11
EP1706403A2 (en) 2006-10-04
NZ595000A (en) 2013-03-28
JP5395844B2 (ja) 2014-01-22
JP2013221030A (ja) 2013-10-28
US7648998B2 (en) 2010-01-19
US20100028301A1 (en) 2010-02-04
SI2161273T1 (sl) 2015-10-30
IL176298A0 (en) 2006-10-05
EP1706403B9 (en) 2012-07-25
JP2007518720A (ja) 2007-07-12
ATE544765T1 (de) 2012-02-15
EP2161273A1 (en) 2010-03-10
JP4970048B2 (ja) 2012-07-04

Similar Documents

Publication Publication Date Title
CY1112733T1 (el) Ενωσεις ιμιδαζο [4,5-c]πυριδινης και μεθοδοι αντι-ιικης θεραπειας
NO20035583D0 (no) Imidazo` 1,2-A pyridinderivater for profylakse og behandling av herpes virale infeksjoner
MXPA04012965A (es) Inhibidores virales.
DK1353911T3 (da) Antivirale midler
ATE296826T1 (de) Pyrazolo(1,5)pyridinderivate
ATE361288T1 (de) N-(3,-dimethylindolin-6-yl)ä2-ä(4-
CY1107301T1 (el) Ιμιδαζο και θειαζολοπυριδινες ως αναστολεις κινασης jak3
IL187438A0 (en) Pyrrolopyridine derivatives and pharmaceutical compositions containing the same
EA201000643A1 (ru) Замещенное производное этилендиамина для лечения микобактериальных заболеваний и фармацевтическая композиция на его основе
SE0102764D0 (sv) Compounds
DE602004024900D1 (de) Substituierte 2,3-dihydro-1h-isoindol-1-one derivate und anwendungsverfahren
DE60003863D1 (de) Dioxocyclopentylhydroxamsäure
ECSP055844A (es) Nuevos compuestos triciclicos
ATE372995T1 (de) Benzo(b)(1,4)dioxepinderivate
PT992509E (pt) Novos derivados macrolidos
WO2003053971A8 (en) Pyridoquinoxaline antivirals
ATE426601T1 (de) Imidazoa4,5-cupyridinverbindung und verfahren zur antiviralen behandlung
BRPI0409376A (pt) derivados de indeno como agentes farmacêuticos
NO20044548L (no) Fremgangsmate for fremstilling av 6-alkaliden-penemderivater
BRPI0408423A (pt) composições farmacêuticas compreendendo uma combinação de rapamicina ou seus derivados e pimecrolimus para o tratamento de doenças mediadas imunologicamente e por inflamação
BR0309996A (pt) Composto, composição farmacêutica, método de tratar ou melhorar doenças ou condições proliferativas, uso de um composto, e, método de tratar ou melhorar doenças inflamatórias
BR0207102A (pt) Forma cristalina, composição farmacêutica, uso de uma forma cristalina, e, método para a prevenção ou o tratamento de doença
NO20063331L (no) Nikotinacetylcholinreseptorligander
PT1404656E (pt) Derivados de benzimidazole para o tratamento de doencas associadas a activacao de microglia como doencas inflamatorias, alergicas, infecciosas ou autoimunes
MY146833A (en) Imidazole[4,5-c]pyridine copmounds and methods of antiviral treatment